{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:10:18Z","timestamp":1793506218843,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ30813"],"award-info":[{"award-number":["2021JJ30813"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42277432"],"award-info":[{"award-number":["42277432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42007391"],"award-info":[{"award-number":["42007391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.envpol.2025.126321","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T22:28:33Z","timestamp":1745706513000},"page":"126321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Independent and synergistic effects of extreme heat and NO2 pollution on diabetic nephropathy in a type II diabetes mouse model"],"prefix":"10.1016","volume":"375","author":[{"given":"Zipeng","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-4685","authenticated-orcid":false,"given":"Faming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-9492","authenticated-orcid":false,"given":"Chan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2025.126321_bib1","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1080\/15548627.2022.2062875","article-title":"Glutamine, MTOR and autophagy: a multiconnection relationship","volume":"18","author":"Bodineau","year":"2022","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.envpol.2025.126321_bib2","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/S2542-5196(17)30117-1","article-title":"Associations of ambient coarse particulate matter, nitrogen dioxide, and carbon monoxide with the risk of kidney disease: a cohort study","volume":"1","author":"Bowe","year":"2017","journal-title":"Lancet Planet. Health"},{"issue":"5","key":"10.1016\/j.envpol.2025.126321_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ki.1991.284","article-title":"Glomeruli synthesize nitrite in active Heymann nephritis; the source is infiltrating macrophages","volume":"40","author":"Cattell","year":"1991","journal-title":"Kidney Int."},{"key":"10.1016\/j.envpol.2025.126321_bib4","doi-asserted-by":"crossref","DOI":"10.1289\/EHP44","article-title":"Time-series analysis of heat waves and emergency department visits in Atlanta 1993 to 2012","volume":"125","author":"Chen","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2025.126321_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41392-020-00389-z","article-title":"Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity","volume":"6","author":"Chen","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.envpol.2025.126321_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107783","article-title":"Associations between short-term temperature exposure and kidney-related conditions in New York State: the influence of temperature metrics across four dimensions","volume":"173","author":"Chu","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126321_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.15585\/mmwr.mm6906a3","article-title":"Trends in incidence of Type 1 and Type 2 diabetes among youths - selected counties and Indian reservations, United States, 2002-2015","volume":"69","author":"Divers","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.envpol.2025.126321_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev-pathol-052016-100200","article-title":"Amyloidosis: insights from proteomics","volume":"12","author":"Dogan","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.envpol.2025.126321_bib9","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1172\/JCI126091","article-title":"Identifying and targeting pathogenic PI3K\/AKT\/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease","volume":"129","author":"Fajgenbaum","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.envpol.2025.126321_bib10","doi-asserted-by":"crossref","first-page":"26105","DOI":"10.1002\/anie.202109464","article-title":"Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein","volume":"60","author":"Fan","year":"2021","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.envpol.2025.126321_bib11","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1172\/JCI76042","article-title":"TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1","volume":"124","author":"Gao","year":"2014","journal-title":"J. Clin. Investig."},{"issue":"9991","key":"10.1016\/j.envpol.2025.126321_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(14)62114-0","article-title":"Mortality risk attributable to high and low ambient temperature: a multicountry observational study","volume":"386","author":"Gasparrini","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.envpol.2025.126321_bib13","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1080\/15548627.2021.1990515","article-title":"Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells","volume":"18","author":"Gong","year":"2022","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.envpol.2025.126321_bib14","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jhep.2021.10.016","article-title":"Exposure to air pollution is associated with an increased risk of metabolic dysfunction-associated fatty liver disease","volume":"76","author":"Guo","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envpol.2025.126321_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102227","article-title":"Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder","volume":"49","author":"Guo","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2025.126321_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2025.126321_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2025.126321_bib18","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s00125-024-06102-x","article-title":"Diabetes and infection: a review of the epidemiology, mechanisms, and principles of treatment","volume":"67","author":"Holt","year":"2024","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.envpol.2025.126321_bib19","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1080\/15548627.2021.1885203","article-title":"Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4","volume":"17","author":"Huang","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.envpol.2025.126321_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.envpol.2025.126321_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Kim","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2025.126321_bib22","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.envpol.2025.126321_bib23","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3523","article-title":"The immune system and kidney disease: basic concepts and clinical implications","volume":"13","author":"Kurts","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envpol.2025.126321_bib24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41419-019-1728-5","article-title":"Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envpol.2025.126321_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106298","article-title":"Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK\/mTOR\/ULK1 signaling pathway","volume":"147","author":"Lin","year":"2021","journal-title":"Environ. Int."