{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:01:00Z","timestamp":1791860460365,"version":"4.3.4"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-23524646"],"award-info":[{"award-number":["RS-2025-23524646"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.envpol.2026.128358","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:59:17Z","timestamp":1778889557000},"page":"128358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Gut microbiome and metabolic responses of adult zebrafish (Danio rerio) to the co-exposure of polyethylene microplastics and levofloxacin"],"prefix":"10.1016","volume":"402","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-8999","authenticated-orcid":false,"given":"Mingcan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwoo","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.128358_bib1","series-title":"Gephi: an Open Source Software for Exploring and Manipulating Networks","author":"Bastian","year":"2009"},{"key":"10.1016\/j.envpol.2026.128358_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118790","article-title":"Fate of microplastics in the drinking water production","volume":"221","author":"Bauerlein","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2026.128358_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2023.127399","article-title":"Potential and prospects of actinobacteria in the bioremediation of environmental pollutants: cellular mechanisms and genetic regulations","volume":"273","author":"Behera","year":"2023","journal-title":"Microbiol. Res."},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-79304-z","article-title":"Currently monitored microplastics pose negligible ecological risk to the global ocean","volume":"10","author":"Beiras","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc. B Stat. Methodol."},{"key":"10.1016\/j.envpol.2026.128358_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceja.2024.100649","article-title":"Microplastics in freshwater systems: a review of classification, sources, and environmental impacts","volume":"20","author":"Bexeitova","year":"2024","journal-title":"Chem. Eng. J. Adv."},{"key":"10.1016\/j.envpol.2026.128358_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120440","article-title":"Fluoroquinolone antibiotics: occurrence, mode of action, resistance, environmental detection, and remediation \u2013 a comprehensive review","volume":"315","author":"Bhatt","year":"2022","journal-title":"Environ. Pollut."},{"issue":"8","key":"10.1016\/j.envpol.2026.128358_bib8","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"issue":"8","key":"10.1016\/j.envpol.2026.128358_bib9","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128358_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2016.04.001","article-title":"Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling","volume":"100","author":"Brand","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2026.128358_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132305","article-title":"Unveiling the impact of short-term polyethylene microplastics exposure on metabolomics and gut microbiota in earthworms (eudrilus euganiae)","volume":"460","author":"Chan","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128358_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.128176","article-title":"Transcriptomic and metabolic responses of earthworms to contaminated soil with polypropylene and polyethylene microplastics at environmentally relevant concentrations","volume":"427","author":"Chen","year":"2022","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1921912","article-title":"Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms","volume":"13","author":"Chi","year":"2021","journal-title":"Gut Microbes"},{"issue":"D1","key":"10.1016\/j.envpol.2026.128358_bib14","doi-asserted-by":"crossref","first-page":"D334","DOI":"10.1093\/nar\/gkaf1247","article-title":"SILVA in 2026: a global core biodata resource for rRNA within the DSMZ digital diversity","volume":"54","author":"Chuvochina","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.128358_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2020.120402","article-title":"Behavior of nitrogen, phosphorus and antibiotic resistance genes under polyvinyl chloride microplastics pressures in an aerobic granular sludge system","volume":"256","author":"Dai","year":"2020","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.envpol.2026.128358_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ecoenv.2016.01.015","article-title":"Significance of metabolite extraction method for evaluating sulfamethazine toxicity in adult zebrafish using metabolomics","volume":"127","author":"De Sotto","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.envpol.2026.128358_bib17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.envpol.2026.128358_bib18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1071\/EN14167","article-title":"Microplastic contamination in an urban area: a case study in greater Paris","volume":"12","author":"Dris","year":"2015","journal-title":"Environ. Chem."},{"issue":"9","key":"10.1016\/j.envpol.2026.128358_bib19","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/etc.5950","article-title":"Ecotoxicological effects of microplastics combined with antibiotics in the aquatic environment: recent developments and prospects","volume":"43","author":"Du","year":"2024","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2026.128358_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2023.117632","article-title":"Microplastics exhibit accumulation and horizontal transfer of antibiotic resistance genes","volume":"336","author":"Feng","year":"2023","journal-title":"J. Environ. Manag."