{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:47:16Z","timestamp":1786117636723,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.envpol.2026.128658","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:00:50Z","timestamp":1782601250000},"page":"128658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Associations and biological pathways between joint exposure to ambient air pollutants and brain disorders: a prospective cohort study"],"prefix":"10.1016","volume":"406","author":[{"given":"Tong-Jie","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun-Xian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-7397","authenticated-orcid":false,"given":"Bao-Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.envpol.2026.128658_bib1","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.1212\/WNL.0000000000201419","article-title":"Air pollution and incidence of dementia: a systematic review and meta-analysis","volume":"100","author":"Abolhasani","year":"2023","journal-title":"Neurology"},{"issue":"34","key":"10.1016\/j.envpol.2026.128658_bib2","doi-asserted-by":"crossref","first-page":"42390","DOI":"10.1007\/s11356-020-10574-w","article-title":"Inflammatory effects of particulate matter air pollution","volume":"27","author":"Arias-P\u00e9rez","year":"2020","journal-title":"Environ. Sci. Pollut. Control Ser."},{"issue":"9","key":"10.1016\/j.envpol.2026.128658_bib3","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1161\/CIRCRESAHA.124.324411","article-title":"Exposure to fine particulate matter air pollution disrupts erythrocyte turnover","volume":"134","author":"Asplund","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.envpol.2026.128658_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.atmosenv.2013.02.037","article-title":"Development of NO2 and NOx land use regression models for estimating air pollution exposure in 36 study areas in Europe \u2013 the ESCAPE project","volume":"72","author":"Beelen","year":"2013","journal-title":"Atmos. Environ."},{"issue":"150111","key":"10.1016\/j.envpol.2026.128658_bib5","article-title":"Oxidative stress-induced mechanisms in neurodegeneration and eryptosis: implications for neurological and systemic disorders","volume":"1872","author":"Boras","year":"2026","journal-title":"Brain Res."},{"key":"10.1016\/j.envpol.2026.128658_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118245","article-title":"Air pollution exposure and depression: a comprehensive updated systematic review and meta-analysis","volume":"292","author":"Borroni","year":"2022","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.envpol.2026.128658_bib7","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.4525","article-title":"Metabolic profile and long-term risk of depression, anxiety, and stress-related disorders","volume":"7","author":"Chourpiliadis","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.envpol.2026.128658_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139859","article-title":"Does ambient air pollution influence biochemical markers of liver injury? Findings of a cross-sectional population-based survey","volume":"340","author":"Dales","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.128658_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/bs.acc.2023.05.005","article-title":"Biomarkers in psychiatric disorders","volume":"116","author":"de Jesus","year":"2023","journal-title":"Adv. Clin. Chem."},{"issue":"1","key":"10.1016\/j.envpol.2026.128658_bib10","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02140-2018","article-title":"Air pollution, lung function and COPD: results from the population-based UK Biobank study","volume":"54","author":"Doiron","year":"2019","journal-title":"Eur. Respir. J."},{"issue":"6","key":"10.1016\/j.envpol.2026.128658_bib11","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1161\/01.STR.0000126609.18735.be","article-title":"Serum albumin level as a predictor of ischemic stroke outcome","volume":"35","author":"Dziedzic","year":"2004","journal-title":"Stroke"},{"issue":"20","key":"10.1016\/j.envpol.2026.128658_bib12","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1021\/es301948k","article-title":"Development of land use regression models for PM2.5, PM2.5 absorbance, PM10 and PMcoarse in 20 European study areas; results of the ESCAPE project","volume":"46","author":"Eeftens","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128658_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7358\/neur-2025-038-eska","article-title":"Neuroinflammation and psychiatry: bridging the gap between the immune system and mental health","author":"Eskandar","year":"2025","journal-title":"Neuropsychol. Trends"},{"issue":"1","key":"10.1016\/j.envpol.2026.128658_bib14","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10391","article-title":"Long-term air pollution, genetic susceptibility, and the risk of depression and anxiety: a prospective study in the UK biobank cohort","volume":"131","author":"Gao","year":"2023","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.envpol.2026.128658_bib15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the global burden of disease study 2019","volume":"9","year":"2022","journal-title":"Lancet Psychiatry"},{"issue":"4","key":"10.1016\/j.envpol.2026.128658_bib16","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the global burden of disease study 2021","volume":"23","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.envpol.2026.128658_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.120131","article-title":"Long-term air pollution exposure and the blood metabolome: the rotterdam study","volume":"263","author":"Ginos","year":"2024","journal-title":"Environ. Res."