},{"issue":"12","key":"10.1016\/j.envpol.2025.126321_bib26","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1080\/15548627.2019.1615822","article-title":"Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys","volume":"15","author":"Livingston","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2025.126321_bib27","doi-asserted-by":"crossref","first-page":"696","DOI":"10.4161\/auto.7.7.15451","article-title":"Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop","volume":"7","author":"L\u00f6ffler","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2025.126321_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161760","article-title":"Interaction of high temperature and NO2 exposure on asthma risk: in vivo experimental evidence of inflammation and oxidative stress","volume":"869","author":"Lu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126321_bib29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2022.10.014","article-title":"Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS\/STING signaling dependent on LKB1\/AMPK\/ULK1-mediated autophagy","volume":"51","author":"Lu","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.envpol.2025.126321_bib30","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1038\/s41467-021-24331-1","article-title":"Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer","volume":"12","author":"Luu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2025.126321_bib31","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jaci.2013.09.016","article-title":"Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma","volume":"133","author":"McGarvey","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.envpol.2025.126321_bib32","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ki.2015.230","article-title":"A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010","volume":"88","author":"Mills","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.envpol.2025.126321_bib33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.semcancer.2019.07.003","article-title":"mTOR: role in cancer, metastasis, and drug resistance","volume":"59","author":"Murugan","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.envpol.2025.126321_bib34","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1001\/jama.2014.13186","article-title":"Climate change: challenges and opportunities for global health","volume":"312","author":"Patz","year":"2014","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.envpol.2025.126321_bib35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.ajkd.2022.09.005","article-title":"Associations between ambient extreme heat exposure and emergency department visits related to kidney disease","volume":"81","author":"Qu","year":"2023","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.envpol.2025.126321_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41581-023-00680-6","article-title":"Environmental pollution, heat stress, and renel health: a need for integrated assessment","volume":"19","author":"Sanders","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.envpol.2025.126321_bib37","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/sj.ki.5002180","article-title":"Phenotypic transitions and fibrosis in diabetic nephropathy","volume":"71","author":"Simonson","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.envpol.2025.126321_bib38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.plipres.2013.11.002","article-title":"TRP-channels as key integrators of lipid pathways in nociceptive neurons","volume":"53","author":"Sisignano","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.envpol.2025.126321_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2025.126321_bib40","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2337\/db06-1226","article-title":"Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors","volume":"56","author":"Sugimoto","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.envpol.2025.126321_bib41","article-title":"Ambient heat and risks of emergency department visits among adults in the United States: time stratified case crossover study","volume":"375","author":"Sun","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.envpol.2025.126321_bib42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41581-019-0234-4","article-title":"Innate immunity in diabetic kidney disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"7","key":"10.1016\/j.envpol.2025.126321_bib43","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tem.2015.05.002","article-title":"Epidemiology of air pollution and diabetes","volume":"26","author":"Thiering","year":"2015","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.envpol.2025.126321_bib44","article-title":"Diabetic kidney disease","volume":"1","author":"Thomas","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.envpol.2025.126321_bib45","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.kint.2022.05.012","article-title":"Molecular mechanisms and therapeutic targets for diabetic kidney disease","volume":"102","author":"Tuttle","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.envpol.2025.126321_bib46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-physiol-020911-153333","article-title":"Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney","volume":"74","author":"Vallon","year":"2012","journal-title":"Annu. Rev. Physiol."},{"issue":"7713","key":"10.1016\/j.envpol.2025.126321_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-018-0100-8","article-title":"Publisher correction: a TRP channel trio mediates acute noxious heat sensing","volume":"559","author":"Vandewauw","year":"2018","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.envpol.2025.126321_bib48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrneph.2017.31","article-title":"The role of the complement system in diabetic nephropathy","volume":"13","author":"Wang","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.envpol.2025.126321_bib49","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.envres.2016.02.022","article-title":"Warm season temperatures and emergency department visits in Atlanta, Georgia","volume":"147","author":"Winquist","year":"2016","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.envpol.2025.126321_bib50","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12916-022-02573-0","article-title":"Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort","volume":"20","author":"Wu","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.envpol.2025.126321_bib51","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/01.j.pain.0000460351.30707.c4","article-title":"Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats","volume":"156","author":"Xiao","year":"2015","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.envpol.2025.126321_bib52","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1080\/15548627.2021.2008752","article-title":"Autophagy inhibition mediated by MCOLN1\/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53\/p53 pathway","volume":"18","author":"Xing","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.envpol.2025.126321_bib53","article-title":"Discovery of PRDM16-Mediated TRPA1 induction as the mechanism for low tubulo-interstitial fibrosis in diabetic kidney disease","volume":"11","author":"Xu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.envpol.2025.126321_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157102","article-title":"Ambient NO2 exposure induces migraine in rats: evidence, mechanisms and interventions","volume":"844","author":"Ye","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.envpol.2025.126321_bib55","article-title":"Controlled activation of TRPV1 channels on microglia to boost their autophagy for clearance of Alpha-Synuclein and enhance therapy of Parkinson's Disease","volume":"34","author":"Yuan","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.envpol.2025.126321_bib56","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1681\/ASN.2012050442","article-title":"TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease","volume":"24","author":"Zaika","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.envpol.2025.126321_bib57","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/CIRCRESAHA.122.321542","article-title":"Loss of macrophage mTORC2 drives atherosclerosis via FoxO1 and IL-1beta signaling","volume":"133","author":"Zhang","year":"2023","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.envpol.2025.126321_bib58","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41392-023-01464-x","article-title":"TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.envpol.2025.126321_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102409","article-title":"Heat stroke: pathogenesis, diagnosis, and current treatment","volume":"100","author":"Zhang","year":"2024","journal-title":"Ageing Res. Rev."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125006943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125006943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T14:24:18Z","timestamp":1747319058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125006943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":59,"alternative-id":["S0269749125006943"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126321","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Independent and synergistic effects of extreme heat and NO2 pollution on diabetic nephropathy in a type II diabetes mouse model","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126321"}}