{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:28:27Z","timestamp":1790443707857,"version":"4.1.0"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"am","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007492","name":"Baylor University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["1P01ES028942"],"award-info":[{"award-number":["1P01ES028942"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.envpol.2025.126921","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T06:35:04Z","timestamp":1753857304000},"page":"126921","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Global occurrence and hazards of benzodiazepines in water resources: Knowledge gaps and future directions"],"prefix":"10.1016","volume":"384","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4951-4197","authenticated-orcid":false,"given":"HyeongYoung","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-2729","authenticated-orcid":false,"given":"Ba Reum","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4608-2518","authenticated-orcid":false,"given":"Alexander R.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6277-9852","authenticated-orcid":false,"given":"Bryan W.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.envpol.2025.126921_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/chemosensors10020074","article-title":"Potentiometric sensors for the selective determination of benzodiazepine drug residues in real wastewater effluents","volume":"10","author":"Abdel-Gawad","year":"2022","journal-title":"Chemosensors"},{"key":"10.1016\/j.envpol.2025.126921_bib2","doi-asserted-by":"crossref","first-page":"109031","DOI":"10.1016\/j.envint.2024.109031","article-title":"Occurrence and potential risks of pharmaceutical contamination in global estuaries: a critical review and analysis","volume":"192","author":"Adedipe","year":"2024","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.envpol.2025.126921_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1001\/jamainternmed.2016.7266","article-title":"Association between 900 steps a day and functional decline in older hospitalized patients","volume":"177","author":"Agmon","year":"2017","journal-title":"JAMA Intern. Med."},{"issue":"24","key":"10.1016\/j.envpol.2025.126921_bib4","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1021\/es072658j","article-title":"Repeating history: pharmaceuticals in the environment","volume":"41","author":"Ankley","year":"2007","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.envpol.2025.126921_bib113","first-page":"209","article-title":"Effects of benzodiazepine and ivermectin on Girardiatigrina (Platyhelminthes: Turbellaria)","volume":"29","author":"Alves","year":"2013","journal-title":"Biosci. J."},{"issue":"3","key":"10.1016\/j.envpol.2025.126921_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"issue":"1656","key":"10.1016\/j.envpol.2025.126921_bib6","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0569","article-title":"Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems","volume":"369","author":"Arnold","year":"2014","journal-title":"Phil. Trans. R. Soc. B."},{"key":"10.1016\/j.envpol.2025.126921_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125231","article-title":"Boosting pharmaceutical removal through aeration in constructed wetlands","volume":"412","author":"\u00c1vila","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envpol.2025.126921_bib8","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1039\/D0AY00560F","article-title":"Determination of prescribed and designer benzodiazepines and metabolites in influent wastewater","author":"Bade","year":"2020","journal-title":"Anal. Methods12"},{"key":"10.1016\/j.envpol.2025.126921_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140045","article-title":"A high-throughput assay for screening environmental pollutants and drugs impairing predator avoidance in Daphnia magna","volume":"740","author":"Bedrossiantz","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149252","article-title":"Aqueous stability and degradation of psychiatric and neuroactive compounds and its biological activity in Daphnia magna","volume":"798","author":"Bellot","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib122","doi-asserted-by":"crossref","first-page":"154684","DOI":"10.1016\/j.scitotenv.2022.154684","article-title":"Phototactic behaviour and neurotransmitter profiles in two Daphnia magna clones: Vertical and horizontal responses to fish kairomones and psychotropic drugs","volume":"830","author":"Bellot","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxlet.2009.12.006","article-title":"Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals","volume":"193","author":"Berninger","year":"2010","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.envpol.2025.126921_bib13","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/etc.2965","article-title":"Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset","volume":"35","author":"Berninger","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.126921_bib102","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/brv.13154","article-title":"EthoCRED: A framework to guide reporting and evaluation of the relevance and reliability of behavioural ecotoxicity","volume":"100","author":"Bertram","year":"2025","journal-title":"Biol. Rev."