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Toxicol."},{"key":"10.1016\/j.envpol.2026.128650_bib110","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3390\/cancers15030583","article-title":"The \u03b2-Blocker carvedilol prevents Benzo(a)pyrene-Induced lung toxicity, inflammation and carcinogenesis","volume":"15","author":"Shahid","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.envpol.2026.128650_bib111","first-page":"45","article-title":"DIFFERENTIAL CARCINOGENICITY OF BENZO[a]PYRENE IN MALE AND FEMALE CD-1 MOUSE LUNG","volume":"52","author":"Sharma","year":"1997","journal-title":"J. Toxicol. Environ. 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