{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:47:56Z","timestamp":1791787676817,"version":"4.3.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019899","name":"National Alliance for Life and Health Sciences","doi-asserted-by":"publisher","award":["ANSES-23-EST-117"],"award-info":[{"award-number":["ANSES-23-EST-117"]}],"id":[{"id":"10.13039\/100019899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007525","name":"University of Rennes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007525","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"National Institute of Health and Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021716","name":"Paris Cit\u00e9 University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.envpol.2026.127975","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:45:33Z","timestamp":1773906333000},"page":"127975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Liver steatosis induced by per- and polyfluoroalkyl substances exerts a limited influence on heterocyclic aromatic amine\u2013mediated DNA damage at population-relevant exposure levels"],"prefix":"10.1016","volume":"397","author":[{"given":"Minna A.","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Ezan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Masaoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-4772","authenticated-orcid":false,"given":"Etienne B.","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-5425","authenticated-orcid":false,"given":"Sophie","family":"Langou\u00ebt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.127975_bib1","first-page":"260","article-title":"Studies on the carcinogenic and myocardial effects of 2-Amino-3-Methylimidazo [4,5-f] quinoline (IQ) in nonhuman Primates","volume":"23","author":"Adamson","year":"1995","journal-title":"Princess Takamatsu Symposia"},{"issue":"septembre","key":"10.1016\/j.envpol.2026.127975_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cbi.2015.07.002","article-title":"\u00ab Hydroxyl metabolite of PCB 180 induces DNA damage signaling and enhances the DNA damaging effect of benzo[a]pyrene","volume":"239","author":"Al-Anati","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2026.127975_bib3","author":"Amivi"},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1124\/dmd.105.006759","article-title":"\u00ab expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells","volume":"34","author":"Aninat","year":"2006","journal-title":"Drug Metabol. Dispos."},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0304-3835(00)00413-4","article-title":"Carcinogenicity of the N-Hydroxy derivative of 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine, 2-Amino-3,8-Dimethyl-Imidazo[4,5-f]Quinoxaline and 3,2\u2032-Dimethyl-4-Aminobiphenyl in the rat","volume":"155","author":"Archer","year":"2000","journal-title":"Cancer Lett."},{"issue":"d\u00e9cembre","key":"10.1016\/j.envpol.2026.127975_bib6","article-title":"Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice","volume":"66","author":"Attema","year":"2022","journal-title":"Mol. Metabol."},{"issue":"2","key":"10.1016\/j.envpol.2026.127975_bib7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1021\/acs.chemrestox.6b00394","article-title":"Metabolism of the tobacco carcinogen 2-Amino-9H-pyrido[2,3-b]indole (A\u03b1C) in primary human hepatocytes","volume":"30","author":"Bellamri","year":"2017","journal-title":"Chem. Res. Toxicol."},{"issue":"24","key":"10.1016\/j.envpol.2026.127975_bib8","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1002\/1873-3468.14465","article-title":"Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors","volume":"596","author":"Bernal","year":"2022","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."},{"issue":"f\u00e9vrier","key":"10.1016\/j.envpol.2026.127975_bib9","article-title":"Assessment of endocrine disruptor impacts on lipid metabolism in a fatty acid-supplemented HepaRG human hepatic cell line","volume":"349","author":"Bernal","year":"2024","journal-title":"Chemosphere"},{"issue":"1-3","key":"10.1016\/j.envpol.2026.127975_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2011.06.012","article-title":"Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes","volume":"288","author":"Bjork","year":"2011","journal-title":"Toxicology"},{"issue":"9","key":"10.1016\/j.envpol.2026.127975_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/ijms22094807","article-title":"Role of endocrine-disrupting chemicals in the pathogenesis of non-alcoholic fatty liver disease: a comprehensive review","volume":"22","author":"Cano","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.envpol.2026.127975_bib12","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/acs.est.1c07176","article-title":"Effect of enterohepatic circulation on the accumulation of Per- and polyfluoroalkyl substances: evidence from experimental and computational studies","volume":"56","author":"Cao","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.envpol.2026.127975_bib13","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1021\/acs.est.8b05564","article-title":"Screening of potential PFOS alternatives to decrease liver bioaccumulation: experimental and computational approaches","volume":"53","author":"Cao","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.envpol.2026.127975_bib14","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2012.04.001","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American gastroenterological association, American association for the study of liver diseases, and American college of