{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:26:31Z","timestamp":1783077991516,"version":"3.54.6"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000139","name":"U.S. Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.envpol.2025.127342","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T16:00:43Z","timestamp":1762012843000},"page":"127342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Bridging in vitro and in vivo inhalation toxicity: Volatile organic compounds elicit similar transcriptomic points of departure in human airway cells and mouse respiratory tract"],"prefix":"10.1016","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-0412","authenticated-orcid":false,"given":"Thomas W.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3936-4982","authenticated-orcid":false,"given":"Jessica R.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-513X","authenticated-orcid":false,"given":"Celia M.","family":"Schacht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Evansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4895-2898","authenticated-orcid":false,"given":"Michael E.","family":"Monsees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-6391","authenticated-orcid":false,"given":"Joshua A.","family":"Harrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-6704","authenticated-orcid":false,"given":"M. Ian","family":"Gilmour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-1777","authenticated-orcid":false,"given":"Wanda C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-9023","authenticated-orcid":false,"given":"Rachel D.","family":"Grindstaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette C.","family":"Schladweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-0218","authenticated-orcid":false,"given":"Samuel A.","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7179-2143","authenticated-orcid":false,"given":"Stephen H.","family":"Gavett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2025.127342_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2023.1280230","article-title":"Differential transcriptomic alterations in nasal versus lung tissue of acrolein-exposed rats","volume":"5","author":"Alewel","year":"2023","journal-title":"Front Toxicol"},{"key":"10.1016\/j.envpol.2025.127342_bib2","series-title":"Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (Etaps)","article-title":"US environmental protection Agency center for computational toxicology and exposure's reports","author":"Auerbach","year":"2024"},{"issue":"7","key":"10.1016\/j.envpol.2025.127342_bib3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrg.2017.19","article-title":"Comparative transcriptomics in human and mouse","volume":"18","author":"Breschi","year":"2017","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.envpol.2025.127342_bib4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11626-020-00517-7","article-title":"Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives","volume":"57","author":"Cao","year":"2021","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0041-008X(92)90109-6","article-title":"Dichloromethane (Methylene chloride): metabolism to formaldehyde and formation of DNA-Protein cross-links in B6C3F1 mice and Syrian golden hamsters","volume":"114","author":"Casanova","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.envpol.2025.127342_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s002040050282","article-title":"Sensory irritation to mixtures of formaldehyde, acrolein, and acetaldehyde in rats","volume":"70","author":"Cassee","year":"1996","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.envpol.2025.127342_bib7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/faat.1996.0024","article-title":"Changes in the nasal epithelium of rats exposed by inhalation to mixtures of formaldehyde, acetaldehyde, and acrolein","volume":"29","author":"Cassee","year":"1996","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.envpol.2025.127342_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104858","article-title":"Evaluation of the carcinogenicity of dichloromethane in rats, mice, hamsters and humans","volume":"120","author":"Dekant","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2025.127342_bib9","first-page":"215","article-title":"Air pollution: sources, regulation, and health effects","volume":"1","author":"Duffney","year":"2024"},{"key":"10.1016\/j.envpol.2025.127342_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2025.1567206","article-title":"How air pollution fuels respiratory infections in children: current insights","volume":"13","author":"Esposito","year":"2025","journal-title":"Front. Public Health"},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005968","article-title":"Reactome graph database: efficient access to complex pathway data","volume":"14","author":"Fabregat","year":"2018","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13073-016-0384-y","article-title":"XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits","volume":"8","author":"Fang","year":"2016","journal-title":"Genome Med."},{"issue":"5","key":"10.1016\/j.envpol.2025.127342_bib13","first-page":"505","article-title":"The benchmark dose method--review of available models, and recommendations for application in health risk assessment","volume":"33","author":"Filipsson","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"issue":"6","key":"10.1016\/j.envpol.2025.127342_bib14","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1016\/S2542-5196(22)00090-0","article-title":"Pollution and health: a progress update","volume":"6","author":"Fuller","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.envpol.2025.127342_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2024.1431790","article-title":"New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report","volume":"6","author":"Haber","year":"2024","journal-title":"Front Toxicol"},{"issue":"6","key":"10.1016\/j.envpol.2025.127342_bib16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/08958378.2019.1654046","article-title":"Smoldering and flaming biomass wood smoke inhibit respiratory responses in mice","volume":"31","author":"Hargrove","year":"2019","journal-title":"Inhal. Toxicol."