},{"issue":"12","key":"10.1016\/j.envpol.2026.128658_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124306","article-title":"Ambient air pollution increases the risk of cerebrovascular and neuropsychiatric disorders through induction of inflammation and oxidative stress","volume":"21","author":"Hahad","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.envpol.2026.128658_bib19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1164\/rccm.202011-4063OC","article-title":"Air pollution, genetic factors, and the risk of lung cancer: a prospective study in the UK Biobank","volume":"204","author":"Huang","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.envpol.2026.128658_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-024-01108-9","article-title":"Long-term ambient air pollution exposure and renal function and biomarkers of renal disease","volume":"23","author":"Kilbo Edlund","year":"2024","journal-title":"Environ. Health"},{"issue":"11","key":"10.1016\/j.envpol.2026.128658_bib21","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jchf.2017.07.009","article-title":"Targeted metabolomic profiling of plasma and survival in heart failure patients","volume":"5","author":"Lanfear","year":"2017","journal-title":"JACC Heart Fail"},{"issue":"12","key":"10.1016\/j.envpol.2026.128658_bib22","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s44284-024-00156-z","article-title":"Long-term exposure to ambient benzene and brain disorders among urban adults","volume":"1","author":"Li","year":"2024","journal-title":"Nature Cities"},{"issue":"8","key":"10.1016\/j.envpol.2026.128658_bib23","doi-asserted-by":"crossref","first-page":"9029","DOI":"10.1007\/s11356-021-12357-3","article-title":"Association between particulate matter air pollution and risk of depression and suicide: a systematic review and meta-analysis","volume":"28","author":"Liu","year":"2021","journal-title":"Environ. Sci. Pollut. Control Ser."},{"issue":"10","key":"10.1016\/j.envpol.2026.128658_bib24","doi-asserted-by":"crossref","DOI":"10.1289\/EHP4757","article-title":"Long-term exposure to particulate air pollution, black carbon, and their source components in relation to ischemic heart disease and stroke","volume":"127","author":"Ljungman","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.envpol.2026.128658_bib25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1212\/WNL.0000000000201630","article-title":"Impacts of climate change and air pollution on neurologic health, disease, and practice","volume":"100","author":"Louis","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.envpol.2026.128658_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2020.00014","article-title":"Environmental and health impacts of air pollution: a review","volume":"8","author":"Manisalidis","year":"2020","journal-title":"Front. Public Health"},{"issue":"12","key":"10.1016\/j.envpol.2026.128658_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9121224","article-title":"HDL proteome and Alzheimer's disease: evidence of a link","volume":"9","author":"Marsillach","year":"2020","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.envpol.2026.128658_bib28","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.128658_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111333","article-title":"Erythrocytes as markers of oxidative stress related pathologies","volume":"191","author":"Massaccesi","year":"2020","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.envpol.2026.128658_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1289\/ehp.11654","article-title":"Is there evidence for synergy among air pollutants in causing health effects?","volume":"117","author":"Mauderly","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.128658_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2024.105900","article-title":"An overview of the relationship between inflammation and cognitive function in humans, molecular pathways and the impact of nutraceuticals","volume":"181","author":"Mekhora","year":"2024","journal-title":"Neurochem. Int."},{"issue":"10","key":"10.1016\/j.envpol.2026.128658_bib32","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/s43587-024-00688-y","article-title":"Accelerometer-derived \u2018weekend warrior\u2019 physical activity pattern and brain health","volume":"4","author":"Min","year":"2024","journal-title":"Nat. Aging"},{"issue":"2","key":"10.1016\/j.envpol.2026.128658_bib33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/wps.21219","article-title":"Impact of air pollution and climate change on mental health outcomes: an umbrella review of global evidence","volume":"23","author":"Radua","year":"2024","journal-title":"World Psychiatry"},{"issue":"7","key":"10.1016\/j.envpol.2026.128658_bib34","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1007\/s11064-023-03873-4","article-title":"Biomarkers: role and scope in neurological disorders","volume":"48","author":"Sharma","year":"2023","journal-title":"Neurochem. Res."