},{"issue":"1","key":"10.1016\/j.envpol.2025.126921_bib15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0147-6513(02)00014-3","article-title":"Studies of peripheral benzodiazepine receptors in mussels: comparison between a polluted and a nonpolluted site","volume":"54","author":"Betti","year":"2003","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"10.1016\/j.envpol.2025.126921_bib107","doi-asserted-by":"crossref","DOI":"10.1002\/etc.5355","article-title":"Assessment of the potential ecotoxicological effects of pharmaceuticals in the world\u2019s rivers","volume":"41","author":"Bouzas\u2010Monroy","year":"2022","journal-title":"Environ. Toxicol. Chem"},{"issue":"9","key":"10.1016\/j.envpol.2025.126921_bib16","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1289\/ehp.1104477","article-title":"Pharmaceuticals and personal care products in the environment: what are the big questions?","volume":"120","author":"Boxall","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2025.126921_bib125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.aquatox.2013.10.005","article-title":"Short-term effects of neuroactive pharmaceutical drugs on a fish species: Biochemical and behavioural effects","volume":"144-145","author":"Brand\u00e3o","year":"2013","journal-title":"Aquat. Toxicol."},{"issue":"6121","key":"10.1016\/j.envpol.2025.126921_bib17","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1126\/science.1226850","article-title":"Dilute concentrations of a psychiatric drug alter behavior of fish from natural populations","volume":"339","author":"Brodin","year":"2013","journal-title":"Science"},{"issue":"1656","key":"10.1016\/j.envpol.2025.126921_bib18","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0580","article-title":"Ecological effects of pharmaceuticals in aquatic systems\u2014impacts through behavioural alterations","volume":"369","author":"Brodin","year":"2014","journal-title":"Phil. Trans. R. Soc. B."},{"key":"10.1016\/j.envpol.2025.126921_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aquatox.2014.01.007","article-title":"Fish on Prozac (and Zoloft): ten years later","volume":"151","author":"Brooks","year":"2014","journal-title":"Aquat. Toxicol."},{"issue":"1","key":"10.1016\/j.envpol.2025.126921_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/conphys\/cox079","article-title":"Urbanization, environment and pharmaceuticals: advancing comparative physiology, pharmacology and toxicology","volume":"6","author":"Brooks","year":"2018","journal-title":"Conserv. Physiol."},{"issue":"10","key":"10.1016\/j.envpol.2025.126921_bib22","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1039\/C8GC03893G","article-title":"Greening chemistry and ecotoxicology towards sustainable environmental quality","volume":"21","author":"Brooks","year":"2019","journal-title":"Green Chem."},{"key":"10.1016\/j.envpol.2025.126921_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10750-004-0189-7","article-title":"Water quality of effluent-dominated ecosystems: ecotoxicological, hydrological, and management considerations","volume":"556","author":"Brooks","year":"2006","journal-title":"Hydrobiologia"},{"issue":"2","key":"10.1016\/j.envpol.2025.126921_bib120","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbr.2009.12.004","article-title":"Modeling withdrawal syndrome in zebrafish","volume":"208","author":"Cachat","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"11","key":"10.1016\/j.envpol.2025.126921_bib112","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/0045-6535(93)90027-3","article-title":"The influence of solvents on the acute toxicity of some lipophilic chemicals to aquatic invertebrates","volume":"26","author":"Calleja","year":"1993","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.envpol.2025.126921_bib25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0197-0186(01)00118-8","article-title":"Peripheral benzodiazepine receptors and mitochondrial function","volume":"40","author":"Casellas","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.envpol.2025.126921_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134780","article-title":"Bioconcentration and behavioral effects of four benzodiazepines and their environmentally relevant mixture in wild fish","volume":"702","author":"Cerveny","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envpol.2025.126921_bib27","first-page":"205","article-title":"Impacts of diazepam on the survival, development, and response to light stimulation in early\u2013life stages of zebrafish (Danio rerio)","volume":"66","author":"Chen","year":"2021","journal-title":"J. Fac. Agric. Kyushu Univ."},{"issue":"6","key":"10.1016\/j.envpol.2025.126921_bib118","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1007\/s11356-014-3477-4","article-title":"Psychotropic drugs in mixture alter swimming behaviour of Japanese medaka (Oryzias latipes) larvae above environmental concentrations","volume":"23","author":"Chiffre","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2","key":"10.1016\/j.envpol.2025.126921_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/glia.21091","article-title":"Translocator protein (18kDa) (TSPO)\/peripheral benzodiazepine receptor (PBR) specific ligands induce microglia functions consistent with an activated state","volume":"59","author":"Choi","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.envpol.2025.126921_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121638","article-title":"Global occurrence of synthetic glucocorticoids and glucocorticoid receptor agonistic activity, and aquatic hazards in effluent discharges and freshwater