{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:15:54Z","timestamp":1792682154319,"version":"4.5.0"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22193051"],"award-info":[{"award-number":["22193051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372463"],"award-info":[{"award-number":["82372463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22136006"],"award-info":[{"award-number":["22136006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172493"],"award-info":[{"award-number":["82172493"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.envpol.2024.124980","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T02:26:47Z","timestamp":1726453607000},"page":"124980","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Persistent organic pollutants and metabolic diseases: From the perspective of lipid droplets"],"prefix":"10.1016","volume":"362","author":[{"given":"Huixin","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoting","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2024.124980_bib1","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.3748\/wjg.v21.i36.10299","article-title":"Chronic hepatitis C virus infection and lipoprotein metabolism","volume":"21","author":"Aizawa","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.envpol.2024.124980_bib2","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1289\/ehp.1509902","article-title":"Diabetes prevalence in relation to serum concentrations of polychlorinated biphenyl (PCB) congener groups and three chlorinated pesticides in a native American population","volume":"124","author":"Aminov","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.124980_bib3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfs277","article-title":"TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL\/6 mice","volume":"131","author":"Angrish","year":"2013","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1289\/ehp.10554","article-title":"Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis","volume":"116","author":"Arsenescu","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.124980_bib6","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.envpol.2019.06.035","article-title":"Bioaccumulation and biomagnification of perfluoroalkyl acids and precursors in East Greenland polar bears and their ringed seal prey","volume":"252","author":"Boisvert","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2024.124980_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chemosphere.2014.06.093","article-title":"Complement activation is involved in the hepatic injury caused by high-dose exposure of mice to perfluorooctanoic acid","volume":"129","author":"Botelho","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2024.124980_bib8","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1074\/jbc.R111.309088","article-title":"Packaging of fat: an evolving model of lipid droplet assembly and expansion","volume":"287","author":"Brasaemle","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2024.124980_bib9","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1194\/jlr.M010256","article-title":"CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance","volume":"51","author":"Brown","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.envpol.2024.124980_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106117","article-title":"Associations between perfluoroalkyl substances and lipid profile in a highly exposed young adult population in the Veneto Region","volume":"145","author":"Canova","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.124980_bib11","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1021\/acs.est.8b05564","article-title":"Screening of potential PFOS alternatives to decrease liver bioaccumulation: experimental and computational approaches","volume":"53","author":"Cao","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.124980_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124963","article-title":"Chronic exposure to PFO4DA and PFO5DoDA, two perfluoroalkyl ether carboxylic acids (PFECAs), suppresses hepatic stress signals and disturbs glucose and lipid metabolism in male mice","volume":"411","author":"Chen","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.124980_bib13","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1172\/JCI10947","article-title":"A novel mouse model of lipotoxic cardiomyopathy","volume":"107","author":"Chiu","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envpol.2024.124980_bib14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fendo.2016.00030","article-title":"Adipose tissue remodeling: its role in energy metabolism and metabolic disorders","volume":"7","author":"Choe","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envpol.2024.124980_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.108978","article-title":"Orientin reduces the inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin signaling pathway in murine 3T3-L1 adipocytes","volume":"318","author":"Choi","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2024.124980_bib16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.bbalip.2012.12.009","article-title":"Autophagy: emerging roles in lipid homeostasis and metabolic control","volume":"1831","author":"Christian","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.envpol.2024.124980_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106204","article-title":"Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat","volume":"146","author":"Conley","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.124980_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s40572-017-0166-8","article-title":"Persistent endocrine-disrupting chemicals and fatty liver disease","volume":"4","author":"Deierlein","year":"2017","journal-title":"Curr. Environ. Health Rep"},{"key":"10.1016\/j.envpol.2024.124980_bib19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chemosphere.2018.10.196","article-title":"Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction","volume":"217","author":"Deng","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2024.124980_bib20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/oby.2010.133","article-title":"Obesity and persistent organic pollutants: possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls","volume":"19","author":"Dirinck","year":"2011","journal-title":"Obes. Silver Spring Md"},{"key":"10.1016\/j.envpol.2024.124980_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108631","article-title":"Serum measures of hexabromocyclododecane (HBCDD) and