{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:25:44Z","timestamp":1790871944684,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42376041"],"award-info":[{"award-number":["42376041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MD057"],"award-info":[{"award-number":["ZR2023MD057"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.envpol.2025.125668","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:30:57Z","timestamp":1736555457000},"page":"125668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Nitric oxide release as a defense mechanism in marine microalgae against microplastic-induced stress"],"prefix":"10.1016","volume":"367","author":[{"given":"Ying-Shun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Xin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-2800","authenticated-orcid":false,"given":"Chun-Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2025.125668_bib1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41396-023-01427-8","article-title":"Aerobic bacteria produce nitric oxide via denitrification and promote algal population collapse","volume":"17","author":"Abada","year":"2023","journal-title":"ISME J."},{"key":"10.1016\/j.envpol.2025.125668_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.envpol.2017.01.015","article-title":"Evidence of microplastic ingestion in the shark Galeus melastomus Rafinesque, 1810 in the continental shelf off the western Mediterranean Sea","volume":"223","author":"Alomar","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.125668_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.aquatox.2017.06.008","article-title":"Long-term toxicity of surface-charged polystyrene nanoplastics to marine planktonic species Dunaliella tertiolecta and Artemia franciscana","volume":"189","author":"Bergami","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.125668_bib4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4319\/lo.1995.40.1.0082","article-title":"Nitrate reductase activity quantitatively predicts the rate of nitrate incorporation under steady state light limitation: a revised assay and characterization of the enzyme in three species of marine phytoplankton","volume":"40","author":"Berges","year":"1995","journal-title":"Limnol. Oceanogr."},{"key":"10.1016\/j.envpol.2025.125668_bib5","doi-asserted-by":"crossref","first-page":"16556","DOI":"10.1021\/jp1054759","article-title":"Physical adsorption of charged plastic nanoparticles affects algal photosynthesis","volume":"114","author":"Bhattacharya","year":"2010","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.envpol.2025.125668_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/pcp\/pcn037","article-title":"Heat stress stimulates nitric oxide production in symbiodinium microadriaticum: a possible linkage between nitric oxide and the coral bleaching phenomenon","volume":"49","author":"Bouchard","year":"2008","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.envpol.2025.125668_bib7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.scitotenv.2018.06.257","article-title":"Effects of nanoplastics on Mytilus galloprovincialis after individual and combined exposure with carbamazepine","volume":"643","author":"Brandts","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.125668_bib8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.scitotenv.2018.03.176","article-title":"Microplastic ingestion by Daphnia magna and its enhancement on algal growth","volume":"633","author":"Canniff","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.125668_bib9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0011-7471(63)90358-9","article-title":"A method for the determination of phytoplankton chlorophyll and phaeophytin by fluorescence","volume":"10","author":"Charles","year":"1963","journal-title":"Deep Sea Res. Oceanogr. Abstr."},{"key":"10.1016\/j.envpol.2025.125668_bib10","article-title":"Nitric oxide, nitric oxide formers and their physiological impacts in bacteria","volume":"23","author":"Chen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2025.125668_bib11","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.1128\/AEM.01481-08","article-title":"Nitric oxide as a signaling factor to upregulate the death-specific protein in a marine diatom, Skeletonema costatum , during blockage of electron flow in photosynthesis","volume":"74","author":"Chung","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2025.125668_bib12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fpls.2013.00398","article-title":"Nitric oxide and phytohormone interactions: current status and perspectives","volume":"4","author":"Freschi","year":"2013","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.envpol.2025.125668_bib13","series-title":"Culture of Marine Invertebrate Animals","first-page":"29","article-title":"Culture of phytoplankton for feeding marine invertebrates","author":"Guillard","year":"1975"},{"key":"10.1016\/j.envpol.2025.125668_bib14","series-title":"Free Radicals in Biology and Medicine","first-page":"2015","author":"Halliwell","year":"2015"},{"key":"10.1016\/j.envpol.2025.125668_bib15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.algal.2018.10.013","article-title":"Reactive oxygen species-mediated caspase-3 pathway involved in cell apoptosis of Karenia mikimotoi induced by linoleic acid","volume":"36","author":"Han","year":"2018","journal-title":"Algal Res."