{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:45:30Z","timestamp":1790765130505,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["19KJB330003"],"award-info":[{"award-number":["19KJB330003"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["NCX2401"],"award-info":[{"award-number":["NCX2401"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273584"],"award-info":[{"award-number":["82273584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903353"],"award-info":[{"award-number":["81903353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX24_0807"],"award-info":[{"award-number":["SJCX24_0807"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.envpol.2025.126877","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:03:49Z","timestamp":1753225429000},"page":"126877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Reversal of neurodevelopmental toxicity induced by combined exposure to the neonicotinoid insecticides acetamiprid and imidacloprid in zebrafish through targeting DRP-1: insights into mitophagy and apoptosis mechanisms"],"prefix":"10.1016","volume":"383","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4692-2152","authenticated-orcid":false,"given":"Yuzhi","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxiu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qitong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou-Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huibin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8452-1214","authenticated-orcid":false,"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2025.126877_bib1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ps.1305","article-title":"Resistance and cross-resistance to imidacloprid and thiamethoxam in the Colorado potato beetle Leptinotarsa decemlineata","volume":"63","author":"Alyokhin","year":"2007","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.envpol.2025.126877_bib2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.apsb.2021.06.014","article-title":"Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease","volume":"12","author":"Austad","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.envpol.2025.126877_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143822","article-title":"Residues of neonicotinoids in soil, water and people's hair: a case study from three agricultural regions of the Philippines","volume":"757","author":"Bonmatin","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126877_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11030450","article-title":"The non-specific Drp1 inhibitor Mdivi-1 has modest biochemical antioxidant activity","volume":"11","author":"Bordt","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.envpol.2025.126877_bib5","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.chemosphere.2010.12.054","article-title":"Spatial and seasonal variations in atrazine and metolachlor surface water concentrations in Ontario (Canada) using ELISA","volume":"82","author":"Byer","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126877_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-ento-120811-153645","article-title":"Neuroactive insecticides: targets, selectivity, resistance, and secondary effects","volume":"58","author":"Casida","year":"2013","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.envpol.2025.126877_bib7","doi-asserted-by":"crossref","first-page":"10286","DOI":"10.1007\/s11356-020-07653-3","article-title":"Combined toxicity of imidacloprid, acetochlor, and tebuconazole to zebrafish (Danio rerio): acute toxicity and hepatotoxicity assessment","volume":"27","author":"Chang","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2025.126877_bib8","doi-asserted-by":"crossref","first-page":"40207","DOI":"10.1074\/jbc.R112.407668","article-title":"The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily","volume":"287","author":"Changeux","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2025.126877_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.envpol.2025.126877_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/cells1030597","article-title":"Heavy metals and metalloids as autophagy inducing agents: focus on cadmium and arsenic","volume":"1","author":"Chiarelli","year":"2012","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2025.126877_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the global burden of disease study 2021","volume":"23","author":"Collaborators","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.envpol.2025.126877_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139825","article-title":"Toxicity effects of pesticides based on zebrafish (Danio rerio) models: advances and perspectives","volume":"340","author":"Cui","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126877_bib13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s12035-014-9002-4","article-title":"Mdivi-1 protects against ischemic brain injury via elevating extracellular adenosine in a cAMP\/CREB-CD39-Dependent manner","volume":"53","author":"Cui","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.envpol.2025.126877_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111689","article-title":"Mdivi-1, a mitochondrial fission inhibitor, reduces angiotensin-II- induced hypertension by mediating VSMC phenotypic switch","volume":"140","author":"Deng","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envpol.2025.126877_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125431","article-title":"Zebrafish neuro-behavioral profiles altered by acesulfame (ACE) within the range of \"no observed effect concentrations (NOECs)\"","volume":"243","author":"Dong","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126877_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2025.107284","article-title":"Antibacterials exert toxic effects on aquatic organisms by inhibiting respiration, inducing oxidative stress, mitochondrial dysfunction and autophagy","volume":"280","author":"Fadda","year":"2025","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.126877_bib17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41420-021-00495-z","article-title":"Mdivi-1 induces spindle abnormalities and augments