polybrominated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom","volume":"177","author":"Drage","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.124980_bib22","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1289\/ehp.1408417","article-title":"In utero and childhood polybrominated diphenyl ether exposures and body mass at age 7 years: the CHAMACOS study","volume":"123","author":"Erkin-Cakmak","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.124980_bib24","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/toxsci\/kfv206","article-title":"2,3,7,8-Tetrachlorodibenzo-p-Dioxin alters lipid metabolism and depletes immune cell populations in the jejunum of C57bl\/6 mice","volume":"148","author":"Fader","year":"2015","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2009.11.005","article-title":"Lipid droplets finally get a little R-E-S-P-E-C-T","volume":"139","author":"Farese","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2024.124980_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI10310","article-title":"Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages","volume":"107","author":"Fazio","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envpol.2024.124980_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105324","article-title":"Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma","volume":"137","author":"Forsthuber","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.124980_bib28","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1210\/clinem\/dgac079","article-title":"The Journal of clinical endocrinology and metabolism","volume":"107","author":"Fourman","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.envpol.2024.124980_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/10408444.2021.1888073","article-title":"Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?","volume":"51","author":"Fragki","year":"2021","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrgastro.2017.32","article-title":"Lipid droplets and liver disease: from basic biology to clinical implications","volume":"14","author":"Gluchowski","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envpol.2024.124980_bib31","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1039\/D0EM00291G","article-title":"An overview of the uses of per- and polyfluoroalkyl substances (PFAS)","volume":"22","author":"Gl\u00fcge","year":"2020","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.envpol.2024.124980_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/CIRCULATIONAHA.118.033704","article-title":"Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 national heart, lung, and blood institute workshop","volume":"138","author":"Goldberg","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2024.124980_bib33","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1021\/acs.est.9b00148","article-title":"Comparative hepatotoxicity of novel PFOA alternatives (perfluoropolyether carboxylic acids) on male mice","volume":"53","author":"Guo","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.124980_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111009","article-title":"Umbilical cord serum PBDE concentrations and child adiposity measures at 7 years","volume":"203","author":"Guo","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.124980_bib35","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s12265-021-10204-x","article-title":"Lipid droplet\u2014a new target in ischemic heart disease","volume":"15","author":"Guo","year":"2022","journal-title":"J. Cardiovasc. Trans. Res."},{"key":"10.1016\/j.envpol.2024.124980_bib36","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/tx034005w","article-title":"Binding of perfluorooctanoic acid to rat and human plasma proteins","volume":"16","author":"Han","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110125","article-title":"Exposure to organochlorine pesticides and the risk of type 2 diabetes in the population of East China","volume":"190","author":"Han","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.124980_bib38","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.envres.2018.07.009","article-title":"Adipose tissue levels of polybrominated diphenyl ethers and breast cancer risk in Chinese women: a case-control study","volume":"167","author":"He","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.124980_bib39","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.envres.2017.03.053","article-title":"Determinants of increasing serum POPs in a population at high risk for cardiovascular disease. Results from the PREDIMED-CANARIAS study","volume":"156","author":"Henr\u00edquez-Hern\u00e1ndez","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.124980_bib41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jhazmat.2010.06.081","article-title":"Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells","volume":"182","author":"Hsu","year":"2010","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.124980_bib42","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1016\/j.apsb.2021.10.014","article-title":"Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver","volume":"11","author":"Jin","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.envpol.2024.124980_bib43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0269-7491(99)00098-6","article-title":"Persistent organic pollutants (POPs): state of the science","volume":"100","author":"Jones","year":"1999","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2024.124980_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12199-018-0692-5","article-title":"Association between diabetes and pesticides: a case-control study among Thai farmers","volume":"23","author":"Juntarawijit","year":"2018","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.envpol.2024.124980_bib45","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ncb3166","article-title":"Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis","volume":"17","author":"Kaushik","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.envpol.2024.124980_bib46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pestbp.2016.01.005","article-title":"4, 4\u2032-Dichlorodiphenyltrichloroethane (DDT) and 4, 4\u2032-dichlorodiphenyldichloroethylene (DDE) promote adipogenesis in 3T3-L1 adipocyte cell culture","volume":"131","author":"Kim","year":"2016","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.envpol.2024.124980_bib47","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s00204-016-1889-2","article-title":"Polychlorinated biphenyls exposure-induced insulin resistance is mediated