{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:18:57Z","timestamp":1767925137808,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20618"],"award-info":[{"award-number":["U22A20618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22122605"],"award-info":[{"award-number":["22122605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.envpol.2024.123729","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T17:24:42Z","timestamp":1709918682000},"page":"123729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Time-course transcriptome analysis discloses PFDMO2OA (C8 HFPO-TA)-induced developmental malformations and cardiovascular toxicities in zebrafish"],"prefix":"10.1016","volume":"347","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6372-0653","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanying","family":"Gui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-5371","authenticated-orcid":false,"given":"Yanbin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2024.123729_bib1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1289\/ehp.0901252","article-title":"Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia","volume":"118","author":"Bartell","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.123729_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104700","article-title":"Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)","volume":"62","author":"Behr","year":"2020","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2024.123729_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr. Environ. Assess. Manage."},{"key":"10.1016\/j.envpol.2024.123729_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ygcen.2009.08.011","article-title":"Induction of Ca2+ signal mediated apoptosis and alteration of IP3R1 and SERCA1 expression levels by stress hormone in differentiating C2C12 myoblasts","volume":"166","author":"Chai","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.envpol.2024.123729_bib5","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/bioinformatics\/btl056","article-title":"maSigPro: a method to identify significantly differential expression profiles in time-course microarray experiments","volume":"22","author":"Conesa","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2024.123729_bib6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/0192623311428473","article-title":"Immunotoxicity of perfluorinated compounds: recent developments","volume":"40","author":"DeWitt","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.envpol.2024.123729_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.813785","article-title":"Emerging chemical risks for human health: endocrine disruption by per-and poly-fluorinated alkyl substances (PFAS)","volume":"12","author":"Di Nisio","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envpol.2024.123729_bib8","doi-asserted-by":"crossref","first-page":"19442","DOI":"10.1021\/acs.est.3c06910","article-title":"Comprehensive assessment of exposure pathways for perfluoroalkyl ether carboxylic acids (PFECAs) in residents near a fluorochemical industrial park: the unanticipated role of cereal consumption","volume":"57","author":"Dong","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.123729_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.chemosphere.2013.01.012","article-title":"Endocrine-related effects of perfluorooctanoic acid (PFOA) in zebrafish, H295R steroidogenesis and receptor reporter gene assays","volume":"91","author":"Du","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2024.123729_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116136","article-title":"In vitro activity of a panel of per-and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays","volume":"449","author":"Evans","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2024.123729_bib11","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.chemosphere.2010.10.076","article-title":"Structure\u2013activity relationship assessment of four perfluorinated chemicals using a prolonged zebrafish early life stage test","volume":"82","author":"Hagenaars","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2024.123729_bib12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4330\/wjc.v7.i9.511","article-title":"Lean heart: role of leptin in cardiac hypertrophy and metabolism","volume":"7","author":"Hall","year":"2015","journal-title":"World J. Cardiol."},{"key":"10.1016\/j.envpol.2024.123729_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mce.2009.02.021","article-title":"Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: low doses induce elevated serum leptin and insulin, and overweight in mid-life","volume":"304","author":"Hines","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envpol.2024.123729_bib14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.scitotenv.2014.07.059","article-title":"A multi-level biological approach to evaluate impacts of a major municipal effluent in wild St. Lawrence River yellow perch (Perca flavescens)","volume":"497","author":"Houde","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.123729_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127656","article-title":"Low-dose perfluorooctanoic acid stimulates steroid hormone synthesis in Leydig cells: integrated proteomics and metabolomics evidence","volume":"424","author":"Huang","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.123729_bib16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/toxsci\/kfp029","article-title":"Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain","volume":"108","author":"Johansson","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2024.123729_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/toxics9030045","article-title":"Perfluoroalkyl acid binding with peroxisome proliferator-activated receptors \u03b1, \u03b3, and \u03b4, and fatty acid binding proteins by equilibrium dialysis with a comparison of methods","volume":"9","author":"Khazaee","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2024.123729_bib18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.envpol.2024.123729_bib19","doi-asserted-by":"crossref","first-page":"bqab194","DOI":"10.1210\/endocr\/bqab194","article-title":"PFAS and potential adverse effects on bone and adipose tissue through interactions with PPAR\u03b3","volume":"162","author":"Kirk","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2024.123729_bib20","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1135\/cccc20081799","article-title":"HFPO trimer-based alkyl triflate, a novel building block for fluorous chemistry. Preparation, reactions and 19 F gCOSY analysis","volume":"73","author":"Kysilka","year":"2008","journal-title":"Collect. Czech Chem. Commun."