taxol cytotoxicity in MDA-MB-231 cells","volume":"7","author":"Fang","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.envpol.2025.126877_bib18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2025.126877_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural effects of developmental toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.envpol.2025.126877_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043757","article-title":"Neurodevelopmental toxicity of emamectin benzoate to the early life stage of zebrafish larvae (Danio rerio)","volume":"24","author":"Gu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2025.126877_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.chemosphere.2017.10.149","article-title":"Human exposure to neonicotinoid insecticides and the evaluation of their potential toxicity: an overview","volume":"192","author":"Han","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126877_bib22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neuro.2023.05.003","article-title":"Developmental exposure of zebrafish to neonicotinoid pesticides: long-term effects on neurobehavioral function","volume":"96","author":"Hawkey","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envpol.2025.126877_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115723","article-title":"Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition","volume":"430","author":"Hirano","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2025.126877_bib24","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1021\/acs.est.7b06388","article-title":"Environmental risks and challenges associated with neonicotinoid insecticides","volume":"52","author":"Hladik","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.126877_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110150","article-title":"Mixture toxicity of cadmium and acetamiprid to the early life stages of zebrafish (Danio rerio)","volume":"366","author":"Hu","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2025.126877_bib26","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1021\/jf101303g","article-title":"Overview of the status and global strategy for neonicotinoids","volume":"59","author":"Jeschke","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envpol.2025.126877_bib27","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/iep.12139","article-title":"Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model","volume":"96","author":"Kara","year":"2015","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.envpol.2025.126877_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091947","article-title":"Mdivi-1 protects adult rat hippocampal neural stem cells against palmitate-induced oxidative stress and apoptosis","volume":"18","author":"Kim","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2025.126877_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2019.110810","article-title":"Antibiotics in coastal water and sediments of the East China Sea: distribution, ecological risk assessment and indicators screening","volume":"151","author":"Li","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envpol.2025.126877_bib30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuro.2022.12.009","article-title":"Investigating the neurotoxicity of environmental pollutants using zebrafish as a model organism: a review and recommendations for future work","volume":"94","author":"Lin","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envpol.2025.126877_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113722","article-title":"Neonicotinoid insecticides in the drinking water system - fate, transportation, and their contributions to the overall dietary risks","volume":"258","author":"Lu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126877_bib32","doi-asserted-by":"crossref","first-page":"12494","DOI":"10.1021\/acs.est.2c04014","article-title":"Long-term exposure to neonicotinoid insecticide acetamiprid at environmentally relevant concentrations impairs endocrine functions in zebrafish: bioaccumulation, feminization, and transgenerational effects","volume":"56","author":"Ma","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.126877_bib33","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.chemosphere.2019.05.040","article-title":"Neonicotinoid insecticides in surface water from the central Yangtze River, China","volume":"229","author":"Mahai","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126877_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2024.104606","article-title":"Evaluating the impact of neonicotinoids on aquatic non-target species: a comprehensive review","volume":"113","author":"Mandal","year":"2025","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2025.126877_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-pharmtox-010818-021747","article-title":"Neonicotinoid insecticides: molecular targets, resistance, and toxicity","volume":"60","author":"Matsuda","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.envpol.2025.126877_bib36","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1021\/acs.est.1c05915","article-title":"In vivo effects of silver nanoparticles on development, behavior, and mitochondrial function are altered by genetic defects in mitochondrial dynamics","volume":"56","author":"Mello","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.126877_bib37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.envint.2014.10.024","article-title":"Neonicotinoid contamination of global surface waters and associated risk to aquatic invertebrates: a review","volume":"74","author":"Morrissey","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126877_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.177626","article-title":"Effects of sublethal concentration of thiamethoxam formulation on the wild stingless bee, Partamona helleri Friese (Hymenoptera: apidae): histopathology, oxidative stress and behavioral changes","volume":"957","author":"Motta","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126877_bib39","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1002\/etc.5065","article-title":"Human exposures to Neonicotinoids in