{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:41:27Z","timestamp":1788259287162,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.envpol.2024.125514","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:18:36Z","timestamp":1733789916000},"page":"125514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Cadmium exposure induces oxidative stress-mediated necroptosis via TLR4\/NF-\u03baB signaling pathway in pig epididymis"],"prefix":"10.1016","volume":"366","author":[{"given":"Yulong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2024.125514_bib1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/and.12426","article-title":"Protective effects of Artocarpus altilis (Moraceae) on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats","volume":"48","author":"Adaramoye","year":"2016","journal-title":"Andrologia"},{"key":"10.1016\/j.envpol.2024.125514_bib2","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/jat.3771","article-title":"Pharmacological inhibition of TLR4\/NF-\u03baB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells","volume":"39","author":"Adegoke","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envpol.2024.125514_bib3","doi-asserted-by":"crossref","first-page":"21713","DOI":"10.1007\/s11356-018-2138-4","article-title":"Ascorbic acid inhibits cadmium-induced disruption of the blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways","volume":"25","author":"Chen","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2024.125514_bib4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.chemosphere.2017.12.026","article-title":"Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating the miR-33-AMPK axis","volume":"194","author":"Chen","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2024.125514_bib5","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3390\/cells8121486","article-title":"Molecular insights into the mechanism of necroptosis: the necrosome as a potential therapeutic target","volume":"8","author":"Chen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2024.125514_bib6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.marpolbul.2019.04.007","article-title":"Assessment of metal contamination in Arabian\/Persian Gulf fish: a review","volume":"143","author":"Cunningham","year":"2019","journal-title":"Mar. Pollut. Bull."},{"issue":"1","key":"10.1016\/j.envpol.2024.125514_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12876-022-02208-x","article-title":"RIP3 knockdown inhibits necroptosis of human intestinal epithelial cells via the TLR4\/MyD88\/NF-\u03baB signaling and ameliorates murine colitis","volume":"22","author":"Duan","year":"2022","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.envpol.2024.125514_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ecoenv.2017.10.016","article-title":"Amelioration of cadmium-induced testes' damage in rats by the bone marrow mesenchymal stem cells","volume":"148","author":"Elbaghdady","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.125514_bib9","doi-asserted-by":"crossref","first-page":"23306","DOI":"10.1007\/s11356-019-05607-y","article-title":"Partial ameliorative effect of Moringa leaf ethanolic extract on the reproductive toxicity and the expression of steroidogenic genes induced by subchronic cadmium in male rats","volume":"26","author":"Elblehi","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2024.125514_bib10","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2741\/3303","article-title":"Crosstalk signaling between mitochondrial Ca2+ and ROS","volume":"14","author":"Feissner","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.envpol.2024.125514_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.imlet.2019.09.001","article-title":"Melatonin protects against lipopolysaccharide-induced epididymitis in sheep epididymal epithelial cells in vitro","volume":"214","author":"Ge","year":"2019","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.envpol.2024.125514_bib12","article-title":"Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2024.125514_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110974","article-title":"Oxidative stress and mitochondrial dysfunction involved in ammonia-induced nephrocyte necroptosis in chickens","volume":"203","author":"Han","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.125514_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112654","article-title":"MiR-182\u20135p\/TLR4\/NF-\u03baB axis contributes to the protective effect of caffeic acid phenethyl ester against cadmium-induced spleen toxicity and associated damage in mice","volume":"158","author":"Hao","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2024.125514_bib15","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.biopha.2018.07.128","article-title":"3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro","volume":"106","author":"He","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envpol.2024.125514_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105181","article-title":"USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4\/NF-\u03baB\/ROS signaling","volume":"75","author":"Jiang","year":"2021","journal-title":"Toxicol. Vitro"},{"issue":"6","key":"10.1016\/j.envpol.2024.125514_bib17","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1002\/jcp.30166","article-title":"The role of toll-like receptor 4 (TLR4) in cancer progression: a possible therapeutic target?","volume":"236","author":"Kashani","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.envpol.2024.125514_bib18","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.3390\/ijms20235896","article-title":"Caspase-8 regulates endoplasmic reticulum stress-induced necroptosis independent of the apoptosis pathway in auditory cells","volume":"20","author":"Kishino","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2024.125514_bib19","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s12011-019-01717-3","article-title":"Selenium-alleviated hepatocyte necrosis and DNA damage in cyclophosphamide-treated geese by mitigating oxidative stress","volume":"193","author":"Li","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2024.125514_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112583","article-title":"2-Amino-3-methylimidazo[4,5-f]quinoline induced oxidative stress and inflammation via TLR4\/MAPK and TLR4\/NF-\u03baB signaling pathway in zebrafish (Danio rerio) livers","volume":"157","author":"Li","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2024.125514_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113345","article-title":"Cadmium induces testosterone synthesis disorder by testicular cell damage via TLR4\/MAPK\/NF-\u03baB signaling pathway leading to reduced sexual behavior in piglets","volume":"233","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.envpol.2024.125514_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12016-013-8402-y","article-title":"TLR2 and TLR4 in autoimmune diseases: a comprehensive review","volume":"47","author":"Liu","year":"2014","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.envpol.2024.125514_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108995","article-title":"Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis, and