{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:59:46Z","timestamp":1788591586144,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.envpol.2024.125031","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T15:51:24Z","timestamp":1729698684000},"page":"125031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"P2","title":["PFOS sub-chronic exposure selectively activates A\u03b2 clearance pathway to improve the cognitive ability of AD mice"],"prefix":"10.1016","volume":"363","author":[{"given":"Haijing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donggang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2024.125031_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141251","article-title":"Per- and polyfluoroalkyl substances in soil and sediments: occurrence, fate, remediation and future outlook","volume":"748","author":"Ahmed","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.125031_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2174\/1567205012666141218140953","article-title":"Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease","volume":"12","author":"Baranello","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.envpol.2024.125031_bib3","doi-asserted-by":"crossref","first-page":"7684","DOI":"10.1021\/acs.est.2c09361","article-title":"PPAR\u03b3 as a potential target for adipogenesis induced by fine particulate matter in 3T3-L1 preadipocytes","volume":"57","author":"Cao","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.125031_bib4","doi-asserted-by":"crossref","DOI":"10.1289\/EHP13503","article-title":"Association between fine particulate matter exposure and cerebrospinal fluid biomarkers of Alzheimer \u2019 s disease among a cognitively healthy population-based cohort","volume":"132","author":"Casey","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.125031_bib5","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209162","article-title":"Association of PM2.5 exposure and Alzheimer disease pathology in brain bank donors-effect modification by APOE genotype","volume":"102","author":"Christensen","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.envpol.2024.125031_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12974-023-02914-7","article-title":"Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging","volume":"20","author":"Corraliza-Gomez","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.envpol.2024.125031_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neulet.2015.01.036","article-title":"Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of A\u03b2 by insulin degrading enzyme (IDE) in Alzheimer's disease","volume":"589","author":"Del Campo","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.envpol.2024.125031_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212113","article-title":"The medial prefrontal cortex and fear memory: dynamics, connectivity, and engrams","volume":"22","author":"Dixsaut","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2024.125031_bib9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbrc.2009.04.047","article-title":"PPAR\u03b3 transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons","volume":"383","author":"Du","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envpol.2024.125031_bib10","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.0230450100","article-title":"Insulin-degrading enzyme regulates the levels of insulin, amyloid \u03b2-protein, and the \u03b2-amyloid precursor protein intracellular domain in vivo","volume":"100","author":"Farris","year":"2003","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.envpol.2024.125031_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/lm.052480.120","article-title":"Emotional arousal impairs association memory: roles of prefrontal cortex regions","volume":"28","author":"Fujiwara","year":"2021","journal-title":"Learn. Mem."},{"key":"10.1016\/j.envpol.2024.125031_bib12","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2024.125031_bib13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.envpol.2024.125031_bib14","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2024.125031_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.14341\/probl13183","article-title":"The role of antidiabetic drugs in the treatment of Alzheimer's disease: systematic review","volume":"69","author":"Ishmuratova","year":"2023","journal-title":"Probl. Endocrinol."},{"key":"10.1016\/j.envpol.2024.125031_bib16","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.scitotenv.2018.04.380","article-title":"A short review on human exposure to and tissue distribution of per- and polyfluoroalkyl substances (PFASs)","volume":"636","author":"Jian","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2024.125031_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.112891","article-title":"Recognition memory impairments and amyloid-beta deposition of the retrosplenial cortex at the early stage of 5XFAD mice","volume":"222","author":"Kim","year":"2020","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.envpol.2024.125031_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.envpol.2024.125031_bib19","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.3390\/cells11071228","article-title":"Insulin-degrading enzyme, an under-estimated potential target to treat cancer?","volume":"11","author":"Lesire","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2024.125031_bib20","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1021\/acs.est.7b06327","article-title":"Chlorinated polyfluorinated ether sulfonates exhibit higher activity toward peroxisome proliferator-activated receptors signaling pathways than perfluorooctanesulfonate","volume":"52","author":"Li","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.125031_bib21","article-title":"Differential DNA methylation in the brain as potential mediator of the association between traffic-related PM2.5 and neuropathology markers of Alzheimer's disease","author":"Li","year":"2024","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.envpol.2024.125031_bib22","article-title":"Neurotoxicity of perfluorooctane sulfonate to hippocampal cells in adult mice","volume":"vol. 8","author":"Long","year":"2013"},{"key":"10.1016\/j.envpol.2024.125031_bib23","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1021\/acs.est.9b01608","article-title":"Mass spectrometry-based metabolomics reveals occupational exposure to per- and polyfluoroalkyl substances relates to oxidative stress, fatty acid \u03b2-oxidation disorder, and kidney injury in a manufactory in China","volume":"53","author":"Lu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2024.125031_bib24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/eurpub\/ckx066","article-title":"Drinking water contamination from perfluoroalkyl substances (PFAS): an ecological mortality study in the Veneto Region, Italy","volume":"28","author":"Mastrantonio","year":"2018","journal-title":"Eur. J. Publ. Health"},{"key":"10.1016\/j.envpol.2024.125031_bib26","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/NEN.0b013e3182345e46","article-title":"A\u03b2-degrading enzymes: potential for treatment of Alzheimer disease","volume":"70","author":"Miners","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.envpol.2024.125031_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40659-022-00404-3","article-title":"Inflammation context in Alzheimer's disease, a relationship intricate to define","volume":"55","author":"Novoa","year":"2022","journal-title":"Biol. Res."