{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:33:37Z","timestamp":1783625617361,"version":"3.55.0"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20180371"],"award-info":[{"award-number":["BK20180371"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21876026"],"award-info":[{"award-number":["21876026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671034"],"award-info":[{"award-number":["31671034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173545"],"award-info":[{"award-number":["82173545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.envpol.2022.120676","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T17:32:01Z","timestamp":1668447121000},"page":"120676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["The DNA damage potential of quantum dots: Toxicity, mechanism and challenge"],"prefix":"10.1016","volume":"317","author":[{"given":"Yongshuai","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4921-9735","authenticated-orcid":false,"given":"Meng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2022.120676_bib1","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.2147\/IJN.S357980","article-title":"Biomedical applications of quantum dots: overview, challenges, and clinical potential","volume":"17","author":"Abdellatif","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.envpol.2022.120676_bib2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.msec.2016.06.055","article-title":"Influence of heavy nanocrystals on spermatozoa and fertility of mammals","volume":"69","author":"Akhavan","year":"2016","journal-title":"Materials Science & Engineering C-Materials for Biological Applications"},{"key":"10.1016\/j.envpol.2022.120676_bib3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.micinf.2014.10.001","article-title":"Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle","volume":"16","author":"Almai-Pallag","year":"2014","journal-title":"Microb. Infect."},{"key":"10.1016\/j.envpol.2022.120676_bib4","doi-asserted-by":"crossref","first-page":"10005","DOI":"10.1021\/jp8018606","article-title":"Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots","volume":"112","author":"Anas","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.envpol.2022.120676_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.freeradbiomed.2017.05.015","article-title":"Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death","volume":"110","author":"Arakha","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2022.120676_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12951-017-0312-3","article-title":"Quantifying engineered nanomaterial toxicity: comparison of common cytotoxicity and gene expression measurements","volume":"15","author":"Atha","year":"2017","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.envpol.2022.120676_bib7","series-title":"Guidance for Industry: Safety of Nanomaterials in Cosmetic Products","year":"2014"},{"key":"10.1016\/j.envpol.2022.120676_bib8","first-page":"1","article-title":"Mechanism of DNA binding and cleavage","volume":"2","author":"Mathew","year":"2014","journal-title":"Biomedicine and Biotechnology"},{"key":"10.1016\/j.envpol.2022.120676_bib9","series-title":"Carbon Dots: an Excellent Fluorescent Probe for Contaminant Sensing and Remediation","author":"Pardhiya","year":"2022"},{"key":"10.1016\/j.envpol.2022.120676_bib10","first-page":"129","article-title":"Genotoxic and mutagenic effects of lipid-coated CdSe\/ZnS quantum dots","volume":"750","author":"Aye","year":"2013","journal-title":"Mutat. Res., Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.envpol.2022.120676_bib11","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/nbt1104-1360","article-title":"Quantum dots as photosensitizers?","volume":"22","author":"Bakalova","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envpol.2022.120676_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.tcb.2019.11.005","article-title":"Coupling DNA damage and repair: an essential safeguard during programmed DNA double-strand breaks?","volume":"30","author":"B\u00e9termier","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.envpol.2022.120676_bib13","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2217\/nnm-2018-0214","article-title":"Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect","volume":"14","author":"Buz","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.envpol.2022.120676_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/mutage\/gew052","article-title":"Impact of nanoparticles on DNA repair processes: current knowledge and working hypotheses","volume":"32","author":"Carriere","year":"2017","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envpol.2022.120676_bib15","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.biomaterials.2011.10.070","article-title":"The cytotoxicity of cadmium-based quantum dots","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.envpol.2022.120676_bib16","article-title":"InP quantum dots: synthesis and lighting applications","volume":"16","author":"Chen","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.envpol.2022.120676_bib17","article-title":"Near\u2010Infrared\u2010II quantum dots for in vivo imaging and cancer therapy","volume":"18","author":"Chen","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.envpol.2022.120676_bib18","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/jat.3598","article-title":"Comparative study of cyto- and genotoxic potential with mechanistic insights of tungsten oxide nano- and microparticles in lung