{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:15:17Z","timestamp":1783754117603,"version":"3.55.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010416","name":"Rollins School of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.envpol.2026.128524","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:46:26Z","timestamp":1780616786000},"page":"128524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association between mixed metal exposure and depressive symptoms in the elderly: The moderating role of magnesium and mediating role of amino acids"],"prefix":"10.1016","volume":"405","author":[{"given":"Qianru","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu-nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangbiao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-1619","authenticated-orcid":false,"given":"Jie","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.128524_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/biom14070869","article-title":"Molybdenum's role as an essential element in enzymes catabolizing redox reactions: a review","volume":"14","author":"Adamus","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.envpol.2026.128524_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0338582","article-title":"Blood draw site and blood matrix influence mineral assessment","volume":"20","author":"Alejandro","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.128524_bib3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00127-023-02495-z","article-title":"Prevalence and associated factors of depression in Sri Lanka: a systematic review and meta-analysis","volume":"59","author":"Alwis","year":"2024","journal-title":"Soc. Psychiatr. Psychiatr. Epidemiol."},{"key":"10.1016\/j.envpol.2026.128524_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135808","article-title":"Manganese exposure leads to depressive-like behavior through disruption of the Gln\u2013Glu\u2013GABA metabolic cycle","volume":"480","author":"Bi","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128524_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12940-018-0413-y","article-title":"Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression","volume":"17","author":"Bobb","year":"2018","journal-title":"Environ. Health"},{"key":"10.1016\/j.envpol.2026.128524_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jpsychires.2021.12.039","article-title":"Alterations in the kynurenine pathway and excitatory amino acid transporter-2 in depression with and without psychosis: evidence of a potential astrocyte pathology","volume":"147","author":"Brown","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.envpol.2026.128524_bib7","doi-asserted-by":"crossref","DOI":"10.5498\/wjp.v15.i5.102618","article-title":"Alterations of serum metabolic profile in major depressive disorder: a case-control study in the Chinese population","volume":"15","author":"Cao","year":"2025","journal-title":"World J. Psychiatr."},{"key":"10.1016\/j.envpol.2026.128524_bib8","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s12011-015-0610-2","article-title":"Effect of stress from cadmium combined with different levels of Molybdenum on serum free radical and expression of related apoptosis genes in goat livers","volume":"172","author":"Cao","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2026.128524_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajp.2025.104502","article-title":"Advances in the study of NMDA receptors in depression pathogenesis and the antidepressant efficacy of their antagonists","volume":"108","author":"Chen","year":"2025","journal-title":"Asian J. Psychiatry"},{"key":"10.1016\/j.envpol.2026.128524_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/nu15040847","article-title":"Beneficial effect of increased tryptophan intake on its metabolism and mental state of the elderly","volume":"15","author":"Chojnacki","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128524_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/nu15030774","article-title":"The association of serum and dietary magnesium with depressive symptoms","volume":"15","author":"Chou","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128524_bib12","article-title":"Influence of molybdenum and organic sources of copper and sulfur on the performance, carcass traits, blood mineral concentration, and ceruloplasmin activity in lambs","volume":"13","author":"Conti","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.envpol.2026.128524_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12877-021-02675-z","article-title":"Factors affecting the evolution of Chinese elderly depression: a cross-sectional study","volume":"22","author":"Cui","year":"2022","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.envpol.2026.128524_bib14","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.2147\/NDT.S347356","article-title":"Recognizing depression in the elderly: practical guidance and challenges for clinical management","volume":"18","author":"Devita","year":"2022","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.envpol.2026.128524_bib15","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1080\/01480545.2025.2525149","article-title":"Heavy metal mixture induced hippocampal toxicity involve biometal accumulation, increase in oxidative stress, inflammation, and caspase-3 activation in rats via Nrf-2\/HO-1\/BDNF pathway","volume":"48","author":"Dooka","year":"2025","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.envpol.2026.128524_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111139","article-title":"Preclinical evidences of aluminum-induced neurotoxicity in hippocampus and pre-frontal cortex of rats exposed to low doses","volume":"206","author":"Fernandes","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128524_bib17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4236\/odem.2022.104020","article-title":"Vulnerability to stress and depression risk related to occupational exposure to aluminum","volume":"10","author":"Ghita","year":"2022","journal-title":"Occup. Dis. Environ. Med."