systems","volume":"329","author":"Cole","year":"2023","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.envpol.2025.126921_bib31","doi-asserted-by":"crossref","DOI":"10.1177\/1559325815598308","article-title":"Global assessment of bisphenol A in the environment: review and analysis of its occurrence and bioaccumulation","volume":"13","author":"Corrales","year":"2015","journal-title":"Dose Response"},{"key":"10.1016\/j.envpol.2025.126921_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73287-x","article-title":"Accelerating growth of human coastal populations at the global and continent levels: 2000\u20132018","volume":"14","author":"Cosby","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.envpol.2025.126921_bib117","doi-asserted-by":"crossref","DOI":"10.1590\/0001-3765202020180595","article-title":"Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae","volume":"92","author":"Da Silva","year":"2020","journal-title":"An. Acad. Bras. Ci\u00eanc."},{"key":"10.1016\/j.envpol.2025.126921_bib33","series-title":"Part III","year":"2003"},{"issue":"23","key":"10.1016\/j.envpol.2025.126921_bib108","doi-asserted-by":"crossref","first-page":"17070","DOI":"10.3390\/ijms242317070","article-title":"Benzodiazepine delorazepam induces locomotory hyperactivity and alterations in pedal mucus texture in the freshwater gastropod Planorbarius corneus","volume":"24","author":"Fogliano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.envpol.2025.126921_bib34","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.3390\/ijms25041969","article-title":"Benzodiazepine interference with fertility and embryo development: a preliminary survey in the sea urchin Paracentrotus lividus","volume":"25","author":"Fogliano","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.envpol.2025.126921_bib35","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3390\/biology13100808","article-title":"Impact of benzodiazepine delorazepam on growth and behaviour of Artemia salina nauplii","volume":"13","author":"Fogliano","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.envpol.2025.126921_bib103","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0166-445X(01)00174-6","article-title":"Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss)","volume":"55","author":"Fitzsimmons","year":"2001","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.126921_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106244","article-title":"Environmental concentrations of a delorazepam-based drug impact on embryonic development of non-target Xenopus laevis","volume":"250","author":"Fogliano","year":"2022","journal-title":"Aquat. Toxicol."},{"issue":"20","key":"10.1016\/j.envpol.2025.126921_bib36","doi-asserted-by":"crossref","first-page":"11979","DOI":"10.1021\/acs.est.9b03228","article-title":"Effects of single and combined low concentrations of neuroactive drugs on Daphnia magna reproduction and transcriptomic responses","volume":"53","author":"Fuertes","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.126921_bib110","doi-asserted-by":"crossref","first-page":"139029","DOI":"10.1016\/j.scitotenv.2020.139029","article-title":"Changes in lipid profiles in Daphnia magna individuals exposed to low environmental levels of neuroactive pharmaceuticals","volume":"733","author":"Fuertes","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib37","article-title":"Behavioral changes and neurochemical responses in Chinese rare minnow exposed to four psychoactive substances","volume":"808","author":"Gao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib38","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/etc.3264","article-title":"Changing tides: adaptive monitoring, assessment and management of pharmaceutical hazards in the environment through time","volume":"35","author":"Gaw","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.126921_bib39","doi-asserted-by":"crossref","first-page":"27041","DOI":"10.1007\/s11356-022-23667-5","article-title":"Occurrence and removal of psychiatric pharmaceuticals in the Tehran south municipal wastewater treatment plant","volume":"30","author":"Golbaz","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2025.126921_bib40","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.chemosphere.2014.03.132","article-title":"Seasonal changes in antibiotics, antidepressants\/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant","volume":"111","author":"Golovko","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126921_bib41","series-title":"Pharmaceuticals in the Environment, Update for the Period 2017\u20132020 [Database]","author":"Graumnitz","year":"2021"},{"issue":"2","key":"10.1016\/j.envpol.2025.126921_bib42","first-page":"214","article-title":"Benzodiazepine pharmacology and central nervous system\u2013mediated effects","volume":"13","author":"Griffin","year":"2013","journal-title":"Ochsner J."},{"issue":"15","key":"10.1016\/j.envpol.2025.126921_bib43","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1021\/es8005173","article-title":"Evolutionary conservation of human drug targets in organisms used for environmental risk assessments","volume":"42","author":"Gunnarsson","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.126921_bib44","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1080\/13102818.2009.10818473","article-title":"Peripheral benzodiazepine receptors in health and disease","volume":"23","author":"Hadjiivanova","year":"2009","journal-title":"Biotechnol. Biotechnol. Equip."