{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:47:03Z","timestamp":1791791223074,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32502325"],"award-info":[{"award-number":["32502325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772962"],"award-info":[{"award-number":["2025M772962"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.envpol.2026.128813","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:36:14Z","timestamp":1784561774000},"page":"128813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lambda-cyhalothrin exposure disrupts microbiota-associated bile acid metabolism and enterohepatic feedback in mice"],"prefix":"10.1016","volume":"407","author":[{"given":"Mengmeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.128813_bib1","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s11095-007-9289-1","article-title":"Bile acid transporters: structure, function, regulation and pathophysiological implications","volume":"24","author":"Alrefai","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.envpol.2026.128813_bib2","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.1021\/acs.est.6b02253","article-title":"Pyrethroid pesticides as endocrine disruptors: molecular mechanisms in vertebrates with a focus on fishes","volume":"50","author":"Brander","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128813_bib3","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/j.2040-4603.2013.tb00517.x","article-title":"Bile acid metabolism and signaling","volume":"3","author":"Chiang","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.envpol.2026.128813_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-nutr-082018-124344","article-title":"Bile acids as metabolic regulators and nutrient sensors","volume":"39","author":"Chiang","year":"2019","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.envpol.2026.128813_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2026.128813_bib6","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2026.128813_bib7","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1053\/j.gastro.2016.12.037","article-title":"Intestinal farnesoid X receptor controls transintestinal cholesterol excretion in mice","volume":"152","author":"de Boer","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.envpol.2026.128813_bib8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1677\/jme.0.0220227","article-title":"Unique multifunctional HSD17B4 gene product: 17beta-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacyl-coenzyme A dehydrogenase\/hydratase involved in Zellweger syndrome","volume":"22","author":"de Launoit","year":"1999","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.envpol.2026.128813_bib9","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3390\/microorganisms9030469","article-title":"Microbial hydroxysteroid dehydrogenases: from alpha to omega","author":"Doden","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.envpol.2026.128813_bib10","first-page":"7","article-title":"High-fat diet alters the expression of reference genes in Male mice","author":"Fan","year":"2020","journal-title":"Front. Nutr."},{"key":"10.1016\/j.envpol.2026.128813_bib11","doi-asserted-by":"crossref","first-page":"10050","DOI":"10.1021\/acs.jafc.3c01881","article-title":"Heptamethoxyflavone alleviates metabolic syndrome in high-fat diet-fed mice by regulating the composition, function, and metabolism of gut microbiota","volume":"71","author":"Feng","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envpol.2026.128813_bib12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00249-016-1195-1","article-title":"Voltage-gated sodium channels as targets for pyrethroid insecticides","volume":"46","author":"Field","year":"2017","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.envpol.2026.128813_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhep.2024.09.032","article-title":"Bile acid metabolism and signalling in liver disease","volume":"82","author":"Fuchs","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.envpol.2026.128813_bib14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory Cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envpol.2026.128813_bib15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s40168-021-01101-1","article-title":"Review: microbial transformations of human bile acids","volume":"9","author":"Guzior","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.envpol.2026.128813_bib16","series-title":"Reviews of Environmental Contamination and Toxicology","first-page":"71","article-title":"Environmental chemistry, ecotoxicity, and fate of lambda-cyhalothrin","author":"He","year":"2008"},{"key":"10.1016\/j.envpol.2026.128813_bib17","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1152\/physrev.00054.2017","article-title":"Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease","volume":"98","author":"Hegyi","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envpol.2026.128813_bib18","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.3390\/plants12234022","article-title":"Pyrethrins and pyrethroids: a comprehensive review of natural occurring compounds and their synthetic derivatives","volume":"12","author":"Hodo\u015fan","year":"2023","journal-title":"Plants"},{"key":"10.1016\/j.envpol.2026.128813_bib19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41467-021-27758-8","article-title":"Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion","volume":"13","author":"Hu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.128813_bib20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.envpol.2026.128813_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cytogfr.2015.07.016","article-title":"Mechanisms of enterohepatic fibroblast growth factor 15\/19 signaling in health and disease","volume":"26","author":"Jahn","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.envpol.2026.128813_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138942","article-title":"Prioritization of currently used pesticides in soils of main European cropping systems and an Argentinian cropping system for assessment of mixture toxicity and risk on terrestrial biota","volume":"495","author":"Jegede","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128813_bib23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid\u2013microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envpol.2026.128813_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1476-069X-14-13","article-title":"Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment","volume":"14","author":"Lagarde","year":"2015","journal-title":"Environ. Health"},{"key":"10.1016\/j.envpol.2026.128813_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2026.110080","article-title":"Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring","volume":"208","author":"Lamichhane","year":"2026","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.128813_bib26","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2172671","article-title":"Bile acids as modulators of gut microbiota composition and function","volume":"15","author":"Larabi","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.envpol.2026.128813_bib27","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.transproceed.2015.06.017","article-title":"Identification of suitable reference genes for normalization of real-time quantitative polymerase chain reaction in an intestinal graft-versus-host disease mouse model","volume":"47","author":"Li","year":"2015","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.envpol.2026.128813_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ese.2022.100185","article-title":"Gut microbiota dysbiosis involves in host non-alcoholic fatty liver disease upon pyrethroid pesticide exposure","volume":"11","author":"Li","year":"2022","journal-title":"Environ. Sci. Ecotechnol."