},{"key":"10.1016\/j.envpol.2026.128524_bib18","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.20259","article-title":"Environmental toxicant exposure and depressive symptoms","volume":"7","author":"Guo","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.envpol.2026.128524_bib19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s12011-014-0033-5","article-title":"Analysis of human serum and whole blood for mineral content by ICP-MS and ICP-OES: development of a mineralomics method","volume":"160","author":"Harrington","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2026.128524_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.8","article-title":"Abnormality in glutamine-glutamate cycle in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder: a 3-year follow-up study","volume":"6","author":"Hashimoto","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.envpol.2026.128524_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.yrtph.2018.08.001","article-title":"Molybdenum bupropion combined neurotoxicity in rats","volume":"98","author":"Helaly","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128524_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032231","article-title":"The utility of amino acid metabolites in the diagnosis of major depressive disorder and correlations with depression severity","volume":"24","author":"Ho","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128524_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/1047322X.1990.10389587","article-title":"Estimation of average concentration in the presence of nondetectable values","volume":"5","author":"Hornung","year":"1990","journal-title":"Appl. Occup. Environ. Hyg"},{"key":"10.1016\/j.envpol.2026.128524_bib24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s42003-024-06547-1","article-title":"Glutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK","volume":"7","author":"Huang","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.envpol.2026.128524_bib25","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1186\/s12888-023-04953-z","article-title":"Association between serum copper, zinc, and selenium concentrations and depressive symptoms in the US adult population, NHANES (2011-2016)","volume":"23","author":"Huang","year":"2023","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.envpol.2026.128524_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/s12877-021-02266-y","article-title":"Is geriatric depression scale a valid instrument to screen depression in Chinese community-dwelling elderly?","volume":"21","author":"Huang","year":"2021","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.envpol.2026.128524_bib27","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.neuron.2025.01.021","article-title":"Structural insights into the diverse actions of magnesium on NMDA receptors","volume":"113","author":"Huang","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.envpol.2026.128524_bib28","doi-asserted-by":"crossref","DOI":"10.5620\/eaht.2025s08","article-title":"Quantitative neurotoxic effects of heavy metals and glutamate in mouse hippocampal neuronal cells","volume":"40","author":"Jamsranjav","year":"2025","journal-title":"Environmental Analysis Health and Toxicology"},{"key":"10.1016\/j.envpol.2026.128524_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biom13010143","article-title":"The combined administration of vitamin C and copper induces a systemic oxidative stress and kidney injury","volume":"13","author":"Jiang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.envpol.2026.128524_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2021.113713","article-title":"Development and validation of a biomonitoring method to measure As, Cr, and Ni in human urine samples by ICP-UCT-MS","volume":"234","author":"Jones","year":"2021","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envpol.2026.128524_bib31","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.talanta.2016.09.060","article-title":"Analysis of whole human blood for Pb, Cd, Hg, Se, and Mn by ICP-DRC-MS for biomonitoring and acute exposures","volume":"162","author":"Jones","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.envpol.2026.128524_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127611","article-title":"Accelerated biological aging underlies the link between heavy metal mixture exposure and depression: a multi-omics study","volume":"391","author":"Kan","year":"2026","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128524_bib33","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/adhm.201300572","article-title":"Fabrication of barium- and strontium-doped silica\/titania hollow nanoparticles and their synergetic effects on promoting neuronal differentiation by activating ERK and p38 pathways","volume":"3","author":"Kim","year":"2014","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.envpol.2026.128524_bib34","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.2174\/0113816128321466240816075041","article-title":"Magnesium (Mg(2+)): essential mineral for neuronal health: from cellular biochemistry to cognitive health and behavior regulation","volume":"30","author":"Kumar","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.envpol.2026.128524_bib35","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1002\/sim.8701","article-title":"Performance of variable and function selection methods for estimating the nonlinear health effects of correlated chemical mixtures: a simulation study","volume":"39","author":"Lazarevic","year":"2020","journal-title":"Stat. Med."},{"key":"10.1016\/j.envpol.2026.128524_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.115460","article-title":"Spatial and temporal characteristics of air pollutants and their health effects in China during 2019-2020","volume":"317","author":"Lei","year":"2022","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.envpol.2026.128524_bib37","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s12011-022-03232-4","article-title":"Comparison and risk assessment of macroelements and trace metals in commercial teas from different regions of China","volume":"201","author":"Li","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2026.128524_bib38","article-title":"Multi-Isotopic compositions of ores from the Shizishan cu\u2013au\u2013mo orefield in the Tongling Region, Eastern China: implications for ore genesis","volume":"13","author":"Li","year":"2023","journal-title":"Minerals"},{"key":"10.1016\/j.envpol.2026.128524_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/metabo15080541","article-title":"Molybdenum-induced oxidative and inflammatory injury and metabolic pathway disruption in goat