{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:40:00Z","timestamp":1784608800056,"version":"3.55.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"am","delay-in-days":330,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100022300","name":"Society for Integrative and Comparative Biology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.envpol.2025.127148","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:41:22Z","timestamp":1758577282000},"page":"127148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Chronic sublethal exposure to methylmercury lengthens telomeres in developing zebra finches"],"prefix":"10.1016","volume":"385","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6453-6586","authenticated-orcid":false,"given":"Rachel L.","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel D.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Fabozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim A.","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cokie L.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Laboune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4009-5844","authenticated-orcid":false,"given":"Casey L.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Kittilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Swaddle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Cristol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt J.","family":"Heidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Douek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2025.127148_bib1","article-title":"Murine hind limb long bone dissection and bone marrow isolation","volume":"110","author":"Amend","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.envpol.2025.127148_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101854","article-title":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","volume":"85","author":"Armstrong","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.envpol.2025.127148_bib3","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1126\/science.1147182","article-title":"Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends","volume":"318","author":"Azzalin","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.envpol.2025.127148_bib4","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1093\/nar\/gkh691","article-title":"Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells","volume":"32","author":"Bailey","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2025.127148_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.trecan.2017.02.001","article-title":"Mitotic DNA damage response: at the crossroads of structural and numerical cancer chromosome instabilities","volume":"3","author":"Bakhoum","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.envpol.2025.127148_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195850","article-title":"Use of capillary Western immunoassay (Wes) for quantification of dystrophin levels in skeletal muscle of healthy controls and individuals with Becker and Duchenne muscular dystrophy","volume":"13","author":"Beekman","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2025.127148_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260037","article-title":"Incubation temperature and physiological aging in the zebra finch","volume":"16","author":"Berntsen","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2025.127148_bib8","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2025.127148_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s13402-022-00660-1","article-title":"PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer","volume":"45","author":"Boyero","year":"2022","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.envpol.2025.127148_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v080.i01","article-title":"Brms: an R package for Bayesian multilevel models using Stan","volume":"80","author":"B\u00fcrkner","year":"2017","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.envpol.2025.127148_bib11","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1083\/jcb.201803003","article-title":"Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function","volume":"218","author":"Byrum","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib12","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere measurement by quantitative PCR","volume":"30","author":"Cawthon","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2025.127148_bib13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cbi.2010.04.007","article-title":"Methylmercury-induced neurotoxicity and apoptosis","volume":"188","author":"Ceccatelli","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2025.127148_bib14","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1158\/0008-5472.CAN-17-1280","article-title":"Atypical G protein \u03b25 promotes cardiac oxidative stress, apoptosis, and fibrotic remodeling in response to multiple cancer chemotherapeutics","volume":"78","author":"Chakraborti","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.envpol.2025.127148_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2008.09.020","article-title":"An assembly chaperone collaborates with the SMN complex to generate spliceosomal snRNPs","volume":"135","author":"Chari","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2025.127148_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123232","article-title":"Disrupting the gut microbiota\/metabolites axis by Di-(2-ethylhexyl) phthalate drives intestinal inflammation via AhR\/NF-\u03baB pathway in mice","volume":"343","author":"Cheng","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2025.127148_bib17","doi-asserted-by":"crossref","first-page":"308","DOI":"10.15698\/mic2015.09.224","article-title":"The many facets of homologous recombination at telomeres","volume":"2","author":"Claussin","year":"2015","journal-title":"Microb. Cell"},{"key":"10.1016\/j.envpol.2025.127148_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/srep43309","article-title":"Transient ALT activation protects human primary cells from chromosome instability induced by low chronic oxidative stress","volume":"7","author":"Coluzzi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2025.127148_bib19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1897\/08-094.1","article-title":"Feather growth influences blood mercury level of young songbirds","volume":"28","author":"Condon","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.127148_bib20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1600-048X.2008.04623.x","article-title":"Real-time quantitative PCR assay for measurement of avian telomeres","volume":"40","author":"Criscuolo","year":"2009","journal-title":"J. Avian Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib21","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1126\/science.1154082","article-title":"The movement of aquatic mercury through terrestrial food webs","volume":"320","author":"Cristol","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.envpol.2025.127148_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102487","article-title":"RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis","volume":"57","author":"Das","year":"2022","journal-title":"Redox Biol."