by lipid droplet enlargement through Fsp27","volume":"91","author":"Kim","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib48","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxlet.2018.04.029","article-title":"Polychlorinated biphenyl 138 exposure-mediated lipid droplet enlargement endows adipocytes with resistance to TNF-\u03b1-induced cell death","volume":"292","author":"Kim","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2024.124980_bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bbadis.2013.05.007","article-title":"Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis","volume":"1842","author":"Konige","year":"2014","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.envpol.2024.124980_bib50","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/emmm.201100671","article-title":"Balancing the fat: lipid droplets and human disease","volume":"5","author":"Krahmer","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.envpol.2024.124980_bib51","first-page":"82","article-title":"Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years","volume":"21","author":"Kupsco","year":"2022","journal-title":"Environ. Health Glob. Access Sci. Source"},{"key":"10.1016\/j.envpol.2024.124980_bib52","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1053\/j.gastro.2010.03.033","article-title":"A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis","volume":"139","author":"Lee","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.envpol.2024.124980_bib53","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1080\/15287390600751447","article-title":"Persistent organic pollutants and adverse health effects in humans","volume":"69","author":"Li","year":"2006","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.envpol.2024.124980_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106665","article-title":"Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study","volume":"155","author":"Liang","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.124980_bib55","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1289\/ehp.1103563","article-title":"Circulating levels of persistent organic pollutants (POPs) and carotid atherosclerosis in the elderly","volume":"120","author":"Lind","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.124980_bib56","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.envres.2016.10.002","article-title":"Circulating levels of perfluoroalkyl substances (PFASs) and carotid artery atherosclerosis","volume":"\u65e0 152","author":"Lind","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.124980_bib57","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1001\/jamacardio.2019.0295","article-title":"Burden of cardiovascular diseases in China, 1990-2016: findings from the 2016 global burden of disease study","volume":"4","author":"Liu","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.envpol.2024.124980_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111724","article-title":"Do perfluoroalkyl substances aggravate the occurrence of obesity-associated glucolipid metabolic disease?","volume":"202","author":"Liu","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.124980_bib59","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"Lopaschuk","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envpol.2024.124980_bib60","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2337\/dc07-0912","article-title":"Glucose indices, health behaviors, and incidence of diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study","volume":"31","author":"Magliano","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.envpol.2024.124980_bib61","article-title":"Trends in incidence of total or type 2 diabetes: systematic review","volume":"366","author":"Magliano","year":"2019","journal-title":"BMJ Br. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.envpol.2024.124980_bib62","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.envint.2017.09.018","article-title":"Morbidity in New Zealand pesticide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"110","author":"Mannetje","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.124980_bib63","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/82630","article-title":"Absence of perilipin results in leanness and reverses obesity in Lepr(db\/db) mice","volume":"26","author":"Martinez-Botas","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.envpol.2024.124980_bib64","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s00204-018-2235-7","article-title":"Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126","volume":"92","author":"Mesnage","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib65","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/jcb.21964","article-title":"Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes","volume":"105","author":"Miyoshi","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.envpol.2024.124980_bib66","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1001\/jama.289.1.76","article-title":"Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001","volume":"289","author":"Mokdad","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.envpol.2024.124980_bib67","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41574-021-00471-8","article-title":"Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics","volume":"17","author":"Morigny","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.envpol.2024.124980_bib68","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00709-011-0329-7","article-title":"The dynamic roles of intracellular lipid droplets: from archaea to mammals","volume":"249","author":"Murphy","year":"2012","journal-title":"Protoplasma"},{"key":"10.1016\/j.envpol.2024.124980_bib69","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1021\/acs.chemrestox.6b00430","article-title":"Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin","volume":"30","author":"Nault","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib70","first-page":"2808","article-title":"FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets","volume":"118","author":"Nishino","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envpol.2024.124980_bib71","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2024.124980_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125437","article-title":"Exposure to a low concentration of mixed organochlorine pesticides impairs glucose metabolism and mitochondrial function in L6 myotubes and zebrafish","volume":"414","author":"Park","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.124980_bib73","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.tjnut.2023.01.018","article-title":"Dysregulation of lipid droplet protein expression in adipose tissues and association with metabolic risk factors in adult females with obesity and type 2 diabetes","volume":"153","author":"Park","year":"2023","journal-title":"J. Nutr."