{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:55:09Z","timestamp":1790614509657,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005568","name":"Water Resources Research Institute, North Carolina State University","doi-asserted-by":"publisher","award":["21-07-W"],"award-info":[{"award-number":["21-07-W"]}],"id":[{"id":"10.13039\/100005568","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.envpol.2023.122670","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T23:30:49Z","timestamp":1696635049000},"page":"122670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Development of a national antibiotic multimetric index for identifying watersheds vulnerable to antibiotic pollution"],"prefix":"10.1016","volume":"339","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-2475","authenticated-orcid":false,"given":"Sara","family":"Kamanmalek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-9359","authenticated-orcid":false,"given":"Jacelyn","family":"Rice-Boayue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.envpol.2023.122670_bib1","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1021\/es405348h","article-title":"Increased waterborne bla NDM-1 resistance gene abundances associated with seasonal human pilgrimages to the Upper Ganges River","volume":"48","author":"Ahammad","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.envpol.2023.122670_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-65635-4","article-title":"Evaluation of antibiotic resistance dissemination by wastewater treatment plant effluents with different catchment areas in Germany","volume":"10","author":"Alexander","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2023.122670_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.scitotenv.2019.02.183","article-title":"Antibiotic resistance in urban runoff","volume":"667","author":"Almakki","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envpol.2023.122670_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/10934529.2015.964602","article-title":"Antibiotic resistance in wastewater: occurrence and fate of enterobacteriaceae producers of Class A and Class C \u03b2-lactamases","volume":"50","author":"Amador","year":"2015","journal-title":"J. Environ. Sci. Health, Part A"},{"issue":"7","key":"10.1016\/j.envpol.2023.122670_bib5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/rra.1011","article-title":"First steps in developing a multimetric macroinvertebrate index for the Ohio River","volume":"23","author":"Applegate","year":"2007","journal-title":"River Res. Appl."},{"issue":"4","key":"10.1016\/j.envpol.2023.122670_bib6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/jac\/17.4.409","article-title":"\u03b2-Lactam antibiotics increase the frequency of plasmid transfer in Staphylococcus aureus","volume":"17","author":"Barr","year":"1986","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"10.1016\/j.envpol.2023.122670_bib7","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/etc.3161","article-title":"Evaluating the extent of pharmaceuticals in surface waters of the United States using a National\u2010scale Rivers and Streams Assessment survey","volume":"35","author":"Batt","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"issue":"6969","key":"10.1016\/j.envpol.2023.122670_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nature02241","article-title":"SOS response promotes horizontal dissemination of antibiotic resistance genes","volume":"427","author":"Beaber","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2023.122670_bib9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.envint.2015.10.015","article-title":"Concentrations of antibiotics predicted to select for resistant bacteria: proposed limits for environmental regulation","volume":"86","author":"Bengtsson-Palme","year":"2016","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envpol.2023.122670_bib10","article-title":"Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics","volume":"5","author":"Berglund","year":"2015","journal-title":"Infect. Ecol. Epidemiol."},{"issue":"1","key":"10.1016\/j.envpol.2023.122670_bib11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/etc.2784","article-title":"Urban wastewater effluent increases antibiotic resistance gene concentrations in a receiving northern European river","volume":"34","author":"Berglund","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"issue":"1","key":"10.1016\/j.envpol.2023.122670_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1475-2743.2005.tb00111.x","article-title":"Definition of sustainable and unsustainable issues in nutrient management of modern agriculture","volume":"21","author":"Bergstr\u00f6m","year":"2005","journal-title":"Soil Use Manag."