{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:35:53Z","timestamp":1775835353326,"version":"3.50.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.716166\/2022\\u201300"],"award-info":[{"award-number":["88887.716166\/2022\\u201300"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2022\/14025-4"],"award-info":[{"award-number":["2022\/14025-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2020\/14368-3"],"award-info":[{"award-number":["2020\/14368-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD030286"],"award-info":[{"award-number":["S10OD030286"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007319","name":"Albert Einstein College of Medicine, Yeshiva University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/11602-0"],"award-info":[{"award-number":["2022\/11602-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032645","name":"Hevolution Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.envpol.2025.127007","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T01:18:22Z","timestamp":1755739102000},"page":"127007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["ACR-16\/\u03b17-nicotinic receptor signaling mediates nicotine-induced mitochondrial dysfunction and suppression of host defense against gram-negative bacteria"],"prefix":"10.1016","volume":"384","author":[{"given":"Pablo","family":"Scharf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Deza-Ponzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Stransky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Sidoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3943-977X","authenticated-orcid":false,"given":"Sandra Helena","family":"Poliselli Farsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2025.127007_bib1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1039\/D0MO00087F","article-title":"Guide for protein fold change and p-value calculation for non-experts in proteomics","volume":"16","author":"Aguilan","year":"2020","journal-title":"Mol. Omics"},{"key":"10.1016\/j.envpol.2025.127007_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009234","article-title":"A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR","volume":"16","author":"Amin","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.envpol.2025.127007_bib3","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/jamainternmed.2017.1419","article-title":"Heat-not-burn tobacco cigarettes: smoke by any other name","volume":"177","author":"Auer","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.envpol.2025.127007_bib4","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02244-2018","article-title":"Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages","volume":"54","author":"Belchamber","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.envpol.2025.127007_bib5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1164\/rccm.201608-1714OC","article-title":"Impaired mitochondrial microbicidal responses in chronic obstructive pulmonary disease macrophages","volume":"196","author":"Bewley","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.envpol.2025.127007_bib6","doi-asserted-by":"crossref","first-page":"s111","DOI":"10.1136\/tobaccocontrol-2018-054340","article-title":"Heated tobacco products: another tobacco industry global strategy to slow progress in tobacco control","volume":"27","author":"Bialous","year":"2018","journal-title":"Tob. Control"},{"key":"10.1016\/j.envpol.2025.127007_bib7","doi-asserted-by":"crossref","first-page":"L803","DOI":"10.1152\/ajplung.00158.2023","article-title":"Nicotine affects mitochondrial structure and function in human airway smooth muscle cells","volume":"325","author":"Borkar","year":"2023","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.envpol.2025.127007_bib8","doi-asserted-by":"crossref","first-page":"L149","DOI":"10.1152\/ajplung.00268.2023","article-title":"Nicotinic receptors in airway disease","volume":"326","author":"Borkar","year":"2024","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.envpol.2025.127007_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.envpol.2025.127007_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.00326","article-title":"Escaping the phagocytic oxidative burst: the role of SODB in the survival of Pseudomonas aeruginosa within macrophages","volume":"11","author":"Cavinato","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2025.127007_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.addbeh.2025.108391","article-title":"Global burden of disease related to tobacco products and trends projected: 1990-2021","volume":"169","author":"Chen","year":"2025","journal-title":"Addict. Behav."},{"key":"10.1016\/j.envpol.2025.127007_bib12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127007_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004606","article-title":"mir-233 modulates the unfolded protein response in C. elegans during Pseudomonas aeruginosa infection","volume":"11","author":"Dai","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.envpol.2025.127007_bib14","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1073\/pnas.1817259116","article-title":"Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3","volume":"116","author":"Deng","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envpol.2025.127007_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcdb.2023.02.002","article-title":"Mitochondrial recovery by the UPRmt: insights from C. elegans","volume":"154","author":"Dodge","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2025.127007_bib16","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fimmu.2017.01085","article-title":"Expression and function of the cholinergic system in immune cells","volume":"8","author":"Fujii","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2025.127007_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41792","article-title":"SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension","volume":"8","author":"Gao","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.envpol.2025.127007_bib18","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1038\/sj.emboj.7600741","article-title":"Identification and characterization of novel nicotinic receptor\u2010associated proteins in Caenorhabditis elegans","volume":"24","author":"Gottschalk","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.envpol.2025.127007_bib19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/emboj\/21.5.1012","article-title":"The C.elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors","volume":"21","author":"Halevi","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.envpol.2025.127007_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ypmed.2020.106099","article-title":"Tobacco harm reduction: past history, current controversies and a proposed approach for the future","volume":"140","author":"Hatsukami","year":"2020","journal-title":"Prev. Med."