carcinoma cells","volume":"38","author":"Chinde","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00109-007-0274-2","article-title":"Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells","volume":"86","author":"Choi","year":"2008","journal-title":"Journal of Molecular Medicine-Jmm"},{"key":"10.1016\/j.envpol.2022.120676_bib20","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1166\/jnn.2012.5781","article-title":"Cyto-\/genotoxic effect of CdSe\/ZnS quantum dots in human lung adenocarcinoma cells for potential photodynamic UV therapy applications","volume":"12","author":"Choi","year":"2012","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.envpol.2022.120676_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41568-020-0267-9","article-title":"Prostate carcinogenesis: inflammatory storms","volume":"20","author":"de Bono","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.envpol.2022.120676_bib22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.msec.2019.04.058","article-title":"Graphene quantum dots unraveling: green synthesis, characterization, radiolabeling with 99mTc, in vivo behavior and mutagenicity","volume":"102","author":"de Menezes","year":"2019","journal-title":"Materials Science & Engineering C-Materials for Biological Applications"},{"key":"10.1016\/j.envpol.2022.120676_bib23","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1021\/acs.analchem.5b01576","article-title":"DNA nanostructure-based magnetic beads for potentiometric aptasensing","volume":"87","author":"Ding","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2022.120676_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2021.109065","article-title":"Toxic effects of ZnSe\/ZnS quantum dots on the reproduction and genotoxiticy of rare minnow (Gobiocypris rarus)","volume":"247","author":"Ding","year":"2021","journal-title":"Comparative Biochemistry and Physiology C-Toxicology & Pharmacology"},{"key":"10.1016\/j.envpol.2022.120676_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151078","article-title":"LncRNA MT1DP promotes cadmium-induced DNA replication stress by inhibiting chromatin recruitment of SMARCAL1","volume":"807","author":"Feng","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.120676_bib26","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1462-5822.2006.00751.x","article-title":"Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages","volume":"8","author":"Fink","year":"2006","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.envpol.2022.120676_bib27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.aquatox.2007.11.013","article-title":"Ecotoxicity of CdTe quantum dots to freshwater mussels: impacts on immune system, oxidative stress and genotoxicity","volume":"86","author":"Gagn\u00e9","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib28","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.2147\/IJN.S107752","article-title":"An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin","volume":"11","author":"Galdiero","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.envpol.2022.120676_bib29","doi-asserted-by":"crossref","first-page":"13458","DOI":"10.1039\/C9NR01021A","article-title":"An automatable platform for genotoxicity testing of nanomaterials based on the fluorometric \u03b3-H2AX assay reveals no genotoxicity of properly surface-shielded cadmium-based quantum dots","volume":"11","author":"Gei\u00dfler","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.envpol.2022.120676_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17113782","article-title":"The effects of cadmium toxicity","volume":"17","author":"Genchi","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envpol.2022.120676_bib31","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.3390\/ijms18112351","article-title":"Autophagy roles in the modulation of DNA repair pathways","volume":"18","author":"Gomes","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2022.120676_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1289\/ehp.8284","article-title":"A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors","volume":"114","author":"Hardman","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2022.120676_bib33","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jat.3745","article-title":"DNA damage in BV-2 cells: an important supplement to the neurotoxicity of CdTe quantum dots","volume":"39","author":"He","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202001371","article-title":"Black phosphorus quantum dots cause nephrotoxicity in organoids, mice, and human cells","volume":"16","author":"He","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.envpol.2022.120676_bib35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tcb.2016.11.011","article-title":"Repair, reuse, recycle: the expanding role of autophagy in genome maintenance","volume":"27","author":"Hewitt","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.envpol.2022.120676_bib36","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/jat.4083","article-title":"Research advance on cell imaging and cytotoxicity of different types of quantum dots","volume":"41","author":"Huang","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/mutage\/geu077","article-title":"Critical factors to be considered when testing nanomaterials for genotoxicity with the comet