{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:17:37Z","timestamp":1778631457167,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013414","name":"Conseil R\u00e9gional des Pays de la Loire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE34-0001-01"],"award-info":[{"award-number":["ANR-18-CE34-0001-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["Project-ANR-18-CE34-0001-01"],"award-info":[{"award-number":["Project-ANR-18-CE34-0001-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.envpol.2025.126239","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:51:03Z","timestamp":1744480263000},"page":"126239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Characterization of POP mixture redistribution and identification of their molecular signature in xenografted fat mice"],"prefix":"10.1016","volume":"374","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-6156","authenticated-orcid":false,"given":"Th\u00e9o","family":"Jamay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4538-803X","authenticated-orcid":false,"given":"Philippe","family":"Noirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-2710","authenticated-orcid":false,"given":"Haidar","family":"Djemai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-0651","authenticated-orcid":false,"given":"Layale","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9268-5471","authenticated-orcid":false,"given":"Justine","family":"Massias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7309-6369","authenticated-orcid":false,"given":"Sadia","family":"Ouzia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"Cano-Sancho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4442-0026","authenticated-orcid":false,"given":"Patricia","family":"Margaritte-Jeannin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7586-6819","authenticated-orcid":false,"given":"Florence","family":"Jornod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"B Blanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Coumoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Guitton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Le Bizec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Antignac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-5546","authenticated-orcid":false,"given":"Covadonga","family":"Lucas-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-339X","authenticated-orcid":false,"given":"Nicolas","family":"Giraud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-763X","authenticated-orcid":false,"given":"Gildas","family":"Bertho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-9331","authenticated-orcid":false,"given":"Min Ji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7525-4089","authenticated-orcid":false,"given":"Karine","family":"Audouze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.envpol.2025.126239_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.envpol.2008.07.008","article-title":"Exposure assessment of French women and their newborn to brominated flame retardants: determination of Tri- to Deca- polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum","volume":"157","author":"Antignac","year":"2009","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.envpol.2025.126239_bib2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1289\/ehp.10554","article-title":"Polychlorinated Biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis","volume":"116","author":"Arsenescu","year":"2008","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.envpol.2025.126239_bib3","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.1021\/es505399w","article-title":"Isomer-specific binding affinity of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) to serum proteins","volume":"49","author":"Beesoon","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.126239_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.envint.2015.07.014","article-title":"Perfluoroalkyl acid (PFAA) levels and profiles in breast milk, maternal and cord serum of French women and their newborns","volume":"84","author":"Cariou","year":"2015","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envpol.2025.126239_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/reveh.2011.009","article-title":"Health effects of persistent organic pollutants: the challenge for the Pacific Basin and for the world","volume":"26","author":"Carpenter","year":"2011","journal-title":"Rev. Environ. Health"},{"issue":"4","key":"10.1016\/j.envpol.2025.126239_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.diabet.2016.05.009","article-title":"Adverse effects of weight loss: are persistent organic pollutants a potential culprit?","volume":"42","author":"Cheikh Rouhou","year":"2016","journal-title":"Diabetes Metab."},{"issue":"4","key":"10.1016\/j.envpol.2025.126239_bib7","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10092","article-title":"Exposure to Per- and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis","volume":"130","author":"Costello","year":"2022","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.envpol.2025.126239_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.chemosphere.2004.02.014","article-title":"Distribution of organochlorine pesticides, polychlorinated biphenyls and Alpha-HCH enantiomers in pork tissues","volume":"56","author":"Covaci","year":"2004","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envpol.2025.126239_bib9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/cells11010110","article-title":"Mitochondrial dysfunction as a hallmark of environmental injury","volume":"11","author":"Duarte-Hospital","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.envpol.2025.126239_bib10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1289\/EHP316","article-title":"Chronic exposure to low doses of dioxin promotes liver fibrosis development in the C57BL\/6J diet-induced obesity mouse model","volume":"125","author":"Duval","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.envpol.2025.126239_bib11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","article-title":"Mitochondrial alterations in fatty liver diseases","volume":"78","author":"Fromenty","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envpol.2025.126239_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tox.2014.12.017","article-title":"Effect of chronic p,p\u2019-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in Male C57BL\/6H mice","volume":"328","author":"Howell","year":"2015","journal-title":"Toxicology"},{"issue":"Pt 2","key":"10.1016\/j.envpol.2025.126239_bib13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.envint.2018.10.027","article-title":"Release and toxicity of adipose tissue-stored TCDD: direct evidence from a xenografted fat model","volume":"121","author":"Joffin","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126239_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153862","article-title":"Legacy and alternative Per- and polyfluoroalkyl substances (PFAS) alter the lipid profile of HepaRG cells","volume":"506","author":"Kashobwe","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2025.126239_bib15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3389\/fendo.2018.00548","article-title":"Developmental exposure to 2,2\u2019,4,4\u2019-Tetrabromodiphenyl ether permanently alters blood-liver balance of lipids in Male mice","volume":"9","author":"Khalil","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.envpol.2025.126239_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1289\/ehp.1002848","article-title":"Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in Obese subjects before and after drastic weight