{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:19:02Z","timestamp":1790083142105,"version":"4.0.1"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["304571\/2021-0"],"award-info":[{"award-number":["304571\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-21\/210.298\/2022"],"award-info":[{"award-number":["E-21\/210.298\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-21\/201.271\/2021"],"award-info":[{"award-number":["E-21\/201.271\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.envpol.2025.126131","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T16:49:22Z","timestamp":1743094162000},"page":"126131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Exposure and coexposure to cocaine and benzoylecgonine at environmentally relevant levels cause long-term oxidative effects in zebrafish"],"prefix":"10.1016","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-0388","authenticated-orcid":false,"given":"Gabriel","family":"de Farias Araujo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8514-5564","authenticated-orcid":false,"given":"Lorena Oliveira","family":"Souza Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Braga","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney Fernandes","family":"Sales J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8564-0952","authenticated-orcid":false,"given":"Vanessa","family":"Farelo dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Marcelo","family":"Gualberto Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Ver\u00edssimo","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-6749","authenticated-orcid":false,"given":"Enrico Mendes","family":"Saggioro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2025.126131_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Oxygen radicals in biological systems","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.envpol.2025.126131_bib2","series-title":"Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment","author":"Aghazadeh Tabrizi","year":"2017"},{"key":"10.1016\/j.envpol.2025.126131_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106122","article-title":"Oxidative stress and metal homeostasis alterations in Danio rerio (zebrafish) under single and combined carbamazepine, acetamiprid and cadmium exposures","volume":"245","author":"Araujo","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.126131_bib4","series-title":"AVMA Guidelines for the Euthanasia of Animals","year":"2013"},{"key":"10.1016\/j.envpol.2025.126131_bib5","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/0024-3205(92)90303-7","article-title":"The presence of cocaine and benzoylecgonine in rat cerebrospinal fluid after the intravenous administration of cocaine","volume":"51","author":"Barbieri","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.envpol.2025.126131_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1590\/S0100-40422006000100021","article-title":"Estresse oxidativo: rela\u00e7\u00e3o entre gera\u00e7\u00e3o de esp\u00e9cies reativas e defesa do organismo","volume":"29","author":"Barreiros","year":"2006","journal-title":"Quim. Nova"},{"key":"10.1016\/j.envpol.2025.126131_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/560235","article-title":"Norfloxacin\u2014toxicity for zebrafish (Danio rerio) focused on oxidative stress parameters","author":"Bartoskova","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.envpol.2025.126131_bib8","series-title":"Disposition of Toxic Drugs and Chemicals in Man","author":"Baselt","year":"1982"},{"key":"10.1016\/j.envpol.2025.126131_bib9","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1196\/annals.1369.061","article-title":"Nitric oxide and oxidative stress in the brain of rats exposed in utero to cocaine","volume":"1074","author":"Bashkatova","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.envpol.2025.126131_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0022-3565(25)39211-6","article-title":"Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice","volume":"243","author":"Benuck","year":"1987","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.envpol.2025.126131_bib11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.scitotenv.2013.11.131","article-title":"Occurrence and behavior of illicit drugs and metabolites in sewage water from the Spanish Mediterranean coast (Valencia region)","volume":"487","author":"Bijlsma","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126131_bib12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/ilar.44.4.286","article-title":"Fish research and the institutional animal care and use committee","volume":"44","author":"Borski","year":"2003","journal-title":"ILAR J."},{"key":"10.1016\/j.envpol.2025.126131_bib13","series-title":"Ecotoxicologia aqu\u00e1tica - Toxicidade aguda - M\u00e9todo de ensaio com peixes (Cyprinidae)","first-page":"3","year":"2016"},{"key":"10.1016\/j.envpol.2025.126131_bib14","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1520\/JFS13190J","article-title":"A rapid method for the determination of cocaine in brain tissue","volume":"36","author":"Browne","year":"1991","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.envpol.2025.126131_bib15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.scitotenv.2016.10.089","article-title":"Occurrence of cocaine and benzoylecgonine in drinking and source water in the S\u00e3o Paulo State region, Brazil","volume":"576","author":"Campestrini","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126131_bib16","series-title":"Guidelines on the Care and Use of Fish in Research, Teaching and Testing. Canadian Council on Animal Care","year":"2005"},{"key":"10.1016\/j.envpol.2025.126131_bib17","first-page":"175","article-title":"Protective effects of pre-and post-administration of nifedipine in cocaine ethanol-induced free radieal toxicity in mice","volume":"28","author":"Cengiz","year":"2003","journal-title":"Fabad J. Pharm. Sci."