},{"key":"10.1016\/j.envpol.2023.122670_bib13","series-title":"The Role of Environmental Buffers in Potable Water Reuse","author":"Brown","year":"2020"},{"key":"10.1016\/j.envpol.2023.122670_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/2049936121991374","article-title":"Climate change and antibiotic resistance: a deadly combination","volume":"8","author":"Burnham","year":"2021","journal-title":"Therap. Adv. Infect. Disease"},{"issue":"1\u20133","key":"10.1016\/j.envpol.2023.122670_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0048-9697(02)00233-4","article-title":"Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations","volume":"299","author":"Campagnolo","year":"2002","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2023.122670_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.marpolbul.2019.07.036","article-title":"Evaluation of the artificial sweetener sucralose as a sanitary wastewater tracer in Narragansett Bay, Rhode Island, USA","volume":"146","author":"Cantwell","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envpol.2023.122670_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.chemosphere.2014.02.004","article-title":"Factory-discharged pharmaceuticals could be a relevant source of aquatic environment contamination: review of evidence and need for knowledge","volume":"115","author":"Cardoso","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2023.122670_bib18","series-title":"Outpatient Antibiotic Prescriptions \u2014 United States","year":"2017"},{"issue":"4","key":"10.1016\/j.envpol.2023.122670_bib20","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1128\/AEM.67.4.1494-1502.2001","article-title":"Occurrence and diversity of tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities","volume":"67","author":"Chee-Sanford","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"issue":"3","key":"10.1016\/j.envpol.2023.122670_bib21","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.2134\/jeq2008.0128","article-title":"Fate and transport of antibiotic residues and antibiotic resistance genes following land application of manure waste","volume":"38","author":"Chee\u2010Sanford","year":"2009","journal-title":"J. Environ. Qual."},{"issue":"11","key":"10.1016\/j.envpol.2023.122670_bib22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/imj.12902","article-title":"Antibiotic resistance: are we all doomed?","volume":"45","author":"Collignon","year":"2015","journal-title":"Intern. Med. J."},{"issue":"7","key":"10.1016\/j.envpol.2023.122670_bib23","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/ismej.2014.8","article-title":"Wastewater as a point source of antibiotic-resistance genes in the sediment of a freshwater lake","volume":"8","author":"Czekalski","year":"2014","journal-title":"ISME J."},{"key":"10.1016\/j.envpol.2023.122670_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.envpol.2017.04.036","article-title":"Rainfall increases the abundance of antibiotic resistance genes within a riverine microbial community","volume":"226","author":"Di Cesare","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2023.122670_bib25","series-title":"Annual Surveillance Reports on Antimicrobial Resistance","year":"2019"},{"key":"10.1016\/j.envpol.2023.122670_bib26","series-title":"Releases Annual Summary Report on Antimicrobials Sold or Distributed in 2017 for Use in Food-Producing Animals","year":"2017"},{"key":"10.1016\/j.envpol.2023.122670_bib27","series-title":"Forests as an Alternative for Swine Manure Application","author":"Furiness","year":"2011"},{"key":"10.1016\/j.envpol.2023.122670_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.watres.2017.06.046","article-title":"Stormwater loadings of antibiotic resistance genes in an urban stream","volume":"123","author":"Garner","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2023.122670_bib29","unstructured":"Google LLC. Google Earth. https:\/\/earth.google.com\/."},{"key":"10.1016\/j.envpol.2023.122670_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136286","article-title":"The seasonal distribution and concentration of antibiotics in rural streams and drinking wells in the piedmont of North Carolina","volume":"710","author":"Gray","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2023.122670_bib31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.microc.2017.02.006","article-title":"Ecological effects of antibiotics on natural ecosystems: a review","volume":"136","author":"Grenni","year":"2018","journal-title":"Microchem. J."},{"issue":"7","key":"10.1016\/j.envpol.2023.122670_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002158","article-title":"Selection of resistant bacteria at very low antibiotic concentrations","volume":"7","author":"Gullberg","year":"2011","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.envpol.2023.122670_bib33","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/msb4100184","article-title":"The complexities of antibiotic action","volume":"3","author":"Hancock","year":"2007","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.envpol.2023.122670_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ecolind.2012.12.030","article-title":"Development of a macroinvertebrate multimetric index for the assessment of low-land streams in the neotropics","volume":"29","author":"Helson","year":"2013","journal-title":"Ecol. Indicat."},{"key":"10.1016\/j.envpol.2023.122670_bib35","series-title":"The Ecological Status of European Rivers: Evaluation and Intercalibration of Assessment Methods","first-page":"311","article-title":"Cook book for the development of a Multimetric Index for biological condition of aquatic ecosystems: experiences from the European AQEM and STAR projects and related initiatives","author":"Hering","year":"2006"},{"key":"10.1016\/j.envpol.2023.122670_bib36","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1016\/j.scitotenv.2018.10.112","article-title":"Revising the index of watershed integrity national maps","volume":"651","author":"Johnson","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2023.122670_bib37","series-title":"An Integrative Approach to Identify and Assess Streams Susceptible to Antibiotic Discharges","author":"Kamanmalek","year":"2021"},{"issue":"3","key":"10.1016\/j.envpol.2023.122670_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1021\/acsestwater.1c00386","article-title":"Spatial