},{"key":"10.1016\/j.envpol.2024.124980_bib74","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/toxsci\/kfx275","article-title":"Dioxin-like PCB 126 increases systemic inflammation and accelerates atherosclerosis in lean LDL receptor-deficient mice","volume":"162","author":"Petriello","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2024.124980_bib75","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.201311051","article-title":"Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites","volume":"204","author":"Pol","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.envpol.2024.124980_bib76","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metab., Clin. Exp."},{"key":"10.1016\/j.envpol.2024.124980_bib77","doi-asserted-by":"crossref","first-page":"34213","DOI":"10.1074\/jbc.M707404200","article-title":"Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage","volume":"282","author":"Puri","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2024.124980_bib78","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1021\/acs.chemrestox.2c00043","article-title":"2,2\u2032,4,4\u2032-Tetrabromodiphenyl ether (PBDE 47) selectively stimulates proatherogenic PPAR\u03b3 signatures in human THP-1 macrophages to contribute to foam cell formation","volume":"35","author":"Ren","year":"2022","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib79","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1242\/jcs.03191","article-title":"Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis","volume":"119","author":"Robenek","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.envpol.2024.124980_bib80","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev-cellbio-031320-101827","article-title":"Protein quality control and lipid droplet metabolism","volume":"36","author":"Roberts","year":"2020","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2024.124980_bib81","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1289\/ehp.0901321","article-title":"Persistent organic pollutant exposure leads to insulin resistance syndrome","volume":"118","author":"Ruzzin","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.124980_bib82","doi-asserted-by":"crossref","first-page":"E289","DOI":"10.1152\/ajpendo.00099.2009","article-title":"Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase\/PNPLA2 or CGI-58\/ABHD5","volume":"297","author":"Schweiger","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.envpol.2024.124980_bib83","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.semcdb.2020.04.011","article-title":"Hepatic lipid droplet homeostasis and fatty liver disease","volume":"108","author":"Seebacher","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2024.124980_bib84","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00204-017-2055-1","article-title":"Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein","volume":"92","author":"Sheng","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib85","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2024.124980_bib86","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/sj.embor.7400559","article-title":"ATGL has a key role in lipid droplet\/adiposome degradation in mammalian cells","volume":"7","author":"Smirnova","year":"2006","journal-title":"EMBO Rep."},{"issue":"Suppl. 1","key":"10.1016\/j.envpol.2024.124980_bib87","article-title":"Prenatal exposure to persistent organic pollutants and childhood obesity: a systematic review and meta-analysis of human studies","volume":"23","author":"Stratakis","year":"2022","journal-title":"Obes. Rev. Off. J. Int. Assoc. Study Obes."},{"key":"10.1016\/j.envpol.2024.124980_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8080262","article-title":"Lipid metabolism in macrophages: focus on atherosclerosis","volume":"8","author":"Sukhorukov","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.envpol.2024.124980_bib89","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1021\/acs.estlett.6b00398","article-title":"Legacy and emerging perfluoroalkyl substances are important drinking water contaminants in the cape fear river watershed of North Carolina","volume":"3","author":"Sun","year":"2016","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envpol.2024.124980_bib90","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1073\/pnas.101042998","article-title":"Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity","volume":"98","author":"Tansey","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.envpol.2024.124980_bib91","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/JOE-16-0449","article-title":"A causal role for hyperinsulinemia in obesity","volume":"232","author":"Templeman","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.envpol.2024.124980_bib92","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1080\/15548627.2017.1319544","article-title":"The constitutive lipid droplet protein PLIN2 regulates autophagy in liver","volume":"13","author":"Tsai","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2024.124980_bib93","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1289\/ehp.1409062","article-title":"Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the rhea mother-child cohort (crete, Greece)","volume":"123","author":"Vafeiadi","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.124980_bib94","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/01.ede.0000220553.84350.c5","article-title":"Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus","volume":"17","author":"Vasiliu","year":"2006","journal-title":"Epidemiol. Camb. Mass"},{"key":"10.1016\/j.envpol.2024.124980_bib95","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1289\/EHP139","article-title":"Prenatal polybrominated diphenyl ether exposure and body mass index in children up to 8 Years of age","volume":"124","author":"Vuong","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.124980_bib96","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bbalip.2008.10.009","article-title":"The life of lipid droplets","volume":"1791","author":"Walther","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.envpol.2024.124980_bib97","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1146\/annurev-biochem-061009-102430","article-title":"Lipid