},{"issue":"9","key":"10.1016\/j.envpol.2026.128358_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002687","article-title":"Inferring correlation networks from genomic survey data","volume":"8","author":"Friedman","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.envpol.2026.128358_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110039","article-title":"The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos","volume":"189","author":"Fu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128358_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112207","article-title":"Adsorption behavior of organic pollutants on microplastics","volume":"217","author":"Fu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128358_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152617","article-title":"Behaviors and biochemical responses of macroinvertebrate Corbicula fluminea to polystyrene microplastics","volume":"813","author":"Fu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128358_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128874","article-title":"The distinct toxicity effects between commercial and realistic polystyrene microplastics on microbiome and histopathology of gut in zebrafish","volume":"434","author":"Guo","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"7","key":"10.1016\/j.envpol.2026.128358_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16071313","article-title":"Targeting dysregulated lipid metabolism in cancer with pharmacological inhibitors","volume":"16","author":"Gupta","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.envpol.2026.128358_bib27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.envint.2018.02.003","article-title":"Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: its potential for resistance development and ecological and human risk","volume":"114","author":"Hanna","year":"2018","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.envpol.2026.128358_bib28","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1097\/01.ALC.0000167953.97205.0A","article-title":"Reinstatement of serum pregnanolone isomers and progesterone during alcohol detoxification therapy in premenopausal women","volume":"29","author":"Hill","year":"2005","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.envpol.2026.128358_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoleng.2020.106023","article-title":"Response mechanism of typical wetland plants and removal of water pollutants under different levofloxacin concentration","volume":"158","author":"Hongbin","year":"2020","journal-title":"Ecol. Eng."},{"key":"10.1016\/j.envpol.2026.128358_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.141838","article-title":"Comparison of lead adsorption on the aged conventional microplastics, biodegradable microplastics and environmentally-relevant tire wear particles","volume":"460","author":"Huang","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"16","key":"10.1016\/j.envpol.2026.128358_bib31","doi-asserted-by":"crossref","first-page":"19544","DOI":"10.1007\/s11356-021-13184-2","article-title":"Effect of microplastics in water and aquatic systems","volume":"28","author":"Issac","year":"2021","journal-title":"Environ. Sci. Pollut. Control Ser."},{"issue":"11","key":"10.1016\/j.envpol.2026.128358_bib32","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/etc.3552","article-title":"Implications of fluoroquinolone contamination for the aquatic environment\u2014A review","volume":"35","author":"Janecko","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s43247-025-02320-2","article-title":"Quantitative assessment on the distribution patterns of microplastics in global inland waters","volume":"6","author":"Jin","year":"2025","journal-title":"Commun. Earth Environ."},{"issue":"8","key":"10.1016\/j.envpol.2026.128358_bib34","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1021\/acs.estlett.5c00322","article-title":"Strong convergence of floating microplastics at a small-scale estuarine surface front","volume":"12","author":"Jong","year":"2025","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envpol.2026.128358_bib35","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3389\/fped.2024.1381742","article-title":"A retrospective study of the efficacy and safety of levofloxacin in children with severe infection","volume":"12","author":"Junqi","year":"2024","journal-title":"Front. Pediatr."},{"issue":"2","key":"10.1016\/j.envpol.2026.128358_bib36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1194\/jlr.M063412","article-title":"Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1\u03b1-dependent manner","volume":"57","author":"Kakazu","year":"2016","journal-title":"JLR (J. Lipid Res.)"},{"issue":"15","key":"10.1016\/j.envpol.2026.128358_bib37","doi-asserted-by":"crossref","first-page":"12076","DOI":"10.1074\/jbc.M009630200","article-title":"Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress","volume":"276","author":"Kondo","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.envpol.2026.128358_bib38","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","article-title":"Antibiotics in the aquatic environment - a review - part I","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib39","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2172671","article-title":"Bile acids as modulators of gut microbiota composition and function","volume":"15","author":"Larabi","year":"2023","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.envpol.2026.128358_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/ecosalplus.3.6.3.4","article-title":"Biosynthesis