{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:52:14Z","timestamp":1777866734820,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2008085J38"],"award-info":[{"award-number":["2008085J38"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["81973079"],"award-info":[{"award-number":["81973079"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2022YFC2702904"],"award-info":[{"award-number":["2022YFC2702904"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["82273664"],"award-info":[{"award-number":["82273664"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2020xkjT005"],"award-info":[{"award-number":["2020xkjT005"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.envpol.2023.121602","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T14:41:10Z","timestamp":1680878470000},"page":"121602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction"],"prefix":"10.1016","volume":"328","author":[{"given":"Yu-Feng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Long","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Xiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2023.121602_bib1","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1007\/s43032-020-00385-2","article-title":"Placental compartmentalization of lipid metabolism: implications for Singleton and Twin pregnancies","volume":"28","author":"Abascal-Saiz","year":"2021","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.envpol.2023.121602_bib2","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.ajpath.2018.07.021","article-title":"Trophoblast-specific conditional Atg7 knockout mice develop gestational hypertension","volume":"188","author":"Aoki","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.envpol.2023.121602_bib3","doi-asserted-by":"crossref","first-page":"105879","DOI":"10.1016\/j.envint.2020.105879","article-title":"Cadmium exposure and risk of breast cancer: a dose-response meta-analysis of cohort studies","volume":"142","author":"Filippini","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2023.121602_bib4","doi-asserted-by":"crossref","first-page":"E4194","DOI":"10.1073\/pnas.1409323111","article-title":"Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor","volume":"111","author":"Gawriluk","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envpol.2023.121602_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/antiox8050112","article-title":"The flavonoid quercetin induces AP-1 activation in FRTL-5 thyroid cells","volume":"8","author":"Giuliani","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.envpol.2023.121602_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1745-6673-1-22","article-title":"The toxicity of cadmium and resulting hazards for human health","volume":"1","author":"Godt","year":"2006","journal-title":"J. Occup. Med. Toxicol."},{"key":"10.1016\/j.envpol.2023.121602_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.531543","article-title":"Maternal-fetal inflammation in the placenta and the developmental origins of health and disease","volume":"11","author":"Goldstein","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2023.121602_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106406","article-title":"Cadmium exposure impairs pancreatic \u03b2-cell function and exaggerates diabetes by disrupting lipid metabolism","volume":"149","author":"Hong","year":"2021","journal-title":"Environ. Int."},{"issue":"Suppl. 2","key":"10.1016\/j.envpol.2023.121602_bib9","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.placenta.2012.05.010","article-title":"The emerging role of mTORC1 signaling in placental nutrient-sensing","volume":"33","author":"Jansson","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.envpol.2023.121602_bib10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1042\/BST20190129","article-title":"Materno-fetal cholesterol transport during pregnancy","volume":"48","author":"Kallol","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.envpol.2023.121602_bib11","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1080\/15548627.2017.1343770","article-title":"Autophagy-monitoring and autophagy-deficient mice","volume":"13","author":"Kuma","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2023.121602_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10654-014-9914-3","article-title":"Maternal and cord blood hormones in relation to birth size","volume":"29","author":"Lagiou","year":"2014","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.envpol.2023.121602_bib13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.7150\/thno.49860","article-title":"Selective autophagy of intracellular organelles: recent research advances","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.envpol.2023.121602_bib14","doi-asserted-by":"crossref","first-page":"626927","DOI":"10.3389\/fcell.2021.626927","article-title":"FSH promotes progesterone synthesis by enhancing autophagy to accelerate lipid droplet degradation in porcine granulosa cells","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2023.121602_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbi.2019.07.033","article-title":"Autophagy alleviates ethanol-induced memory impairment in association with anti-apoptotic and anti-inflammatory pathways","volume":"82","author":"Liu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.envpol.2023.121602_bib16","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1210\/en.2017-03020","article-title":"Lipophagy contributes to testosterone biosynthesis in male rat Leydig cells","volume":"159","author":"Ma","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2023.121602_bib17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1039\/b206045k","article-title":"Kidney, liver and bone cadmium content in the western sandpiper in relation to migration","volume":"4","author":"McFarland","year":"2002","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.envpol.2023.121602_bib18","first-page":"1","article-title":"Eating your own fat to stay fit: lipophagy sustains lymphangiogenesis","author":"Mece","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2023.121602_bib19","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nprot.2013.055","article-title":"Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease","volume":"8","author":"Mehlem","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.envpol.2023.121602_bib20","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.reprotox.2012.09.002","article-title":"Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: the EDEN mother-child cohort study","volume":"34","author":"Menai","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envpol.2023.121602_bib21","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41586-022-04787-x","article-title":"ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids","volume":"606","author":"Patel","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2023.121602_bib22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.toxlet.2009.04.008","article-title":"Cadmium exposure during pregnancy reduces birth weight and increases maternal and foetal glucocorticoids","volume":"188","author":"Ronco","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2023.121602_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tox.2018.02.007","article-title":"Cadmium exposure exacerbates hyperlipidemia in cholesterol-overloaded hepatocytes via autophagy