hazards of antibiotic resistance in wastewater-impacted streams during low instream flow conditions","volume":"2","author":"Kamanmalek","year":"2022","journal-title":"Acs Es&T Water"},{"issue":"21","key":"10.1016\/j.envpol.2023.122670_bib39","doi-asserted-by":"crossref","first-page":"14960","DOI":"10.1021\/acs.est.2c00813","article-title":"Geospatial patterns of antimicrobial resistance genes in the US EPA national rivers and streams assessment survey","volume":"56","author":"Keely","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2023.122670_bib40","series-title":"Geospatial Patterns of Antimicrobial Resistance Genes in the US EPA National Rivers and Streams Assessment Survey","author":"Keely","year":"2022"},{"issue":"1","key":"10.1016\/j.envpol.2023.122670_bib41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jece.2017.11.059","article-title":"Antibiotic resistance and wastewater: correlation, impact and critical human health challenges","volume":"6","author":"Kumar","year":"2018","journal-title":"J. Environ. Chem. Eng."},{"issue":"11","key":"10.1016\/j.envpol.2023.122670_bib42","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3390\/w10111539","article-title":"Microbial community composition and antibiotic resistance genes within a North Carolina urban water system","volume":"10","author":"Lambirth","year":"2018","journal-title":"Water"},{"issue":"19","key":"10.1016\/j.envpol.2023.122670_bib43","doi-asserted-by":"crossref","first-page":"11509","DOI":"10.1021\/acs.est.5b02803","article-title":"Multiple discharges of treated municipal wastewater have a small effect on the quantities of numerous antibiotic resistance determinants in the Upper Mississippi River","volume":"49","author":"LaPara","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.envpol.2023.122670_bib44","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jhazmat.2007.07.008","article-title":"Effluent from drug manufactures contains extremely high levels of pharmaceuticals","volume":"148","author":"Larsson","year":"2007","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2023.122670_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2011.03.004","article-title":"Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China","volume":"42","author":"Leung","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2023.122670_bib46","article-title":"Source tracking of antibiotic resistance genes in the environment\u2014challenges, progress, and prospects","author":"Li","year":"2020","journal-title":"Water Res."},{"issue":"2","key":"10.1016\/j.envpol.2023.122670_bib47","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jglr.2018.01.006","article-title":"Use of manure nutrients from concentrated animal feeding operations","volume":"44","author":"Long","year":"2018","journal-title":"J. Great Lake. Res."},{"key":"10.1016\/j.envpol.2023.122670_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.tust.2019.103089","article-title":"Monte Carlo simulation (MCS)-based uncertainty analysis of rock mass quality Q in underground construction","volume":"94","author":"Lu","year":"2019","journal-title":"Tunn. Undergr. Space Technol."},{"issue":"6","key":"10.1016\/j.envpol.2023.122670_bib49","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41558-018-0161-6","article-title":"Antibiotic resistance increases with local temperature","volume":"8","author":"MacFadden","year":"2018","journal-title":"Nat. Clim. Change"},{"issue":"45","key":"10.1016\/j.envpol.2023.122670_bib50","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.45.1900414","article-title":"Rates of increase of antibiotic resistance and ambient temperature in Europe: a cross-national analysis of 28 countries between 2000 and 2016","volume":"25","author":"McGough","year":"2020","journal-title":"Euro Surveill."},{"issue":"2","key":"10.1016\/j.envpol.2023.122670_bib51","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ecolind.2010.08.005","article-title":"The CIEPT: a macroinvertebrate-based multimetric index for assessing the ecological quality of Swiss lowland ponds","volume":"11","author":"Menetrey","year":"2011","journal-title":"Ecol. Indicat."},{"key":"10.1016\/j.envpol.2023.122670_bib52","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ecolind.2013.01.026","article-title":"Development of a multimetric index based on benthic macroinvertebrates for the assessment of natural wetlands in Southwest Ethiopia","volume":"29","author":"Mereta","year":"2013","journal-title":"Ecol. Indicat."},{"key":"10.1016\/j.envpol.2023.122670_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149391","article-title":"Spatiotemporal land use change and environmental degradation surrounding CAFOs in Michigan and North Carolina","volume":"800","author":"Miralha","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2023.122670_bib54","series-title":"J. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations","author":"O'Neill","year":"2016"},{"issue":"12","key":"10.1016\/j.envpol.2023.122670_bib55","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.watres.2006.04.017","article-title":"Effect of river landscape on the sediment concentrations of antibiotics and corresponding antibiotic resistance genes (ARG)","volume":"40","author":"Pei","year":"2006","journal-title":"Water Res."},{"issue":"23","key":"10.1016\/j.envpol.2023.122670_bib56","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1021\/es060413l","article-title":"Antibiotic resistance genes as emerging contaminants: studies in northern Colorado","volume":"40","author":"Pruden","year":"2006","journal-title":"Environ. Sci. Technol."