},{"issue":"1","key":"10.1016\/j.envpol.2025.126921_bib132","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/jai.13980","article-title":"Environmentally relevant concentrations of the common anxiolytic pharmaceutical oxazepam do not have acute effect on spawning behavior in mature male Atlantic salmon (Salmo salar) parr","volume":"36","author":"Hellstr\u00f6m","year":"2019","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.envpol.2025.126921_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.750554","article-title":"Comparative assessment of TSPO modulators on electroencephalogram activity and exploratory behavior","volume":"13","author":"Hines","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.envpol.2025.126921_bib46","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10863-021-09905-4","article-title":"TSPO protein binding partners in bacteria, animals, and plants","volume":"53","author":"Hiser","year":"2021","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.envpol.2025.126921_bib130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ntt.2019.01.006","article-title":"Varying the exposure period and duration of neuroactive pharmaceuticals and their metabolites modulates effects on the visual motor response in zebrafish (Danio rerio) larvae","volume":"72","author":"Huang","year":"2019","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envpol.2025.126921_bib47","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1016\/j.chroma.2009.11.007","article-title":"Fast liquid chromatography\u2013quadrupole-linear ion trap mass spectrometry for the analysis of pharmaceuticals and hormones in water resources","volume":"1217","author":"Huerta-Fontela","year":"2010","journal-title":"J. Chromatogr. A."},{"issue":"7","key":"10.1016\/j.envpol.2025.126921_bib48","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1080\/714044797","article-title":"A theoretical model for utilizing Mammalian pharmacology and safety data to prioritize potential impacts of human pharmaceuticals to fish","volume":"9","author":"Huggett","year":"2003","journal-title":"Hum. Ecol. Risk Assess."},{"issue":"5","key":"10.1016\/j.envpol.2025.126921_bib121","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/toxics10050256","article-title":"Developmental neurotoxicity and behavioral screening in larval zebrafish with a comparison to other published results","volume":"10","author":"Jarema","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2025.126921_bib115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.etap.2015.11.014","article-title":"Waterborne psychoactive drugs impair the initial development of zebrafish","volume":"41","author":"Kalichak","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2025.126921_bib49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/bs.pmbts.2018.07.004","article-title":"Chapter three - global aquatic hazard assessment of ciprofloxacin: exceedances of antibiotic resistance development and ecotoxicological thresholds","volume":"159","author":"Kelly","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.envpol.2025.126921_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114437","article-title":"Comparison of constructed wetland performance coupled with aeration and tubesettler for pharmaceutical compound removal from hospital wastewater","volume":"216","author":"Khan","year":"2023","journal-title":"Environ. Res."},{"issue":"8","key":"10.1016\/j.envpol.2025.126921_bib52","doi-asserted-by":"crossref","DOI":"10.1088\/1748-9326\/9\/8\/084003","article-title":"The conceptual imperfection of aquatic risk assessment tests: highlighting the need for tests designed to detect therapeutic effects of pharmaceutical contaminants","volume":"9","author":"Klaminder","year":"2014","journal-title":"Environ. Res. Lett."},{"issue":"1656","key":"10.1016\/j.envpol.2025.126921_bib53","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0586","article-title":"Potential ecological footprints of active pharmaceutical ingredients: an examination of risk factors in low-, middle- and high-income countries","volume":"369","author":"Kookana","year":"2014","journal-title":"Phil. Trans. R. Soc. B."},{"key":"10.1016\/j.envpol.2025.126921_bib54","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.scitotenv.2017.03.120","article-title":"Global scanning of antihistamines in the environment: analysis of occurrence and hazards in aquatic systems","volume":"592","author":"Kristofco","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envpol.2025.126921_bib55","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/toxsci\/kfw119","article-title":"Editor's highlight: sequence alignment to predict across species susceptibility (SeqAPASS): a web-based tool for addressing the challenges of cross-species extrapolation of chemical toxicity","volume":"153","author":"LaLone","year":"2016","journal-title":"Toxicol. Sci."},{"issue":"9","key":"10.1016\/j.envpol.2025.126921_bib116","doi-asserted-by":"crossref","DOI":"10.3390\/w14091484","article-title":"Anxiety in duckweed\u2013metabolism and effect of diazepam on Lemna minor","volume":"14","author":"Lamaczov\u00e1","year":"2022","journal-title":"Water"},{"issue":"4","key":"10.1016\/j.envpol.2025.126921_bib56","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2989\/16085914.2019.1680339","article-title":"Occurrence of selected pharmaceuticals in industrial wastewater, receiving waters and fish","volume":"44","author":"Lan","year":"2019","journal-title":"Afr. J. Aquat. Sci."