{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:47:00Z","timestamp":1791791220140,"version":"4.3.4"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42307530"],"award-info":[{"award-number":["42307530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42177410"],"award-info":[{"award-number":["42177410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42130611"],"award-info":[{"award-number":["42130611"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.envpol.2026.128786","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:04:05Z","timestamp":1784127845000},"page":"128786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Toxic mechanisms and biomarkers of Staphylococcus aureus aerosol exposure to human respiratory cells at the air-liquid interface"],"prefix":"10.1016","volume":"407","author":[{"given":"Zhishu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanran","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasheng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1885-7883","authenticated-orcid":false,"given":"Simin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.128786_bib1","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1007\/s12013-025-01686-6","article-title":"Regulatory roles and therapeutic potential of miR-122-5p in hypoxic-ischemic brain injury: comprehensive review","volume":"83","author":"Bamahel","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.envpol.2026.128786_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1478-811X-7-13","article-title":"Crk and CrkL adaptor proteins: networks for physiological and pathological signaling","volume":"7","author":"Birge","year":"2009","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.envpol.2026.128786_bib3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41577-023-00914-5","article-title":"Bacteria form unique biofilms to kill immune cells","volume":"23","author":"Bordon","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envpol.2026.128786_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2024.105889","article-title":"Aerosol exposure at air-liquid-interface (AE-ALI) in vitro toxicity system characterisation: particle deposition and the importance of air control responses","volume":"100","author":"Buckley","year":"2024","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2026.128786_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118420","article-title":"MicroRNA expression in response to environmental hazards: implications for health","volume":"300","author":"Chaiwangyen","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128786_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73000-y","article-title":"Cleistocalyx nervosum var. paniala mitigates oxidative stress and inflammation induced by PM(10) soluble extract in trophoblast cells via miR-146a-5p","volume":"14","author":"Chaiwangyen","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128786_bib7","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41401-020-00603-2","article-title":"NOD-like receptors in autoimmune diseases","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.envpol.2026.128786_bib8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ecoenv.2018.09.034","article-title":"Summer\u2013winter differences of PM2.5 toxicity to human alveolar epithelial cells (A549) and the roles of transition metals","volume":"165","author":"Chen","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128786_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173404","article-title":"Online monitoring system for qualitative and quantitative analysis of bioaerosols by combined ATP bioluminescence assay with loop-mediated isothermal amplification","volume":"937","author":"Chen","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128786_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113961","article-title":"microRNAs expression in relation to particulate matter exposure: a systematic review","volume":"260","author":"Cheng","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128786_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10453-020-09687-z","article-title":"Morning-evening variation and determinants of bacterial and fungal aerosol concentration in historical objects in Krakow","volume":"37","author":"Chmiel","year":"2021","journal-title":"Aerobiologia"},{"key":"10.1016\/j.envpol.2026.128786_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jhin.2017.12.011","article-title":"Virulence patterns of Staphylococcus aureus strains from nasopharyngeal colonization","volume":"100","author":"Deinhardt-Emmer","year":"2018","journal-title":"J. Hosp. Infect."},{"key":"10.1016\/j.envpol.2026.128786_bib13","doi-asserted-by":"crossref","first-page":"22593","DOI":"10.1073\/pnas.1011624108","article-title":"T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism","volume":"107","author":"Edfeldt","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128786_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00248-007-9216-3","article-title":"Culturable airborne bacteria in outdoor environments in Beijing, China","volume":"54","author":"Fang","year":"2007","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.envpol.2026.128786_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009759","article-title":"Altered microRNA expression in COVID-19 patients enables identification of SARS-CoV-2 infection","volume":"17","author":"Farr","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.envpol.2026.128786_bib16","first-page":"1","article-title":"Review on Staphylococcus Aureus","volume":"1","author":"Fayisa","year":"2023","journal-title":"Int. J. Nurs. Health Care Res."},{"key":"10.1016\/j.envpol.2026.128786_bib17","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/microorganisms11071656","article-title":"Roles of the Crp\/Fnr family regulator ArcR in the hemolysis and biofilm of Staphylococcus aureus","volume":"11","author":"Fu","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.envpol.2026.128786_bib18","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: Role in Redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.envpol.2026.128786_bib19","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1021\/acs.est.4c09497","article-title":"Airborne Staphylococcus aureus exposure induces depression-like behaviors in mice via abnormal neural oscillation and mitochondrial dysfunction","volume":"59","author":"Gao","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128786_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1343385","article-title":"The biological interplay between air pollutants and miRNAs regulation in cancer","volume":"12","author":"Giammona","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2026.128786_bib21","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1093\/nar\/gkv249","article-title":"Pathway