},{"issue":"2","key":"10.1016\/j.envpol.2025.127342_bib17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1089\/aivt.2021.0005","article-title":"Use of the MucilAir airway assay, a new approach methodology, for evaluating the safety and inhalation risk of agrochemicals","volume":"7","author":"Hargrove","year":"2021","journal-title":"Appl In Vitro Toxicol"},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/toxsci\/kfab009","article-title":"High-throughput transcriptomics platform for screening environmental chemicals","volume":"181","author":"Harrill","year":"2021","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.envpol.2025.127342_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-\u03baB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin. Immunol."},{"issue":"2","key":"10.1016\/j.envpol.2025.127342_bib20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.resp.2007.09.003","article-title":"Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1","volume":"160","author":"Hazari","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.envpol.2025.127342_bib21","article-title":"AnnotationDbi: manipulation of SQLite-based annotations in bioconductor","author":"Herv\u00e9 Pag\u00e8s","year":"2025","journal-title":"Version R package 1.70.0)"},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12989-020-00355-1","article-title":"Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke","volume":"17","author":"Ihantola","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2025.127342_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2023.105718","article-title":"How to use an in vitro approach to characterize the toxicity of airborne compounds","volume":"94","author":"Jaber","year":"2024","journal-title":"Toxicol. Vitro"},{"issue":"10","key":"10.1016\/j.envpol.2025.127342_bib24","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/0002889778507665","article-title":"Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice","volume":"38","author":"Kane","year":"1977","journal-title":"Am. Ind. Hyg. Assoc. J."},{"issue":"8","key":"10.1016\/j.envpol.2025.127342_bib25","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envpol.2025.127342_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2025.105819","article-title":"Human health risk assessment for exposures to 1,3-butadiene in the United States with input from an independent science advisory panel","volume":"160","author":"Kirman","year":"2025","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/toxsci\/kfy220","article-title":"Identifying attributes that influence in vitro-to-in vivo concordance by comparing in vitro Tox21 bioactivity versus in vivo DrugMatrix transcriptomic responses across 130 chemicals","volume":"167","author":"Klaren","year":"2019","journal-title":"Toxicol. Sci."},{"issue":"Pt 20","key":"10.1016\/j.envpol.2025.127342_bib28","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1242\/jcs.051011","article-title":"mTOR signaling at a glance","volume":"122","author":"Laplante","year":"2009","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib29","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev-pharmtox-022724-120525","article-title":"Trichloroethylene: an update on an environmental contaminant with multiple health effects","volume":"65","author":"Lash","year":"2025","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.envpol.2025.127342_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.907511","article-title":"Temporal whole-transcriptomic analysis of characterized in vitro and Ex vivo primary nasal epithelia","volume":"10","author":"Legebeke","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.envpol.2025.127342_bib31","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41370-020-0238-y","article-title":"Development and evaluation of a high throughput inhalation model for organic chemicals","volume":"30","author":"Linakis","year":"2020","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envpol.2025.127342_bib32","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"10.1016\/j.envpol.2025.127342_bib33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.envpol.2025.127342_bib34","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1021\/es506048k","article-title":"Differential effects of particulate matter upwind and downwind of an urban freeway in an allergic mouse model","volume":"49","author":"McGee","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2025.127342_bib35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tiv.2018.01.027","article-title":"Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays","volume":"48","author":"McMullen","year":"2018","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2025.127342_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tiv.2019.02.014","article-title":"Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures","volume":"58","author":"McMullen","year":"2019","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2025.127342_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104968","article-title":"Development of an in vitro approach to point-of-contact inhalation toxicity testing of volatile compounds, using organotypic culture and air-liquid interface exposure","volume":"69","author":"Mistry","year":"2020","journal-title":"Toxicol. Vitro"},{"issue":"5","key":"10.1016\/j.envpol.2025.127342_bib38","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/jappl.1999.87.5.1877","article-title":"Sensory