droplets and cellular lipid metabolism","volume":"81","author":"Walther","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.envpol.2024.124980_bib98","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-cellbio-100616-060608","article-title":"Lipid droplet biogenesis","volume":"33","author":"Walther","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2024.124980_bib99","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1038\/srep02174","article-title":"Specific accumulation of lipid droplets in hepatocyte nuclei of PFOA-exposed BALB\/c mice","volume":"3","author":"Wang","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2024.124980_bib100","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1038\/srep04582","article-title":"PFOS induced lipid metabolism disturbances in BALB\/c mice through inhibition of low density lipoproteins excretion","volume":"4","author":"Wang","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2024.124980_bib101","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.scitotenv.2017.11.049","article-title":"Legacy and novel brominated flame retardants in indoor dust from Beijing, China: occurrence, human exposure assessment and evidence for PBDEs replacement","volume":"618","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.124980_bib102","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/acs.estlett.0c00048","article-title":"Perfluorooctanesulfonate induces hepatomegaly and lipoatrophy in mice through phosphoenolpyruvate carboxykinase-mediated glyceroneogenesis inhibition","volume":"7","author":"Wang","year":"2020","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envpol.2024.124980_bib103","doi-asserted-by":"crossref","first-page":"R470","DOI":"10.1016\/j.cub.2015.04.004","article-title":"Expanding roles for lipid droplets","volume":"25","author":"Welte","year":"2015","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.envpol.2024.124980_bib104","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bbalip.2017.07.006","article-title":"Lipid droplet functions beyond energy storage","volume":"1862","author":"Welte","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.envpol.2024.124980_bib105","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1007\/s11033-013-2671-7","article-title":"The genetic contribution of CIDEA polymorphisms, haplotypes and loci interaction to obesity in a Han Chinese population","volume":"40","author":"Wu","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.envpol.2024.124980_bib106","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.redox.2017.02.026","article-title":"Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of ROS\/NF-\u03baB signaling via downregulation of HNF1b","volume":"12","author":"Wu","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2024.124980_bib107","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.bbadis.2017.07.019","article-title":"Lipid droplet proteins and metabolic diseases","volume":"1864","author":"Xu","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.envpol.2024.124980_bib108","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00204-014-1322-7","article-title":"Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days","volume":"89","author":"Yan","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib109","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.scitotenv.2018.07.087","article-title":"The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation","volume":"644","author":"Yang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.124980_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.120766","article-title":"Chronic exposure to tetrabromodiphenyl ether (BDE-47) aggravates hepatic steatosis and liver fibrosis in diet-induced obese mice","volume":"378","author":"Yang","year":"2019","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.124980_bib111","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9833","article-title":"Evaluation of early biomarkers of atherosclerosis associated with polychlorinated biphenyl exposure: an in vitro and in vivo study","volume":"130","author":"Yang","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.124980_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150350","article-title":"Lipid metabolism dysfunction and toxicity of BDE-47 exposure in white adipose tissue revealed by the integration of lipidomics and metabolomics","volume":"806","author":"Yang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.124980_bib113","doi-asserted-by":"crossref","first-page":"13389","DOI":"10.1021\/acs.est.0c02888","article-title":"Novel perfluoroalkyl ether carboxylic acids (PFECAs) and sulfonic acids (PFESAs): occurrence and association with serum biochemical parameters in residents living near a fluorochemical plant in China","volume":"54","author":"Yao","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.124980_bib114","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: review of the underlying molecular mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.envpol.2024.124980_bib115","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13238-012-2025-6","article-title":"Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis","volume":"3","author":"Yuan","year":"2012","journal-title":"Protein Cell"},{"key":"10.1016\/j.envpol.2024.124980_bib116","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.fct.2018.09.024","article-title":"Decabromodiphenyl ether (BDE-209) enhances foam cell formation in human macrophages via augmenting Toll-like receptor 4-dependent lipid uptake","volume":"121","author":"Zhi","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2024.124980_bib117","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep.31150","article-title":"Epidemiological features of NAFLD from 1999 to 2018 in China","volume":"71","author":"Zhou","year":"2020","journal-title":"Hepatology"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124016956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124016956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:08:21Z","timestamp":1780499301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749124016956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":114,"alternative-id":["S0269749124016956"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2024.124980","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistent organic pollutants and metabolic diseases: From the perspective of lipid droplets","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2024.124980","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124980"}}