immunosuppression in grass carp through the ROS-regulated TLR4\/MyD88\/NF-\u03baB pathway","volume":"140","author":"Lei","year":"2023","journal-title":"Fish Shellfish Immun"},{"key":"10.1016\/j.envpol.2024.125514_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115014","article-title":"Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2\/HO-1 and TLR4\/NF-\u03baB pathways","volume":"397","author":"Ma","year":"2020","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.envpol.2024.125514_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/and.13064","article-title":"Profertility effects of Shilajit on cadmium-induced infertility in male mice","volume":"50","author":"Mishra","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.envpol.2024.125514_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.962519","article-title":"Zinc restores functionality in porcine prepubertal Sertoli cells exposed to subtoxic cadmium concentration via regulating the Nrf2 signaling pathway","volume":"14","author":"Mancuso","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envpol.2024.125514_bib27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3390\/biom12030360","article-title":"Metallothionein and cadmium toxicology-historical review and commentary","volume":"12","author":"Nordberg","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.envpol.2024.125514_bib28","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s12011-016-0663-x","article-title":"Effects of arctium lappa on cadmium-induced damage to the testis and epididymis of adult wistar rats","volume":"173","author":"Predes","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2024.125514_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111516","article-title":"Cadmium exposure induces inflammation and necroptosis in porcine adrenal gland via activating NF-\u03baB\/MAPK pathway","volume":"223","author":"Qi","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.envpol.2024.125514_bib30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10661-019-7528-7","article-title":"The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview","volume":"191","author":"Rahman","year":"2019","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.envpol.2024.125514_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108024","article-title":"Investigation of the ameliorative effects of baicalin against arsenic trioxide-induced cardiac toxicity in mice","volume":"99","author":"Sun","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.envpol.2024.125514_bib32","article-title":"Pig lung fibrosis is active in the subacute CdCl2 exposure model and exerts cumulative toxicity through the M1\/M2 imbalance","volume":"225","author":"Shi","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.125514_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118659","article-title":"AMPK\/PPAR-\u03b3\/NF-\u03baB axis participates in ROS-mediated apoptosis and autophagy caused by cadmium in pig liver. Environmental","volume":"294","author":"Wang","year":"2022","journal-title":"Pollution"},{"key":"10.1016\/j.envpol.2024.125514_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111310","article-title":"Protective effect of naringenin against cadmium-induced testicular toxicity in male SD rats","volume":"214","author":"Wang","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.envpol.2024.125514_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112566","article-title":"Artemisia ordosica polysaccharide alleviated lipopolysaccharide-induced oxidative stress of broilers via nrf2\/keap1 and TLR4\/NF-\u03baB pathway","volume":"223","author":"Xing","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.125514_bib36","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1002\/jcp.30105","article-title":"MiR-1696\/GPx3 axis is involved in oxidative stress mediated neutrophil extracellular traps inhibition in chicken neutrophils","volume":"236","author":"Yang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.envpol.2024.125514_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116497","article-title":"MAPK\/iNOS pathway is involved in swine kidney necrosis caused by cadmium exposure","volume":"274","author":"Yang","year":"2021","journal-title":"Environmental. Pollution"},{"key":"10.1016\/j.envpol.2024.125514_bib38","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/and.12568","article-title":"Efficacy of Crocus sativus L. on reduction of cadmium-induced toxicity on spermatogenesis in adult rats","volume":"48","author":"Yari","year":"2016","journal-title":"Andrologia"},{"key":"10.1016\/j.envpol.2024.125514_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115449","article-title":"Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1\/MEK\/ERK and NF-\u03baB pathways","volume":"415","author":"Zhang","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2024.125514_bib40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/kjm2.12065","article-title":"Protective effects of the suppressed NF-\u03baB\/TLR4 signaling pathway on oxidative stress of lung tissue in rat with acute lung injury","volume":"35","author":"Zhang","year":"2019","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.envpol.2024.125514_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115610","article-title":"Selenium sources differ in their potential to alleviate the cadmium-induced testicular dysfunction","volume":"267","author":"Zhang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2024.125514_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127341","article-title":"Cadmium-induced oxidative stress promotes apoptosis and necrosis through the regulation of the miR-216a-PI3K\/AKT axis in common carp lymphocytes and antagonized by selenium","volume":"258","author":"Zhang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2024.125514_bib43","article-title":"The antagonistic effect of selenium on lead-induced necroptosis via MAPK\/NF-\u03baB pathway and HSPs activation in the chicken spleen","volume":"204","author":"Zhang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.125514_bib44","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3389\/fgene.2020.00527","article-title":"Toxicological effects of cadmium on mammalian testis","volume":"11","author":"Zhu","year":"2020","journal-title":"Front. Genet."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124022310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124022310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T22:18:30Z","timestamp":1737584310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749124022310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":44,"alternative-id":["S0269749124022310"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2024.125514","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium exposure induces oxidative stress-mediated necroptosis via TLR4\/NF-\u03baB signaling pathway in pig epididymis","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2024.125514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125514"}}