{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:37:33Z","timestamp":1792003053755,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005667","name":"Foundation for Research Support and Innovation of Santa Catarina State","doi-asserted-by":"publisher","award":["2025TR1577"],"award-info":[{"award-number":["2025TR1577"]}],"id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CODE 001"],"award-info":[{"award-number":["CODE 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.envpol.2026.128298","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:28:45Z","timestamp":1778167725000},"page":"128298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The invisible burden: A meta-analysis of methodological evolutions and the reassessment of microplastic concentrations in human tissues"],"prefix":"10.1016","volume":"400","author":[{"given":"Jaque Willian","family":"Scotton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8255-4511","authenticated-orcid":false,"given":"Alessandro Cazonatto","family":"Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Ortigosa","family":"Stolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia do Carmo Cruz","family":"Robazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-8777","authenticated-orcid":false,"given":"Weber da Silva","family":"Robazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.128298_bib1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s13530-025-00287-3","article-title":"The impact of microplastics on global pollution health, distribution, and contamination: a systematic review and meta-analysis","volume":"17","author":"Adamopoulos","year":"2025","journal-title":"Toxicol Environ Health Sci"},{"key":"10.1016\/j.envpol.2026.128298_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108932","article-title":"The effects of exposure to microplastics on female reproductive health and pregnancy outcomes: a systematic review and meta-analysis","volume":"135","author":"Ali-Hassanzadeh","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envpol.2026.128298_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid Based Ment Health"},{"key":"10.1016\/j.envpol.2026.128298_bib4","series-title":"Introduction to Meta-Analysis","author":"Borenstein","year":"2021"},{"issue":"7","key":"10.1016\/j.envpol.2026.128298_bib5","first-page":"921","article-title":"Detection of microplastic in human placenta and meconium in a clinical setting","volume":"13","author":"Braun","year":"2021","journal-title":"Pharm. Times"},{"key":"10.1016\/j.envpol.2026.128298_bib6","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.3390\/foods14132190","article-title":"Preliminary study on PCC-Chitosan\u2019s ability to enhance microplastic excretion in human stools from healthy volunteers","volume":"14","author":"Casella","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.envpol.2026.128298_bib7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/toxics13050387","article-title":"Plastic smell: a review of the hidden threat of airborne micro and nanoplastics to human health and the environment","volume":"13","author":"Casella","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.128298_bib8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/toxics13070597","article-title":"Health risks from microplastics in intravenous infusions: evidence from Italy, Spain, and Ecuador","volume":"13","author":"Casella","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.128298_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2025.102332","article-title":"Microplastics in Spanish eye drops: hidden contaminants in ophthalmic formulations","volume":"15","author":"Casella","year":"2025","journal-title":"Results Chem."},{"key":"10.1016\/j.envpol.2026.128298_bib10","article-title":"Laser Direct Infrared Spectroscopy: a cutting-edge approach to microplastic detection in environmental samples","volume":"284","author":"Chandran","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2026.128298_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/microplastics4040093","article-title":"Definition of emerging microplastic syndrome based on clinical and epidemiological evidence: a narrative review","volume":"4","author":"Cornelli","year":"2025","journal-title":"Microplastics"},{"key":"10.1016\/j.envpol.2026.128298_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/greenhealth2020009","article-title":"Mapping clinical disease patterns potentially associated with microplastic exposure: a narrative review across twenty-one disease categories","volume":"2","author":"Cornelli","year":"2026","journal-title":"Green Health"},{"issue":"2","key":"10.1016\/j.envpol.2026.128298_bib13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/1475-6773.12122","article-title":"Computation of standard errors","volume":"49","author":"Dowd","year":"2013","journal-title":"Health Serv. Res."},{"key":"10.1016\/j.envpol.2026.128298_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/diseases14030088","article-title":"Harmful effects of microplastics and nanoplastics in human body systems: a systematic review","volume":"14","author":"Edet","year":"2026","journal-title":"Diseases"},{"issue":"18","key":"10.1016\/j.envpol.2026.128298_bib15","doi-asserted-by":"crossref","first-page":"10230","DOI":"10.1021\/acs.est.8b01611","article-title":"Quality criteria for the analysis of microplastics in biota samples: a critical review","volume":"52","author":"Hermsen","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128298_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12989-020-00387-7","article-title":"Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature","volume":"17","author":"Hirt","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2026.128298_bib17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jgh3.12457","article-title":"Detection of microplastics in human colectomy specimens","volume":"5","author":"Ibrahim","year":"2021","journal-title":"JGH Open"},{"key":"10.1016\/j.envpol.2026.128298_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154907","article-title":"Detection of microplastics in human lung tissue using \u03bcFTIR spectroscopy","volume":"831","author":"Jenner","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128298_bib19","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.3390\/polym17121699","article-title":"Risk assessment of microplastics in humans: distribution, exposure, and toxicological effects","volume":"17","author":"Li","year":"2025","journal-title":"Polymers"},{"key":"10.1016\/j.envpol.2026.128298_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114721","article-title":"Are we underestimating microplastic abundance in the marine environment? A comparison of microplastic capture with nets of different mesh size","volume":"265","author":"Lindeque","year":"2020","journal-title":"Environ Pollut"},{"issue":"6","key":"10.1016\/j.envpol.2026.128298_bib21","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat. Methods Med. Res."