loss","volume":"119","author":"Kim","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.envpol.2025.126239_bib17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1289\/ehp.1104282","article-title":"Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells","volume":"120","author":"Kim","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.envpol.2025.126239_bib18","first-page":"117","article-title":"Environmental chemicals, breast cancer progression and drug resistance","volume":"19","author":"Koual","year":"2020","journal-title":"Environ. Health Glob. Access Sci. Source"},{"issue":"2","key":"10.1016\/j.envpol.2025.126239_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1289\/ehp.1205485","article-title":"Toxicological function of adipose tissue: Focus on persistent organic pollutants","volume":"121","author":"La Merrill","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2025.126239_bib20","series-title":"Perfluoroalkylated Substances: PFOA, PFOS and PFOSA","author":"Larsen","year":"2015"},{"key":"10.1016\/j.envpol.2025.126239_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108628","article-title":"A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG","volume":"178","author":"Leblanc","year":"2019","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.envpol.2025.126239_bib22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1210\/er.2013-1084","article-title":"Chlorinated persistent organic pollutants, obesity, and type 2 diabetes","volume":"35","author":"Lee","year":"2014","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.envpol.2025.126239_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/oemed-2017-104651","article-title":"Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water","volume":"75","author":"Li","year":"2018","journal-title":"Occup. Environ. Med."},{"issue":"9","key":"10.1016\/j.envpol.2025.126239_bib24","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1007\/s00204-020-02808-0","article-title":"Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells","volume":"94","author":"Louisse","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"11","key":"10.1016\/j.envpol.2025.126239_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.5006","article-title":"NMR metabolomics study of chronic low-dose exposure to a cocktail of persistent organic pollutants","volume":"36","author":"Lucas-Torres","year":"2023","journal-title":"NMR Biomed."},{"issue":"1","key":"10.1016\/j.envpol.2025.126239_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabet.2013.09.006","article-title":"Persistent organic pollutants and diabetes: a review of the epidemiological evidence","volume":"40","author":"Magliano","year":"2014","journal-title":"Diabetes Metab."},{"issue":"8","key":"10.1016\/j.envpol.2025.126239_bib27","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s00204-018-2235-7","article-title":"Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126","volume":"92","author":"Mesnage","year":"2018","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.envpol.2025.126239_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/toxics11010041","article-title":"Partitioning of persistent organic pollutants between adipose tissue and serum in human studies","volume":"11","author":"Moriceau","year":"2022","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.envpol.2025.126239_bib29","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/tox.22334","article-title":"Exposure to an environmentally relevant mixture of organochlorine compounds and polychlorinated biphenyls promotes hepatic steatosis in Male Ob\/Ob mice","volume":"32","author":"Mulligan","year":"2017","journal-title":"Environ. Toxicol."},{"issue":"2","key":"10.1016\/j.envpol.2025.126239_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/toxics10020044","article-title":"PFAS molecules: a major concern for the human health and the environment","volume":"10","author":"Panieri","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2025.126239_bib31","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2013.06.004","article-title":"Accumulation of perfluoroalkyl substances in human tissues","volume":"59","author":"P\u00e9rez","year":"2013","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envpol.2025.126239_bib32","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1038\/s41598-017-02885-9","article-title":"Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p\u2019-DDE","volume":"7","author":"Pestana","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2025.126239_bib33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.envint.2016.08.011","article-title":"Distribution of persistent organic pollutants in serum, omental, and parietal adipose tissue of French women with deep infiltrating endometriosis and circulating versus stored ratio as new marker of exposure","volume":"97","author":"Ploteau","year":"2016","journal-title":"Environ. Int."},{"issue":"17","key":"10.1016\/j.envpol.2025.126239_bib34","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.3390\/cancers15174237","article-title":"Polybrominated diphenyl ethers (PBDEs) and human health: effects on metabolism, diabetes and cancer","volume":"15","author":"Renzelli","year":"2023","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.envpol.2025.126239_bib35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00204-023-03649-3","article-title":"Impact of perfluoroalkyl substances (PFAS) and PFAS mixtures on lipid metabolism in differentiated HepaRG cells as a model for human hepatocytes","volume":"98","author":"Sadrabadi","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2025.126239_bib36","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.envint.2018.04.052","article-title":"Changes in markers of liver function in relation to changes in perfluoroalkyl substances - a longitudinal study","volume":"117","author":"Salihovic","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126239_bib37","article-title":"Gene expression profiling after exposure to a chemical carcinogen, pentabrominated diphenyl ether, at different life stages","volume":"4","author":"Shockley","year":"2022","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.envpol.2025.126239_bib38","unstructured":"The POPs. https:\/\/chm.pops.int\/TheConvention\/ThePOPs\/tabid\/673\/Default.aspx (accessed 2024-July-24)."},{"issue":"4","key":"10.1016\/j.envpol.2025.126239_bib39","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1515\/reveh-2018-0018","article-title":"Exposure to persistent organic pollutants: impact on women's health","volume":"33","author":"Wahlang","year":"2018","journal-title":"Rev. Environ. Health"},{"issue":"12","key":"10.1016\/j.envpol.2025.126239_bib40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11892-017-0966-0","article-title":"Persistent organic pollutants as risk factors for obesity and diabetes","volume":"17","author":"Yang","year":"2017","journal-title":"Curr. Diab. Rep."},{"issue":"5","key":"10.1016\/j.envpol.2025.126239_bib41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J. Integr. Biol."},{"key":"10.1016\/j.envpol.2025.126239_bib42","article-title":"Effects of perfluorooctanoic acid on metabolic profiles in brain and liver of mouse revealed by a high-throughput targeted metabolomics approach","volume":"6","author":"Yu","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125006128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125006128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:43:02Z","timestamp":1778629382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125006128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":42,"alternative-id":["S0269749125006128"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126239","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of POP mixture redistribution and identification of their molecular signature in xenografted fat mice","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"126239"}}