analysis from lists of microRNAs: common pitfalls and alternative strategy","volume":"43","author":"Godard","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.128786_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.658141","article-title":"Staphylococcus aureus \u03b2-Hemolysin Up-Regulates the expression of IFN-\u03b3 by human CD56(bright) NK cells","volume":"11","author":"Guan","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.envpol.2026.128786_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s12013-024-01526-z","article-title":"PM2.5 exposure aggravates inflammatory response and mucus production in 16HBE cells through inducing oxidative stress and RAGE expression","volume":"83","author":"Han","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.envpol.2026.128786_bib24","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species","volume":"44","author":"He","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.envpol.2026.128786_bib25","doi-asserted-by":"crossref","first-page":"8831","DOI":"10.1038\/s41598-025-92538-z","article-title":"RAC1 promotes the occurrence and development of tongue squamous cell carcinoma by regulating RAC1\/PAK1\/LIMK1 signaling pathway","volume":"15","author":"He","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128786_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrc1251","article-title":"Mucins in cancer: protection and control of the cell surface","volume":"4","author":"Hollingsworth","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.envpol.2026.128786_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.125739","article-title":"Pollution profiles, pathogenicity, and toxicity of bioaerosols in the atmospheric environment of urban general hospital in China","volume":"368","author":"Huang","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128786_bib28","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3390\/ijms13011173","article-title":"microRNA response to Listeria monocytogenes infection in epithelial cells","volume":"13","author":"Izar","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128786_bib29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3390\/toxins10070286","article-title":"Synergistic effects of influenza and Staphylococcus aureus toxins on inflammation activation and cytotoxicity in human monocytic cell lines","volume":"10","author":"Jeannoel","year":"2018","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.envpol.2026.128786_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02227-23","article-title":"Staphylococcus aureus \u03b2-hemolysin causes skin inflammation by acting as an agonist of epidermal growth factor receptor","volume":"12","author":"Jia","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.envpol.2026.128786_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adp5227","article-title":"Impact of air pollution exposure on cytokines and histone modification profiles at single-cell levels during pregnancy","volume":"10","author":"Jung","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.envpol.2026.128786_bib32","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1080\/10934529.2022.2083429","article-title":"Comparison of biological responses between submerged, pseudo-air-liquid interface, and air-liquid interface exposure of A549 and differentiated THP-1 co-cultures to combustion-derived particles","volume":"57","author":"Kaur","year":"2022","journal-title":"J. Environ. Sci. Health Part A"},{"key":"10.1016\/j.envpol.2026.128786_bib33","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.immuni.2015.03.014","article-title":"Dysbiosis and Staphylococcus aureus colonization drives inflammation in atopic dermatitis","volume":"42","author":"Kobayashi","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.envpol.2026.128786_bib34","doi-asserted-by":"crossref","first-page":"34741","DOI":"10.1007\/s11356-019-06557-1","article-title":"Airborne Staphylococcus aureus in different environments\u2014a review","volume":"26","author":"Kozajda","year":"2019","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.envpol.2026.128786_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.envint.2018.01.014","article-title":"The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution","volume":"113","author":"Krauskopf","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.128786_bib36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nm864","article-title":"Activation and regulation of Toll-like receptors 2 and 1 in human leprosy","volume":"9","author":"Krutzik","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.envpol.2026.128786_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/08958378.2026.2623547","article-title":"Application of a human bronchoepithelial\u2014air\u2013liquid interface model to assess respiratory hazard of VOCs using a benchmark concentration modeling approach","volume":"38","author":"Lampe","year":"2026","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.envpol.2026.128786_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-36863-1","article-title":"Development of a novel air\u2013liquid interface airway tissue equivalent model for in vitro respiratory modeling studies","volume":"13","author":"Leach","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128786_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.33","article-title":"Methicillin-resistant Staphylococcus aureus","volume":"4","author":"Lee","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.envpol.2026.128786_bib40","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41392-025-02249-0","article-title":"Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives","volume":"10","author":"Lee","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.envpol.2026.128786_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23590","article-title":"Differential microRNA expression in the peripheral blood from human patients with COVID-19","volume":"34","author":"Li","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.envpol.2026.128786_bib42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.envpol.2026.128786_bib43","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.envpol.2019.06.059","article-title":"Activation of NF-\u03baB pathways mediating the inflammation and pulmonary diseases associated with atmospheric methylamine exposure","volume":"252","author":"Li","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128786_bib44","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.7150\/jca.16961","article-title":"MiR-146b-5p functions as a suppressor miRNA and prognosis predictor in non-small cell lung cancer","volume":"8","author":"Li","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.envpol.2026.128786_bib45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/toxins14010029","article-title":"Staphylococcal enterotoxin A induces intestinal barrier dysfunction and activates NLRP3 inflammasome via NF-\u03baB\/MAPK signaling pathways in mice","volume":"14","author":"Liu","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.envpol.2026.128786_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112544","article-title":"The expression and function of miR-622 in a variety of tumors","volume":"146","author":"Lu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envpol.2026.128786_bib47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s40726-025-00354-w","article-title":"Bioaerosols in various working and living environments and their control measure: a review","volume":"11","author":"Lu","year":"2025","journal-title":"Curr. Pollut. Rep."