},{"key":"10.1016\/j.envpol.2025.126131_bib18","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1021\/acschembio.6b00277","article-title":"Metabolic enzymes of cocaine metabolite benzoylecgonine","volume":"11","author":"Chen","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.envpol.2025.126131_bib19","series-title":"Diretriz da pr\u00e1tica de eutan\u00e1sia do CONCEA","year":"2015"},{"key":"10.1016\/j.envpol.2025.126131_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/00007691-199810000-00019","article-title":"Cocaine metabolism and urinary excretion after different routes of administration","volume":"20","author":"Cone","year":"1998","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.envpol.2025.126131_bib21","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1590\/S0100-40422008000700038","article-title":"A toxicidade em ambientes aqu\u00e1ticos: discuss\u00e3o e m\u00e9todos de avalia\u00e7\u00e3o","volume":"31","author":"Costa","year":"2008","journal-title":"Quim. Nova"},{"key":"10.1016\/j.envpol.2025.126131_bib22","series-title":"An Introduction to Organosulfur Chemistry","author":"Cremlyn","year":"1996"},{"key":"10.1016\/j.envpol.2025.126131_bib23","series-title":"Encyclopedia of the Neurological Sciences","first-page":"811","article-title":"Cocaine","author":"Cubo","year":"2014"},{"key":"10.1016\/j.envpol.2025.126131_bib24","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainresrev.2008.03.002","article-title":"Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs","volume":"58","author":"Cunha-Oliveira","year":"2008","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.envpol.2025.126131_bib25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.forsciint.2018.11.012","article-title":"Assessment of illicit drugs in wastewater and estimation of drugs of abuse in Adana Province, Turkey","volume":"294","author":"Daglioglu","year":"2019","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.envpol.2025.126131_bib26","doi-asserted-by":"crossref","first-page":"28459","DOI":"10.1007\/s11356-023-25402-0","article-title":"Zebrafish (Danio rerio) as a model to assess the effects of cocaine as a drug of abuse and its environmental implications","volume":"30","author":"De Farias Araujo","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2025.126131_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157025","article-title":"Differential biochemical and behavioral responses induced by cocaine and benzoylecgonine exposure to the red swamp crayfish Procambarus clarkii","volume":"844","author":"De Felice","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126131_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103475","article-title":"Effects of single and combined exposure to cocaine and benzoylecgonine on the oxidative status of Mytilus galloprovincialis","volume":"80","author":"De Felice","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2025.126131_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.scitotenv.2019.06.383","article-title":"Biochemical and behavioral effects induced by cocaine exposure to Daphnia magna","volume":"689","author":"De Felice","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126131_bib30","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.neuropharm.2005.01.018","article-title":"Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures","volume":"48","author":"Dietrich","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.envpol.2025.126131_bib31","series-title":"Assessing Illicit Drugs in Wastewater: Advances in Wastewater Based Drug Epidemiology","year":"2016"},{"key":"10.1016\/j.envpol.2025.126131_bib32","first-page":"746A","article-title":"A comparison of the epileptogenic potential of cocaine and benzoylecgonine following intraventricular administration in nonanesthetized rats","volume":"4","author":"Erickson","year":"1990","journal-title":"FASEB J."},{"key":"10.1016\/j.envpol.2025.126131_bib95","unstructured":"F\u00e1vero and Belfiore, P. An\u00e1lise de dados: t\u00e9cnicas multivariadas explorat\u00f3rias. 1. ed. Brazil: Elsevier Brazil, 2015."},{"key":"10.1016\/j.envpol.2025.126131_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2019.110545","article-title":"Seasonal monitoring of cocaine and benzoylecgonine in a subtropical coastal zone (Santos Bay, Brazil)","volume":"149","author":"Fontes","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envpol.2025.126131_bib34","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jhazmat.2015.08.019","article-title":"Environmental concentrations of the cocaine metabolite benzoylecgonine induced sublethal toxicity in the development of plants but not in a zebrafish embryo\u2013larval model","volume":"300","author":"Garc\u00eda-Cambero","year":"2015","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2025.126131_bib35","article-title":"A rapid zebrafish embryo behavioral biosensor that is capable of