nerve-mediated immediate nasal responses to inspired acrolein","volume":"87","author":"Morris","year":"1999","journal-title":"J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.envpol.2025.127342_bib39","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1152\/japplphysiol.00572.2002","article-title":"Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased mice","volume":"94","author":"Morris","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.envpol.2025.127342_bib40","first-page":"13","article-title":"Acrolein acute exposure guideline levels","volume":"8","year":"2010"},{"key":"10.1016\/j.envpol.2025.127342_bib41","first-page":"1","article-title":"NTP toxicology and carcinogenesis studies of 1,3-Butadiene (CAS no. 106-99-0) in B6C3F1 mice (inhalation studies)","volume":"434","year":"1993","journal-title":"Natl Toxicol Program Tech Rep Ser"},{"key":"10.1016\/j.envpol.2025.127342_bib42","series-title":"NTP Research Report on National Toxicology Program Approach to Genomic Dose-Response Modeling: Research Report 5","article-title":"NTP research reports","year":"2018"},{"issue":"2","key":"10.1016\/j.envpol.2025.127342_bib43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/toxsci\/kfae145","article-title":"Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities","volume":"203","author":"O'Brien","year":"2025","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib44","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1186\/s12864-015-1726-7","article-title":"Identification of in vitro and in vivo disconnects using transcriptomic data","volume":"16","author":"Otava","year":"2015","journal-title":"BMC Genom."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib45","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41392-023-01608-z","article-title":"Multifaceted role of mTOR (Mammalian target of rapamycin) signaling pathway in human health and disease","volume":"8","author":"Panwar","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12012-014-9272-0","article-title":"Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure","volume":"15","author":"Perez","year":"2015","journal-title":"Cardiovasc. Toxicol."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib47","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12989-025-00624-x","article-title":"Unique transcriptomic responses of rat and human alveolar macrophages in an in vitro model of overload with TiO(2) and carbon black","volume":"22","author":"Perez","year":"2025","journal-title":"Part. Fibre Toxicol."},{"issue":"4","key":"10.1016\/j.envpol.2025.127342_bib48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/aivt.2016.0041","article-title":"An In vitro versus In vivo toxicogenomic investigation of prenatal exposures to tobacco smoke","volume":"4","author":"Perry","year":"2018","journal-title":"Appl In Vitro Toxicol"},{"issue":"10","key":"10.1016\/j.envpol.2025.127342_bib49","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/bioinformatics\/bty878","article-title":"BMDExpress 2: enhanced transcriptomic dose-response analysis workflow","volume":"35","author":"Phillips","year":"2019","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.envpol.2025.127342_bib50","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1177\/0192623319879091","article-title":"Cardiopulmonary health effects of airborne particulate matter: correlating animal toxicology to human epidemiology","volume":"47","author":"Pinkerton","year":"2019","journal-title":"Toxicol. Pathol."},{"issue":"20","key":"10.1016\/j.envpol.2025.127342_bib51","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1073\/pnas.94.20.10925","article-title":"Reduced stress defense in heme oxygenase 1-deficient cells","volume":"94","author":"Poss","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envpol.2025.127342_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2023.1194895","article-title":"From vision toward best practices: evaluating in vitro transcriptomic points of departure for application in risk assessment using a uniform workflow","volume":"5","author":"Reardon","year":"2023","journal-title":"Front Toxicol"},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/15376516.2024.2382794","article-title":"Fifteen day repeat air: liquid Interface air-only exposures can cause respiratory epithelium injury in mucilAir(\u2122) nasal respiratory epithelial cells that parallels chemically induced cytotoxicity","volume":"35","author":"Recio","year":"2025","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.envpol.2025.127342_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109600","article-title":"1,3-Butadiene, styrene and selected outcomes among synthetic rubber polymer workers: updated exposure-response analyses","volume":"347","author":"Sathiakumar","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib55","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tiv.2012.10.007","article-title":"In vivo-in vitro comparison of acute respiratory tract toxicity using human 3D airway epithelial models and human A549 and murine 3T3 monolayer cell systems","volume":"27","author":"Sauer","year":"2013","journal-title":"Toxicol. Vitro"},{"issue":"2","key":"10.1016\/j.envpol.2025.127342_bib56","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1289\/ehp.1308030","article-title":"Human health effects of dichloromethane: key findings and scientific issues","volume":"123","author":"Schlosser","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2025.127342_bib57","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.3389\/fimmu.2018.01956","article-title":"Heme Oxygenase-1 as a modulator of intestinal inflammation development and