assay","volume":"30","author":"Huk","year":"2015","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envpol.2022.120676_bib38","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cell.2012.07.019","article-title":"The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model","volume":"150","author":"Hulsmann","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2022.120676_bib39","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1002\/ijc.23173","article-title":"Inflammation and cancer: an ancient link with novel potentials","volume":"121","author":"Hussain","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.envpol.2022.120676_bib40","series-title":"Carbon Black, Titanium Dioxide, and Talc","year":"2010"},{"key":"10.1016\/j.envpol.2022.120676_bib41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-8977-6-2","article-title":"Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-\/- mice","volume":"6","author":"Jacobsen","year":"2009","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib42","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1074\/jbc.273.16.9357","article-title":"Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis","volume":"273","author":"Janicke","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2022.120676_bib43","first-page":"54","article-title":"Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation","volume":"753","author":"Ju","year":"2013","journal-title":"Mutat. Res., Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.envpol.2022.120676_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031068","article-title":"CdSe\/ZnS core-shell-type quantum dot nanoparticles disrupt the cellular homeostasis in cellular blood-brain barrier models","volume":"22","author":"Kania","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2022.120676_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquatox.2014.02.003","article-title":"Cytotoxicity and cellular mechanisms involved in the toxicity of CdS quantum dots in hemocytes and gill cells of the mussel Mytilus galloprovincialis","volume":"153","author":"Katsumiti","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib46","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0960327119843578","article-title":"Dose- and duration-dependent cytotoxicity and genotoxicity in human hepato carcinoma cells due to CdTe QDs exposure","volume":"38","author":"Katubi","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081808","article-title":"Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis","volume":"18","author":"Kawanishi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2022.120676_bib48","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.2147\/IJN.S89593","article-title":"Carcinogenic activity of PbS quantum dots screened using exosomal biomarkers secreted from HEK293 cells","volume":"10","author":"Kim","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.envpol.2022.120676_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201700217","article-title":"Ultrathin quantum dot display integrated with wearable electronics","volume":"29","author":"Kim","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.envpol.2022.120676_bib50","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.1021\/acs.jpcb.0c05882","article-title":"Theoretical evaluation of DNA genotoxicity of graphene quantum dots: a combination of density functional theory and molecular dynamics simulations","volume":"124","author":"Kong","year":"2020","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.envpol.2022.120676_bib51","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/abaa71","article-title":"Synergistic effect of CdSe quantum dots (QDs) and PC (61) BM on ambient-air processed ZnO QDs\/PCDTBT: PC (61) BM:CdSe QDs\/MoO3 based ternary organic solar cells","volume":"31","author":"Kumar","year":"2020","journal-title":"Nanotechnology"},{"key":"10.1016\/j.envpol.2022.120676_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/397657","article-title":"Effects of exposure to semiconductor nanoparticles on aquatic organisms","author":"Leigh","year":"2012","journal-title":"J. Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.etap.2011.08.001","article-title":"Noncovalent interactions between hydroxylated polycyclic aromatic hydrocarbon and DNA: molecular docking and QSAR study","volume":"32","author":"Li","year":"2011","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2022.120676_bib54","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-94-017-8739-0_6","article-title":"Atomic force microscopy study of the interaction of DNA and nanoparticles","volume":"811","author":"Li","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.envpol.2022.120676_bib55","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.biomaterials.2016.04.014","article-title":"Evaluation of toxic effects of CdTe quantum dots on the reproductive system in adult male mice","volume":"96","author":"Li","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.envpol.2022.120676_bib56","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/kfy090","article-title":"Hydroxylated-graphene quantum dots induce DNA damage and disrupt microtubule structure in human esophageal epithelial cells","volume":"164","author":"Li","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2022.120676_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141385","article-title":"Microarray analysis of gene expression differences in microglia after exposure to graphene quantum dots","volume":"749","author":"Liang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.120676_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104827","article-title":"CdTe and CdTe@ZnS quantum dots induce IL-1\u03b2-mediated