{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:14:11Z","timestamp":1792120451283,"version":"4.4.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P30038-BBL"],"award-info":[{"award-number":["P30038-BBL"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020344","name":"Society for Research Promotion Lower Austria","doi-asserted-by":"publisher","award":["LS15-014"],"award-info":[{"award-number":["LS15-014"]}],"id":[{"id":"10.13039\/100020344","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["7940628"],"award-info":[{"award-number":["7940628"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001821","name":"Vienna Science and Technology Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.envpol.2024.125595","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T11:46:07Z","timestamp":1735299967000},"page":"125595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Perfluorodecanoic acid (PFDA) increases oxidative stress through inhibition of mitochondrial \u03b2-oxidation"],"prefix":"10.1016","volume":"367","author":[{"given":"Raimund","family":"Widhalm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0963-5275","authenticated-orcid":false,"given":"Sebastian","family":"Granitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Natha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-5434","authenticated-orcid":false,"given":"Ottavia","family":"Zoboli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-088X","authenticated-orcid":false,"given":"Julia","family":"Derx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Zeisler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Salzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3036-866X","authenticated-orcid":false,"given":"Nicole","family":"Schmitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin A.","family":"Kimmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0983-9582","authenticated-orcid":false,"given":"Tamina","family":"\u00d6sterreicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-4130","authenticated-orcid":false,"given":"Raimund","family":"Oberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hengstschl\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Distel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-3780","authenticated-orcid":false,"given":"Claudia","family":"Gundacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2024.125595_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109047","article-title":"Kinetics of 15 per- and polyfluoroalkyl substances (PFAS) after single oral application as a mixture - a pilot investigation in a male volunteer","volume":"193","author":"Abraham","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.125595_bib2","series-title":"Toxicological Profile for Perfluoroalkyls","year":"2021"},{"key":"10.1016\/j.envpol.2024.125595_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2021.103652","article-title":"The role of transcription factor Nrf2 in the toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in C57BL\/6 mouse astrocytes","volume":"86","author":"Alharthy","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"11","key":"10.1016\/j.envpol.2024.125595_bib4","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1039\/C9EM00290A","article-title":"Partition coefficients of four perfluoroalkyl acid alternatives between bovine serum albumin (BSA) and water in comparison to ten classical perfluoroalkyl acids","volume":"21","author":"Allendorf","year":"2019","journal-title":"Environ Sci Process Impacts"},{"key":"10.1016\/j.envpol.2024.125595_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153312","article-title":"Investigating the cytotoxicity of per- and polyfluoroalkyl substances in HepG2 cells: a structure-activity relationship approach","volume":"480","author":"Amstutz","year":"2022","journal-title":"Toxicology"},{"issue":"6","key":"10.1016\/j.envpol.2024.125595_bib6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.cmet.2020.11.007","article-title":"SCENITH: a flow cytometry-based method to functionally profile energy metabolism with single-cell resolution","volume":"32","author":"Arguello","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.envpol.2024.125595_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.881347","article-title":"A high-throughput toxicity screen of 42 per- and polyfluoroalkyl substances (PFAS) and functional assessment of migration and gene expression in human placental trophoblast cells","volume":"4","author":"Blake","year":"2022","journal-title":"Front Toxicol"},{"issue":"1","key":"10.1016\/j.envpol.2024.125595_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/taap.1993.1003","article-title":"Perfluorodecanoic acid noncompetitively inhibits the peroxisomal enzymes enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase","volume":"118","author":"Borges","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"12","key":"10.1016\/j.envpol.2024.125595_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14122919","article-title":"Toward a mechanistic understanding of poly- and perfluoroalkylated substances and cancer","volume":"14","author":"Boyd","year":"2022","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.envpol.2024.125595_bib10","article-title":"PFAS: forever chemicals\u2014persistent, bioaccumulative and mobile. Reviewing the status and the need for their phase out and remediation of contaminated sites","volume":"35","author":"Brunn","year":"2023","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.envpol.2024.125595_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1114231","article-title":"Mitochondria: it is all about energy","volume":"14","author":"Casanova","year":"2023","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jbt.6","article-title":"Peroxisome proliferator perfluorodecanoic acid alters glutathione and related enzymes","volume":"15","author":"Chen","year":"2001","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"14","key":"10.1016\/j.envpol.2024.125595_bib13","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1021\/acs.est.8b01268","article-title":"Predicting relative protein affinity of novel