},{"key":"10.1016\/j.envpol.2024.125031_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau6328","article-title":"Sodium rutin ameliorates Alzheimer's disease\u2013like pathology by enhancing microglial amyloid-\u03b2 clearance","volume":"5","author":"Pan","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.envpol.2024.125031_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110346","article-title":"Perfluoroalkyl substances and cognitive function in older adults: should we consider non-monotonic dose-responses and chronic kidney disease?","volume":"192","author":"Park","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2024.125031_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101867","article-title":"The pollutome-connectome axis: a putative mechanism to explain pollution effects on neurodegeneration","volume":"86","author":"Pini","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.envpol.2024.125031_bib32","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1080\/07853890.2016.1197416","article-title":"Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?","volume":"48","author":"Pivovarova","year":"2016","journal-title":"Ann. Med."},{"key":"10.1016\/j.envpol.2024.125031_bib33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000342310","article-title":"Cross-Sectional association between polyfluoroalkyl chemicals and cognitive limitation in the national health and nutrition examination survey","volume":"40","author":"Power","year":"2013","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.envpol.2024.125031_bib34","doi-asserted-by":"crossref","first-page":"44659","DOI":"10.1007\/s11356-020-08243-z","article-title":"Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases","volume":"27","author":"Rahman","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2024.125031_bib35","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41586-021-03452-z","article-title":"Mouse prefrontal cortex represents learned rules for categorization","volume":"593","author":"Reinert","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2024.125031_bib36","article-title":"The China Alzheimer report 2022","volume":"35","author":"Ren","year":"2022","journal-title":"Gen Psychiatry"},{"key":"10.1016\/j.envpol.2024.125031_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/srep12531","article-title":"Insulin-degrading enzyme prevents \u03b1-synuclein fibril formation in a nonproteolytical manner","volume":"5","author":"Sharma","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2024.125031_bib38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease","volume":"19","author":"Singh","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.envpol.2024.125031_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.envint.2015.11.016","article-title":"Serum perfluorinated chemicals, glucose homeostasis and the risk of diabetes in working-aged Taiwanese adults","volume":"88","author":"Su","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.125031_bib40","doi-asserted-by":"crossref","DOI":"10.1289\/EHP2619","article-title":"Plasma concentrations of perfluoroalkyl substances and risk of type 2 diabetes: a prospective investigation among U.S. Women","volume":"126","author":"Sun","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2024.125031_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","article-title":"Neuroinflammation in Alzheimer's disease: current progress in molecular signaling and therapeutics","volume":"46","author":"Thakur","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.envpol.2024.125031_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2015.00025","article-title":"Clearance of amyloid \u03b2-protein and its role in the spreading of Alzheimer's disease pathology","volume":"7","author":"Thal","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.envpol.2024.125031_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101999","article-title":"Insulin-degrading enzyme: roles and pathways in ameliorating cognitive impairment associated with Alzheimer's disease and diabetes","volume":"90","author":"Tian","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.envpol.2024.125031_bib44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12302-022-00675-3","article-title":"Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010\u20132011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)","volume":"34","author":"Van Larebeke","year":"2022","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.envpol.2024.125031_bib45","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1523\/JNEUROSCI.20-05-01657.2000","article-title":"Neurons regulate extracellular levels of amyloid \u03b2-protein via proteolysis by insulin-degrading enzyme","volume":"20","author":"Vekrellis","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.envpol.2024.125031_bib46","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.drudis.2006.08.004","article-title":"Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives","volume":"11","author":"Wang","year":"2006","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.envpol.2024.125031_bib47","doi-asserted-by":"crossref","first-page":"32093","DOI":"10.1007\/s11356-021-17789-5","article-title":"Mixed effects of perfluoroalkyl and polyfluoroalkyl substances exposure on cognitive function among people over 60 years old from NHANES","volume":"29","author":"Weng","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2024.125031_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107779","article-title":"Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: a nationally representative cross-sectional study","volume":"172","author":"Wu","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.125031_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119020","article-title":"Serum concentrations of per-\/polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant: a cross-sectional study","volume":"302","author":"Xie","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2024.125031_bib50","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/1567205012666150204121719","article-title":"Role of environmental contaminants in the etiology of Alzheimer's disease: a review","volume":"12","author":"Yegambaram","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.envpol.2024.125031_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121650","article-title":"Effects of subchronic exposure of perfluorooctane sulfonate on cognitive function of mice and its mechanism","volume":"329","author":"Zhang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2024.125031_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107951","article-title":"Insight into the binding model of per- and polyfluoroalkyl substances to proteins and membranes","volume":"175","author":"Zhao","year":"2023","journal-title":"Environ. Int."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124017469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124017469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:14:14Z","timestamp":1732320854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749124017469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":50,"alternative-id":["S0269749124017469"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2024.125031","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PFOS sub-chronic exposure selectively activates A\u03b2 clearance pathway to improve the cognitive ability of AD mice","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2024.125031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125031"}}