{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:23:08Z","timestamp":1793161388220,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"Agencia Nacional De Promoci\u00f3n Cient\u00edfica Y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2018\\u201303617"],"award-info":[{"award-number":["PICT 2018\\u201303617"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"Agencia Nacional De Promoci\u00f3n Cient\u00edfica Y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2020\\u201308917"],"award-info":[{"award-number":["PICT 2020\\u201308917"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.envpol.2024.123840","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T09:44:12Z","timestamp":1711359852000},"page":"123840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["In vitro blastocyst implantation and trophoblast migration are disrupted by the UV filter benzophenone-3 (BP3)"],"prefix":"10.1016","volume":"349","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0497-4043","authenticated-orcid":false,"given":"Juli\u00e1n El\u00edas","family":"Abud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Pagotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Galliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Teglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Culzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Bollati-Fogol\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-080X","authenticated-orcid":false,"given":"Maria Laura","family":"Zenclussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio Adolfo","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2024.123840_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/humupd\/dmaa017","article-title":"Investigation of human trophoblast invasion in vitro","volume":"26","author":"Abbas","year":"2020","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.envpol.2024.123840_bib2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0021-9797(02)00082-6","article-title":"On the determination of the critical micelle concentration by the pyrene 1:3 ratio metho","volume":"258","author":"Aguiar","year":"2003","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.envpol.2024.123840_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110185","article-title":"Bisphenol A and benzophenone-3 exposure alters milk protein expression and its transcriptional regulation during functional differentiation of the mammary gland in vitro","volume":"191","author":"Altamirano","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.123840_bib4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1021\/es040055r","article-title":"Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss Lakes","volume":"39","author":"Balmer","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.123840_bib5","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1289\/ehp.11269","article-title":"Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National health and Nutrition Examination survey 2003--2004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.123840_bib6","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00216-006-0927-y","article-title":"Determination of UV filters and antimicrobial agents in environmental water samples","volume":"387","author":"Cuderman","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"issue":"Pt 2","key":"10.1016\/j.envpol.2024.123840_bib7","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1016\/j.scitotenv.2018.10.008","article-title":"Personal care products reconnaissance in EVROTAS river (Greece): water-sediment partition and bioaccumulation in fish","volume":"651","author":"D\u00edaz-Cruz","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.123840_bib8","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1067\/mai.2001.112430","article-title":"Anaphylaxis to oxybenzone, a frequent constituent of sunscreens","volume":"107","author":"Emonet","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.envpol.2024.123840_bib9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/1091581812459893","article-title":"Metabolic disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and skin administration in rats","volume":"31","author":"Fediuk","year":"2012","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.envpol.2024.123840_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1600-0897.2007.00557.x","article-title":"Supporting the hypothesis of pregnancy as a tumor: survivin is upregulated in normal pregnant mice and participates in human trophoblast proliferation","volume":"59","author":"Fest","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.envpol.2024.123840_bib11","article-title":"Dissecting the impact of maternal androgen exposure on Offspring health through targeting the androgen receptor in developmental Programming","author":"Haojiang","year":"2023","journal-title":"bioRxiv The PrePrint server For Biology"},{"key":"10.1016\/j.envpol.2024.123840_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1468-3083.2007.02492.x","article-title":"Sunscreens in human plasma and urine after repeated whole-body topical application","volume":"22","author":"Janjua","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol. : JEADV"},{"key":"10.1016\/j.envpol.2024.123840_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014409","article-title":"Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation","volume":"5","author":"Jensen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2024.123840_bib14","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.18632\/aging.202323","article-title":"Melatonin protects against oxybenzone-induced deterioration of mouse oocytes during maturation","volume":"13","author":"Jin","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.envpol.2024.123840_bib15","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.18632\/oncotarget.27831","article-title":"Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent","volume":"11","author":"Kariagina","year":"2020","journal-title":"Oncotarget"},{"key":"10.1016\/j.envpol.2024.123840_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.envint.2014.05.015","article-title":"Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: a mini-review","volume":"70","author":"Kim","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.123840_bib17","doi-asserted-by":"crossref","DOI":"10.3791\/58942","article-title":"In vitro assays to evaluate the migration, invasion, and proliferation of immortalized human first-trimester trophoblast cell lines","author":"Kisanga","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.envpol.2024.123840_bib18","doi-asserted-by":"crossref","first-page":"73648","DOI":"10.1007\/s11356-022-22895-z","article-title":"Environmental contamination status with common ingredients of household and personal care products exhibiting endocrine-disrupting potential","volume":"29","author":"Klancic","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2024.123840_bib19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.toxlet.2018.08.006","article-title":"The effects of benzophenone-3 on apoptosis and the expression of sex hormone receptors in the frontal cortex and hippocampus of rats","volume":"296","author":"Krzyzanowska","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2024.123840_bib20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1210\/js.2018-00024","article-title":"Oxybenzone alters mammary gland morphology in mice exposed during pregnancy and Lactation","volume":"2","author":"LaPlante","year":"2018","journal-title":"Journal of the Endocrine Society"},{"key":"10.1016\/j.envpol.2024.123840_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.envpol.2024.123840_bib22","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/jat.3227","article-title":"Benzo(a)pyrene inhibits migration and invasion of extravillous trophoblast HTR-8\/SVneo cells via activation of the ERK and JNK pathway","volume":"36","author":"Liu","year":"2016","journal-title":"J. Appl. Toxicol. : J. Anal. Toxicol."