of pantothenic acid and coenzyme A","volume":"2","author":"Leonardi","year":"2007","journal-title":"EcoSal Plus"},{"key":"10.1016\/j.envpol.2026.128358_bib41","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.envpol.2018.02.050","article-title":"Adsorption of antibiotics on microplastics","volume":"237","author":"Li","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128358_bib42","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.envpol.2018.02.050","article-title":"Adsorption of antibiotics on microplastics","volume":"237","author":"Li","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128358_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.eti.2024.103860","article-title":"Impact of microplastics pollution on ciprofloxacin bioaccumulation in the edible mussel ( Perna viridis): implications for human gut health risks","volume":"36","author":"Li","year":"2024","journal-title":"Environ. Technol. Innov."},{"issue":"7","key":"10.1016\/j.envpol.2026.128358_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003123","article-title":"Predicting network activity from high throughput metabolomics","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.envpol.2026.128358_bib45","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.biombioe.2012.03.010","article-title":"Novel molecular insights into nitrogen starvation-induced triacylglycerols accumulation revealed by differential gene expression analysis in green algae Micractinium pusillum","volume":"42","author":"Li","year":"2012","journal-title":"Biomass Bioenergy"},{"issue":"2","key":"10.1016\/j.envpol.2026.128358_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/wer.70021","article-title":"Adsorption behavior of levofloxacin hydrochloride on non-degradable microplastics aging with H2O2","volume":"97","author":"Li","year":"2025","journal-title":"Water Environ. Res."},{"key":"10.1016\/j.envpol.2026.128358_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134865","article-title":"Adsorption behaviour of microplastics on the heavy metal Cr(VI) before and after ageing","volume":"302","author":"Li","year":"2022","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52292-5","article-title":"Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish","volume":"9","author":"Limonta","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128358_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116326","article-title":"Integrated physiological, intestinal microbiota, and metabolomic responses of adult zebrafish (Danio rerio) to subacute exposure to antimony at environmentally relevant concentrations","volume":"277","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128358_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116326","article-title":"Integrated physiological, intestinal microbiota, and metabolomic responses of adult zebrafish (Danio rerio) to subacute exposure to antimony at environmentally relevant concentrations","volume":"277","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib51","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1021\/envhealth.5c00087","article-title":"Neurotoxicity of Micro- and nanoplastics: a comprehensive review of central nervous system impacts","volume":"4","author":"Ma","year":"2026","journal-title":"Environ Health (Wash)"},{"key":"10.1016\/j.envpol.2026.128358_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127705","article-title":"Plastic nanoparticles cause mild inflammation, disrupt metabolic pathways, change the gut microbiota and affect reproduction in zebrafish: a full generation multi-omics study","volume":"424","author":"Marana","year":"2022","journal-title":"J. Hazard Mater."},{"issue":"3","key":"10.1016\/j.envpol.2026.128358_bib53","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ismej.2011.139","article-title":"An improved greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea","volume":"6","author":"McDonald","year":"2012","journal-title":"ISME J."},{"key":"10.1016\/j.envpol.2026.128358_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114125","article-title":"Acute exposure to microplastics induces metabolic disturbances and gut dysbiosis in adult zebrafish (Danio rerio)","volume":"245","author":"Medriano","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128358_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136691","article-title":"Chronic exposure of adult zebrafish to polyethylene and polyester-based microplastics: metabolomic and gut microbiome alterations reflecting dysbiosis and resilience","volume":"484","author":"Medriano","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"10","key":"10.1016\/j.envpol.2026.128358_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0240792","article-title":"Bioaccumulation and biomagnification of microplastics in marine organisms: a review and meta-analysis of current data","volume":"15","author":"Miller","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.128358_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1148806","article-title":"Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inflammatory reactions","volume":"15","author":"Neb","year":"2025","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.envpol.2026.128358_bib58","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1194\/jlr.M400102-JLR200","article-title":"Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor","volume":"45","author":"Nishimaki-Mogami","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.envpol.2026.128358_bib59","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"7747","key":"10.1016\/j.envpol.2026.128358_bib60","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41586-019-0984-y","article-title":"An integrative systems genetic analysis of mammalian lipid metabolism","volume":"567","author":"Parker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.128358_bib61","article-title":"Plastics\u2014The fast facts 2023","author":"Plastics Europe","year":"2023","journal-title":"Plast Eur."