gastroenterology","volume":"142","author":"Chalasani","year":"2012","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.envpol.2026.127975_bib15","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1210\/endo.135.2.8033830","article-title":"Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation","volume":"135","author":"Chawla","year":"1994","journal-title":"Endocrinology"},{"issue":"ao\u00fbt","key":"10.1016\/j.envpol.2026.127975_bib16","article-title":"\u00ab Per- and polyfluoroalkyl substances as potentiators of hepatotoxicity in an exposome framework: current challenges of environmental toxicology","volume":"515","author":"Choi","year":"2025","journal-title":"Toxicology"},{"issue":"ao\u00fbt","key":"10.1016\/j.envpol.2026.127975_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.yrtph.2019.05.005","article-title":"\u00ab can sustained exposure to PFAS trigger a genotoxic response? A comprehensive genotoxicity assessment in mice after subacute oral administration of PFOA and PFBA","volume":"106","author":"Crebelli","year":"2019","journal-title":"Regul. Toxicol. Pharmacol.: RTP (Regul. Toxicol. Pharmacol.)"},{"issue":"ao\u00fbt","key":"10.1016\/j.envpol.2026.127975_bib18","article-title":"\u00ab in vitro activity of a panel of Per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays","volume":"449","author":"Evans","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"ao\u00fbt","key":"10.1016\/j.envpol.2026.127975_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.866717","article-title":"Identification of the mutagens in cooked beef","volume":"67","author":"Felton","year":"1986","journal-title":"Environ. Health Perspect."},{"issue":"3-4","key":"10.1016\/j.envpol.2026.127975_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0165-1218(91)90118-6","article-title":"Occurrence, identification, and bacterial mutagenicity of heterocyclic amines in cooked food","volume":"259","author":"Felton","year":"1991","journal-title":"Mutat. Res. Genet. Toxicol."},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12072-020-10121-2","article-title":"How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?","volume":"15","author":"Geng","year":"2021","journal-title":"Hepatol. Int."},{"issue":"septembre","key":"10.1016\/j.envpol.2026.127975_bib22","article-title":"A novel molecular pathway of lipid accumulation in human hepatocytes caused by PFOA and PFOS","volume":"191","author":"Gou","year":"2024","journal-title":"Environ. Int."},{"issue":"24","key":"10.1016\/j.envpol.2026.127975_bib23","doi-asserted-by":"crossref","first-page":"15655","DOI":"10.1073\/pnas.232137699","article-title":"Infection of a human hepatoma cell line by hepatitis B virus","volume":"99","author":"Gripon","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mce.2009.02.018","article-title":"\u00ab Endocrine disrupters as obesogens","volume":"304","author":"Gr\u00fcn","year":"2009","journal-title":"Molecular and Cellular Endocrinology, Special Issue: Endocrine Disruptors from the Environment in the Aetiology of Obesity and Diabetes"},{"issue":"6","key":"10.1016\/j.envpol.2026.127975_bib25","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/ng.2256","article-title":"Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma","volume":"44","author":"Guichard","year":"2012","journal-title":"Nat. Genet."},{"issue":"21-22","key":"10.1016\/j.envpol.2026.127975_bib26","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1080\/15287394.2020.1822972","article-title":"Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment","volume":"83","author":"Guo","year":"2020","journal-title":"J. Toxicol. Environ. Health, Part A"},{"issue":"mai","key":"10.1016\/j.envpol.2026.127975_bib27","article-title":"Obesity II: establishing causal links between chemical exposures and obesity","volume":"199","author":"Heindel","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.envpol.2026.127975_bib28","article-title":"Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS)","year":"2025","journal-title":"International agency for research on cancer"},{"issue":"3","key":"10.1016\/j.envpol.2026.127975_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12199-013-0328-8","article-title":"Developmental origins of obesity and type 2 diabetes: molecular aspects and role of chemicals","volume":"18","author":"Inadera","year":"2013","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.envpol.2026.127975_bib30","volume":"vol. 56","year":"1993"},{"issue":"10","key":"10.1016\/j.envpol.2026.127975_bib31","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.3390\/ijerph18105227","article-title":"Non-alcoholic fatty liver disease: Metabolic, genetic, epigenetic and environmental risk factors","volume":"18","author":"Juanola","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/carcin\/23.1.115","article-title":"Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine in rat and human hepatocytes","volume":"23","author":"Langou\u00ebt","year":"2002","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.envpol.2026.127975_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1021\/tx000176e","article-title":"Metabolism of 2-Amino-3,8-dimethylimidazo[4,5-f]- quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxication pathway catalyzed by cytochrome P450 1A2","volume":"14","author":"Langou\u00ebt","year":"2001","journal-title":"Chem. Res. Toxicol."},{"issue":"6","key":"10.1016\/j.envpol.2026.127975_bib34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/mutage\/geq039","article-title":"Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays","volume":"25","author":"Le Hegarat","year":"2010","journal-title":"Mutagenesis"},{"issue":"4","key":"10.1016\/j.envpol.2026.127975_bib35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/embor.2009.8","article-title":"Activation of RXR\u2013PPAR heterodimers by organotin environmental endocrine disruptors","volume":"10","author":"Le Maire","year":"2009","journal-title":"EMBO Rep."