{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:59:28Z","timestamp":1790830768455,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["825753"],"award-info":[{"award-number":["825753"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002808","name":"Carlsberg Foundation","doi-asserted-by":"publisher","award":["CF20-0422"],"award-info":[{"award-number":["CF20-0422"]}],"id":[{"id":"10.13039\/501100002808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus University","doi-asserted-by":"publisher","award":["AUFF-T-2017- FLS-7-4"],"award-info":[{"award-number":["AUFF-T-2017- FLS-7-4"]}],"id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.envpol.2023.122783","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T12:29:00Z","timestamp":1697804940000},"page":"122783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P2","title":["Effect of in utero and lactational exposure to a thyroid hormone system disrupting chemical on mouse metabolome and brain transcriptome"],"prefix":"10.1016","volume":"340","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0475-9834","authenticated-orcid":false,"given":"Rikke","family":"Poulsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanis","family":"Zekri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Guyot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Flamant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2023.122783_bib1","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1210\/en.2017-03125","article-title":"Effects of mild perinatal hypothyroidism on cognitive function of adult male offspring","volume":"159","author":"Amano","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2023.122783_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq-A Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2023.122783_bib41","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/1471-0528.12681","article-title":"Attention deficit hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a Danish nationwide cohort study","volume":"121","author":"Andersen","year":"2014","journal-title":"BJOG An Int. J. Obstet. Gynaecol."},{"key":"10.1016\/j.envpol.2023.122783_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2008.05.020","article-title":"Developmental neurotoxicity of propylthiouracil (PTU) in rats: relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes","volume":"232","author":"Axelstad","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2023.122783_bib4","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1242\/dev.120.5.1097","article-title":"A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development","volume":"120","author":"Barres","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.envpol.2023.122783_bib5","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.envpol.2023.122783_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/thy.2008.0341","article-title":"Delayed Neurobehavioral development in children Born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation","volume":"19","author":"Berbel","year":"2009","journal-title":"Thyroid"},{"key":"10.1016\/j.envpol.2023.122783_bib7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/dbio.2001.0293","article-title":"Role of thyroid hormone receptors in timing oligodendrocyte differentiation","volume":"235","author":"Billon","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.envpol.2023.122783_bib8","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1089\/thy.2018.0730","article-title":"Metabolomic profiling of body fluids in mouse models demonstrates that nuclear magnetic resonance is a putative diagnostic tool for the presence of thyroid hormone receptor \u03b11 mutations","volume":"29","author":"Boumaza","year":"2019","journal-title":"Thyroid"},{"key":"10.1016\/j.envpol.2023.122783_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tiv.2019.03.039","article-title":"Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - evolution versus revolution","volume":"59","author":"Burgdorf","year":"2019","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2023.122783_bib45","first-page":"1","volume":"12","author":"Cai","year":"2022","journal-title":"Plasma Lipid Profile and Intestinal Microflora in Pregnancy Women With Hypothyroidism and Their Correlation With Pregnancy Outcomes, Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.envpol.2023.122783_bib10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/17446651.2022.2044788","article-title":"Impact of endocrine disrupting chemicals on neurodevelopment: the need for better testing strategies for endocrine disruption-induced developmental neurotoxicity","volume":"17","author":"Cediel-Ulloa","year":"2022","journal-title":"Expet Rev. Endocrinol. Metabol."},{"key":"10.1016\/j.envpol.2023.122783_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/(SICI)1521-1878(200001)22:1<64::AID-BIES11>3.0.CO;2-Q","article-title":"A cell-intrinsic timer that operates during oligodendrocyte development","volume":"22","author":"Durand","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.envpol.2023.122783_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00315705","article-title":"Observations on the development of the striatum in mice and rats","volume":"163","author":"Fentress","year":"1981","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.envpol.2023.122783_bib13","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1124\/pr.58.4.3","article-title":"International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors","volume":"58","author":"Flamant","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.envpol.2023.122783_bib14","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.3390\/ijms23084248","article-title":"Uncontrolled thyroid during pregnancy alters the circulative and exerted metabolome","volume":"23","author":"Fotakis","year":"2022","journal-title":"IJMS"},{"key":"10.1016\/j.envpol.2023.122783_bib15","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa106","article-title":"Regulation of thyroid-disrupting chemicals to protect the developing brain","volume":"161","author":"Gilbert","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2023.122783_bib16","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/en.2015-1643","article-title":"Mild thyroid hormone insufficiency during development compromises activity-dependent neuroplasticity in the hippocampus of adult male rats","volume":"157","author":"Gilbert","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2023.122783_bib17","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1210\/en.2012-2189","article-title":"Role of thyroid hormone receptor subtypes \u03b1 and \u03b2 on gene expression in the cerebral cortex and striatum of postnatal mice","volume":"154","author":"Gil-Iba\u00f1ez","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2023.122783_bib18","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.3390\/nu15102249","article-title":"Iodine deficiency, maternal hypothyroxinemia and endocrine disrupters affecting fetal brain development: a scoping Review","volume":"15","author":"Grossklaus","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2023.122783_bib19","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1007\/s00216-016-9614-9","article-title":"Quantification