},{"key":"10.1016\/j.envpol.2026.128813_bib29","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/j.1742-4658.2008.06290.x","article-title":"\u03b1-Methylacyl-CoA racemase \u2013 an \u2018obscure\u2019 metabolic enzyme takes centre stage","volume":"275","author":"Lloyd","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.envpol.2026.128813_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00805-21","article-title":"Dominant bacterial phyla from the human gut show widespread ability to transform and conjugate bile acids","volume":"6","author":"Lucas","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.envpol.2026.128813_bib31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41575-024-00914-3","article-title":"The changing metabolic landscape of bile acids \u2013 keys to metabolism and immune regulation","volume":"21","author":"Mohanty","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envpol.2026.128813_bib32","series-title":"OECD Guidelines for the Testing of Chemicals","article-title":"Test no. 407: repeated dose 28-day oral toxicity study in rodents","year":"2008"},{"key":"10.1016\/j.envpol.2026.128813_bib33","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41586-022-04480-z","article-title":"Human gut bacteria produce \u03a4\u039717-modulating bile acid metabolites","volume":"603","author":"Paik","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.128813_bib34","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.3390\/cells10081846","article-title":"Farnesoid X receptor as target for therapies to treat cholestasis-induced liver injury","volume":"10","author":"Petrescu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2026.128813_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"JLR (J. Lipid Res.)"},{"key":"10.1016\/j.envpol.2026.128813_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.envpol.2026.128813_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108280","article-title":"Pesticide residues with hazard classifications relevant to non-target species including humans are omnipresent in the environment and farmer residences","volume":"181","author":"Silva","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.128813_bib38","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1158\/0008-5472.CAN-24-3898","article-title":"The microbial bile acid metabolite 3-Oxo-LCA inhibits colorectal cancer progression","volume":"85","author":"Sun","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.envpol.2026.128813_bib39","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrd2619","article-title":"Targeting bile-acid signalling for metabolic diseases","volume":"7","author":"Thomas","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.envpol.2026.128813_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/j.2040-4603.2020.tb00108.x","article-title":"Intestinal absorption of bile acids in health and disease","volume":"10","author":"Ticho","year":"2020","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.envpol.2026.128813_bib41","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/physrev.00027.2002","article-title":"Bile salt transporters: molecular characterization, function, and regulation","volume":"83","author":"Trauner","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envpol.2026.128813_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44360-8","article-title":"The influence of sex difference on behavior and adult hippocampal neurogenesis in C57BL\/6 mice","volume":"13","author":"Tsao","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128813_bib43","series-title":"Endangered Species Litigation Status Effects Determination for Red-Legged Frog","article-title":"Appendix J: lambda-cyhalothrin risk assessments","year":"2012"},{"key":"10.1016\/j.envpol.2026.128813_bib44","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envpol.2026.128813_bib45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstr\u00f6m","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.envpol.2026.128813_bib46","first-page":"11","article-title":"Mechanism of hydrophobic bile acid-induced hepatocyte injury and drug discovery","author":"Wei","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128813_bib47","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s40168-023-01709-5","article-title":"Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia","volume":"11","author":"Xu","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.envpol.2026.128813_bib48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/15376516.2014.985355","article-title":"Actions of the pyrethroid insecticide bifenthrin on sodium channels expressed in rat cerebral cortical neurons","volume":"25","author":"Yang","year":"2015","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.envpol.2026.128813_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127579","article-title":"The interaction between polyethylene microplastics and ciprofloxacin on inducing hepatotoxicity in Carassius auratus via the gut-liver axis","volume":"391","author":"Zhang","year":"2026","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.128813_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136417","article-title":"Effects of lambda-cyhalothrin on gut microbiota and related bile acid metabolism in mice","volume":"480","author":"Zheng","year":"2024","journal-title":"J. Hazard Mater."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126011838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126011838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:06:27Z","timestamp":1791788787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126011838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":50,"alternative-id":["S0269749126011838"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128813","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lambda-cyhalothrin exposure disrupts microbiota-associated bile acid metabolism and enterohepatic feedback in mice","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128813","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128813"}}