},{"key":"10.1016\/j.envpol.2025.126921_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105694","article-title":"Low concentrations of oxazepam induce feeding and molecular changes in Radix balthica juveniles","volume":"230","author":"Lebreton","year":"2021","journal-title":"Aquat. Toxicol."},{"issue":"5","key":"10.1016\/j.envpol.2025.126921_bib59","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3390\/metabo13050619","article-title":"Interactive effect of dietary gamma-aminobutyric acid (GABA) and water temperature on growth performance, blood plasma indices, heat shock proteins and GABAergic gene expression in juvenile olive flounder Paralichthys olivaceus","volume":"13","author":"Lee","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.envpol.2025.126921_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106688","article-title":"Flunitrazepam and its metabolites exposure disturb the zebrafish gut-liver axis: combined microbiome and metabolomic analysis","volume":"263","author":"Lin","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.126921_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133113","article-title":"Flunitrazepam and its metabolites induced brain toxicity: insights from molecular dynamics simulation and transcriptomic analysis","volume":"465","author":"Lin","year":"2024","journal-title":"J. Hazard. Mater"},{"issue":"5","key":"10.1016\/j.envpol.2025.126921_bib128","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/tox.22069","article-title":"Effects of environmental exposure to diazepam on the reproductive behavior of fathead minnow, Pimephales promelas","volume":"31","author":"Lorenzi","year":"2016","journal-title":"Environ. Toxicol."},{"issue":"5","key":"10.1016\/j.envpol.2025.126921_bib62","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1071\/MF18373","article-title":"Global scanning of anatoxins in aquatic systems: environment and health hazards, and research needs","volume":"71","author":"Lovin","year":"2020","journal-title":"Mar. Freshw. Res."},{"key":"10.1016\/j.envpol.2025.126921_bib104","doi-asserted-by":"crossref","first-page":"117860","DOI":"10.1016\/j.marpolbul.2025.117860","article-title":"A robust method to quantify pharmaceuticals for the United Nations endorsed Global Estuaries Monitoring (GEM) Programme","volume":"215","author":"Luo","year":"2025","journal-title":"Mar. Pollut. Bull."},{"issue":"9","key":"10.1016\/j.envpol.2025.126921_bib63","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1890\/150038","article-title":"Wastewater-effluent-dominated streams as ecosystem-management tools in a drier climate","volume":"13","author":"Luthy","year":"2015","journal-title":"Front. Ecol. Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib135","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13750-025-00357-6","article-title":"Evidence of the impacts of pharmaceuticals on aquatic animal behaviour (EIPAAB): A systematic map and open access database","volume":"14","author":"Martin","year":"2025","journal-title":"Environmental Evidence"},{"issue":"8","key":"10.1016\/j.envpol.2025.126921_bib134","doi-asserted-by":"crossref","DOI":"10.1002\/eap.2454","article-title":"Social status modulates the behavioral and physiological consequences of a chemical pollutant in animal groups","volume":"31","author":"McCallum","year":"2021","journal-title":"Ecol. Appl."},{"key":"10.1016\/j.envpol.2025.126921_bib133","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.aquatox.2018.11.028","article-title":"Investigating tissue bioconcentration and the behavioural effects of two pharmaceutical pollutants on sea trout (Salmo trutta) in the laboratory and field","volume":"207","author":"McCallum","year":"2019","journal-title":"Aquat. Toxicol."},{"issue":"5","key":"10.1016\/j.envpol.2025.126921_bib66","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/etc.3259","article-title":"CRED: criteria for reporting and evaluating ecotoxicity data","volume":"35","author":"Moermond","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.126921_bib67","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.envpol.2019.04.118","article-title":"Global scanning of selective serotonin reuptake inhibitors: occurrence, wastewater treatment and hazards in aquatic systems","volume":"250","author":"Mole","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126921_bib114","doi-asserted-by":"crossref","first-page":"112500","DOI":"10.1016\/j.jenvman.2021.112500","article-title":"Toxicity reduction of persistent pollutants through the photo-fenton process and radiation\/H2O2 using different sources of radiation and neutral pH","volume":"289","author":"Nippes","year":"2021","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.envpol.2025.126921_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103538","article-title":"Acute and chronic effects of diazepam on the polychaete hediste Diversicolor: Antioxidant, metabolic, pharmacologic, neurotoxic and behavioural mechanistic traits","volume":"82","author":"Nogueira","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.envpol.2025.126921_bib69","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ecoenv.2004.08.010","article-title":"Acute toxicity of widely used pharmaceuticals in aquatic species: gambusia holbrooki, Artemia parthenogenetica and Tetraselmis chuii","volume":"61","author":"Nunes","year":"2005","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"19","key":"10.1016\/j.envpol.2025.126921_bib70","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.1021\/es100980r","article-title":"Effects of diazepam on gene expression and link to physiological effects in different life stages in zebrafish (Danio rerio)","volume":"44","author":"Oggier","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.envpol.2025.126921_bib71","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/etc.4879","article-title":"High concentrations of pharmaceuticals in a Nigerian river catchment","volume":"41","author":"Ogunbanwo","year":"2020","journal-title":"Environ. Toxicol. Chem."