inflammation and pyroptosis in microglia","volume":"65","author":"Liang","year":"2020","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2022.120676_bib59","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3109\/17435390.2010.539712","article-title":"Cd\/Se\/Te-based quantum dot 705 modulated redox homeostasis with hepatotoxicity in mice","volume":"5","author":"Lin","year":"2011","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.envpol.2022.120676_bib60","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1002\/jcp.28062","article-title":"The effects of graphene quantum dots on the maturation of mouse oocytes and development of offspring","volume":"234","author":"Lin","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.envpol.2022.120676_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122606","article-title":"Toxicity of different types of quantum dots to mammalian cells in vitro: an update review","volume":"399","author":"Liu","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.120676_bib62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cbpc.2017.04.009","article-title":"CuInS2\/ZnS QD exposure induces developmental toxicity, oxidative stress and DNA damage in rare minnow (Gobiocypris rarus) embryos and larvae","volume":"198","author":"Liu","year":"2017","journal-title":"Comparative Biochemistry and Physiology C-Toxicology & Pharmacology"},{"key":"10.1016\/j.envpol.2022.120676_bib63","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/17435390.2013.773464","article-title":"Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles","volume":"8","author":"Magdolenova","year":"2013","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.envpol.2022.120676_bib64","first-page":"97","article-title":"Genotoxic capacity of Cd\/Se semiconductor quantum dots with differing surface chemistries","volume":"31","author":"Manshian","year":"2016","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envpol.2022.120676_bib65","doi-asserted-by":"crossref","first-page":"7084","DOI":"10.1016\/j.biomaterials.2012.06.060","article-title":"Graphene quantum dots as autophagy-inducing photodynamic agents","volume":"33","author":"Markovic","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.envpol.2022.120676_bib66","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.envpol.2017.02.043","article-title":"Multigenerational effects and DNA alterations of QDs-Indolicidin on Daphnia magna","volume":"224","author":"Maselli","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2022.120676_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ma13102221","article-title":"Susceptibility of HepG2 cells to silver nanoparticles in combination with other metal\/metal oxide nanoparticles","volume":"13","author":"Meczynska-wielgosz","year":"2020","journal-title":"Materials"},{"key":"10.1016\/j.envpol.2022.120676_bib68","doi-asserted-by":"crossref","first-page":"20399","DOI":"10.1021\/acsami.7b02900","article-title":"Black phosphorus quantum dot induced oxidative stress and toxicity in living cells and mice","volume":"9","author":"Mu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.envpol.2022.120676_bib69","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0748233718763517","article-title":"Cadmium telluride quantum dots induce apoptosis in human breast cancer cell lines","volume":"34","author":"Naderi","year":"2018","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.envpol.2022.120676_bib70","doi-asserted-by":"crossref","first-page":"8397","DOI":"10.1021\/nn305532k","article-title":"Functionalization-dependent induction of cellular survival pathways by CdSe quantum dots in primary normal human bronchial epithelial cells","volume":"7","author":"Nagy","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.envpol.2022.120676_bib71","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cbi.2018.06.032","article-title":"Effects of silver sulfide quantum dots coated with 2-mercaptopropionic acid on genotoxic and apoptotic pathways in vitro","volume":"291","author":"Ozkan","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2022.120676_bib72","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tox.2016.11.012","article-title":"Markers for toxicity to HepG2 exposed to cadmium sulphide quantum dots; damage to mitochondria","volume":"374","author":"Paesano","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2022.120676_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102157","article-title":"Reactive oxygen species trigger NF-\u03baB-mediated NLRP3 inflammasome activation involvement in low-dose CdTe QDs exposure-induced hepatotoxicity","volume":"47","author":"Pang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2022.120676_bib74","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0889-8553(21)00265-X","article-title":"Helicobacter pylori and gastric cancer","volume":"22","author":"Parsonnet","year":"1993","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.envpol.2022.120676_bib75","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1001-0742(12)60015-1","article-title":"In vitro cytotoxicity of CdSe\/ZnS quantum dots with different surface coatings to human keratinocytes HaCaT cells","volume":"25","author":"Pathakoti","year":"2013","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.envpol.2022.120676_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ma12101702","article-title":"Endocytosis and lack of cytotoxicity of alkyl-capped silicon quantum dots prepared from porous silicon","volume":"12","author":"Phatvej","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.envpol.2022.120676_bib77","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1111\/j.1742-4658.2009.07324.x","article-title":"Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability","volume":"276","author":"Przybytkowski","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.envpol.2022.120676_bib78","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/09603123.2013.835032","article-title":"Cellular mechanisms of cadmium-induced toxicity: a review","volume":"24","author":"Rani","year":"2014","journal-title":"Int. J. Environ. Health Res."