},{"key":"10.1016\/j.envpol.2024.123840_bib23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/es051380x","article-title":"Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in southern California","volume":"40","author":"Loraine","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.123840_bib24","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/HYPERTENSIONAHA.113.01892","article-title":"Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome","volume":"62","author":"Lyall","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.envpol.2024.123840_bib25","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5221","article-title":"Effects of benzophenone-3 and Propylparaben on estrogen receptor-dependent R-Loops and DNA Damage in breast epithelial cells and mice","volume":"128","author":"Majhi","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.123840_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107405","article-title":"Assessment of human exposure to benzophenone-type UV filters: a review","volume":"167","author":"Mao","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.123840_bib27","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.reprotox.2019.08.002","article-title":"Exposure to low doses of oxybenzone during perinatal development alters mammary gland morphology in male and female mice","volume":"92","author":"Matouskova","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envpol.2024.123840_bib28","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1001\/jama.2019.5586","article-title":"Effect of sunscreen application under maximal use conditions on plasma concentration of sunscreen active ingredients: a randomized clinical trial","volume":"321","author":"Matta","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.envpol.2024.123840_bib29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/jama.2019.20747","article-title":"Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical trial","volume":"323","author":"Matta","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.envpol.2024.123840_bib30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.envres.2017.11.033","article-title":"Determination of UV filters in human breast milk using turbulent flow chromatography and babies' daily intake estimation","volume":"161","author":"Molins-Delgado","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.123840_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107739","article-title":"Benzophenone-3: comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies","volume":"173","author":"Mustieles","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.123840_bib32","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.envpol.2024.123840_bib33","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2024.123840_bib34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxlet.2018.12.016","article-title":"The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures","volume":"303","author":"Santamaria","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2024.123840_bib35","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1007\/s00204-020-02776-5","article-title":"Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice","volume":"94","author":"Santamaria","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2024.123840_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tox.2004.06.044","article-title":"Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats","volume":"205","author":"Schlecht","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2024.123840_bib37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1289\/ehp.01109239","article-title":"In vitro and in vivo estrogenicity of UV screens","volume":"109","author":"Schlumpf","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.123840_bib38","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.placenta.2015.04.008","article-title":"Laminin alpha4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas","volume":"36","author":"Shan","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.envpol.2024.123840_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138503","article-title":"Occurrence and transfer of benzophenone-type ultraviolet filters from the pregnant women to fetuses","volume":"726","author":"Song","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.123840_bib40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.scitotenv.2004.03.015","article-title":"Persistence of pharmaceutical compounds and other organic wastewater contaminants in a conventional drinking-water-treatment plant","volume":"329","author":"Stackelberg","year":"2004","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.123840_bib41","first-page":"14355","article-title":"Effect of Bisphenol A on invasion ability of human trophoblastic cell line BeWo","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.envpol.2024.123840_bib42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.placenta.2010.03.002","article-title":"Cellular and molecular regulation of spiral artery remodelling: lessons from the cardiovascular field","volume":"31","author":"Whitley","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.envpol.2024.123840_bib43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/path.2946","article-title":"Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide","volume":"225","author":"Zenclussen","year":"2011","journal-title":"J. Pathol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124005542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124005542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T22:58:01Z","timestamp":1747177081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749124005542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":43,"alternative-id":["S0269749124005542"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2024.123840","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3210668\/v1","asserted-by":"object"}]},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro blastocyst implantation and trophoblast migration are disrupted by the UV filter benzophenone-3 (BP3)","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2024.123840","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123840"}}