},{"issue":"Suppl. 3","key":"10.1016\/j.envpol.2025.127148_bib23","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1542\/peds.113.S3.1023","article-title":"Mercury exposure and child development outcomes","volume":"113","author":"Davidson","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.envpol.2025.127148_bib24","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nrc2393","article-title":"Telomere dysfunction and tumour suppression: the senescence connection","volume":"8","author":"Deng","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.envpol.2025.127148_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2025.127148_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41571-020-0408-9","article-title":"ROS1-dependent cancers\u2014biology, diagnostics and therapeutics","volume":"18","author":"Drilon","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.envpol.2025.127148_bib27","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112362","article-title":"eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content","volume":"42","author":"Duan","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.envpol.2025.127148_bib28","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1073\/pnas.0611405104","article-title":"A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia","volume":"104","author":"Duriez","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.envpol.2025.127148_bib29","doi-asserted-by":"crossref","first-page":"9350","DOI":"10.1128\/MCB.25.21.9350-9359.2005","article-title":"Nuclear dynamics of PCNA in DNA replication and repair","volume":"25","author":"Essers","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.15283\/ijsc.2016.9.1.107","article-title":"L-carnitine effectively induces hTERT gene expression of human adipose tissue-derived mesenchymal stem cells obtained from the aged subjects","volume":"9","author":"Farahzadi","year":"2016","journal-title":"Int. J. Stem Cells"},{"key":"10.1016\/j.envpol.2025.127148_bib31","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1093\/nar\/gkad448","article-title":"The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase+ cells and telomeric recombination in ALT+ cells","volume":"51","author":"Fernandes","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2025.127148_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/532691","article-title":"MeHg developing exposure causes DNA double-strand breaks and elicits cell cycle arrest in spinal cord cells","volume":"2015","author":"Ferreira","year":"2015","journal-title":"J. Toxicol."},{"key":"10.1016\/j.envpol.2025.127148_bib33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.molcel.2019.04.024","article-title":"Targeted and persistent 8-oxoguanine base damage at telomeres promotes telomere loss and crisis","volume":"75","author":"Fouquerel","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envpol.2025.127148_bib34","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ecoenv.2010.11.011","article-title":"Delayed biochemical changes induced by mercury intoxication are prevented by zinc pre-exposure","volume":"74","author":"Franciscato","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2025.127148_bib35","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1007\/s00216-025-05817-z","article-title":"Development of a reference material for mercury in fish: certified for total mercury and characterized for methylmercury","volume":"417","author":"Garz\u00f3n","year":"2025","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envpol.2025.127148_bib36","series-title":"Regression and Other Stories","author":"Gelman","year":"2021"},{"key":"10.1016\/j.envpol.2025.127148_bib37","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/ncb2621","article-title":"Telomerase directly regulates NF-\u03baB-dependent transcription","volume":"14","author":"Ghosh","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/ece3.10825","article-title":"Why and when should organisms elongate their telomeres? Elaborations on the 'excess resources elongation' and 'last resort elongation' hypotheses","volume":"13","author":"G\u00f3mez-Blanco","year":"2023","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.envpol.2025.127148_bib39","author":"Goodrich"},{"key":"10.1016\/j.envpol.2025.127148_bib40","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.200312112","article-title":"The mechanism of spindle assembly: functions of Ran and its target TPX2","volume":"166","author":"Gruss","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib41","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/345458a0","article-title":"Telomeres shorten during ageing of human fibroblasts","volume":"345","author":"Harley","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2025.127148_bib42","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1242\/jeb.054643","article-title":"Fibroblasts from long-lived bird species are resistant to multiple forms of stress","volume":"214","author":"Harper","year":"2011","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/dbio.2000.0134","article-title":"TBX5 transcription factor regulates cell proliferation during cardiogenesis","volume":"230","author":"Hatcher","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib44","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.exger.2007.03.004","article-title":"Telomerase activity is maintained throughout the lifespan of long-lived birds","volume":"42","author":"Haussmann","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.envpol.2025.127148_bib45","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s10646-019-02074-6","article-title":"Continuous exposure to mercury during embryogenesis and chick development affects later survival and reproduction of zebra finch (Taeniopygia guttata)","volume":"29","author":"Heddle","year":"2020","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.envpol.2025.127148_bib46","article-title":"Longer telomeres during early life predict higher lifetime reproductive success in females but not males","volume":"288","author":"Heidinger","year":"2021","journal-title":"Proc. R. Soc. A B"},{"key":"10.1016\/j.envpol.2025.127148_bib47","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ncomms1708","article-title":"Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence","volume":"3","author":"Hewitt","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2025.127148_bib48","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ceb.2008.06.007","article-title":"\u03b1v\u03b23 integrin and angiogenesis: a moody integrin in a changing environment","volume":"20","author":"Hodivala-Dilke","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib49","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1126\/science.1218370","article-title":"Wnt\/\u03b2-catenin signaling regulates telomerase in stem cells and cancer cells","volume":"336","author":"Hoffmeyer","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.envpol.2025.127148_bib50","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.canlet.2012.01.028","article-title":"Surrogate tissue telomere length and cancer risk: shorter or