},{"key":"10.1016\/j.envpol.2026.128298_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2021.636640","article-title":"Micro and nanoplastics identification: classic methods and innovative detection techniques","volume":"3","author":"Mariano","year":"2021","journal-title":"Front Toxicol"},{"key":"10.1016\/j.envpol.2026.128298_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165922","article-title":"Raman Microspectroscopy evidence of microplastics in human semen","volume":"901","author":"Montano","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envpol.2026.128298_bib24","article-title":"Microplastics in human body: a narrative on routes of exposure to contamination and potential health effects","volume":"37","author":"Nouri","year":"2025","journal-title":"Environ Pollut Bioavail"},{"key":"10.1016\/j.envpol.2026.128298_bib25","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Br. Med. J."},{"key":"10.1016\/j.envpol.2026.128298_bib26","series-title":"R: a Language and Environment for Statistical Computing","year":"2024"},{"key":"10.1016\/j.envpol.2026.128298_bib27","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.3390\/polym14132700","article-title":"Raman microspectroscopy detection and characterisation of microplastics in human breastmilk","volume":"14","author":"Ragusa","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.envpol.2026.128298_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: first evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.128298_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2026.141557","article-title":"The presence of microplastics in human semen and the protective role of nicotinamide mononucleotide against polystyrene nanoplastics-induced reproductive and early embryonic toxicity","volume":"505","author":"Ren","year":"2026","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envpol.2026.128298_bib30","article-title":"Impact of microplastic exposure on human health: a systematic review of mechanisms, biomarkers, and clinical outcomes","volume":"17","author":"Ririe","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.envpol.2026.128298_bib31","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.14.04179","article-title":"Detection of microplastics in human tissues and organs: a scoping review","volume":"14","author":"Roslan","year":"2024","journal-title":"J. Glob. Health"},{"issue":"7","key":"10.1016\/j.envpol.2026.128298_bib32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of various microplastics in human stool: a prospective case series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"issue":"45","key":"10.1016\/j.envpol.2026.128298_bib33","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1021\/acs.est.5c05922","article-title":"The human plastisphere: a bioparticulate system challenging microplastic risk assessment and governance","volume":"59","author":"Shruti","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128298_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167760","article-title":"Detection and quantification of various microplastics in human endometrium based on laser direct infrared spectroscopy","volume":"906","author":"Sun","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128298_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2026.107871","article-title":"Characterization and potential risks of microplastics in marine mollusks using the laser direct infrared (LDIR) technique","volume":"216","author":"Teng","year":"2026","journal-title":"Mar. Environ. Res."},{"issue":"6720","key":"10.1016\/j.envpol.2026.128298_bib36","doi-asserted-by":"crossref","first-page":"eadl2746","DOI":"10.1126\/science.adl2746","article-title":"Twenty years of microplastic pollution research \u2013 what have we learned?","volume":"386","author":"Thompson","year":"2024","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.envpol.2026.128298_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analysis in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Softw"},{"key":"10.1016\/j.envpol.2026.128298_bib38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.envpol.2026.128298_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105118","article-title":"Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites","volume":"103","author":"Wang","year":"2024","journal-title":"EBioMedicine"},{"issue":"12","key":"10.1016\/j.envpol.2026.128298_bib40","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","article-title":"Plastic and human health: a micro issue?","volume":"51","author":"Wright","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128298_bib41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jare.2022.09.004","article-title":"Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence","volume":"49","author":"Wu","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.envpol.2026.128298_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140431","article-title":"Elevated blood microplastics and their potential association with Parkinson's disease","volume":"500","author":"Xu","year":"2025","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envpol.2026.128298_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2026.141054","article-title":"Quantitative human biomonitoring of micro- and nanoplastics: exposure profiles, mechanistic insights, and health implications","volume":"502","author":"Xu","year":"2026","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envpol.2026.128298_bib44","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s40726-023-00273-8","article-title":"Human microplastics exposure and potential health risks to target organs by different routes: a review","volume":"9","author":"Yang","year":"2023","journal-title":"Curr. Pollut. Rep."},{"key":"10.1016\/j.envpol.2026.128298_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.119831","article-title":"Size-dependent toxicological effects of microplastics: a review","volume":"311","author":"Zhou","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126006688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126006688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:53:55Z","timestamp":1783115635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126006688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":45,"alternative-id":["S0269749126006688"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128298","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The invisible burden: A meta-analysis of methodological evolutions and the reassessment of microplastic concentrations in human tissues","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128298","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"128298"}}