},{"issue":"3","key":"10.1016\/j.envpol.2026.128658_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/bib\/bbr001","article-title":"Using cross-validation to evaluate predictive accuracy of survival risk classifiers based on high-dimensional data","volume":"12","author":"Simon","year":"2011","journal-title":"Brief Bioinform"},{"issue":"3","key":"10.1016\/j.envpol.2026.128658_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med."},{"key":"10.1016\/j.envpol.2026.128658_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123758","article-title":"Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: a population-based longitudinal study","volume":"347","author":"Tian","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128658_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136498","article-title":"Metabolomic profiling identifies signatures and biomarkers linking air pollution to dementia risk: a prospective cohort study","volume":"480","author":"Tian","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"5","key":"10.1016\/j.envpol.2026.128658_bib39","article-title":"Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders","volume":"1867","author":"Turri","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.envpol.2026.128658_bib40","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.i582","article-title":"Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank","author":"Tyrrell","year":"2016","journal-title":"Bmj"},{"key":"10.1016\/j.envpol.2026.128658_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108725","article-title":"Association of residential air pollution, noise, and greenspace with initial ischemic stroke severity","volume":"179","author":"Vivanco-Hidalgo","year":"2019","journal-title":"Environ. Res."},{"issue":"18","key":"10.1016\/j.envpol.2026.128658_bib42","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221097120","article-title":"High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation","volume":"120","author":"Wang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"16","key":"10.1016\/j.envpol.2026.128658_bib43","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehaa1031","article-title":"Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank","volume":"42","author":"Wang","year":"2021","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.envpol.2026.128658_bib44","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000983","article-title":"Short\u2010term changes in ambient particulate matter and risk of stroke: a systematic review and meta\u2010analysis","volume":"3","author":"Wang","year":"2014","journal-title":"J. Am. Heart Assoc."},{"issue":"4","key":"10.1016\/j.envpol.2026.128658_bib46","doi-asserted-by":"crossref","DOI":"10.1001\/jamapsychiatry.2022.4812","article-title":"Long-term exposure to multiple ambient air pollutants and association with incident depression and anxiety","volume":"80","author":"Yang","year":"2023","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.envpol.2026.128658_bib47","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/febs.16344","article-title":"Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise","volume":"290","author":"Yin","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.envpol.2026.128658_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107622","article-title":"Ambient air pollution exposure and depressive symptoms: findings from the French CONSTANCES cohort","volume":"170","author":"Zare Sakhvidi","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.128658_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173009","article-title":"Air pollutants, genetic susceptibility, and incident schizophrenia in later life: a prospective study in the UK Biobank","volume":"934","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.envpol.2026.128658_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24351","article-title":"Association between red blood cell distribution width\u2010to\u2010albumin ratio and diabetic retinopathy","volume":"36","author":"Zhao","year":"2022","journal-title":"J. Clin. Lab. Anal."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126010286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126010286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:13:46Z","timestamp":1786025626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126010286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":49,"alternative-id":["S0269749126010286"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128658","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations and biological pathways between joint exposure to ambient air pollutants and brain disorders: a prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128658","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128658"}}