},{"key":"10.1016\/j.envpol.2022.120676_bib79","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.marenvres.2014.07.009","article-title":"Immunocytotoxicity, cytogenotoxicity and genotoxicity of cadmium-based quantum dots in the marine mussel Mytilus galloprovincialis","volume":"101","author":"Rocha","year":"2014","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.envpol.2022.120676_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122875","article-title":"Cytotoxicity of black phosphorus quantum dots on lung-derived cells and the underlying mechanisms","volume":"402","author":"Ruan","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.120676_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrrev.2020.108296","article-title":"Genotoxicity assessment of carbon-based nanomaterials; Have their unique physicochemical properties made them double-edged swords?","volume":"783","author":"Samadian","year":"2020","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.envpol.2022.120676_bib82","series-title":"Guidance on the Safety Assessment of Nanomaterials in Cosmetics; SCCS\/1611\/19","year":"2019"},{"key":"10.1016\/j.envpol.2022.120676_bib83","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/10408444.2010.494174","article-title":"Review: do engineered nanoparticles pose a significant threat to the aquatic environment?","volume":"40","author":"Scown","year":"2010","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib84","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jsps.2019.05.006","article-title":"Graphene quantum dots: synthesis, characterization, cell viability, genotoxicity for biomedical applications","volume":"27","author":"Senel","year":"2019","journal-title":"Saudi Pharmaceut. J."},{"key":"10.1016\/j.envpol.2022.120676_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70796-3","article-title":"DNA-damage and cell cycle arrest initiated anti-cancer potency of super tiny carbon dots on MCF7 cell line","volume":"10","author":"\u015eim\u015fek","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2022.120676_bib86","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1016\/j.biomaterials.2009.04.009","article-title":"NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials","volume":"30","author":"Singh","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.envpol.2022.120676_bib87","doi-asserted-by":"crossref","first-page":"22049","DOI":"10.1039\/D0NR03957H","article-title":"Toxicity of nanomaterials due to photochemical degradation and the release of heavy metal ions","volume":"12","author":"Sobhanan","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.envpol.2022.120676_bib88","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1166\/jbn.2015.1853","article-title":"The effect of intracellular degradation on cytotoxicity and cell labeling efficacy of inorganic ligand-stabilized colloidal CdSe\/CdS quantum dots","volume":"11","author":"Soenen","year":"2015","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.envpol.2022.120676_bib89","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.taap.2013.06.004","article-title":"Cadmium sulfate and CdTe-quantum dots alter DNA repair in zebrafish (Danio rerio) liver cells","volume":"272","author":"Tang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2022.120676_bib90","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.chemosphere.2014.06.011","article-title":"Distinct expression profiles of stress defense and DNA repair genes in Daphnia pulex exposed to cadmium, zinc, and quantum dots","volume":"120","author":"Tang","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2022.120676_bib91","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1039\/C6TX00209A","article-title":"Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner","volume":"5","author":"Tian","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.envpol.2022.120676_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2022.120676_bib93","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/sj.cdd.4400944","article-title":"Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation","volume":"8","author":"van Loo","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.envpol.2022.120676_bib94","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4274\/tjps.galenos.2018.85619","article-title":"An in vitro study on the cytotoxicity and genotoxicity of silver sulfide quantum dots coated with meso-2,3-dimercaptosuccinic acid","volume":"16","author":"Vardar","year":"2019","journal-title":"Turk. J. Pharm. Sci."