},{"key":"10.1016\/j.envpol.2025.125668_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.12733","article-title":"Hydrogen sulfide signaling: interactions with nitric oxide and reactive oxygen species","volume":"1365","author":"Hancock","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.envpol.2025.125668_bib17","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.freeradbiomed.2018.04.040","article-title":"Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation","volume":"120","author":"Hancock","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2025.125668_bib18","article-title":"Effects of climate-induced changes in temperature and salinity on phytoplankton physiology and stress responses in coastal Antarctica","volume":"530\u2013531","author":"Hernando","year":"2020","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.envpol.2025.125668_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/plankt\/fbi145","article-title":"Nitric oxide synthase-like enzyme mediated nitric oxide generation by harmful red tide phytoplankton, Chattonella marina","volume":"28","author":"Kim","year":"2006","journal-title":"J. Plankton Res."},{"key":"10.1016\/j.envpol.2025.125668_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2014.10.014","article-title":"Toxicity of nano-TiO2 on algae and the site of reactive oxygen species production","volume":"158","author":"Li","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.125668_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.niox.2013.06.007","article-title":"Protective function of nitric oxide on marine phytoplankton under abiotic stresses","volume":"33","author":"Li","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.envpol.2025.125668_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111451","article-title":"Comparative analysis of kinetics and mechanisms for Pb(II) sorption onto three kinds of microplastics","volume":"208","author":"Lin","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2025.125668_bib23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.niox.2014.09.003","article-title":"Evidence for the mutual effects of dimethylsulfoniopropionate and nitric oxide during the growth of marine microalgae","volume":"42","author":"Liu","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.envpol.2025.125668_bib24","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0176-1617(00)80084-X","article-title":"Evidence for the non-involvement of nitric oxide synthase in nitric oxide production by the green alga scenedesmus obliquus","volume":"156","author":"Mallick","year":"2000","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.envpol.2025.125668_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146433","article-title":"Ecotoxicological and physiological risks of microplastics on fish and their possible mitigation measures","volume":"779","author":"Mallik","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.125668_bib26","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1093\/jxb\/erz289","article-title":"Nitric oxide in plant\u2013fungal interactions","volume":"70","author":"Mart\u00ednez-Medina","year":"2019","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.envpol.2025.125668_bib27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11120-004-3548-3","article-title":"Is nitrate reductase a major player in the plant NO (nitric oxide) game?","volume":"83","author":"Meyer","year":"2005","journal-title":"Photosynth. Res."},{"key":"10.1016\/j.envpol.2025.125668_bib28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1360-1385(02)02312-9","article-title":"Oxidative stress, antioxidants and stress tolerance","volume":"7","author":"Mittler","year":"2002","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.envpol.2025.125668_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116476","article-title":"A critical review of interactions between microplastics, microalgae and aquatic ecosystem function","volume":"188","author":"Nava","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2025.125668_bib30","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.1021\/ac901128y","article-title":"Development of an analytical method for nitric oxide radical determination in natural waters","volume":"81","author":"Olasehinde","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2025.125668_bib31","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1462-5822.2004.00428.x","article-title":"Nitric oxide signalling functions in plant-pathogen interactions: NO signalling during the plant HR","volume":"6","author":"Romero-Puertas","year":"2004","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.envpol.2025.125668_bib32","doi-asserted-by":"crossref","first-page":"33508","DOI":"10.1007\/s11356-018-3079-7","article-title":"Efficient biodegradation of low-density polyethylene by cyanobacteria isolated from submerged polyethylene surface in domestic sewage water","volume":"25","author":"Sarmah","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2025.125668_bib33","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1104\/pp.108.130716","article-title":"Rice aldehyde Dehydrogenase7 is needed for seed maturation and viability","volume":"149","author":"Shin","year":"2009","journal-title":"Plant Physiol"},{"key":"10.1016\/j.envpol.2025.125668_bib34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.aquatox.2015.12.002","article-title":"Do plastic particles affect microalgal photosynthesis and growth?","volume":"170","author":"Sjollema","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.125668_bib35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s40572-018-0206-z","article-title":"Microplastics in seafood and the implications for human health","volume":"5","author":"Smith","year":"2018","journal-title":"Curr. Environ. Health Rep"},{"key":"10.1016\/j.envpol.2025.125668_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/science.1094559","article-title":"Lost at sea: where is all the