per- and polyfluoroalkyl substances (PFASs) by an efficient molecular dynamics approach","volume":"52","author":"Cheng","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.envpol.2024.125595_bib15","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1039\/D0EM00147C","article-title":"Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health","volume":"22","author":"Cousins","year":"2020","journal-title":"Environ Sci Process Impacts"},{"key":"10.1016\/j.envpol.2024.125595_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152884","article-title":"Perfluorodecanoic acid induces meiotic defects and deterioration of mice oocytes in vitro","volume":"460","author":"Deng","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2024.125595_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129120","article-title":"A review of recent studies on toxicity, sequestration, and degradation of per- and polyfluoroalkyl substances (PFAS)","volume":"436","author":"Dickman","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.125595_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.102425","article-title":"Electrophilic metabolites targeting the KEAP1\/NRF2 partnership","volume":"78","author":"Dinkova-Kostova","year":"2024","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/19440049.2021.1991004","article-title":"Half-lives of several polyfluoroalkyl substances (PFAS) in cattle serum and tissues","volume":"39","author":"Drew","year":"2022","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"issue":"6580","key":"10.1016\/j.envpol.2024.125595_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg9065","article-title":"Per- and polyfluoroalkyl substances in the environment","volume":"375","author":"Evich","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.envpol.2024.125595_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128083","article-title":"Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by (19)F NMR","volume":"263","author":"Fedorenko","year":"2021","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.envpol.2024.125595_bib22","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per- and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research","volume":"40","author":"Fenton","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"issue":"5","key":"10.1016\/j.envpol.2024.125595_bib23","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/ieam.4735","article-title":"A proposed approach to defining per- and polyfluoroalkyl substances (PFAS) based on molecular structure and formula","volume":"19","author":"Gaines","year":"2023","journal-title":"Integr Environ Assess Manag"},{"key":"10.1016\/j.envpol.2024.125595_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122444","article-title":"Cytotoxicity of perfluorodecanoic acid on mouse primary nephrocytes through oxidative stress: combined analysis at cellular and molecular levels","volume":"393","author":"Gao","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.125595_bib25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.freeradbiomed.2017.08.008","article-title":"Assessment of glutathione\/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells","volume":"112","author":"Giustarini","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.envpol.2024.125595_bib26","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1039\/D0EM00291G","article-title":"An overview of the uses of per- and polyfluoroalkyl substances (PFAS)","volume":"22","author":"Gl\u00fcge","year":"2020","journal-title":"Environ Sci Process Impacts"},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"Graham","year":"1993","journal-title":"Exp. Cell Res."},{"issue":"11","key":"10.1016\/j.envpol.2024.125595_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10110684","article-title":"Reduced birth weight and exposure to per- and polyfluoroalkyl substances: a review of possible underlying mechanisms using the AOP-HelpFinder","volume":"10","author":"Gundacker","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2024.125595_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131718","article-title":"Perfluorooctanoic acid dominates the molecular-level effects of a mixture of equal masses of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm","volume":"457","author":"Han","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.125595_bib30","series-title":"The Laboratory Zebrafish","author":"Harper","year":"2011"},{"key":"10.1016\/j.envpol.2024.125595_bib31","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.redox.2017.04.035","article-title":"Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation","volume":"12","author":"Ho","year":"2017","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.envpol.2024.125595_bib32","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: the good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.envpol.2024.125595_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115006","article-title":"Prenatal exposure to per- and polyfluoroalkyl substances and pregnancy outcome in Austria","volume":"259","author":"Kaiser","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"Suppl. 1","key":"10.1016\/j.envpol.2024.125595_bib34","article-title":"Tol2: a versatile gene transfer vector in vertebrates","volume":"8","author":"Kawakami","year":"2007","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.envpol.2024.125595_bib35","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.tiv.2007.04.020","article-title":"Analysis of structure-cytotoxicity in vitro relationship (SAR) for perfluorinated carboxylic acids","volume":"21","author":"Kleszczynski","year":"2007","journal-title":"Toxicol. Vitro"},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.taap.2011.01.002","article-title":"Mechanism of cytotoxic action of perfluorinated acids. III. Disturbance in Ca(2)+ homeostasis","volume":"251","author":"Kleszczynski","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.taap.2008.11.021","article-title":"Mechanism of cytotoxic action of perfluorinated acids II. Disruption of mitochondrial bioenergetics","volume":"235","author":"Kleszczynski","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"16","key":"10.1016\/j.envpol.2024.125595_bib38","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1021\/acs.est.9b01608","article-title":"Mass spectrometry-based metabolomics reveals occupational exposure to per- and polyfluoroalkyl substances relates to oxidative stress, fatty acid beta-oxidation disorder, and kidney injury in a manufactory in China","volume":"53","author":"Lu","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.envpol.2024.125595_bib39","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/jat.3418","article-title":"Comparative in vitro toxicity assessment of perfluorinated carboxylic acids","volume":"37","author":"Mahapatra","year":"2017","journal-title":"J. Appl. Toxicol."