},{"issue":"2","key":"10.1016\/j.envpol.2026.128358_bib62","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1570-0232(02)00914-5","article-title":"Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography\u2013tandem mass spectrometry","volume":"785","author":"Polson","year":"2003","journal-title":"J. Chromatogr. B"},{"issue":"3","key":"10.1016\/j.envpol.2026.128358_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030277","article-title":"A new targeted lipidomics approach reveals lipid droplets in liver, muscle and heart as a repository for diacylglycerol and ceramide species in non-alcoholic fatty liver","volume":"8","author":"Preuss","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2026.128358_bib64","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.marpolbul.2018.05.022","article-title":"Microplastics pollution in different aquatic environments and biota: a review of recent studies","volume":"133","author":"Rezania","year":"2018","journal-title":"Mar. Pollut. Bull."},{"issue":"2","key":"10.1016\/j.envpol.2026.128358_bib65","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1897\/04-210R.1","article-title":"Toxicity of fluoroquinolone antibiotics to aquatic organisms","volume":"24","author":"Robinson","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2026.128358_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2024.106977","article-title":"Advances of microplastics ingestion on the morphological and behavioral conditions of model zebrafish: a review","volume":"272","author":"Rojoni","year":"2024","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2026.128358_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioflm.2025.100290","article-title":"Unfolding the collective functional potential of a synergistic multispecies community through genotypic and phenotypic analyses","volume":"10","author":"Ronin","year":"2025","journal-title":"Biofilm"},{"key":"10.1016\/j.envpol.2026.128358_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.envadv.2023.100396","article-title":"Microplastics in aquatic systems: a review of occurrence, monitoring and potential environmental risks","volume":"13","author":"Rossatto","year":"2023","journal-title":"Environ. Adv."},{"issue":"15","key":"10.1016\/j.envpol.2026.128358_bib69","doi-asserted-by":"crossref","first-page":"8331","DOI":"10.3390\/ijms25158331","article-title":"Do microplastics have neurological implications in relation to schizophrenia zebrafish models? A brain immunohistochemistry, neurotoxicity assessment, and oxidative stress analysis","volume":"25","author":"Savuca","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.envpol.2026.128358_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.envpol.2026.128358_bib71","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.etap.2019.02.002","article-title":"Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure","volume":"67","author":"Sehonova","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128358_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1225282","article-title":"Genome insight and probiotic potential of three novel species of the genus Corynebacterium","volume":"14","author":"Shamsuzzaman","year":"2023","journal-title":"Front. Microbiol."},{"issue":"12","key":"10.1016\/j.envpol.2026.128358_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11120966","article-title":"Occurrence, bioaccumulation, metabolism and ecotoxicity of fluoroquinolones in the aquatic environment: a review","volume":"11","author":"Shen","year":"2023","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.envpol.2026.128358_bib74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3390\/metabo14040189","article-title":"Sex-specific effects of polystyrene microplastic and lead (II) co-exposure on the gut microbiome and fecal metabolome in C57BL\/6 mice","volume":"14","author":"Shen","year":"2024","journal-title":"Metabolites"},{"issue":"5","key":"10.1016\/j.envpol.2026.128358_bib75","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1471-4159.2004.02589.x","article-title":"Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects","volume":"90","author":"Shirayama","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.envpol.2026.128358_bib76","series-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Statistics for Biology and Health","article-title":"LIMMA: linear models for microarray data","author":"Smyth","year":"2005"},{"key":"10.1016\/j.envpol.2026.128358_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156068","article-title":"Interactions of microplastics with organic, inorganic and bio-pollutants and the ecotoxicological effects on terrestrial and aquatic organisms","volume":"838","author":"Song","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128358_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.eti.2021.101803","article-title":"Cellular adaptation responses in a halotolerant exiguobacterium exhibiting organic solvent tolerance with simultaneous protease production","volume":"23","author":"Srivastava","year":"2021","journal-title":"Environ. Technol. Innov."