pancreas","volume":"15","author":"Li","year":"2025","journal-title":"Metabolites"},{"key":"10.1016\/j.envpol.2026.128524_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.120290","article-title":"The association between heavy metals co-exposures and depression: a convergence of network toxicology and epidemiology","volume":"393","author":"Li","year":"2026","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.envpol.2026.128524_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.geomorph.2011.01.010","article-title":"Major element chemistry in the upper Yangtze river: a case study of the Longchuanjiang river","volume":"129","author":"Li","year":"2011","journal-title":"Geomorphology"},{"key":"10.1016\/j.envpol.2026.128524_bib42","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12964-023-01267-1","article-title":"Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death","volume":"21","author":"Li","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.envpol.2026.128524_bib43","article-title":"Unveiling chiral amino acid alterations and glycine dysregulation in late-life depression through targeted metabolomics","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.envpol.2026.128524_bib44","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1002\/sim.7947","article-title":"Bayesian varying coefficient kernel machine regression to assess neurodevelopmental trajectories associated with exposure to complex mixtures","volume":"37","author":"Liu","year":"2018","journal-title":"Stat. Med."},{"key":"10.1016\/j.envpol.2026.128524_bib45","doi-asserted-by":"crossref","first-page":"7429","DOI":"10.1038\/s41598-023-34688-6","article-title":"Driving factors on accumulation of cadmium, lead, copper, zinc in agricultural soil and products of the North China plain","volume":"13","author":"Liu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128524_bib46","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1017\/S0007114523000740","article-title":"Association between serum iron, blood lead, cadmium, mercury, selenium, manganese and low cognitive performance in old adults from national health and nutrition examination survey (NHANES): a cross-sectional study","volume":"130","author":"Lu","year":"2023","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.envpol.2026.128524_bib47","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s10311-020-01146-y","article-title":"Increased depression risk for elderly women with high blood levels of strontium and barium","volume":"19","author":"Lv","year":"2021","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.envpol.2026.128524_bib48","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41380-018-0252-9","article-title":"Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies","volume":"24","author":"Moriguchi","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.envpol.2026.128524_bib49","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/nyas.12669","article-title":"Diagnosis and treatment of depression and cognitive impairment in late life","volume":"1345","author":"Morimoto","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128524_bib50","doi-asserted-by":"crossref","first-page":"632","DOI":"10.5219\/1665","article-title":"The xanthine oxidase and its associated activities in the ovine milk and liver: distinctive in impact of in vivo molybdenum","volume":"15","author":"Mukhamejanova","year":"2021","journal-title":"Potravinarstvo Slovak Journal of Food Sciences"},{"key":"10.1016\/j.envpol.2026.128524_bib51","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12888-021-03145-x","article-title":"Prevalence of depression and associated factors among elderly people in Womberma District, north-west, Ethiopia","volume":"21","author":"Mulat","year":"2021","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.envpol.2026.128524_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1406455","article-title":"Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline","volume":"15","author":"Patel","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envpol.2026.128524_bib53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1192\/bjo.2018.22","article-title":"Magnesium and mood disorders: systematic review and meta-analysis","volume":"4","author":"Phelan","year":"2018","journal-title":"BJPsych Open"},{"key":"10.1016\/j.envpol.2026.128524_bib54","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/14737175.2019.1643237","article-title":"An update on NMDA antagonists in depression","volume":"19","author":"Pochwat","year":"2019","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.envpol.2026.128524_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/nu15092221","article-title":"Clinical outcomes of the deleterious effects of aluminum on neuro-cognition, inflammation, and health: a review","volume":"15","author":"Renke","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128524_bib56","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neuro.2021.07.004","article-title":"Manganese-induced reactive oxygen species activate IkappaB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro","volume":"86","author":"Rizor","year":"2021","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envpol.2026.128524_bib57","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1007\/s12011-024-04289-z","article-title":"Iron metabolism, calcium, magnesium and trace elements: a review","volume":"203","author":"Rolic","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2026.128524_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109436","article-title":"Oxidative stress mitigation and initiation of antioxidant and osmoprotectant responses mediated by ascorbic acid in Brassica juncea L. subjected to copper (II) stress","volume":"182","author":"Sharma","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128524_bib59","first-page":"1","article-title":"Molecular mechanisms of aluminum neurotoxicity: update on adverse effects and therapeutic strategies","volume":"5","author":"Skalny","year":"2021","journal-title":"Adv Neurotoxicol"},{"key":"10.1016\/j.envpol.2026.128524_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26189247","article-title":"Copper dysregulation in major depression: a systematic review and meta-analytic evidence for a putative trait marker","volume":"26","author":"Squitti","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128524_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1454273","article-title":"Structural