},{"issue":"1","key":"10.1016\/j.envpol.2024.125595_bib40","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.taap.2010.01.011","article-title":"The rise of antioxidant signaling--the evolution and hormetic actions of Nrf2","volume":"244","author":"Maher","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib41","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/toxsci\/kfn177","article-title":"Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid","volume":"106","author":"Maher","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"11","key":"10.1016\/j.envpol.2024.125595_bib42","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1089\/ars.2009.2695","article-title":"Mitochondrial glutathione, a key survival antioxidant","volume":"11","author":"Mar\u00ed","year":"2009","journal-title":"Antioxid Redox Signal"},{"issue":"Suppl. A","key":"10.1016\/j.envpol.2024.125595_bib43","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.placenta.2005.11.006","article-title":"Stereology and the placenta: where's the point? -- a review","volume":"27","author":"Mayhew","year":"2006","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.envpol.2024.125595_bib44","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cmet.2020.03.012","article-title":"NADH ties one-carbon metabolism to cellular respiration","volume":"31","author":"Maynard","year":"2020","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.envpol.2024.125595_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/biom13040688","article-title":"The multifaceted role of glutathione S-transferases in health and Disease","volume":"13","author":"Mazari","year":"2023","journal-title":"Biomolecules"},{"issue":"25","key":"10.1016\/j.envpol.2024.125595_bib46","doi-asserted-by":"crossref","first-page":"24104","DOI":"10.1074\/jbc.M502518200","article-title":"Molecular conversion of NAD kinase to NADH kinase through single amino acid residue substitution","volume":"280","author":"Mori","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"Pt A","key":"10.1016\/j.envpol.2024.125595_bib47","article-title":"New insights into organ-specific oxidative stress mechanisms using a novel biosensor zebrafish","volume":"133","author":"Mourabit","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.125595_bib48","article-title":"NRF2 signalling in cytoprotection and metabolism","author":"Murakami","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"2\u20133","key":"10.1016\/j.envpol.2024.125595_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0300-483X(02)00573-5","article-title":"Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length","volume":"184","author":"Ohmori","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2024.125595_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126827","article-title":"Combined effects of mixed per- and polyfluoroalkyl substances on the Nrf2-ARE pathway in ARE reporter-HepG2 cells","volume":"421","author":"Ojo","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2024.125595_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130808","article-title":"Evaluation of the individual and combined toxicity of perfluoroalkyl substances to human liver cells using biomarkers of oxidative stress","volume":"281","author":"Ojo","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2024.125595_bib52","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.freeradbiomed.2013.10.001","article-title":"A biophysically based mathematical model for the catalytic mechanism of glutathione reductase","volume":"65","author":"Pannala","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.envpol.2024.125595_bib53","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.bbabio.2010.10.022","article-title":"Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells","volume":"1807","author":"Pike","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.envpol.2024.125595_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.envpol.2024.125595_bib55","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.bbamcr.2006.08.034","article-title":"Peroxisomal beta-oxidation--a metabolic pathway with multiple functions","volume":"1763","author":"Poirier","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.envpol.2024.125595_bib56","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/15287391003689317","article-title":"Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability","volume":"73","author":"Qian","year":"2010","journal-title":"J. Toxicol. Environ. Health"},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib57","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/toxsci\/kfad051","article-title":"Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity","volume":"194","author":"Rericha","year":"2023","journal-title":"Toxicol. Sci."