longer?","volume":"319","author":"Hou","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.envpol.2025.127148_bib51","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1046\/j.1432-1327.2001.02228.x","article-title":"Regulation of cellular senescence by p53","volume":"268","author":"Itahana","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.envpol.2025.127148_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173577","article-title":"Mercury-induced toxicity: mechanisms, molecular pathways, and gene regulation","volume":"943","author":"Kang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.127148_bib53","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.3390\/genes12111734","article-title":"Alternative lengthening of telomeres: lessons to be learned from telomeric DNA double-strand break repair","volume":"12","author":"Kent","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.envpol.2025.127148_bib54","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.envpol.2025.127148_bib55","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/cells12081106","article-title":"The RUNX family of proteins, DNA repair, and cancer","volume":"12","author":"Krishnan","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2025.127148_bib56","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106048","article-title":"Neutrophils induce paracrine telomere dysfunction and senescence in ROS\u2010dependent manner","volume":"40","author":"Lagnado","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.envpol.2025.127148_bib57","author":"Lenth","year":"2024","journal-title":"emmeans: Estimated marginal means, aka least-squares means"},{"key":"10.1016\/j.envpol.2025.127148_bib58","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00418-005-0003-2","article-title":"Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis","volume":"124","author":"Leung","year":"2005","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib59","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1101\/gad.314351.118","article-title":"The impact of mitotic errors on cell proliferation and tumorigenesis","volume":"32","author":"Levine","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.envpol.2025.127148_bib60","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00244-012-9830-z","article-title":"Decreased immune response in zebra finches exposed to sublethal doses of mercury","volume":"64","author":"Lewis","year":"2013","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2025.127148_bib61","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s12031-018-1132-0","article-title":"PAC1 receptors: shapeshifters in motion","volume":"68","author":"Liao","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.envpol.2025.127148_bib62","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkt214","article-title":"The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote","volume":"41","author":"Liao","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2025.127148_bib63","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.envpol.2025.127148_bib64","first-page":"1671","article-title":"Role of ALK5\/SMAD2\/3 signaling in the regulation of NOX expression in cerebral ischemia\/reperfusion injury","volume":"16","author":"Lou","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.envpol.2025.127148_bib65","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173014","article-title":"Early life exposure to mercury and relationships with telomere length and mitochondrial DNA content in European children","volume":"932","author":"Lozano","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2025.127148_bib67","first-page":"6702","article-title":"The oncogenic potential of small nuclear ribonucleoprotein polypeptide G: a comprehensive and perspective view","volume":"11","author":"Mabonga","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.envpol.2025.127148_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112148","article-title":"DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops","volume":"42","author":"Marchena-Cruz","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.envpol.2025.127148_bib69","doi-asserted-by":"crossref","first-page":"D933","DOI":"10.1093\/nar\/gkac958","article-title":"Ensembl 2023","volume":"51","author":"Martin","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2025.127148_bib70","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/taap.1999.8781","article-title":"The involvement of microtubular disruption in methylmercury-induced apoptosis in neuronal and nonneuronal cell lines","volume":"160","author":"Miura","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2025.127148_bib71","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.3390\/cells10092351","article-title":"The manifold cellular functions of von Willebrand factor","volume":"10","author":"Mojzisch","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2025.127148_bib72","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2007.05.003","article-title":"PCNA, the maestro of the replication fork","volume":"129","author":"Moldovan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2025.127148_bib73","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/etc.2521","article-title":"Lifelong exposure to methylmercury disrupts stress-induced corticosterone response in zebra finches (Taeniopygia guttata)","volume":"33","author":"Moore","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.127148_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201801138","article-title":"Primary cilia as signaling hubs in health and disease","volume":"6","author":"Nishimura","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.envpol.2025.127148_bib75","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36559","article-title":"Dynein\u2013Dynactin\u2013NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble","volume":"7","author":"Okumura","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.envpol.2025.127148_bib76","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1038\/emboj.2013.217","article-title":"The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening","volume":"32","author":"Pfeiffer","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.envpol.2025.127148_bib77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molcel.2012.04.019","article-title":"mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription","volume":"47","author":"Pont","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envpol.2025.127148_bib78","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/labinvest.2017.109","article-title":"Nuclear functions of NME proteins","volume":"98","author":"Puts","year":"2018","journal-title":"Lab. Invest."