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Biol."},{"issue":"8","key":"10.1016\/j.envpol.2025.125725_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111263","article-title":"A small RNA-guided PRC2 complex eliminates DNA as an extreme form of transposon silencing","volume":"40","author":"Wang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.envpol.2025.125725_bib79","first-page":"595","article-title":"Evaluation of heavy metal pollution in bijiang Basin in Yunnan Province. Res","volume":"22","author":"Wang","year":"2009","journal-title":"Environ. 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