{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:14:16Z","timestamp":1792149256970,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MI 486\/10\u20131"],"award-info":[{"award-number":["MI 486\/10\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.envpol.2023.121660","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T08:38:42Z","timestamp":1681807122000},"page":"121660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Tire components, age and temperature accelerate neurodegeneration in C. elegans models of Alzheimer's and Parkinson's disease"],"prefix":"10.1016","volume":"328","author":[{"given":"Annette","family":"Limke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Scharpf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Blesing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-2140","authenticated-orcid":false,"given":"Anna","family":"von Mikecz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2023.121660_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140591","article-title":"Parkinson's disease and pesticides: are microRNAs the missing link?","volume":"744","author":"Aloizou","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envpol.2023.121660_bib2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0192623307313011","volume":"36","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2008","journal-title":"Toxicol. Pathol."},{"issue":"Suppl. 1","key":"10.1016\/j.envpol.2023.121660_bib3","first-page":"110","article-title":"Nanoparticle-induced cell culture models for degenerative protein aggregation diseases","volume":"21","author":"Chen","year":"2009","journal-title":"Inhal. Toxicol."},{"issue":"10070","key":"10.1016\/j.envpol.2023.121660_bib4","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0140-6736(16)32399-6","article-title":"Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: a population-based cohort study","volume":"389","author":"Chen","year":"2017","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.envpol.2023.121660_bib5","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.atmosenv.2005.10.029","article-title":"Traffic-generated emissions of ultrafine particles from pavement\u2013tire interface","volume":"40","author":"Dahl","year":"2006","journal-title":"Atmos. Environ."},{"issue":"5","key":"10.1016\/j.envpol.2023.121660_bib6","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.bpj.2019.07.046","article-title":"The roles of microtubules and membrane tension in axonal beading, retraction, and atrophy","volume":"117","author":"Datar","year":"2019","journal-title":"Biophys. J."},{"key":"10.1016\/j.envpol.2023.121660_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/srep33781","article-title":"Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model","volume":"6","author":"Fong","year":"2016","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.envpol.2023.121660_bib8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","year":"2018","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.envpol.2023.121660_bib9","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","year":"2022","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.envpol.2023.121660_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102525","article-title":"Temperature sensing and context-dependent thermal behavior in nematodes","volume":"73","author":"Glauser","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"issue":"17","key":"10.1016\/j.envpol.2023.121660_bib11","doi-asserted-by":"crossref","first-page":"9970","DOI":"10.1021\/acs.est.9b01505","article-title":"Airborne, vehicle-derived Fe-bearing nanoparticles in the urban environment: a review","volume":"53","author":"Gonet","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"2\u20133","key":"10.1016\/j.envpol.2023.121660_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.scitotenv.2007.12.030","article-title":"Properties and toxicological effects of particles from the interaction between tyres, road pavement and winter traction material","volume":"393","author":"Gustafsson","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2023.121660_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119574","article-title":"Chronic di(2-ethylhexyl) phthalate exposure leads to dopaminergic neuron degeneration through mitochondrial dysfunction in C. elegans","volume":"307","author":"Huang","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2023.121660_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120378","article-title":"SAHmap: synergistic-antagonistic heatmap to evaluate the combined synergistic effect of mixtures of three pesticides on multiple endpoints of Caenorhabditis elegans","volume":"315","author":"Huang","year":"2022","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.envpol.2023.121660_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2031","article-title":"Finding function in novel targets: C. elegans as a model organism","volume":"5","author":"Kaletta","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.envpol.2023.121660_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrneurol.2015.249","article-title":"Parkinson disease in 2015: evolving basic, pathological and clinical concepts in PD","volume":"12","author":"Kalia","year":"2016","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.envpol.2023.121660_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1083\/jcb.201709072","article-title":"Pathways of cellular proteostasis in aging and disease","volume":"217","author":"Klaips","year":"2018","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.envpol.2023.121660_bib18","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1111\/gcb.16060","article-title":"Global maps of soil temperature","volume":"28","author":"Lembrechts","year":"2022","journal-title":"Global Change Biol."