},{"key":"10.1016\/j.envpol.2026.128358_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2023.119790","article-title":"Antibiotic sorption onto microplastics in water: a critical review of the factors, mechanisms and implications","volume":"233","author":"Stapleton","year":"2023","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2026.128358_bib116","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2021.779321","article-title":"Combined effects of microplastics and benzo[a]pyrene on the marine diatom Chaetoceros muelleri","volume":"8","author":"Su","year":"2022","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.envpol.2026.128358_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123220","article-title":"Acute and chronic effects of polystyrene microplastics on brine shrimp: first evidence highlighting the molecular mechanism through transcriptome analysis","volume":"400","author":"Suman","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128358_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.708495","article-title":"Distinct bile acid profiles in patients with chronic hepatitis B virus infection reveal metabolic interplay between host, virus and Gut microbiome","volume":"8","author":"Sun","year":"2021","journal-title":"Front. Med."},{"issue":"12","key":"10.1016\/j.envpol.2026.128358_bib82","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.3390\/w17121741","article-title":"Microplastics in aquatic ecosystems: a global review of distribution, ecotoxicological impacts, and human health risks","volume":"17","author":"Sunny","year":"2025","journal-title":"Water"},{"issue":"19","key":"10.1016\/j.envpol.2026.128358_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914857","article-title":"The physiological and pathological role of Acyl-CoA oxidation","volume":"24","author":"Szrok-Jurga","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.envpol.2026.128358_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105592","article-title":"Development of a prokaryotic universal primer for simultaneous analysis of bacteria and archaea using next-generation sequencing","volume":"9","author":"Takahashi","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-58163-8","article-title":"Defining the environmental adaptations of Genus devosia: insights into its expansive short peptide transport system and positively selected genes","volume":"10","author":"Talwar","year":"2020","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.envpol.2026.128358_bib86","first-page":"2294","article-title":"N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant","volume":"15","author":"Tan","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.envpol.2026.128358_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121020","article-title":"Microplastic pollution destabilized the osmoregulatory metabolism but did not affect intestinal microbial biodiversity of earthworms in soil","volume":"320","author":"Tang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128358_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130034","article-title":"Nanoplastics induce molecular toxicity in earthworm: integrated multi-omics, morphological, and intestinal microorganism analyses","volume":"442","author":"Tang","year":"2023","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib89","doi-asserted-by":"crossref","DOI":"10.1080\/20964129.2021.1926337","article-title":"Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia","volume":"7","author":"Thiang","year":"2021","journal-title":"Ecosys. Health Sustain."},{"issue":"11","key":"10.1016\/j.envpol.2026.128358_bib90","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1177\/1535370214538743","article-title":"Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer","volume":"239","author":"Tsuei","year":"2014","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.envpol.2026.128358_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128592","article-title":"Exposure to polystyrene microplastics induced gene modulated biological responses in zebrafish (Danio rerio)","volume":"281","author":"Umamaheswari","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.128358_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161022","article-title":"Adsorption of antibiotics on different microplastics (MPs): behavior and mechanism","volume":"863","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"15","key":"10.1016\/j.envpol.2026.128358_bib93","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153683","article-title":"Arachidonic acid metabolism and kidney inflammation","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128358_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117123","article-title":"Microplastics generated from a biodegradable plastic in freshwater and seawater","volume":"198","author":"Wei","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.envpol.2026.128358_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124912","article-title":"Toxicological mechanisms and molecular impacts of tire particles and antibiotics on zebrafish","volume":"362","author":"Wen","year":"2024","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.envpol.2026.128358_bib96","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0149-2918(98)80104-5","article-title":"Levofloxacin: a therapeutic review","volume":"20","author":"Wimer","year":"1998","journal-title":"Clin. Ther."