bases for blockade and activation of BK channels by Ba(2+) ions","volume":"11","author":"Srivastava","year":"2024","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.envpol.2026.128524_bib62","article-title":"On the mechanism of calcium permeability and magnesium block in NMDA receptors - a central molecular paradigm in neuroplasticity","author":"Steigerwald","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.envpol.2026.128524_bib63","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/mus.20928","article-title":"Paradoxical depolarization of BA2+- treated muscle exposed to low extracellular K+: insights into resting potential abnormalities in hypokalemic paralysis","volume":"37","author":"Struyk","year":"2008","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.envpol.2026.128524_bib64","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jad.2018.12.114","article-title":"Dietary magnesium intake and risk of depression","volume":"246","author":"Sun","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.envpol.2026.128524_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1450983","article-title":"Association between serum and urinary environmental metal levels and major depressive disorder: a study based on logistic regression and quantile regression","volume":"12","author":"Sun","year":"2024","journal-title":"Front. Public Health"},{"key":"10.1016\/j.envpol.2026.128524_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16030325","article-title":"Seasonal variation and quality assessment of the major and trace elements of atmospheric dust in a typical Karst City, Southwest China","volume":"16","author":"Tang","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envpol.2026.128524_bib67","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.4103\/jfmpc.jfmpc_1813_20","article-title":"Translation, validation and cross-cultural adaptation of the geriatric depression scale (GDS-30) for utilization amongst speakers of Malayalam; the regional language of the South Indian State of Kerala","volume":"10","author":"Thomas","year":"2021","journal-title":"J. Fam. Med. Prim. Care"},{"key":"10.1016\/j.envpol.2026.128524_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111065","article-title":"Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress","volume":"40","author":"Tsai","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.envpol.2026.128524_bib69","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/15622975.2019.1612090","article-title":"Lowered zinc and copper levels in drug-naive patients with major depression: effects of antidepressants, ketoprofen and immune activation","volume":"21","author":"Twayej","year":"2020","journal-title":"World J. Biol. Psychiatr."},{"key":"10.1016\/j.envpol.2026.128524_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/nu17132216","article-title":"The role of magnesium in depression, migraine, Alzheimer's disease, and cognitive health: a comprehensive review","volume":"17","author":"Varga","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128524_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121157","article-title":"Molybdenum and cadmium co-induce oxidative stress and apoptosis through mitochondria-mediated pathway in duck renal tubular epithelial cells","volume":"383","author":"Wang","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128524_bib72","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1021\/acs.est.2c07210","article-title":"Bayesian-based approaches to exploring the long-term alteration in trace metals of surface water and its driving forces","volume":"57","author":"Wang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128524_bib73","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jes.2017.09.018","article-title":"Fog composition along the Yangtze river basin: detecting emission sources of pollutants in fog water","volume":"71","author":"Xu","year":"2018","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.envpol.2026.128524_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118458","article-title":"The significance of dysregulated serine metabolism in depression","volume":"191","author":"Yan","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envpol.2026.128524_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132968","article-title":"Whole blood cadmium levels and depressive symptoms in Chinese young adults: a prospective cohort study combing metabolomics","volume":"465","author":"Yang","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128524_bib76","article-title":"Factors associated with violence in bipolar disorder versus major depressive disorder: insights from a retrospective cross-sectional study of 141 aged patients with mood disorders","volume":"16","author":"Ye","year":"2025","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.envpol.2026.128524_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119356","article-title":"A review of practical statistical methods used in epidemiological studies to estimate the health effects of multi-pollutant mixture","volume":"306","author":"Yu","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128524_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116963","article-title":"Associations between blood nickel and lung function in young Chinese: an observational study combining epidemiology and metabolomics","volume":"284","author":"Zhao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128524_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.oregeorev.2023.105432","article-title":"Geology, geochronology, and geochemistry of the Gaojiabang tungsten-molybdenum deposit, Anhui Province, Southeast China","volume":"157","author":"Zheng","year":"2023","journal-title":"Ore Geol. Rev."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126008948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126008948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:49:48Z","timestamp":1783752588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126008948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":79,"alternative-id":["S0269749126008948"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128524","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between mixed metal exposure and depressive symptoms in the elderly: The moderating role of magnesium and mediating role of amino acids","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128524"}}