{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:50:39Z","timestamp":1782100239414,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM136597"],"award-info":[{"award-number":["T32 GM136597"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA241666"],"award-info":[{"award-number":["R01 CA241666"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS13065"],"award-info":[{"award-number":["R01 NS13065"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2238995"],"award-info":[{"award-number":["2238995"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["S 10 OD028584"],"award-info":[{"award-number":["S 10 OD028584"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.envpol.2026.127730","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:03:31Z","timestamp":1769533411000},"page":"127730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Spatial and spectral mapping of traffic-related nanoparticles in hippocampal subregions of an Alzheimer disease model"],"prefix":"10.1016","volume":"393","author":[{"given":"Hannah J.","family":"O'Toole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchaleena","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2793-5787","authenticated-orcid":false,"given":"Nathifa","family":"Nasim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin J.","family":"Hadley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5273-8834","authenticated-orcid":false,"given":"Elizabeth J.","family":"Hale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4865-2951","authenticated-orcid":false,"given":"Keith J.","family":"Bein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-355X","authenticated-orcid":false,"given":"Anthony","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-1353","authenticated-orcid":false,"given":"Tatu","family":"Rojalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany N.","family":"Dugger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Wexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-7584","authenticated-orcid":false,"given":"Pamela J.","family":"Lein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-1664","authenticated-orcid":false,"given":"Randy P.","family":"Carney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.127730_bib1","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.1021\/acs.est.1c07047","article-title":"Emulating near-roadway exposure to traffic-related air pollution via real-time emissions from a major freeway tunnel system","volume":"56","author":"Bein","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.127730_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108418","article-title":"Traffic-related air pollution and dementia incidence in the adult changes in thought study","volume":"183","author":"Blanco","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.127730_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107262","article-title":"Long-term exposure to traffic-related air pollution and selected health outcomes: a systematic review and meta-analysis","volume":"164","author":"Boogaard","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.127730_bib4","doi-asserted-by":"crossref","first-page":"e1022","DOI":"10.1038\/tp.2016.280","article-title":"Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models","volume":"7","author":"Cacciottolo","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.envpol.2026.127730_bib5","series-title":"Statewide Sips: 9 \u03bcg\/m3 PM2.5 (Webpage)","year":"2024"},{"key":"10.1016\/j.envpol.2026.127730_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12989-020-00388-6","article-title":"Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats","volume":"17","author":"Chuang","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2026.127730_bib7","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1523\/JNEUROSCI.3672-12.2013","article-title":"A transgenic alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric A\u03b2, and frank neuronal loss","volume":"33","author":"Cohen","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.envpol.2026.127730_bib8","series-title":"Advances in Neurotoxicology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ant.2017.07.001","article-title":"Traffic-related air pollution and neurodegenerative diseases: epidemiological and experimental evidence, and potential underlying mechanisms","author":"Costa","year":"2017"},{"key":"10.1016\/j.envpol.2026.127730_bib9","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7045","article-title":"Pathological cardiopulmonary evaluation of rats chronically exposed to traffic-related air pollution","volume":"128","author":"Edwards","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.127730_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fnana.2019.00099","article-title":"Subregional density of neurons, neurofibrillary tangles and amyloid plaques in the hippocampus of patients with alzheimer's disease","volume":"13","author":"Furcila","year":"2019","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.envpol.2026.127730_bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neuro.2016.07.007","article-title":"Neurodegenerative and neurological disorders by small inhaled particles","volume":"56","author":"Heusinkveld","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envpol.2026.127730_bib12","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/antiox14060730","article-title":"Pathways to the brain: impact of fine particulate matter components on the central nervous system","volume":"14","author":"Ishihara","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.envpol.2026.127730_bib13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s40572-017-0142-3","article-title":"Outdoor ambient air pollution and neurodegenerative diseases: the neuroinflammation Hypothesis","volume":"4","author":"Jayaraj","year":"2017","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envpol.2026.127730_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153456","article-title":"Olfactory bulb microglia activation mediated neuronal death in real-ambient particulate matter exposure mice with depression-like behaviors","volume":"821","author":"Ji","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.127730_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep46427","article-title":"Early neurovascular dysfunction in a transgenic rat model of Alzheimer's