},{"key":"10.1016\/j.envpol.2026.128786_bib48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1126\/science.2185544","article-title":"The staphylococcal enterotoxins and their relatives","volume":"248","author":"Marrack","year":"1990","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.envpol.2026.128786_bib49","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1042\/BJ20041501","article-title":"MSK1 activity is controlled by multiple phosphorylation sites","volume":"387","author":"McCoy","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.envpol.2026.128786_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.784028","article-title":"Extracellular vesicle associated miRNAs regulate signaling pathways involved in COVID-19 pneumonia and the progression to severe acute respiratory Corona Virus-2 syndrome","volume":"12","author":"Meidert","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2026.128786_bib51","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/iub.2325","article-title":"Role of microRNAs in Staphylococcus aureus infection: potential biomarkers and mechanism","volume":"72","author":"Mirzaei","year":"2020","journal-title":"IUBMB Life"},{"key":"10.1016\/j.envpol.2026.128786_bib52","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/cts.12113","article-title":"Salivary epithelial cells as model to study immune response against cutaneous pathogens","volume":"7","author":"Negrini","year":"2014","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.envpol.2026.128786_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.177790","article-title":"Concentration, pathogenic composition, and exposure risks of bioaerosol in large indoor public environments: a comparative study of urban and suburban areas","volume":"957","author":"Ni","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128786_bib54","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1074\/jbc.M606878200","article-title":"Keratinocyte growth factor\/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-kappaB transcription factors","volume":"282","author":"Niu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.128786_bib55","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1021\/envhealth.5c00063","article-title":"Pseudomonas aeruginosa activates the NOD-like receptor signaling pathway by targeting nasopharyngeal cells throughout the whole respiratory tract","volume":"4","author":"Peng","year":"2025","journal-title":"Environ. Health"},{"key":"10.1016\/j.envpol.2026.128786_bib56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12989-017-0214-4","article-title":"Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation","volume":"14","author":"Pergoli","year":"2017","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2026.128786_bib57","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1200\/JCO.2025.43.4_suppl.244","article-title":"Prognostic implications and therapeutic response in GNAS-mutated colorectal adenocarcinoma: a retrospective cohort analysis","volume":"43","author":"Polani","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.envpol.2026.128786_bib58","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.jid.2017.11.038","article-title":"Staphylococcus aureus triggers induction of miR-15B-5P to diminish DNA repair and deregulate inflammatory response in diabetic foot ulcers","volume":"138","author":"Ramirez","year":"2018","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.envpol.2026.128786_bib59","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41580-020-0234-z","article-title":"Regulation of human telomerase in homeostasis and disease","volume":"21","author":"Roake","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2026.128786_bib60","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrmicro2421","article-title":"Interactions between bacterial pathogens and mitochondrial cell death pathways","volume":"8","author":"Rudel","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2026.128786_bib61","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3390\/microorganisms8040577","article-title":"Staphylococcus aureus lung infection results in down-regulation of surfactant Protein-A mainly caused by pro-inflammatory macrophages","volume":"8","author":"Schicke","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.envpol.2026.128786_bib62","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12920-020-00748-3","article-title":"Exosomal microRNAs are novel circulating biomarkers in cigarette, waterpipe smokers, E-cigarette users and dual smokers","volume":"13","author":"Singh","year":"2020","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.envpol.2026.128786_bib63","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/jor.70042","article-title":"Identification of miRNA biomarkers associated with staphylococcal musculoskeletal infections","volume":"43","author":"Siverino","year":"2025","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.envpol.2026.128786_bib64","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1016\/j.csbj.2021.06.012","article-title":"Staphylococcus aureus induces neutrophil extracellular traps (NETs) and neutralizes their bactericidal potential","volume":"19","author":"Speziale","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.envpol.2026.128786_bib65","first-page":"484","article-title":"A killer biofilm","volume":"21","author":"Taglialegna","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2026.128786_bib66","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1128\/microbiolspec.GPP3-0039-2018","article-title":"Staphylococcus aureus secreted toxins and extracellular