},{"issue":"6","key":"10.1016\/j.envpol.2024.125595_bib58","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nprot.2010.74","article-title":"Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells","volume":"5","author":"Rosner","year":"2010","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.envpol.2024.125595_bib59","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1074\/jbc.M802683200","article-title":"Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione","volume":"284","author":"Seefeldt","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib60","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/toxsci\/kfq066","article-title":"The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos","volume":"115","author":"Shi","year":"2010","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.envpol.2024.125595_bib61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0378-4274(90)90053-O","article-title":"Perfluoro-N-decanoic acid effects on enzymes of fatty acid metabolism","volume":"54","author":"Singer","year":"1990","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2024.125595_bib14","unstructured":"Stockholm Convention, 2019. Stockholm Convention on Persistent Organic Pollutants (POPS)."},{"issue":"10","key":"10.1016\/j.envpol.2024.125595_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102509","article-title":"ERK: a double-edged sword in cancer. ERK-dependent apoptosis as a potential therapeutic strategy for cancer","volume":"10","author":"Sugiura","year":"2021","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.envpol.2024.125595_bib63","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1007\/s11064-018-2672-y","article-title":"Nrf2 signaling elicits a neuroprotective role against PFOS-mediated oxidative damage and apoptosis","volume":"43","author":"Sun","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.envpol.2024.125595_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107541","article-title":"Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy","volume":"169","author":"Taibl","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2024.125595_bib65","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.envpol.2018.02.037","article-title":"Role of the Nrf2-ARE pathway in perfluorooctanoic acid (PFOA)-induced hepatotoxicity in Rana nigromaculata","volume":"238","author":"Tang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2024.125595_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128615","article-title":"Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish","volume":"431","author":"Truong","year":"2022","journal-title":"J. Hazard Mater."},{"issue":"2","key":"10.1016\/j.envpol.2024.125595_bib67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1095\/biolreprod.113.113217","article-title":"The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice","volume":"90","author":"Tsai","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.envpol.2024.125595_bib68","series-title":"Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (Interagency Science Discussion Draft, 2024)","year":"2024"},{"key":"10.1016\/j.envpol.2024.125595_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137549","article-title":"Assessment of the per- and polyfluoroalkyl substances analysis under the Stockholm Convention - 2018\/2019","volume":"313","author":"van der Veen","year":"2023","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.envpol.2024.125595_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28031447","article-title":"Glutathione-related enzymes and proteins: a review","volume":"28","author":"Vaskova","year":"2023","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.envpol.2024.125595_bib71","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1021\/acs.est.8b07188","article-title":"Toxicokinetics of perfluorinated alkyl acids influences their toxic potency in the zebrafish embryo (Danio rerio)","volume":"53","author":"Vogs","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.envpol.2024.125595_bib72","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.toxlet.2013.07.025","article-title":"Structure-activity relationships for perfluoroalkane-induced in vitro interference with rat liver mitochondrial respiration","volume":"222","author":"Wallace","year":"2013","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.envpol.2024.125595_bib73","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00204-023-03477-5","article-title":"A review of cardiovascular effects and underlying mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFAS)","volume":"97","author":"Wen","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2024.125595_bib74","series-title":"The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio)","author":"Westerfield","year":"2007"},{"key":"10.1016\/j.envpol.2024.125595_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fenvs.2022.850019","article-title":"Assembly and curation of lists of per- and polyfluoroalkyl substances (PFAS) to support environmental science research","volume":"10","author":"Williams","year":"2022","journal-title":"Front. Environ. Sci."},{"key":"10.1016\/j.envpol.2024.125595_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109699","article-title":"Perfluorodecanoic acid-induced oxidative stress and DNA damage investigated at the cellular and molecular levels","volume":"185","author":"Xu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2024.125595_bib77","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.envint.2019.03.002","article-title":"Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies","volume":"126","author":"Zeng","year":"2019","journal-title":"Environ. Int."},{"issue":"18","key":"10.1016\/j.envpol.2024.125595_bib78","doi-asserted-by":"crossref","first-page":"10619","DOI":"10.1021\/es401905e","article-title":"Biomonitoring of perfluoroalkyl acids in human urine and estimates of biological half-life","volume":"47","author":"Zhang","year":"2013","journal-title":"Environ. Sci. Technol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124023121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749124023121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:53:04Z","timestamp":1778680384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749124023121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":78,"alternative-id":["S0269749124023121"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2024.125595","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perfluorodecanoic acid (PFDA) increases oxidative stress through inhibition of mitochondrial \u03b2-oxidation","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2024.125595","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"125595"}}