},{"issue":"22","key":"10.1016\/j.envpol.2026.127975_bib36","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1093\/bioinformatics\/btw413","article-title":"MorphoLibJ: Integrated library and plugins for mathematical morphology with ImageJ","volume":"32","author":"Legland","year":"2016","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.envpol.2026.127975_bib37","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"8","key":"10.1016\/j.envpol.2026.127975_bib38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41575-023-00754-7","article-title":"Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment","volume":"20","author":"Llovet","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.envpol.2026.127975_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0269-7491(91)90013-M","article-title":"\u00ab detection of carcinogenic Amino-\u03b1-Carbolines and Amino-\u03b3-Carbolines in diesel-exhaust particles","volume":"70","author":"Manabe","year":"1991","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47114-7","article-title":"\u00ab three-dimensional HepaRG spheroids as a liver model to study human genotoxicity in vitro with the single cell gel electrophoresis assay","volume":"9","author":"Mandon","year":"2019","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.envpol.2026.127975_bib41","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1210\/endo.141.11.7771","volume":"141","author":"Memon","year":"2000","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.envpol.2026.127975_bib42","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.127975_bib43","series-title":"Toward a New Comprehensive Global Database of per- and Polyfluoroalkyl Substances (Pfass): Summary Report on Updating the OECD 2007 List of per- and Polyfluorinated Substances (Pfass) OECD Report","year":"2018"},{"issue":"d\u00e9cembre","key":"10.1016\/j.envpol.2026.127975_bib44","article-title":"Genotoxicity assessment of Per- and polyfluoroalkyl substances mixtures in human liver cells (HepG2)","volume":"482","author":"Ojo","year":"2022","journal-title":"Toxicology"},{"issue":"9","key":"10.1016\/j.envpol.2026.127975_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.563","article-title":"Using the HepaCometChip assay for broad\u2010spectrum DNA damage analysis","volume":"2","author":"Owiti","year":"2022","journal-title":"Curr. Protoc."},{"issue":"avril","key":"10.1016\/j.envpol.2026.127975_bib46","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.35371\/aoem.2024.36.e10","article-title":"Association between serum perfluoroalkyl substances concentrations and non-alcoholic fatty liver disease among Korean adults: a cross-sectional study using the national environmental health survey cycle 4","volume":"36","author":"Park","year":"2024","journal-title":"Annals of Occupational and Environmental Medicine"},{"issue":"septembre","key":"10.1016\/j.envpol.2026.127975_bib47","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2013.06.004","article-title":"Accumulation of perfluoroalkyl substances in human tissues","volume":"59","author":"P\u00e9rez","year":"2013","journal-title":"Environ. Int."},{"issue":"septembre","key":"10.1016\/j.envpol.2026.127975_bib48","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.fct.2013.06.030","article-title":"Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells","volume":"59","author":"Pezdirc","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"ao\u00fbt","key":"10.1016\/j.envpol.2026.127975_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yrtph.2019.05.008","article-title":"Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria","volume":"106","author":"Pizzurro","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"mars","key":"10.1016\/j.envpol.2026.127975_bib50","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/tox.23680","article-title":"Per\u2010 and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells","volume":"38","author":"Qi","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"8-9","key":"10.1016\/j.envpol.2026.127975_bib52","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/em.22575","article-title":"Genotoxicity assessment in HepaRG TM cells as a new approach methodology follow up to a positive response in the human TK6 cell micronucleus assay: naphthalene case study","volume":"64","author":"Recio","year":"2023","journal-title":"Environ. Mol. Mutagen."},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00204-021-03178-x","article-title":"DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies","volume":"96","author":"Rose","year":"2022","journal-title":"Arch. Toxicol."},{"issue":"novembre","key":"10.1016\/j.envpol.2026.127975_bib54","article-title":"Computerized predictive approaches of genotoxicity and mutagenesis in 3D hepoid of normal and transformed human hepatocytes","volume":"517","author":"Rose","year":"2025","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.envpol.2026.127975_bib55","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0192623308318208","article-title":"Gene profiling in the livers of wild-type and PPAR\u03b1-Null mice exposed to perfluorooctanoic acid","volume":"36","author":"Rosen","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.envpol.2026.127975_bib56","article-title":"Associations between Per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult national health and nutrition examination survey 2017-2018","volume":"16","author":"Samala","year":"2024","journal-title":"Toxicol. Sci.: An Official Journal of the Society of Toxicology, ao\u00fbt"},{"issue":"septembre","key":"10.1016\/j.envpol.2026.127975_bib57","doi-asserted-by":"crossref","DOI":"10.1101\/2021.04.03.438316","article-title":"Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPAR\u03b1 