},{"issue":"5","key":"10.1016\/j.envpol.2025.126921_bib72","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.watres.2009.10.044","article-title":"Fate of nine recycled water trace organic contaminants and metal(loid)s during managed aquifer recharge into a anaerobic aquifer: column studies","volume":"44","author":"Patterson","year":"2010","journal-title":"Water Res."},{"issue":"6","key":"10.1016\/j.envpol.2025.126921_bib124","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0045-6535(02)00860-3","article-title":"Do pharmaceuticals affect freshwater invertebrates? A study with the cnidarian Hydra vulgaris","volume":"51","author":"Pascoe","year":"2003","journal-title":"Chemosphere"},{"issue":"1\u20134","key":"10.1016\/j.envpol.2025.126921_bib73","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jconhyd.2010.11.003","article-title":"Behaviour and fate of nine recycled water trace organics during managed aquifer recharge in an aerobic aquifer","volume":"122","author":"Patterson","year":"2011","journal-title":"J. Contam. Hydrol."},{"key":"10.1016\/j.envpol.2025.126921_bib105","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.envres.2014.09.041","article-title":"Environmental impact of pharmaceuticals from Portuguese wastewaters: geographical and seasonal occurrence, removal and risk assessment","volume":"136","author":"Pereira","year":"2015","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.envpol.2025.126921_bib74","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1021\/acs.est.1c04158","article-title":"Outside the safe operating space of the planetary boundary for novel entities","volume":"56","author":"Persson","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.126921_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135021","article-title":"Pharmaceuticals, pesticides, personal care products and microplastics contamination assessment of Al-Hassa irrigation network (saudi arabia) and its shallow Lakes","volume":"701","author":"Pic\u00f3","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib129","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chemosphere.2019.03.034","article-title":"Embryotoxicity of ozonated diclofenac, carbamazepine, and oxazepam in zebrafish (Danio rerio)","volume":"225","author":"Pohl","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126921_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170521","article-title":"Neurotoxic effects induced by flunitrazepam and its metabolites in zebrafish: oxidative stress, apoptosis, and histone hypoacetylation","volume":"917","author":"Qin","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib126","doi-asserted-by":"crossref","first-page":"106773","DOI":"10.1016\/j.aquatox.2023.106773","article-title":"Diazepam at environmentally relevant concentrations disturbed social interactions and brain neurotransmitters in adult Japanese medaka (Oryzias latipes)","volume":"265","author":"Qiu","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.126921_bib77","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.aquatox.2015.07.019","article-title":"Low environmental levels of neuro-active pharmaceuticals alter phototactic behaviour and reproduction in Daphnia magna","volume":"170","author":"Rivetti","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2025.126921_bib78","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.chemosphere.2017.09.058","article-title":"Global scanning assessment of calcium channel blockers in the environment: review and analysis of occurrence, ecotoxicology and hazards in aquatic systems","volume":"189","author":"Saari","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.126921_bib79","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.scitotenv.2018.11.228","article-title":"Behavioural effects of psychoactive pharmaceutical exposure on European perch (Perca fluviatilis) in a multi-stressor environment","volume":"655","author":"Saaristo","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139807","article-title":"Global scanning of cylindrospermopsin: critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards","volume":"738","author":"Scarlett","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib81","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.envpol.2018.03.052","article-title":"Global review and analysis of erythromycin in the environment: occurrence, bioaccumulation and antibiotic resistance hazards","volume":"238","author":"Schafhauser","year":"2018","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.envpol.2025.126921_bib82","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/etc.3147","article-title":"Complex mixtures, complex responses: assessing pharmaceutical mixtures using field and laboratory approaches","volume":"35","author":"Schoenfuss","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.126921_bib83","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.scitotenv.2019.01.187","article-title":"Using a new high-throughput video-tracking platform to assess behavioural changes in Daphnia magna exposed to