dysregulation","volume":"398-399","author":"Rosales-Cruz","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2023.121602_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/humupd\/dmw004","article-title":"The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding","volume":"22","author":"Schatz","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.envpol.2023.121602_bib24","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1083\/jcb.201803153","article-title":"Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes","volume":"218","author":"Schott","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.envpol.2023.121602_bib25","doi-asserted-by":"crossref","first-page":"112632","DOI":"10.1016\/j.ecoenv.2021.112632","article-title":"Gestational cadmium exposure impairs placental angiogenesis via activating GC\/GR signaling","volume":"224","author":"Shi","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2023.121602_bib26","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1172\/JCI68140","article-title":"Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation","volume":"125","author":"Solano","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envpol.2023.121602_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080842","article-title":"Lasting DNA damage and aberrant DNA repair gene expression profile are associated with post-chronic cadmium exposure in human bronchial epithelial cells","volume":"8","author":"Tan","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2023.121602_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010071","article-title":"Autophagy attenuation hampers progesterone synthesis during the development of pregnant corpus luteum","volume":"9","author":"Tang","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2023.121602_bib29","doi-asserted-by":"crossref","DOI":"10.1242\/dev.161893","article-title":"Forced lipophagy reveals that lipid droplets are required for early embryonic development in mouse","volume":"145","author":"Tatsumi","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.envpol.2023.121602_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176493","article-title":"Differential microRNA expression in human placentas of term intra-uterine growth restriction that regulates target genes mediating angiogenesis and amino acid transport","volume":"12","author":"Thamotharan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2023.121602_bib31","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1038\/s41467-019-11274-x","article-title":"ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy","volume":"10","author":"Tian","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2023.121602_bib32","doi-asserted-by":"crossref","first-page":"22631","DOI":"10.1038\/srep22631","article-title":"Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2023.121602_bib33","doi-asserted-by":"crossref","first-page":"117002","DOI":"10.1289\/EHP11208","article-title":"Cardiac development in the presence of cadmium: an in vitro study using human embryonic stem cells and cardiac organoids","volume":"130","author":"Wu","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2023.121602_bib34","doi-asserted-by":"crossref","first-page":"123438","DOI":"10.1016\/j.jhazmat.2020.123438","article-title":"Environmental exposure to cadmium impairs fetal growth and placental angiogenesis via GCN-2-mediated mitochondrial stress","volume":"401","author":"Xiong","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2023.121602_bib35","doi-asserted-by":"crossref","first-page":"109879","DOI":"10.1016\/j.ecoenv.2019.109879","article-title":"Maternal cadmium exposure during late pregnancy causes fetal growth restriction via inhibiting placental progesterone synthesis","volume":"187","author":"Xiong","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2023.121602_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tox.2017.08.003","article-title":"Dysregulation of DNA methylation and expression of imprinted genes in mouse placentas of fetal growth restriction induced by maternal cadmium exposure","volume":"390","author":"Xu","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2023.121602_bib37","first-page":"1","article-title":"A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence","author":"Yang","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2023.121602_bib38","doi-asserted-by":"crossref","first-page":"516051","DOI":"10.1155\/2013\/516051","article-title":"Oxidative stress and mitogen-activated protein kinase pathways involved in cadmium-induced BRL 3A cell apoptosis","volume":"2013","author":"Yiran","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.envpol.2023.121602_bib39","doi-asserted-by":"crossref","first-page":"104085","DOI":"10.1016\/j.isci.2022.104085","article-title":"The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy","volume":"25","author":"Zhang","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.envpol.2023.121602_bib40","doi-asserted-by":"crossref","first-page":"129891","DOI":"10.1016\/j.jhazmat.2022.129891","article-title":"Assessment of soil heavy metal pollution in provinces of China based on different soil types: from normalization to soil quality criteria and ecological risk assessment","volume":"441","author":"Zhang","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2023.121602_bib41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00404-020-05607-1","article-title":"Physiological and pathological regulation of autophagy in pregnancy","volume":"302","author":"Zhao","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.envpol.2023.121602_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116241","article-title":"Autophagy in Sertoli cell protects against environmental cadmium-induced germ cell apoptosis in mouse testes","volume":"270","author":"Zhou","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2023.121602_bib43","doi-asserted-by":"crossref","first-page":"127268","DOI":"10.1016\/j.jhazmat.2021.127268","article-title":"Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation","volume":"424","author":"Zhu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2023.121602_bib44","doi-asserted-by":"crossref","first-page":"106319","DOI":"10.1016\/j.envint.2020.106319","article-title":"Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts","volume":"147","author":"Zhu","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2023.121602_bib45","doi-asserted-by":"crossref","first-page":"101854","DOI":"10.1016\/j.redox.2021.101854","article-title":"Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2\/ATF4\/BNIP3-dependent mitophagy in placental trophoblasts","volume":"40","author":"Zhu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2023.121602_bib46","doi-asserted-by":"crossref","first-page":"112991","DOI":"10.1016\/j.envpol.2019.112991","article-title":"Activation of autophagy inhibits cadmium-triggered apoptosis in human placental trophoblasts and mouse placenta","volume":"254","author":"Zhu","year":"2019","journal-title":"Environ. Pollut."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749123006048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749123006048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:14:12Z","timestamp":1777540452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749123006048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":47,"alternative-id":["S0269749123006048"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2023.121602","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2023.121602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121602"}}