detecting environmental b-blockers","volume":"10","author":"Gauthier","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib36","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1021\/jf504895h","article-title":"Oxidative stress and DNA damage induced by imidacloprid in zebrafish (Danio rerio)","volume":"63","author":"Ge","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envpol.2025.126131_bib37","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.ecoenv.2019.01.041","article-title":"Sublethal psychotropic pharmaceutical effects on the model organism Danio rerio: oxidative stress and metal dishomeostasis","volume":"171","author":"Gomes","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2025.126131_bib38","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0026-895X(25)13536-0","article-title":"Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells <em>in vitro<\/em&gt","volume":"14","author":"Graham","year":"1978","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.envpol.2025.126131_bib39","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2025.126131_bib40","volume":"vol. 1","author":"Halliwell","year":"2007"},{"key":"10.1016\/j.envpol.2025.126131_bib41","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1073\/pnas.93.5.1956","article-title":"Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections","volume":"93","author":"Hastings","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.envpol.2025.126131_bib42","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/15376510903147132","article-title":"Detection of cocaine and benzoylecgonine in formalin fixed rat tissues","volume":"19","author":"Hilal","year":"2009","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.envpol.2025.126131_bib43","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1046\/j.1471-4159.2000.0742296.x","article-title":"Dopamine\u2010induced apoptosis is mediated by oxidative stress and is enhanced by cyanide in differentiated PC12 cells","volume":"74","author":"Jones","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.envpol.2025.126131_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138069","article-title":"New efficient methodology for screening of selected organic micropollutants in raw- and drinking water from 90 Swedish water treatment plants","volume":"724","author":"Karki","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126131_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114893","article-title":"Occurrence of pharmaceuticals in the Danube and drinking water wells: efficiency of riverbank filtration","volume":"265","author":"Kondor","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.devbrainres.2003.08.006","article-title":"Prenatal cocaine administration increases glutathione and alpha-tocopherol oxidation in fetal rat brain","volume":"147","author":"Lipton","year":"2003","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.envpol.2025.126131_bib47","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0024-3205(94)00501-I","article-title":"Cocaine and benzoylecgonine constrict cerebral arteries by different mechanisms","volume":"56","author":"Madden","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.envpol.2025.126131_bib48","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1046\/j.1471-4159.1998.70062406.x","article-title":"Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor","volume":"70","author":"McLaughlin","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.envpol.2025.126131_bib49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ab.2014.04.034","article-title":"Simplified 2,4-dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins","volume":"458","author":"Mesquita","year":"2014","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.envpol.2025.126131_bib50","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1016\/j.envpol.2010.07.002","article-title":"Illicit drugs in Canadian municipal wastewater and estimates of community drug use","volume":"158","author":"Metcalfe","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib51","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/jat\/24.7.458","article-title":"Cocaine and metabolite elimination patterns in chronic cocaine users during cessation: plasma and saliva analysis","volume":"24","author":"Moolchan","year":"2000","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.envpol.2025.126131_bib52","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0892-0362(01)00136-2","article-title":"The disposition of benzoylecgonine in maternal and fetal rats","volume":"23","author":"Morishima","year":"2001","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envpol.2025.126131_bib55","doi-asserted-by":"crossref","first-page":"27569","DOI":"10.1007\/s11356-018-1600-7","article-title":"Detoxification, oxidative stress, and cytogenotoxicity of crack cocaine in the brown mussel Perna perna","volume":"26","author":"Ortega","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2025.126131_bib56","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.envpol.2017.09.097","article-title":"Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos","volume":"232","author":"Parolini","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib57","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.envpol.2017.09.038","article-title":"Benzoylecgonine exposure induced oxidative stress and altered swimming behavior and reproduction in