plastic?","volume":"304","author":"Thompson","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.envpol.2025.125668_bib37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.febslet.2004.09.004","article-title":"Mitochondrial electron transport as a source for nitric oxide in the unicellular green alga Chlorella sorokiniana","volume":"576","author":"Tischner","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.envpol.2025.125668_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127344","article-title":"Microplastics mixture exposure at environmentally relevant conditions induce oxidative stress and neurotoxicity in the wedge clam Donax trunculus","volume":"258","author":"Tlili","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.125668_bib39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2307\/3593094","article-title":"Increased Zooxanthellae nitric oxide synthase activity is associated with coral bleaching","volume":"208","author":"Trapido-Rosenthal","year":"2005","journal-title":"Biol. Bull."},{"key":"10.1016\/j.envpol.2025.125668_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140479","article-title":"Effect of microplastics and microplastic-metal combinations on growth and chlorophyll a concentration of Chlorella vulgaris","volume":"743","author":"Tunali","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.125668_bib41","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1371\/journal.pbio.0040060","article-title":"A stress surveillance system based on calcium and nitric oxide in marine diatoms","volume":"4","author":"Vardi","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.envpol.2025.125668_bib42","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/1365-2664.13587","article-title":"Macroalgal blooms caused by marine nutrient changes resulting from human activities","volume":"57","author":"Wang","year":"2020","journal-title":"J. Appl. Ecol."},{"key":"10.1016\/j.envpol.2025.125668_bib43","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1021\/acs.est.6b01187","article-title":"Effect of microplastic on the gills of the shore crab Carcinus maenas","volume":"50","author":"Watts","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.125668_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126914","article-title":"Adverse physiological and molecular level effects of polystyrene microplastics on freshwater microalgae","volume":"255","author":"Xiao","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.125668_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jwpe.2021.102291","article-title":"Comparative toxic effects of microplastics and nanoplastics on Chlamydomonas reinhardtii: growth inhibition, oxidative stress, and cell morphology","volume":"43","author":"Yan","year":"2021","journal-title":"J. Water Process Eng."},{"key":"10.1016\/j.envpol.2025.125668_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115429","article-title":"Effects of microplastics exposure on ingestion, fecundity, development, and dimethylsulfide production in Tigriopus japonicus (Harpacticoida, copepod)","volume":"267","author":"Yu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.125668_bib47","first-page":"75","article-title":"Detection of nitric oxide in culture media and studies on nitric oxide formation by marine microalgae","volume":"12","author":"Zhang","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.envpol.2025.125668_bib48","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.envpol.2016.11.005","article-title":"Toxic effects of microplastic on marine microalgae Skeletonema costatum: interactions between microplastic and algae","volume":"220","author":"Zhang","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.125668_bib49","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1360\/03yb0166","article-title":"Study on patterns and chemical features of NO effect on marine phytoplankton growth","volume":"48","author":"Zhang","year":"2005","journal-title":"Sci. China, Ser. B"},{"key":"10.1016\/j.envpol.2025.125668_bib50","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11802-003-0049-5","article-title":"The effect of nitric oxide on the growth of marine phytoplankton","volume":"2","author":"Zhang","year":"2003","journal-title":"J. Ocean Univ. Qingdao"},{"key":"10.1016\/j.envpol.2025.125668_bib51","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11426-006-2017-6","article-title":"Discovery of nitric oxide in marine ecological system and the chemical characteristics of nitric oxide","volume":"49","author":"Zhang","year":"2006","journal-title":"Sci. China, Ser. B: Chem."},{"key":"10.1016\/j.envpol.2025.125668_bib52","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.envpol.2019.01.114","article-title":"The interactions between micro polyvinyl chloride (mPVC) and marine dinoflagellate Karenia mikimotoi: the inhibition of growth, chlorophyll and photosynthetic efficiency","volume":"247","author":"Zhao","year":"2019","journal-title":"Environ. Pollut."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125000417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125000417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T11:14:05Z","timestamp":1747653245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125000417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":52,"alternative-id":["S0269749125000417"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.125668","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide release as a defense mechanism in marine microalgae against microplastic-induced stress","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.125668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125668"}}