},{"issue":"21","key":"10.1016\/j.envpol.2023.122670_bib57","doi-asserted-by":"crossref","first-page":"11541","DOI":"10.1021\/es302657r","article-title":"Correlation between upstream human activities and riverine antibiotic resistance genes","volume":"46","author":"Pruden","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.envpol.2023.122670_bib58","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1021\/es5048057","article-title":"Spatial and temporal variation in de facto wastewater reuse in drinking water systems across the USA","volume":"49","author":"Rice","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2023.122670_bib59","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.watres.2014.11.021","article-title":"Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river","volume":"69","author":"Rodriguez-Mozaz","year":"2015","journal-title":"Water Res."},{"issue":"4","key":"10.1016\/j.envpol.2023.122670_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101024","article-title":"Compounding effects of climate warming and antibiotic resistance","volume":"23","author":"Rodr\u00edguez-Verdugo","year":"2020","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.envpol.2023.122670_bib61","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1139\/er-2015-0069","article-title":"Antibiotic resistance genes as an emerging environmental contaminant","volume":"24","author":"Sanderson","year":"2016","journal-title":"Environ. Rev."},{"issue":"4","key":"10.1016\/j.envpol.2023.122670_bib62","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1899\/08-053.1","article-title":"A process for creating multimetric indices for large-scale aquatic surveys","volume":"27","author":"Stoddard","year":"2008","journal-title":"J. North Am. Benthol. Soc."},{"issue":"19","key":"10.1016\/j.envpol.2023.122670_bib63","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1021\/es101657s","article-title":"Tracking antibiotic resistance genes in the South Platte River basin using molecular signatures of urban, agricultural, and pristine sources","volume":"44","author":"Storteboom","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.envpol.2023.122670_bib64","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1289\/ehp.1104650","article-title":"Selective pressure of antibiotic pollution on bacteria of importance to public health","volume":"120","author":"Tello","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2023.122670_bib65","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ecolind.2017.10.070","article-title":"Mapping watershed integrity for the conterminous United States","volume":"85","author":"Thornbrugh","year":"2018","journal-title":"Ecol. Indicat."},{"key":"10.1016\/j.envpol.2023.122670_bib66","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jclepro.2018.02.286","article-title":"The construction dust-induced occupational health risk using Monte-Carlo simulation","volume":"184","author":"Tong","year":"2018","journal-title":"J. Clean. Prod."},{"issue":"3","key":"10.1016\/j.envpol.2023.122670_bib67","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1365-2958.2005.04584.x","article-title":"Antibiotic\u2010induced SOS response promotes horizontal dissemination of pathogenicity island\u2010encoded virulence factors in staphylococci","volume":"56","author":"\u00dabeda","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.envpol.2023.122670_bib70","unstructured":"United States Environmental Protection Agency (US EPA). Healthy Watersheds Protection. https:\/\/www.epa.gov\/hwp."},{"key":"10.1016\/j.envpol.2023.122670_bib72","series-title":"Identifying and Protecting Healthy Watersheds","year":"2012"},{"issue":"9","key":"10.1016\/j.envpol.2023.122670_bib74","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3390\/antibiotics10091066","article-title":"Antibiotic-resistant genes and bacteria as evolving contaminants of emerging concerns (e-CEC): is it time to include evolution in risk assessment?","volume":"10","author":"Vassallo","year":"2021","journal-title":"Antibiotics"},{"issue":"1670","key":"10.1016\/j.envpol.2023.122670_bib75","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0083","article-title":"Antimicrobial resistance in humans, livestock and the wider environment","volume":"370","author":"Woolhouse","year":"2015","journal-title":"Phil. Trans. Biol. Sci."},{"key":"10.1016\/j.envpol.2023.122670_bib76","unstructured":"World Health Organization (WHO) Antimicrobial resistance. 2020. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance."},{"issue":"11","key":"10.1016\/j.envpol.2023.122670_bib77","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance","volume":"49","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Technol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912301672X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912301672X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:07:12Z","timestamp":1778738832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026974912301672X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":72,"alternative-id":["S026974912301672X"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2023.122670","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a national antibiotic multimetric index for identifying watersheds vulnerable to antibiotic pollution","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2023.122670","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122670"}}