},{"issue":"10248","key":"10.1016\/j.envpol.2023.121660_bib19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.envpol.2023.121660_bib20","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1073\/pnas.042497999","article-title":"Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans","volume":"99","author":"Nass","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.envpol.2023.121660_bib21","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ana.23687","article-title":"Meta-analysis of early nonmotor features and risk factors for Parkinson disease","volume":"72","author":"Noyce","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.envpol.2023.121660_bib22","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.envpol.2017.10.012","article-title":"Life span-resolved nanotoxicology enables identification of age-associated neuromuscular vulnerabilities in the nematode Caenorhabditis elegans","volume":"233","author":"Piechulek","year":"2018","journal-title":"Environ. Pollut."},{"issue":"8","key":"10.1016\/j.envpol.2023.121660_bib23","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1080\/17435390.2019.1643048","article-title":"Silica nanoparticles disrupt OPT-2\/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium","volume":"13","author":"Piechulek","year":"2019","journal-title":"Nanotoxicology"},{"issue":"2","key":"10.1016\/j.envpol.2023.121660_bib24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tcb.2008.11.002","article-title":"Integrating the stress response: lessons for neurodegenerative diseases from C. elegans","volume":"19","author":"Prahlad","year":"2009","journal-title":"Trends Cell Biol."},{"issue":"12","key":"10.1016\/j.envpol.2023.121660_bib25","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1021\/nn403443r","article-title":"Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans","volume":"7","author":"Scharf","year":"2013","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.envpol.2023.121660_bib26","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3109\/17435390.2015.1073399","article-title":"Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans","volume":"10","author":"Scharf","year":"2016","journal-title":"Nanotoxicology"},{"issue":"9","key":"10.1016\/j.envpol.2023.121660_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105027","article-title":"Pollutants corrupt resilience pathways of aging in the nematode C. elegans","volume":"25","author":"Scharf","year":"2022","journal-title":"iScience"},{"issue":"6","key":"10.1016\/j.envpol.2023.121660_bib28","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1093\/ije\/dyy172","article-title":"Effects of ambient air pollution on incident Parkinson's disease in Ontario, 2001 to 2013: a population-based cohort study","volume":"47","author":"Shin","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envpol.2023.121660_bib29","series-title":"Chapter 21 \u2013 Toxicology of Neurodegenerative Diseases. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure","first-page":"247","author":"Siokas","year":"2021"},{"issue":"49","key":"10.1016\/j.envpol.2023.121660_bib30","first-page":"2496","article-title":"Measuring Caenorhabditis elegans life span in 96 well microtiter plates","author":"Solis","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"7","key":"10.1016\/j.envpol.2023.121660_bib31","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3390\/nano10071349","article-title":"Effects of airborne nanoparticles on the nervous system: amyloid protein aggregation, neurodegeneration and neurodegenerative diseases","volume":"10","author":"von Mikecz","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.envpol.2023.121660_bib32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.envpol.2018.01.004","article-title":"Dynamic probabilistic material flow analysis of nano-SiO2, nano iron oxides, nano-CeO2, nano-Al2O3, and quantum dots in seven European regions","volume":"235","author":"Wang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2023.121660_bib33","article-title":"Evidence of non-tailpipe emission contributions to PM2.5 and PM10 near southern California highways","author":"Wang","year":"2022","journal-title":"Environ. Pollut."},{"issue":"21","key":"10.1016\/j.envpol.2023.121660_bib34","doi-asserted-by":"crossref","first-page":"11851","DOI":"10.1073\/pnas.211376098","article-title":"Morphological properties of atmospheric aerosol aggregates","volume":"98","author":"Xiong","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749123006620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749123006620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T22:59:06Z","timestamp":1759445946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749123006620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":34,"alternative-id":["S0269749123006620"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2023.121660","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tire components, age and temperature accelerate neurodegeneration in C. elegans models of Alzheimer's and Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2023.121660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"121660"}}