Daphnia magna","volume":"232","author":"Parolini","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib58","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.envpol.2017.04.046","article-title":"Environmental concentrations of cocaine and its main metabolites modulated antioxidant response and caused cyto-genotoxic effects in zebrafish embryo cells","volume":"226","author":"Parolini","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib59","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.chemosphere.2014.12.092","article-title":"Realistic mixture of illicit drugs impaired the oxidative status of the zebra mussel (Dreissena polymorpha)","volume":"128","author":"Parolini","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126131_bib60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.scitotenv.2012.11.076","article-title":"Sub-lethal effects caused by the cocaine metabolite benzoylecgonine to the freshwater mussel Dreissena polymorpha","volume":"444","author":"Parolini","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126131_bib61","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/dta.1409","article-title":"A redox proteomic investigation of oxidative stress caused by benzoylecgonine in the freshwater bivalve Dreissena polymorpha: a redox proteomic investigation of oxidative stress caused by benzoylecgonine in the freshwater bivalve Dreissena polymorpha","volume":"5","author":"Pedriali","year":"2013","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.envpol.2025.126131_bib62","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0003-2697(77)90043-4","article-title":"A simplification of the protein assay method of Lowry et al. which is more generally applicable","volume":"83","author":"Peterson","year":"1977","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.envpol.2025.126131_bib63","volume":"vol. 10","author":"Peterson","year":"2008"},{"key":"10.1016\/j.envpol.2025.126131_bib64","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuint.2006.06.012","article-title":"Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells","volume":"50","author":"Poon","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.envpol.2025.126131_bib65","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1021\/ac702060j","article-title":"Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solid-phase extraction-liquid Chromatography\u2212Electrospray-tandem mass spectrometry","volume":"80","author":"Postigo","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envpol.2025.126131_bib66","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/fishes8030166","article-title":"Side effects of human drug use: an overview of the consequences of eels' exposure to cocaine","volume":"8","author":"Rosati","year":"2023","journal-title":"Fishes"},{"key":"10.1016\/j.envpol.2025.126131_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117351","article-title":"Long-term landfill leachate exposure modulates antioxidant responses and causes cyto-genotoxic effects in Eisenia andrei earthworms","volume":"287","author":"Sales Junior","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib68","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jms.4077","article-title":"Comprehensive analysis by liquid chromatography Q\u2010Orbitrap mass spectrometry: fast screening of peptides and organic molecules","volume":"53","author":"Sardela","year":"2018","journal-title":"J. Mass Spectrom."},{"issue":"2","key":"10.1016\/j.envpol.2025.126131_bib69","first-page":"100","article-title":"Implementa\u00e7\u00e3o de um novo modelo de experimenta\u00e7\u00e3o animal: zebrafish","volume":"29","author":"Schneider","year":"2009","journal-title":"Revista HCPA"},{"key":"10.1016\/j.envpol.2025.126131_bib70","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1590\/S1517-86922004000400008","article-title":"Radicais livres de oxig\u00eanio e exerc\u00edcio: mecanismos de forma\u00e7\u00e3o e adapta\u00e7\u00e3o ao treinamento f\u00edsico","volume":"10","author":"Schneider","year":"2004","journal-title":"Rev Bras Med Esporte"},{"key":"10.1016\/j.envpol.2025.126131_bib71","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1152\/jappl.1994.77.2.834","article-title":"Effects of cocaine, benzoylecgonine, and cocaine metabolites in cannulated pressurized fetal sheep cerebral arteries","volume":"77","author":"Schreiber","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.envpol.2025.126131_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/gep.2017.513001","article-title":"Guarapiranga reservoir\u2014pharmaceuticals and historical urban occupation in a water source","volume":"5","author":"Shihomatsu","year":"2017","journal-title":"J. Geosci. Environ. Protect."},{"key":"10.1016\/j.envpol.2025.126131_bib73","first-page":"377","article-title":"A role of mitochondrial glutathione peroxidase in modulating mitochondrial oxidations in liver","volume":"84","author":"Sies","year":"1978","journal-title":"FEBS J."