},{"key":"10.1016\/j.envpol.2026.128358_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136616","article-title":"Female zebrafish are more affected than males under polystyrene microplastics exposure","volume":"482","author":"Wu","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128358_bib98","doi-asserted-by":"crossref","first-page":"W71","DOI":"10.1093\/nar\/gkq329","article-title":"MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data","volume":"38","author":"Xia","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.128358_bib99","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3389\/fphar.2024.1435923","article-title":"Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database","volume":"15","author":"Xie","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128358_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127650","article-title":"Adsorption behavior of the antibiotic levofloxacin on microplastics in the presence of different heavy metals in an aqueous solution","volume":"260","author":"Yu","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.128358_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126059","article-title":"Distribution, abundance and risks of microplastics in the environment","volume":"249","author":"Yu","year":"2020","journal-title":"Chemosphere"},{"issue":"15","key":"10.1016\/j.envpol.2026.128358_bib102","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1093\/bioinformatics\/btp291","article-title":"apLCMS\u2014adaptive processing of high-resolution LC\/MS data","volume":"25","author":"Yu","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2026.128358_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131130","article-title":"Microplastics exacerbate co-occurrence and horizontal transfer of antibiotic resistance genes","volume":"451","author":"Yu","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128358_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172503","article-title":"Meta-analysis unravels the complex combined toxicity of microplastics and antibiotics in aquatic ecosystems","volume":"929","author":"Yu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.envpol.2026.128358_bib105","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00383-21","article-title":"Comparative genomics of Exiguobacterium reveals what makes a cosmopolitan bacterium","volume":"6","author":"Zhang","year":"2021","journal-title":"mSystems"},{"issue":"1","key":"10.1016\/j.envpol.2026.128358_bib106","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/bbrc.1996.0065","article-title":"Effect of cystathionine ketimine on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors","volume":"218","author":"Zhang","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.envpol.2026.128358_bib107","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1080\/10643389.2020.1845531","article-title":"Transport of micro- and nanoplastics in the environment: Trojan-horse effect for organic contaminants","volume":"52","author":"Zhang","year":"2022","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128358_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.121833","article-title":"Combined effect and mechanism of microplastic with different particle sizes and levofloxacin on developing Rana nigromaculata : insights from thyroid axis regulation and immune system","volume":"366","author":"Zhang","year":"2024","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.envpol.2026.128358_bib115","doi-asserted-by":"crossref","first-page":"140638","DOI":"10.1016\/j.scitotenv.2020.140638","article-title":"Combined toxicity of microplastics and cadmium on the zebrafish embryos (Danio rerio)","volume":"743","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128358_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.120329","article-title":"The effect and mechanism of variable particle size microplastics and levofloxacin on the neurotoxicity of Rana nigromaculata based on the microorganism-intestine-brain axis","volume":"354","author":"Zhang","year":"2024","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.envpol.2026.128358_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140196","article-title":"Adsorption of levofloxacin by ultraviolet aging microplastics","volume":"343","author":"Zhang","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.128358_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167359","article-title":"Gut microbiota related response of Oryzias melastigma to combined exposure of polystyrene microplastics and tetracycline","volume":"905","author":"Zhao","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.envpol.2026.128358_bib112","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ame2.12227","article-title":"Application of zebrafish in the study of the gut microbiome","volume":"5","author":"Zhong","year":"2022","journal-title":"Animal Model. Exp. Med."},{"key":"10.1016\/j.envpol.2026.128358_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139499","article-title":"Adverse effects of levo floxacin and oxytetracycline on aquatic microbial communities","volume":"734","author":"Zhou","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128358_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165414","article-title":"Interaction between antibiotics and microplastics: recent advances and perspective","volume":"897","author":"Zhuang","year":"2023","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126007281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126007281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:38:32Z","timestamp":1783161512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126007281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":116,"alternative-id":["S0269749126007281"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128358","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiome and metabolic responses of adult zebrafish (Danio rerio) to the co-exposure of polyethylene microplastics and levofloxacin","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128358"}}