},{"key":"10.1016\/j.envpol.2022.120676_bib95","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/etc.4080","article-title":"Environmental risk assessment of engineered nano-SiO2, nano iron oxides, nano-CeO2, nano-Al2O3, and quantum dots","volume":"37","author":"Wang","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2022.120676_bib96","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.2147\/IJN.S157135","article-title":"Dysfunction of various organelles provokes multiple cell death after quantum dot exposure","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.envpol.2022.120676_bib97","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.scitotenv.2017.12.334","article-title":"Review of in vitro toxicological research of quantum dot and potentially involved mechanisms","volume":"625","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.120676_bib98","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.talanta.2009.09.014","article-title":"Study the damage of DNA molecules induced by three kinds of aqueous nanoparticles","volume":"80","author":"Wang","year":"2010","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2022.120676_bib99","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.1166\/jnn.2010.2681","article-title":"Bioeffects of CdTe quantum dots on human umbilical vein endothelial cells","volume":"10","author":"Wang","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.envpol.2022.120676_bib100","doi-asserted-by":"crossref","first-page":"9894","DOI":"10.1039\/C5NR01734C","article-title":"Can graphene quantum dots cause DNA damage in cells?","volume":"7","author":"Wang","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.envpol.2022.120676_bib101","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.aca.2020.02.028","article-title":"MoS2 QDs-Based sensor for measurement of fluazinam with triple signal output","volume":"1108","author":"Wang","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.envpol.2022.120676_bib102","doi-asserted-by":"crossref","first-page":"20820","DOI":"10.1039\/C9NR06778G","article-title":"The role of NLRP3 inflammasome activation in the neuroinflammatory responses to Ag2Se quantum dots in microglia","volume":"11","author":"Wu","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.envpol.2022.120676_bib103","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4016402","article-title":"Developmental toxicity of carbon quantum dots to the embryos\/larvae of rare minnow (gobiocypris rarus)","volume":"2016","author":"Xiao","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.envpol.2022.120676_bib104","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12989-018-0279-8","article-title":"Graphene quantum dots in alveolar macrophage: uptake-exocytosis, accumulation in nuclei, nuclear responses and DNA cleavage","volume":"15","author":"Xu","year":"2018","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2022.120676_bib105","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.scitotenv.2019.01.356","article-title":"Genotoxic response and damage recovery of macrophages to graphene quantum dots","volume":"664","author":"Xu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2022.120676_bib106","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1039\/c1nr10238a","article-title":"A facile method for the assessment of DNA damage induced by UV-activated nanomaterials","volume":"3","author":"Yamazaki","year":"2011","journal-title":"Nanoscale"},{"key":"10.1016\/j.envpol.2022.120676_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122327","article-title":"CdSe\/ZnS quantum dots induced spermatogenesis dysfunction via autophagy activation","volume":"398","author":"Yang","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2022.120676_bib108","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1080\/17435390.2019.1668068","article-title":"Oral administration of hydroxylated-graphene quantum dots induces intestinal injury accompanying the loss of intestinal stem cells and proliferative progenitor cells","volume":"13","author":"Yu","year":"2019","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.envpol.2022.120676_bib109","series-title":"Apoptotic DNA Fragmentation and Tissue Homeostasis","first-page":"84","author":"Zhang","year":"2002"},{"key":"10.1016\/j.envpol.2022.120676_bib110","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1021\/nn301218z","article-title":"Ag2S quantum dot: a bright and biocompatible fluorescent nanoprobe in the second near-infrared window","volume":"6","author":"Zhang","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.envpol.2022.120676_bib111","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.3390\/ijerph121013435","article-title":"Threshold dose of three types of quantum dots (QDs) induces oxidative stress triggers DNA damage and apoptosis in mouse fibroblast L929 cells","volume":"12","author":"Zhang","year":"2015","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envpol.2022.120676_bib112","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/ptr.4942","article-title":"Potential genotoxicity of traditional Chinese medicinal plants and phytochemicals: an overview","volume":"27","author":"Zhou","year":"2013","journal-title":"Phytother Res."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749122018905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749122018905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:00:51Z","timestamp":1759446051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749122018905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":112,"alternative-id":["S0269749122018905"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2022.120676","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The DNA damage potential of quantum dots: Toxicity, mechanism and challenge","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2022.120676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120676"}}