enzymes","volume":"7","author":"Tam","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.envpol.2026.128786_bib67","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.1242255","article-title":"Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death","volume":"342","author":"Thammavongsa","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.envpol.2026.128786_bib68","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research","volume":"17","author":"Turner","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2026.128786_bib69","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/toxsci\/kfy053","article-title":"Air-liquid interface: relevant in vitro models for investigating air pollutant-induced pulmonary toxicity","volume":"164","author":"Upadhyay","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2026.128786_bib70","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cellsig.2018.09.002","article-title":"TGF-\u03b2 receptors: in and beyond TGF-\u03b2 signaling","volume":"52","author":"Vander Ark","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.envpol.2026.128786_bib71","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/08830185.2017.1380200","article-title":"Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals","volume":"37","author":"Vidya","year":"2018","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.envpol.2026.128786_bib72","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1071553","article-title":"The fas signaling pathway: more than a paradigm","volume":"296","author":"Wajant","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.envpol.2026.128786_bib73","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1538\/expanim.18-0102","article-title":"The acute pulmonary toxicity in mice induced by Staphylococcus aureus, particulate matter, and their combination","volume":"68","author":"Wang","year":"2019","journal-title":"Exp. Anim."},{"key":"10.1016\/j.envpol.2026.128786_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2020.129672","article-title":"Oxidative stress-mediated epidermal growth factor receptor activation regulates PM2.5-induced over-secretion of pro-inflammatory mediators from human bronchial epithelial cells","volume":"1864","author":"Wang","year":"2020","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.envpol.2026.128786_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2020.101931","article-title":"The proliferative and anti-apoptosis functions of KGF\/KGFR contributes to bronchial epithelial repair in asthma","volume":"63","author":"Wang","year":"2020","journal-title":"Pulm. Pharmacol. Therapeut."},{"key":"10.1016\/j.envpol.2026.128786_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2020.113608","article-title":"Impact of dust on airborne Staphylococcus aureus' viability, culturability, inflammogenicity, and biofilm forming capacity","volume":"230","author":"White","year":"2020","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envpol.2026.128786_bib77","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.envpol.2026.128786_bib78","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1745-7254.2006.00315.x","article-title":"SRC-3\/AIB1: transcriptional coactivator in oncogenesis","volume":"27","author":"Yan","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.envpol.2026.128786_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110211","article-title":"MiRNA-106b-5p in human cancers: diverse functions and promising biomarker","volume":"127","author":"Yang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envpol.2026.128786_bib80","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.yexcr.2015.02.007","article-title":"Regulation of high glucose-mediated mucin expression by matrix metalloproteinase-9 in human airway epithelial cells","volume":"333","author":"Yu","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.envpol.2026.128786_bib81","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/infdis\/jiv319","article-title":"An essential role for coagulase in Staphylococcus aureus biofilm development reveals new therapeutic possibilities for device-related infections","volume":"212","author":"Zapotoczna","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.envpol.2026.128786_bib82","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res."},{"key":"10.1016\/j.envpol.2026.128786_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111734","article-title":"MiR-106a-5p modulates apoptosis and metabonomics changes by TGF-\u03b2\/Smad signaling pathway in cleft palate","volume":"386","author":"Zhang","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.envpol.2026.128786_bib84","first-page":"16","article-title":"Acinetobacter baumannii outer membrane protein A induces pulmonary epithelial barrier dysfunction and bacterial translocation through the TLR2\/IQGAP1 axis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2026.128786_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115229","article-title":"The air pollutant PM2.5 aggravates airway inflammation via NF-\u03baB\/NLRP3-induced pyroptosis: partially inhibited by the TLR4 inhibitor TAK242","volume":"163","author":"Zhang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.envpol.2026.128786_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.119672","article-title":"People with respiratory inflammation may be at higher health risk of bioaerosols: a comparative study of air-liquid interface and submerged exposure models","volume":"309","author":"Zhang","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.128786_bib87","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13568-018-0606-3","article-title":"Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells","volume":"8","author":"Zhao","year":"2018","journal-title":"AMB Express"},{"key":"10.1016\/j.envpol.2026.128786_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.buildenv.2025.113056","article-title":"Indoor and outdoor bioaerosol distributions and concentration profiles during different seasons and pollution events in Qingdao city","volume":"279","author":"Zhao","year":"2025","journal-title":"Build. Environ."},{"key":"10.1016\/j.envpol.2026.128786_bib89","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","article-title":"DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation","volume":"15","author":"Zindel","year":"2020","journal-title":"Annu. Rev. Pathol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126011565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126011565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:05:23Z","timestamp":1791788723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126011565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":89,"alternative-id":["S0269749126011565"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128786","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxic mechanisms and biomarkers of Staphylococcus aureus aerosol exposure to human respiratory cells at the air-liquid interface","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128786"}}