neuro-active drugs","volume":"662","author":"Sim\u00e3o","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151535","article-title":"Global occurrence and probabilistic environmental health hazard assessment of per- and polyfluoroalkyl substances (PFASs) in groundwater and surface waters","volume":"816","author":"Sims","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.envpol.2025.126921_bib85","article-title":"GABAA receptors activate fish feeding behaviour via two distinct functional pathways","volume":"221","author":"Snigirov","year":"2017","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.envpol.2025.126921_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165418","article-title":"A novel approach for the assessment of invertebrate behavior and its use in behavioral ecotoxicology","volume":"897","author":"Soose","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.envpol.2025.126921_bib86","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1176\/ajp.134.6.665","article-title":"Benzodiazepines: behavioral and neurochemical mechanisms","volume":"134","author":"Stein","year":"1977","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.envpol.2025.126921_bib87","first-page":"1003","article-title":"Discharge of per- and polyfluoroalkyl substances in reclaimed wastewater: temporal water quality implications for effluent-dominated systems","volume":"5","author":"Stroski","year":"2025","journal-title":"Environ. Sci. Technol. Water"},{"key":"10.1016\/j.envpol.2025.126921_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144360","article-title":"Occurrence of pharmaceutical residues, personal care products, lifestyle chemicals, illicit drugs and metabolites in wastewater and receiving surface waters of krakow agglomeration in south Poland","volume":"768","author":"Styszko","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib131","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.scitotenv.2019.02.049","article-title":"Behavioural alterations induced by the anxiolytic pollutant oxazepam are reversible after depuration in a freshwater fish","volume":"665","author":"Sundin","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.envpol.2025.126921_bib89","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/S0043-1354(98)00099-2","article-title":"Occurrence of drugs in German sewage treatment plants and Rivers","volume":"32","author":"Ternes","year":"1998","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2025.126921_bib90","series-title":"United Nations Human Settlements Programme (UN-Habitat) and World Health Organization (WHO)","article-title":"Progress on the proportion of domestic and industrial wastewater flows safely treated \u2013 mid-Term status of SDG indicator 6.3.1 and acceleration needs, with a special focus on climate change, wastewater reuse and health","year":"2024"},{"key":"10.1016\/j.envpol.2025.126921_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134701","article-title":"Low concentrations of the benzodiazepine drug oxazepam induce anxiolytic effects in wild-caught but not in laboratory zebrafish","volume":"703","author":"Vossen","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib127","first-page":"109812","article-title":"Effects of chronic diazepam exposure on the behaviors and oxidative stress homeostasis in the eyes and brains of female Japanese medaka","volume":"276","author":"Wang","year":"2024","journal-title":"Comp\/ Biochem. Physol. C."},{"issue":"8","key":"10.1016\/j.envpol.2025.126921_bib95","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113947119","article-title":"Pharmaceutical pollution of the world's Rivers","volume":"119","author":"Wilkinson","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.envpol.2025.126921_bib96","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/etc.5763","article-title":"Pharmaceuticals and personal care products in the aquatic environment: how can regions at risk be identified in the future?","volume":"43","author":"Wilkinson","year":"2024","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.126921_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121042","article-title":"Global occurrence and aquatic hazards of antipsychotics in sewage influents, effluent discharges and surface waters","volume":"320","author":"Wronski","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.126921_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140392","article-title":"Short-term and persistent impacts of sublethal exposure to diazepam on behavioral traits and brain GABA levels in juvenile zebrafish (Danio rerio)","volume":"740","author":"Wu","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.126921_bib99","series-title":"The United Nations World Water Development Report 2017. Wastewater: the Untapped Resource","year":"2017"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125012941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125012941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:57:22Z","timestamp":1772809042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125012941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":118,"alternative-id":["S0269749125012941"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126921","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global occurrence and hazards of benzodiazepines in water resources: Knowledge gaps and future directions","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126921","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126921"}}