},{"key":"10.1016\/j.envpol.2025.127148_bib79","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0165-9936(95)00109-3","article-title":"Certified reference materials (CRMs 463 and 464) for the quality control of total and methyl mercury determination in tuna fish","volume":"15","author":"Quevauviller","year":"1996","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.envpol.2025.127148_bib80","series-title":"R: a Language and Environment for Statistical Computing","year":"2020"},{"key":"10.1016\/j.envpol.2025.127148_bib81","series-title":"R: a Language and Environment for Statistical Computing","year":"2023"},{"key":"10.1016\/j.envpol.2025.127148_bib82","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/tra.12370","article-title":"Ferlins show tissue-specific expression and segregate as plasma membrane\/late endosomal or trans-Golgi\/recycling ferlins","volume":"17","author":"Redpath","year":"2016","journal-title":"Traffic"},{"key":"10.1016\/j.envpol.2025.127148_bib83","doi-asserted-by":"crossref","first-page":"978","DOI":"10.2307\/1934545","article-title":"A graphical method of fitting equations to growth curves","volume":"48","author":"Ricklefs","year":"1967","journal-title":"Ecology"},{"key":"10.1016\/j.envpol.2025.127148_bib84","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/cvr\/cvaa034","article-title":"RUNX1: an emerging therapeutic target for cardiovascular disease","volume":"116","author":"Riddell","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.envpol.2025.127148_bib85","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fcell.2018.00177","article-title":"Mapping mitotic death: functional integration of mitochondria, spindle assembly checkpoint and apoptosis","volume":"6","author":"Ruan","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib86","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.1157425","article-title":"Bora and Aurora A cooperatively activate Plk1 and control the entry into mitosis","volume":"320","author":"Seki","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.envpol.2025.127148_bib87","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/bies.201200084","article-title":"Early life stress and telomere length: investigating the connection and possible mechanisms","volume":"34","author":"Shalev","year":"2012","journal-title":"Bioessays"},{"key":"10.1016\/j.envpol.2025.127148_bib88","doi-asserted-by":"crossref","first-page":"33972","DOI":"10.18632\/oncotarget.15687","article-title":"The regulation of \u03b2-catenin activity and function in cancer: therapeutic opportunities","volume":"8","author":"Shang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.envpol.2025.127148_bib90","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11978-4","article-title":"Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation","volume":"7","author":"Tang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2025.127148_bib91","doi-asserted-by":"crossref","first-page":"13901","DOI":"10.1073\/pnas.241525498","article-title":"BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia","volume":"98","author":"Tanner","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.envpol.2025.127148_bib92","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.cub.2022.12.017","article-title":"NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles","volume":"33","author":"van Toorn","year":"2023","journal-title":"Curr. Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib93","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095674","article-title":"Mercury reduces avian reproductive success and imposes selection: an experimental study with adult- or lifetime-exposure in zebra finch","volume":"9","author":"Varian-Ramos","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2025.127148_bib94","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ebiom.2017.03.027","article-title":"Telomeres and cell senescence \u2013 size matters not","volume":"21","author":"Victorelli","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.envpol.2025.127148_bib95","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","author":"von Zglinicki","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.envpol.2025.127148_bib96","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1002\/etc.3888","article-title":"Rapid depuration of mercury in songbirds accelerated by feather molt","volume":"36","author":"Whitney","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2025.127148_bib97","first-page":"113","article-title":"Impacts of sublethal mercury exposure on birds: a detailed review","volume":"244","author":"Whitney","year":"2018","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envpol.2025.127148_bib98","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026070","article-title":"p53 in the DNA-damage-repair process","volume":"6","author":"Williams","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.envpol.2025.127148_bib99","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.3390\/cancers13225650","article-title":"Microtubule targeting agents in disease: classic drugs, novel roles","volume":"13","author":"Wordeman","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.envpol.2025.127148_bib100","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/6010","article-title":"Direct activation of TERT transcription by c-MYC","volume":"21","author":"Wu","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.envpol.2025.127148_bib101","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3390\/toxics11020191","article-title":"Subchronic low-dose methylmercury exposure accelerated cerebral telomere shortening in relevant with declined urinary aMT6s level in rats","volume":"11","author":"Wu","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2025.127148_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125586","article-title":"Toxicity of mercury: molecular evidence","volume":"245","author":"Yang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2025.127148_bib103","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1016\/j.semcancer.2015.03.007","article-title":"Therapeutic targeting of replicative immortality","volume":"35","author":"Yaswen","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.envpol.2025.127148_bib104","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.3945\/jn.117.253021","article-title":"PUFA status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the Seychelles child development study","volume":"147","author":"Yeates","year":"2017","journal-title":"J. Nutr."},{"key":"10.1016\/j.envpol.2025.127148_bib105","article-title":"Stressors interact across generations to influence offspring telomeres and survival","volume":"289","author":"Young","year":"2022","journal-title":"Proc. R. Soc. A B"},{"key":"10.1016\/j.envpol.2025.127148_bib106","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3390\/biology12121511","article-title":"Expanding roles of the E2F-RB-p53 pathway in tumor suppression","volume":"12","author":"Zhou","year":"2023","journal-title":"Biology"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125015222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125015222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:59:36Z","timestamp":1773133176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125015222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":105,"alternative-id":["S0269749125015222"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.127148","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic sublethal exposure to methylmercury lengthens telomeres in developing zebra finches","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.127148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127148"}}