},{"key":"10.1016\/j.envpol.2024.123729_bib21","doi-asserted-by":"crossref","first-page":"692","DOI":"10.2307\/2668517","article-title":"The Stockholm Convention on persistent organic pollutants","volume":"95","author":"Lallas","year":"2001","journal-title":"Am. J. Int. Law"},{"key":"10.1016\/j.envpol.2024.123729_bib22","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/toxsci\/kfj105","article-title":"Effects of perfluorooctanoic acid exposure during pregnancy in the mouse","volume":"90","author":"Lau","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2024.123729_bib23","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1021\/acs.est.8b06978","article-title":"Adipogenic activity of oligomeric hexafluoropropylene oxide (perfluorooctanoic acid alternative) through peroxisome proliferator-activated receptor \u03b3 pathway","volume":"53","author":"Li","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.123729_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106344","article-title":"Gestational and childhood exposure to per-and polyfluoroalkyl substances and cardiometabolic risk at age 12 years","volume":"147","author":"Li","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.123729_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106627","article-title":"Exposure to legacy and novel perfluoroalkyl substance disturbs the metabolic homeostasis in pregnant women and fetuses: a metabolome-wide association study","volume":"156","author":"Li","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.123729_bib26","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1021\/acs.est.2c03041","article-title":"Emerging contaminants: fluorinated alternatives to existing PFAS","volume":"56","author":"Ruan","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.123729_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.etap.2017.12.023","article-title":"Sensitivity of medaka (Oryzias latipes) to 4-nonylphenol subacute exposure; erythrocyte alterations and apoptosis","volume":"58","author":"Sayed","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2024.123729_bib28","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1074\/jbc.M114.633701","article-title":"The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1\/dedicator of cytokinesis 180 (elmo1\/dock180) protects endothelial cells from apoptosis in blood vessel development","volume":"290","author":"Sch\u00e4ker","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2024.123729_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.aquatox.2017.06.023","article-title":"6: 2 fluorotelomer carboxylic acid (6: 2 FTCA) exposure induces developmental toxicity and inhibits the formation of erythrocytes during zebrafish embryogenesis","volume":"190","author":"Shi","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2024.123729_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111905","article-title":"Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort","volume":"204","author":"Shih","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.123729_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151535","article-title":"Global occurrence and probabilistic environmental health hazard assessment of per-and polyfluoroalkyl substances (PFASs) in groundwater and surface waters","volume":"816","author":"Sims","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.123729_bib32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1039\/c9mt00125e","article-title":"Common responses of fish embryos to metals: an integrated analysis of transcriptomes and methylomes in zebrafish embryos under the stress of copper ions or silver nanoparticles","volume":"11","author":"Tai","year":"2019","journal-title":"Metallomics"},{"key":"10.1016\/j.envpol.2024.123729_bib34","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1289\/ehp.11190","article-title":"Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout","volume":"116","author":"Tilton","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.123729_bib35","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00204-023-03477-5","article-title":"A review of cardiovascular effects and underlying mechanisms of legacy and emerging per-and polyfluoroalkyl substances (PFAS)","volume":"97","author":"Wen","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2024.123729_bib36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/toxsci\/kfq219","article-title":"Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates","volume":"117","author":"Yang","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2024.123729_bib37","doi-asserted-by":"crossref","first-page":"7986","DOI":"10.1021\/acs.est.2c00891","article-title":"Nontargeted identification and temporal trends of per-and polyfluoroalkyl substances in a fluorochemical industrial zone and adjacent Taihu Lake","volume":"56","author":"Yao","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.123729_bib38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ecoenv.2018.07.069","article-title":"Protective effects of zinc and N-acetyl-L-cysteine supplementation against cadmium induced erythrocyte cytotoxicity in Arbor Acres broiler chickens (Gallus gallus domesticus)","volume":"163","author":"Zhang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.123729_bib39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/tox.22039","article-title":"2, 4\u2010dichlorophenol induces ER stress\u2010mediated apoptosis via e IF 2\u03b1 dephosphorylation in vitro","volume":"31","author":"Zhang","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envpol.2024.123729_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024019","article-title":"Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung","volume":"6","author":"Zheng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2024.123729_bib41","article-title":"Adverse effects of gestational exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) homologs on maternal, fetal, and placental health in mice","author":"Zhu","year":"2023","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124004433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124004433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:33:38Z","timestamp":1759448018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749124004433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":40,"alternative-id":["S0269749124004433"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2024.123729","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time-course transcriptome analysis discloses PFDMO2OA (C8 HFPO-TA)-induced developmental malformations and cardiovascular toxicities in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2024.123729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123729"}}