},{"key":"10.1016\/j.envpol.2025.126131_bib74","doi-asserted-by":"crossref","first-page":"11042J","DOI":"10.1520\/JFS11042J","article-title":"Brain concentrations of cocaine and benzoylecgonine in fatal cases","volume":"30","author":"Spiehler","year":"1985","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.envpol.2025.126131_bib75","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.chemosphere.2018.06.046","article-title":"Emerging contaminants in Brazilian rivers: occurrence and effects on gene expression in zebrafish (Danio rerio) embryos","volume":"209","author":"Sposito","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126131_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.paf.0000118960.58334.a9","article-title":"Criteria for the interpretation of cocaine levels in human biological samples and their relation to the cause of death","volume":"25","author":"Stephens","year":"2004","journal-title":"Am. J. Forensic Med. Pathol"},{"key":"10.1016\/j.envpol.2025.126131_bib77","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/cpt1979254464","article-title":"Cocaine metabolism: cocaine and norcocaine hydrolysis by liver and serum esterases","volume":"25","author":"Stewart","year":"1979","journal-title":"Clin Pharma and Therapeutics"},{"key":"10.1016\/j.envpol.2025.126131_bib78","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/0024-3205(77)90448-9","article-title":"Hydrolysis of cocaine in human plasma by cholinesterase","volume":"20","author":"Stewart","year":"1977","journal-title":"Life Sci."},{"key":"10.1016\/j.envpol.2025.126131_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116777","article-title":"Gene alteration in zebrafish exposed to a mixture of substances of abuse","volume":"278","author":"Subedi","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-61628-5","article-title":"Urban wastewater analysis as an effective tool for monitoring illegal drugs, including new psychoactive substances, in the Eastern European region","volume":"10","author":"Sulej-Suchomska","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2025.126131_bib81","series-title":"The Effects of Drug Abuse on the Human Nervous System","first-page":"103","article-title":"Chapter five - cocaine: mechanism and effects in the human brain","author":"Trifilieff","year":"2014"},{"key":"10.1016\/j.envpol.2025.126131_bib82","series-title":"Global Report on Cocaine 2023 \u2013 Local Dynamics, Global Challenges","year":"2023"},{"key":"10.1016\/j.envpol.2025.126131_bib83","series-title":"Global Overview of Drug Demand and Drug Supply","article-title":"World drug report 2022","year":"2022"},{"key":"10.1016\/j.envpol.2025.126131_bib84","series-title":"WORLD DRUG REPORT 2020. Drug Use and Health Consequences","year":"2021"},{"key":"10.1016\/j.envpol.2025.126131_bib85","series-title":"World Drug Report 2018","year":"2018"},{"key":"10.1016\/j.envpol.2025.126131_bib86","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.watres.2008.12.020","article-title":"Spatial and temporal variations in the occurrence of cocaine and benzoylecgonine in waste- and surface water from Belgium and removal during wastewater treatment","volume":"43","author":"van Nuijs","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2025.126131_bib87","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1179\/174329211X12989133691530","article-title":"Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats","volume":"16","author":"Vitcheva","year":"2011","journal-title":"Redox Rep."},{"key":"10.1016\/j.envpol.2025.126131_bib88","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s11270-020-04565-3","article-title":"Occurrence of stimulant drugs of abuse in a San Diego, CA, stream and their consumption rates in the neighboring community","volume":"231","author":"Watanabe","year":"2020","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.envpol.2025.126131_bib89","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.aquaculture.2004.11.024","article-title":"Effect of different oxygen tensions on weight gain, feed conversion, and antioxidant status in piapara, Leporinus elongatus (Valenciennes, 1847)","volume":"244","author":"Wilhelm Filho","year":"2005","journal-title":"Aquaculture"},{"key":"10.1016\/j.envpol.2025.126131_bib90","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0165-3806(94)00169-Z","article-title":"Long-lasting microencephaly following exposure to cocaine during the brain growth spurt in the rat","volume":"84","author":"Xiao","year":"1995","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.envpol.2025.126131_bib91","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ecoenv.2015.06.030","article-title":"Toxic effects of nitenpyram on antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers","volume":"122","author":"Yan","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2025.126131_bib92","article-title":"A fresh look at zebrafish from the perspective of cancer research","volume":"9","author":"Zhao","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.envpol.2025.126131_bib54","unstructured":"ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT. OECD Guideline for Testing Chemicals. Fish, Acute Toxicity Test. v.1; p. 1-9. France, 1992."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125005044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125005044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T09:58:25Z","timestamp":1745575105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125005044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":92,"alternative-id":["S0269749125005044"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126131","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure and coexposure to cocaine and benzoylecgonine at environmentally relevant levels cause long-term oxidative effects in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126131"}}