},{"key":"10.1016\/j.envpol.2025.127007_bib21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ccell.2024.01.013","article-title":"Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment","volume":"42","author":"He","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.envpol.2025.127007_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151097","article-title":"Toxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor inhalation on rheumatoid arthritis","volume":"809","author":"Heluany","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.127007_bib23","doi-asserted-by":"crossref","first-page":"17469","DOI":"10.1073\/pnas.0809527105","article-title":"Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions","volume":"105","author":"Irazoqui","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envpol.2025.127007_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000982","article-title":"Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus","volume":"6","author":"Irazoqui","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.envpol.2025.127007_bib25","doi-asserted-by":"crossref","DOI":"10.18332\/tid\/189302","article-title":"The effect of smoking on tumor immunoediting: friend or foe?","volume":"22","author":"Jiang","year":"2024","journal-title":"Tob. Induc. Dis."},{"key":"10.1016\/j.envpol.2025.127007_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.18332\/tid\/123845","article-title":"Smoking increases the risk of infectious diseases: a narrative review","volume":"18","author":"Jiang","year":"2020","journal-title":"Tob. Induc. Dis."},{"key":"10.1016\/j.envpol.2025.127007_bib27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1242\/dmm.003871","article-title":"It takes nerves to fight infections: insights on neuro-immune interactions from C. elegans","volume":"3","author":"Kawli","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.envpol.2025.127007_bib28","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1038\/s41467-023-39393-6","article-title":"Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response","volume":"14","author":"Kim","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2025.127007_bib29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.devcel.2019.03.010","article-title":"Lifespan extension in C. elegans caused by bacterial colonization of the intestine and subsequent activation of an innate immune response","volume":"49","author":"Kumar","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.envpol.2025.127007_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.crimmu.2024.100077","article-title":"Mitochondrial electron transport chain in macrophage reprogramming: potential role in antibacterial immune response","volume":"5","author":"Kumar","year":"2024","journal-title":"Curr Res Immunol"},{"key":"10.1016\/j.envpol.2025.127007_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101852","article-title":"Host and microbial regulation of mitochondrial reactive oxygen species during mycobacterial infections","volume":"75","author":"Kyung Kim","year":"2024","journal-title":"Mitochondrion"},{"key":"10.1016\/j.envpol.2025.127007_bib32","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/s41467-020-20054-x","article-title":"Heat shock factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer","volume":"11","author":"Levi-Galibov","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2025.127007_bib33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.envpol.2025.127007_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122730","article-title":"Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: a review","volume":"339","author":"Liu","year":"2023","journal-title":"Environ Pollut"},{"key":"10.1016\/j.envpol.2025.127007_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109698","article-title":"ATF4 knockdown in macrophage impairs glycolysis and mediates immune tolerance by targeting HK2 and HIF-1\u03b1 ubiquitination in sepsis","volume":"254","author":"Liu","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.envpol.2025.127007_bib36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/thoraxjnl-2020-216296","article-title":"Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease","volume":"77","author":"Lugg","year":"2022","journal-title":"Thorax"},{"key":"10.1016\/j.envpol.2025.127007_bib37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/15376510802255184","article-title":"In vitro nicotine-induced oxidative stress in mice peritoneal macrophages: a dose-dependent approach","volume":"19","author":"Mahapatra","year":"2009","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.envpol.2025.127007_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10863-019-09800-z","article-title":"Mitochondria as a possible target for nicotine action","volume":"51","author":"Mali\u0144ska","year":"2019","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.envpol.2025.127007_bib39","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s11064-013-1054-8","article-title":"Early-life exposure to methylmercury in wildtype and pdr-1\/parkin knockout C. elegans","volume":"38","author":"Martinez-Finley","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.envpol.2025.127007_bib40","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.3390\/cells12172124","article-title":"Mitochondria in the spotlight: C. elegans as a model organism to evaluate xenobiotic-induced dysfunction","volume":"12","author":"Martins","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2025.127007_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/jleuko\/qiaf094","article-title":"Metainflammation alters neutrophil function and migration in vivo in response to tissue injury","author":"Michael","year":"2025","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.envpol.2025.127007_bib42","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1073\/pnas.1218599110","article-title":"Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production","volume":"110","author":"Michelucci","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envpol.2025.127007_bib43","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/ni.3704","article-title":"Mitochondria are the powerhouses of immunity","volume":"18","author":"Mills","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.envpol.2025.127007_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113189","article-title":"A bacterial pathogen induces developmental slowing by high reactive oxygen species and mitochondrial dysfunction in Caenorhabditis elegans","volume":"42","author":"Mirza","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.envpol.2025.127007_bib45","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cell.2013.06.016","article-title":"The NAD+\/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling","volume":"154","author":"Mouchiroud","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2025.127007_bib46","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2567.2003.01655.x","article-title":"Evidence for the immunosuppressive role of nicotine on human dendritic cell functions","volume":"109","author":"Nouri-Shirazi","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.envpol.2025.127007_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102140","article-title":"Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress","volume":"24","author":"Nourse","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.envpol.2025.127007_bib48","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1089\/ars.2013.5447","article-title":"Are reactive oxygen species always detrimental to pathogens?","volume":"20","author":"Paiva","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.envpol.2025.127007_bib49","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03402177","article-title":"The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation","volume":"9","author":"Pavlov","year":"2003","journal-title":"Mol