disease","volume":"7","author":"Joo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.127730_bib16","article-title":"Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model","volume":"16","author":"Lee","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.127730_bib17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1289\/ehp.6000","article-title":"Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage","volume":"111","author":"Li","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.127730_bib18","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/acs.nanolett.1c04184","article-title":"Bioeffects of inhaled nanoplastics on neurons and alteration of animal behaviors through deposition in the brain","volume":"22","author":"Liu","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.envpol.2026.127730_bib19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/enrs.2001.4269","article-title":"Human alveolar macrophage phagocytic function is impaired by aggregates of ultrafine carbon particles","volume":"86","author":"Lundborg","year":"2001","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2026.127730_bib20","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41578-023-00552-2","article-title":"The protein corona from nanomedicine to environmental science","volume":"8","author":"Mahmoudi","year":"2023","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.envpol.2026.127730_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/693851","article-title":"Proliferation in the alzheimer Hippocampus is due to Microglia, not astroglia, and occurs at sites of amyloid deposition","volume":"2014","author":"Marlatt","year":"2014","journal-title":"Neural Plast."},{"key":"10.1016\/j.envpol.2026.127730_bib22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.21105\/joss.00861","article-title":"UMAP: uniform manifold approximation and projection","volume":"3","author":"McInnes","year":"2018","journal-title":"JOSS"},{"key":"10.1016\/j.envpol.2026.127730_bib23","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1021\/acsnano.6b08551","article-title":"Inhaled nanoparticles accumulate at sites of vascular disease","volume":"11","author":"Miller","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.envpol.2026.127730_bib24","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuron.2014.12.032","article-title":"Blood-Brain barrier breakdown in the aging human hippocampus","volume":"85","author":"Montagne","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.envpol.2026.127730_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33549\/physiolres.935464","article-title":"Insights from TgF344-AD, a double transgenic rat model in alzheimer's disease research","author":"Nataraj","year":"2025","journal-title":"Physiol. Res."},{"key":"10.1016\/j.envpol.2026.127730_bib26","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.molmed.2022.06.004","article-title":"Particulate matter and Alzheimer's disease: an intimate connection","volume":"28","author":"O'Piela","year":"2022","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.envpol.2026.127730_bib27","doi-asserted-by":"crossref","DOI":"10.18103\/mra.v12i10.5825","article-title":"Air pollution as an environmental risk factor for alzheimer's disease and related dementias","volume":"12","author":"Park","year":"2024","journal-title":"MRAJ"},{"key":"10.1016\/j.envpol.2026.127730_bib28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41398-020-0845-3","article-title":"Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats","volume":"10","author":"Patten","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.envpol.2026.127730_bib29","doi-asserted-by":"crossref","DOI":"10.1289\/EHP8905","article-title":"The effects of chronic exposure to ambient traffic-related air pollution on alzheimer's disease phenotypes in wildtype and genetically predisposed Male and female rats","volume":"129","author":"Patten","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.127730_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.861733","article-title":"Hippocampal but not Serum cytokine levels are altered by traffic-related air pollution in TgF344-AD and wildtype fischer 344 rats in a Sex- and age-dependent manner","volume":"16","author":"Patten","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.envpol.2026.127730_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/srep22595","article-title":"An unexpected transient breakdown of the blood brain barrier triggers passage of large intravenously administered nanoparticles","volume":"6","author":"Smith","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.127730_bib32","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3390\/biom14070833","article-title":"Targeting microglia in alzheimer's disease: pathogenesis and potential therapeutic strategies","volume":"14","author":"Sun","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.envpol.2026.127730_bib33","doi-asserted-by":"crossref","DOI":"10.1289\/EHP8716","article-title":"Exposure to air pollution in relation to risk of dementia and related outcomes: an updated systematic review of the epidemiological literature","volume":"129","author":"Weuve","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.127730_bib34","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.3390\/ijms12096267","article-title":"Nanoparticles and neurotoxicity","volume":"12","author":"Win-Shwe","year":"2011","journal-title":"IJMS"},{"key":"10.1016\/j.envpol.2026.127730_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116386","article-title":"PM2.5 exposure upregulates pro-inflammatory protein expression in human microglial cells via oxidant stress and TLR4\/NF-\u03baB pathway","volume":"277","author":"Zhang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.127730_bib36","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/nsr\/nwz124","article-title":"High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice","volume":"6","author":"Zhang","year":"2019","journal-title":"Natl. Sci. Rev."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126001004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126001004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:41:03Z","timestamp":1782099663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126001004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":36,"alternative-id":["S0269749126001004"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.127730","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial and spectral mapping of traffic-related nanoparticles in hippocampal subregions of an Alzheimer disease model","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.127730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127730"}}