Kumasi, Ghana","volume":"40","author":"Nimako","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.126877_bib40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/toxsci\/kfae138","article-title":"The impact of neonicotinoid pesticides on reproductive health","volume":"203","author":"Oladosu","year":"2025","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2025.126877_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107180","article-title":"Prenatal neonicotinoid insecticides exposure, oxidative stress, and birth outcomes","volume":"163","author":"Pan","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126877_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121168","article-title":"Effects of neonicotinoid pesticide exposure in the first trimester on gestational diabetes mellitus based on interpretable machine learning","volume":"273","author":"Pan","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2025.126877_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126981","article-title":"Fate of selected neonicotinoid insecticides in soil-water systems: current state of the art and knowledge gaps","volume":"255","author":"Pietrzak","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126877_bib44","doi-asserted-by":"crossref","DOI":"10.1177\/00368504211028361","article-title":"Glutathione and its dependent enzymes' modulatory responses to neonicotinoid insecticide sulfoxaflor induced oxidative damage in zebrafish in vivo","volume":"104","author":"Piner Benli","year":"2021","journal-title":"Sci. Prog."},{"key":"10.1016\/j.envpol.2025.126877_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166531","article-title":"Improving mitochondrial function protects bumblebees from neonicotinoid pesticides","volume":"11","author":"Powner","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2025.126877_bib46","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1096\/fj.201801289R","article-title":"Fenvalerate induces oxidative hepatic lesions through an overload of intracellular calcium triggered by the ERK\/IKK\/NF-kappaB pathway","volume":"33","author":"Qiu","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.envpol.2025.126877_bib47","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1038\/s41598-017-04654-0","article-title":"Synergistic cellular effects including mitochondrial destabilization, autophagy and apoptosis following low-level exposure to a mixture of lipophilic persistent organic pollutants","volume":"7","author":"Rainey","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2025.126877_bib48","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1038\/s41467-023-40043-0","article-title":"Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction","volume":"14","author":"Rios","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2025.126877_bib49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fnmol.2018.00003","article-title":"Mitochondrial division inhibitor 1 (mdivi-1) protects neurons against excitotoxicity through the modulation of mitochondrial function and intracellular Ca(2+) signaling","volume":"11","author":"Ruiz","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.envpol.2025.126877_bib50","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nature14420","article-title":"Seed coating with a neonicotinoid insecticide negatively affects wild bees","volume":"521","author":"Rundlof","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2025.126877_bib51","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00128-011-0515-5","article-title":"Detections of the neonicotinoid insecticide imidacloprid in surface waters of three agricultural regions of California, USA, 2010-2011","volume":"88","author":"Starner","year":"2012","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2025.126877_bib52","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s12967-023-04270-9","article-title":"Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization","volume":"21","author":"Su","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.envpol.2025.126877_bib53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-024-00785-1","article-title":"Molecular mechanisms of mitochondrial dynamics","volume":"26","author":"Tabara","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2025.126877_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103924","article-title":"Imidacloprid-based commercial pesticide causes behavioral, biochemical, and hematological impairments in Wistar rats","volume":"94","author":"Tonietto","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2025.126877_bib55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chemosphere.2017.04.017","article-title":"Diuron and diazinon alter the behavior of zebrafish embryos and larvae in the absence of acute toxicity","volume":"180","author":"Velki","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126877_bib56","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.scitotenv.2019.04.267","article-title":"Neonicotinoids in raw, finished, and tap water from Wuhan, Central China: assessment of human exposure potential","volume":"675","author":"Wan","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126877_bib57","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.scitotenv.2019.02.272","article-title":"Isoliquiritigenin as an antioxidant phytochemical ameliorates the developmental anomalies of zebrafish induced by 2,2',4,4'-tetrabromodiphenyl ether","volume":"666","author":"Wang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126877_bib58","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1080\/17435390.2021.1966538","article-title":"Bioaccumulation of BDE47 in testes by TiO(2) nanoparticles aggravates the reproductive impairment of male zebrafish by disrupting intercellular junctions","volume":"15","author":"Wang","year":"2021","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.envpol.2025.126877_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125394","article-title":"Pollution characteristics, environmental issues, and green development of neonicotinoid insecticides in China: insights from Imidacloprid","volume":"365","author":"Wang","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126877_bib60","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev-pharmtox-010617-052429","article-title":"Mechanism