Med"},{"key":"10.1016\/j.envpol.2025.127007_bib50","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.biocel.2015.06.013","article-title":"Nicotine-induced cellular stresses and autophagy in human cancer colon cells: a supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production","volume":"65","author":"Pelissier-Rota","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127007_bib51","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nature13818","article-title":"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection","volume":"516","author":"Pellegrino","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2025.127007_bib52","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/aps.2009.67","article-title":"Nicotine and inflammatory neurological disorders","volume":"30","author":"Piao","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.envpol.2025.127007_bib53","article-title":"Basic Caenorhabditis elegans methods: synchronization and observation","volume":"e4019","author":"Porta-de-la-Riva","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.envpol.2025.127007_bib54","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.chom.2010.03.009","article-title":"Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production","volume":"7","author":"Radek","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.envpol.2025.127007_bib55","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/S0140-6736(21)01169-7","article-title":"Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990\u20132019: a systematic analysis from the global burden of disease study 2019","volume":"397","author":"Reitsma","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.envpol.2025.127007_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111575","article-title":"Cholinergic receptor-Wnt pathway controls immune activation by sensing intestinal dysfunction","volume":"41","author":"Ren","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.envpol.2025.127007_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106727","article-title":"Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes","volume":"191","author":"Richter","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.envpol.2025.127007_bib58","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.3390\/ijms21196996","article-title":"Cellular and molecular mechanisms of environmental pollutants on hematopoiesis","volume":"21","author":"Scharf","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2025.127007_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115863","article-title":"Immunotoxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor on Jurkat T cell functions","volume":"268","author":"Scharf","year":"2021","journal-title":"Environmental Pollution"},{"key":"10.1016\/j.envpol.2025.127007_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153859","article-title":"A single and short exposure to heated tobacco vapor or cigarette smoke affects macrophage activation and polarization","volume":"506","author":"Scharf","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2025.127007_bib61","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1038\/s41467-020-18501-w","article-title":"Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity","volume":"11","author":"Shao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2025.127007_bib62","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1365-2958.2011.07612.x","article-title":"How does the oxidative burst of macrophages kill bacteria? Still an open question","volume":"80","author":"Slauch","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.envpol.2025.127007_bib63","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nri.2016.136","article-title":"Disease tolerance and immunity in host protection against infection","volume":"17","author":"Soares","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envpol.2025.127007_bib64","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202101182","article-title":"Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors","volume":"4","author":"Soo","year":"2021","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.envpol.2025.127007_bib65","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.cell.2016.04.011","article-title":"Mitochondrial stress induces chromatin reorganization to promote longevity and UPR(mt)","volume":"165","author":"Tian","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2025.127007_bib66","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.4049\/jimmunol.2001016","article-title":"Loss of mitochondrial protease CLPP activates type I IFN responses through the mitochondrial DNA-cGAS-STING signaling axis","volume":"206","author":"Torres-Odio","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.envpol.2025.127007_bib67","doi-asserted-by":"crossref","first-page":"27013","DOI":"10.1074\/jbc.M502818200","article-title":"acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction","volume":"280","author":"Touroutine","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2025.127007_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2019.11.007","article-title":"Nervous system control of intestinal host defense in C. elegans","volume":"62","author":"Wani","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.envpol.2025.127007_bib69","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.immuni.2015.02.002","article-title":"Mitochondria in the regulation of innate and adaptive immunity","volume":"42","author":"Weinberg","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.envpol.2025.127007_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108256","article-title":"Nicotinic acetylcholine receptors and nicotine addiction: a brief introduction","volume":"177","author":"Wittenberg","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.envpol.2025.127007_bib71","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/ncb1996","article-title":"Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling","volume":"11","author":"Woo","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127007_bib72","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1158\/0008-5472.CAN-19-0063","article-title":"Phosphorylation of HSF1 by PIM2 induces PD-L1 expression and promotes tumor growth in breast cancer","volume":"79","author":"Yang","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.envpol.2025.127007_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003660","article-title":"The DAF-16\/FOXO transcription factor functions as a regulator of epidermal innate immunity","volume":"9","author":"Zou","year":"2013","journal-title":"PLoS Pathog."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125013806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125013806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:56:20Z","timestamp":1772808980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125013806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":73,"alternative-id":["S0269749125013806"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.127007","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACR-16\/\u03b17-nicotinic receptor signaling mediates nicotine-induced mitochondrial dysfunction and suppression of host defense against gram-negative bacteria","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.127007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127007"}}