of 11 thyroid hormones and associated metabolites in blood using isotope-dilution liquid chromatography tandem mass spectrometry","volume":"408","author":"Hansen","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envpol.2023.122783_bib20","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.envpol.2023.122783_bib44","first-page":"1","article-title":"Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes","volume":"11","author":"Li","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2023.122783_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.envpol.2023.122783_bib22","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.envpol.2023.122783_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105866","article-title":"Body mass, mercury exposure, biochemistry and untargeted metabolomics of incubating common eiders (Somateria mollissima) in three Baltic colonies","volume":"142","author":"Ma","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2023.122783_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/metabo11010051","article-title":"L-carnitine and acylcarnitines: mitochondrial biomarkers for precision medicine","volume":"11","author":"McCann","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.envpol.2023.122783_bib25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yrtph.2016.06.019","article-title":"A comparison of potency differences among thyroid peroxidase (TPO) inhibitors to induce developmental toxicity and other thyroid gland-linked toxicities in humans and rats","volume":"80","author":"Motonaga","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2023.122783_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid hormone regulation of metabolism","volume":"94","author":"Mullur","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envpol.2023.122783_bib27","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1210\/endo-118-4-1598","article-title":"A New class of propylthiouracil analogs: comparison of 5\u2019-deiodinase inhibition and antithyroid activity","volume":"118","author":"Nogimori","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2023.122783_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/toxsci\/kfy016","article-title":"Developmental thyroid hormone insufficiency induces a cortical brain malformation and learning impairments: a cross-fostering study","volume":"163","author":"O'Shaughnessy","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2023.122783_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10050186","article-title":"Metaboanalystr 3.0: Toward an optimized workflow for global metabolomics","volume":"10","author":"Pang","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.envpol.2023.122783_bib29","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5314","article-title":"Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library","volume":"127","author":"Paul-Friedman","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2023.122783_bib30","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1210\/me.2011-1316","article-title":"A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation","volume":"26","author":"Picou","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.envpol.2023.122783_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fendo.2018.00265","article-title":"Regulation of T3 availability in the developing brain: the mouse genetics contribution","volume":"9","author":"Richard","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envpol.2023.122783_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100899","article-title":"A pivotal genetic program controlled by thyroid hormone during the maturation of GABAergic neurons","volume":"23","author":"Richard","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.envpol.2023.122783_bib33","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1172\/JCI116301","article-title":"Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain","volume":"91","author":"Rodriguez-Pe\u00f1a","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envpol.2023.122783_bib34","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/j.1365-2826.2008.01793.x","article-title":"A genomic analysis of subclinical hypothyroidism in hippocampus and neocortex of the developing rat brain","volume":"20","author":"Royland","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.envpol.2023.122783_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2826.2009.01947.x","article-title":"The nature of the compensatory response to low thyroid hormone in the developing brain","volume":"22","author":"Sharlin","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.envpol.2023.122783_bib36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ntt.2016.05.007","article-title":"Thyroid hormone-dependent formation of a subcortical band heterotopia (SBH) in the neonatal brain is not exacerbated under conditions of low dietary iron (FeD)","volume":"56","author":"Spring","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envpol.2023.122783_bib37","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envpol.2023.122783_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/17446651.2021.1917991","article-title":"Endocrine disrupting chemicals: strategies to protect present and future generations","volume":"16","author":"Vandenberg","year":"2021","journal-title":"Expert Rev Endocrinol Metab"},{"key":"10.1016\/j.envpol.2023.122783_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(01)00140-1","article-title":"Thyroid hormone regulation of rhes, a novel Ras homolog gene expressed in the striatum","volume":"94","author":"Vargiu","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.envpol.2023.122783_bib39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/JME-12-0068","article-title":"Thyroid hormone and the central control of homeostasis","volume":"49","author":"Warner","year":"2012","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.envpol.2023.122783_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jpba.2012.09.030","article-title":"Serum metabonomics coupled with Ingenuity Pathway Analysis characterizes metabolic perturbations in response to hypothyroidism induced by propylthiouracil in rats","volume":"72","author":"Wu","year":"2013","journal-title":"J. Pharm. Biomed. Anal."}],"updated-by":[{"DOI":"10.1016\/j.envpol.2024.124646","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000}}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749123017852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749123017852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:14:57Z","timestamp":1723065297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749123017852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":45,"alternative-id":["S0269749123017852"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2023.122783","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.envpol.2024.124646","asserted-by":"object"}]},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of in utero and lactational exposure to a thyroid hormone system disrupting chemical on mouse metabolome and brain transcriptome","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2023.122783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"122783"}}