mice fed an American diet","volume":"426","author":"Schlezinger","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"octobre","key":"10.1016\/j.envpol.2026.127975_bib58","doi-asserted-by":"crossref","DOI":"10.1101\/2020.01.30.926642","article-title":"Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPAR\u03b1 mice fed an American diet","volume":"405","author":"Schlezinger","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.envpol.2026.127975_bib59","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jhep.2021.09.039","article-title":"Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease","volume":"76","author":"Sen","year":"2022","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib60","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00204-017-2055-1","article-title":"Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein","volume":"92","author":"Sheng","year":"2018","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.envpol.2026.127975_bib61","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0278-6915(97)00021-5","article-title":"Polar and non-polar heterocyclic amines in cooked fish and meat products and their corresponding pan residues","volume":"35","author":"Skog","year":"1997","journal-title":"Food Chem. Toxicol."},{"issue":"juin","key":"10.1016\/j.envpol.2026.127975_bib62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nfs.2023.03.004","article-title":"Endocrine-active and endocrine-disrupting compounds in food \u2013 occurrence, formation and relevance","volume":"31","author":"Stiefel","year":"2023","journal-title":"NFS Journal"},{"issue":"11","key":"10.1016\/j.envpol.2026.127975_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224405","article-title":"Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells","volume":"14","author":"Stossi","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib64","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"issue":"ao\u00fbt","key":"10.1016\/j.envpol.2026.127975_bib65","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1289\/ehp.86675","article-title":"\u00ab past, present, and future of mutagens in cooked foods","volume":"67","author":"Sugimura","year":"1986","journal-title":"Environ. Health Perspect."},{"issue":"1-2","key":"10.1016\/j.envpol.2026.127975_bib66","first-page":"211","article-title":"Overview of carcinogenic heterocyclic amines","volume":"376","author":"Sugimura","year":"1997","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"issue":"4","key":"10.1016\/j.envpol.2026.127975_bib67","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1349-7006.2004.tb03205.x","article-title":"Heterocyclic amines: mutagens\/carcinogens produced during cooking of meat and fish","volume":"95","author":"Sugimura","year":"2004","journal-title":"Cancer Sci."},{"issue":"f\u00e9vrier","key":"10.1016\/j.envpol.2026.127975_bib68","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: an open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.envpol.2026.127975_bib70","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0300-483X(97)00083-8","article-title":"Peroxisome proliferators increase the formation of BPDE-DNA adducts in isolated rat hepatocytes","volume":"122","author":"Voskoboinik","year":"1997","journal-title":"Toxicology"},{"issue":"6","key":"10.1016\/j.envpol.2026.127975_bib71","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00204-023-03488-2","article-title":"Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes","volume":"97","author":"Walls","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2026.127975_bib72","article-title":"Heterocyclic amines disrupt lipid homeostasis in cryopreserved human hepatocytes","volume":"8","author":"Walls","year":"2024","journal-title":"Cardiovascular Toxicology, publication en ligne anticip\u00e9e, juin"},{"issue":"3","key":"10.1016\/j.envpol.2026.127975_bib74","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jhep.2023.04.036","article-title":"Changing epidemiology, global trends and implications for outcomes of NAFLD","volume":"79","author":"Wong","year":"2023","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.envpol.2026.127975_bib75","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1600-0773.1989.tb01172.x","article-title":"Stimulation by oestradiol of the urinary excretion of perfluorooctanoic acid in the Male rat","volume":"65","author":"Ylinen","year":"1989","journal-title":"Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.envpol.2026.127975_bib76","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0304-3835(80)90037-3","article-title":"Amino-\u03b1-Carbolines as mutagenic agents in cigarette smoke condensate","volume":"10","author":"Yoshida","year":"1980","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.envpol.2026.127975_bib77","article-title":"Association of Per- and polyfluoroalkyl substance exposure with fatty liver disease risk in US adults","volume":"5","author":"Zhang","year":"2023","journal-title":"JHEP Rep."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126003453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126003453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:26:09Z","timestamp":1791786369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126003453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":75,"alternative-id":["S0269749126003453"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.127975","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liver steatosis induced by per- and polyfluoroalkyl substances exerts a limited influence on heterocyclic aromatic amine\u2013mediated DNA damage at population-relevant exposure levels","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.127975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127975"}}