progression","volume":"9","author":"Sebasti\u00e1n","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2025.127342_bib58","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.addr.2020.06.029","article-title":"Correlation and clinical relevance of animal models for inhaled pharmaceuticals and biopharmaceuticals","volume":"167","author":"S\u00e9cher","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"12","key":"10.1016\/j.envpol.2025.127342_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0315464","article-title":"Respiratory symptoms and pulmonary function in paint industry workers exposed to volatile organic compounds: a systematic review and meta-analysis","volume":"19","author":"Sekhar","year":"2024","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.envpol.2025.127342_bib60","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/toxsci\/kfad074","article-title":"Human cell-based in vitro systems to assess respiratory toxicity: a case study using silanes","volume":"195","author":"Sharma","year":"2023","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib61","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/toxsci\/kfi004","article-title":"A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints","volume":"84","author":"Slob","year":"2005","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib62","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/toxsci\/kfac040","article-title":"Benchmark dose modeling approaches for volatile organic chemicals using a novel air-liquid interface in vitro exposure system","volume":"188","author":"Speen","year":"2022","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.envpol.2025.127342_bib63","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00441-016-2464-0","article-title":"Epithelial-mesenchymal transition in tissue repair and fibrosis","volume":"365","author":"Stone","year":"2016","journal-title":"Cell Tissue Res."},{"issue":"43","key":"10.1016\/j.envpol.2025.127342_bib64","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib65","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/toxsci\/kfm092","article-title":"A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure","volume":"98","author":"Thomas","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2025.127342_bib67","series-title":"Hazardous Air Pollutants: Sources and Exposure","year":"2024"},{"key":"10.1016\/j.envpol.2025.127342_bib68","series-title":"U.S. EPA Conference on the State of Science on Development and Use of New Approach Methods (Nams) for Chemical Safety Testing","article-title":"U.S. EPA conference on the state of science on development and use of new approach methods (NAMs) for chemical safety testing","year":"2025"},{"issue":"1","key":"10.1016\/j.envpol.2025.127342_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/ph18010113","article-title":"Two- and three-dimensional culture systems: respiratory in vitro tissue models for chemical screening and risk-based decision making","volume":"18","author":"Wallace","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.envpol.2025.127342_bib70","article-title":"An absorption model of volatile organic compound by plant leaf: the most influential site in the absorption pathway","volume":"23","author":"Yamane","year":"2024","journal-title":"Atmos. Environ. X"},{"key":"10.1016\/j.envpol.2025.127342_bib71","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/1471-2164-8-387","article-title":"BMDExpress: a software tool for the benchmark dose analyses of genomic data","volume":"8","author":"Yang","year":"2007","journal-title":"BMC Genom."},{"key":"10.1016\/j.envpol.2025.127342_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2021.107832","article-title":"Recent advances in human respiratory epithelium models for drug discovery","volume":"54","author":"Yaqub","year":"2022","journal-title":"Biotechnol. Adv."},{"issue":"2","key":"10.1016\/j.envpol.2025.127342_bib73","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/toxsci\/kfw051","article-title":"Proposed mode of action for acrolein respiratory toxicity associated with inhaled tobacco smoke","volume":"151","author":"Yeager","year":"2016","journal-title":"Toxicol. Sci."},{"issue":"9","key":"10.1016\/j.envpol.2025.127342_bib74","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41580-024-00733-z","article-title":"Epithelial-mesenchymal transition in tissue repair and degeneration","volume":"25","author":"Youssef","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2025.127342_bib75","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fpubh.2018.00261","article-title":"Bridging the data gap from in vitro toxicity testing to chemical safety assessment through computational modeling","volume":"6","author":"Zhang","year":"2018","journal-title":"Front. Public Health"},{"key":"10.1016\/j.envpol.2025.127342_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174029","article-title":"Trichloroethylene exposure, multi-organ injury, and potential mechanisms: a narrative review","volume":"946","author":"Zhu","year":"2024","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125017166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749125017166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:37:11Z","timestamp":1773279431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749125017166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":75,"alternative-id":["S0269749125017166"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2025.127342","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bridging in vitro and in vivo inhalation toxicity: Volatile organic compounds elicit similar transcriptomic points of departure in human airway cells and mouse respiratory tract","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2025.127342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127342"}}