of neonicotinoid toxicity: impact on oxidative stress and metabolism","volume":"58","author":"Wang","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.envpol.2025.126877_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175422","article-title":"Imidacloprid affects human cells through mitochondrial dysfunction and oxidative stress","volume":"951","author":"Wei","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126877_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131296","article-title":"Neonicotinoids residues in cow milk and health risks to the Chinese general population","volume":"452","author":"Wei","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2025.126877_bib63","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s11064-017-2201-4","article-title":"Mdivi-1 alleviates early brain injury after experimental subarachnoid hemorrhage in rats, possibly via inhibition of Drp1-Activated mitochondrial fission and oxidative stress","volume":"42","author":"Wu","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.envpol.2025.126877_bib64","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.envpol.2017.12.120","article-title":"Joint toxic effects of triazophos and imidacloprid on zebrafish (Danio rerio)","volume":"235","author":"Wu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126877_bib65","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-023-27026-w","article-title":"Rapid determination and health risk assessment of neonicotinoids in source water and tap water of the tropical Hainan Island, China","author":"Xiong","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2025.126877_bib66","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00204-022-03267-5","article-title":"Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage","volume":"96","author":"Xu","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2025.126877_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141873","article-title":"Oxidative stress, growth inhibition, and DNA damage in earthworms induced by the combined pollution of typical neonicotinoid insecticides and heavy metals","volume":"754","author":"Yan","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126877_bib68","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.envpol.2019.05.062","article-title":"Occurrence and distribution of neonicotinoid insecticides in surface water and sediment of the Guangzhou section of the Pearl River, South China","volume":"251","author":"Yi","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126877_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109111","article-title":"Prenatal exposure to neonicotinoid insecticides, fetal endocrine hormones and birth size: findings from SMBCS","volume":"193","author":"Zhang","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126877_bib70","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.chemosphere.2018.11.024","article-title":"Occurrence, distribution and seasonal variation of five neonicotinoid insecticides in surface water and sediment of the Pearl Rivers, South China","volume":"217","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126877_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105719","article-title":"Contamination of neonicotinoid insecticides in soil-water-sediment systems of the urban and rural areas in a rapidly developing region: guangzhou, South China","volume":"139","author":"Zhang","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126877_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108038","article-title":"An integrated approach to evaluate acetamiprid-induced oxidative damage to tRNA in human cells based on oxidized nucleotide and tRNA profiling","volume":"178","author":"Zhang","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126877_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121082","article-title":"The partitioning and distribution of neonicotinoid insecticides in human blood","volume":"320","author":"Zhang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126877_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105114","article-title":"A nationwide survey of urinary concentrations of neonicotinoid insecticides in China","volume":"132","author":"Zhang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2025.126877_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114953","article-title":"Environmental occurrence, toxicity concerns, and biodegradation of neonicotinoid insecticides","volume":"218","author":"Zhang","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2025.126877_bib76","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/etc.4842","article-title":"Toxicities of neonicotinoid-containing pesticide mixtures on nontarget organisms","volume":"39","author":"Zhao","year":"2020","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.126877_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124935","article-title":"Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics","volume":"362","author":"Zhao","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126877_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125336","article-title":"Fenvalerate triggers parkinson-like symptom during zebrafish development through initiation of autophagy and p38 MAPK\/mTOR signaling pathway","volume":"243","author":"Zhu","year":"2020","journal-title":"Chemosphere"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125012503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125012503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:45:51Z","timestamp":1772772351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125012503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":78,"alternative-id":["S0269749125012503"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126877","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reversal of neurodevelopmental toxicity induced by combined exposure to the neonicotinoid insecticides acetamiprid and imidacloprid in zebrafish through targeting DRP-1: insights into mitophagy and apoptosis mechanisms","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126877"}}