{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:01:01Z","timestamp":1790424061955,"version":"4.1.0"},"reference-count":287,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.envpol.2026.128877","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:17:00Z","timestamp":1785698220000},"page":"128877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The impact of climatic extreme temperatures on gut microbiome-mediated cardio-metabolic health"],"prefix":"10.1016","volume":"408","author":[{"given":"Avaneesh","family":"Shukla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devansh","family":"Rughwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek Kumar","family":"Aditya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini Kumar","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.128877_bib1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1152\/physiolgenomics.00081.2016","article-title":"Alterations in the gut microbiota can elicit hypertension in rats","volume":"49","author":"Adnan","year":"2017","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.envpol.2026.128877_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3390\/molecules28020619","article-title":"Leaky gut and the ingredients that help treat it: a review","volume":"28","author":"Aleman","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.envpol.2026.128877_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.anifeedsci.2014.10.012","article-title":"Effects of dietary Bacillus subtilis on heat-stressed broilers performance, intestinal morphology and microflora composition","volume":"198","author":"Al-Fataftah","year":"2014","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128877_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104169","article-title":"Prebiotic effect of dietary polyphenols: a systematic review","volume":"74","author":"Alves-Santos","year":"2020","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.envpol.2026.128877_bib5","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.3390\/molecules24213992","article-title":"Circulating metabolites originating from gut microbiota control endothelial cell function","volume":"24","author":"Amedei","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.envpol.2026.128877_bib6","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1136\/gutjnl-2014-307142","article-title":"A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice","volume":"64","author":"Anh\u00ea","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.128877_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148824","article-title":"An integrated metabolomic and microbiome analysis identified specific gut microbiota associated with fecal cholesterol and coprostanol in Clostridium difficile infection","volume":"11","author":"Antharam","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.128877_bib8","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3390\/nu10101499","article-title":"Impact of diet-modulated butyrate production on intestinal barrier function and inflammation","volume":"10","author":"Bach Knudsen","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib9","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41419-020-02985-x","article-title":"NLRP3 inflammasome in endothelial dysfunction","volume":"11","author":"Bai","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envpol.2026.128877_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1574-695X.2007.00294.x","article-title":"Enhancement of the immune response and protection induced by probiotic lactic acid bacteria against furunculosis in rainbow trout (Oncorhynchus mykis)","volume":"51","author":"Balc\u00c3\u00a1zar","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib11","first-page":"200","article-title":"Examination of intestinal conversion of cholesterol to coprostanol in 633 healthy subjects reveals an age- and sex-dependent pattern","volume":"17","author":"Benno","year":"2005","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.envpol.2026.128877_bib12","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.clnu.2014.10.004","article-title":"A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity","volume":"34","author":"Beserra","year":"2015","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41559-017-0161","article-title":"Climate warming reduces gut microbiota diversity in a vertebrate ectotherm","volume":"1","author":"Bestion","year":"2017","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.envpol.2026.128877_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.930928","article-title":"Lactic acid bacterial supplementation ameliorated the lipopolysaccharide-induced gut inflammation and dysbiosis in mice","volume":"13","author":"Bhatia","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3390\/d5030627","article-title":"Untangling the genetic basis of fibrolytic specialization by Lachnospiraceae and Ruminococcaceae in diverse gut communities","volume":"5","author":"Biddle","year":"2013","journal-title":"Diversity"},{"key":"10.1016\/j.envpol.2026.128877_bib16","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1038\/s41396-019-0492-y","article-title":"The microbiota\u2013gut\u2013brain interaction in regulating host metabolic adaptation to cold in male Brandt's voles (Lasiopodomys brandtii)","volume":"13","author":"Bo","year":"2019","journal-title":"ISME J."},{"key":"10.1016\/j.envpol.2026.128877_bib17","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1152\/jappl.1991.70.6.2640","article-title":"Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke","volume":"70","author":"Bouchama","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.envpol.2026.128877_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01385-21","article-title":"Wildlife symbiotic bacteria are indicators of the health status of the host and its ecosystem","volume":"88","author":"Bravo","year":"2022","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.cmet.2015.07.002","article-title":"The bile acid chenodeoxycholic acid increases human brown adipose tissue activity","volume":"22","author":"Broeders","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.envpol.2026.128877_bib20","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The orphan G Protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.128877_bib21","series-title":"Contribution of Working Groups I, II and III to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change [Core Writing Team","article-title":"IPCC, 2023: climate change 2023: synthesis report","author":"Calvin","year":"2023"},{"key":"10.1016\/j.envpol.2026.128877_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13099-017-0162-4","article-title":"Strain-specific probiotic properties of lactic acid bacteria and their interference with human intestinal pathogens invasion","volume":"9","author":"Campana","year":"2017","journal-title":"Gut Pathog."},{"key":"10.1016\/j.envpol.2026.128877_bib23","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1136\/gutjnl-2019-318776","article-title":"Is colonic propionate delivery a novel solution to improve metabolism and inflammation in overweight or obese subjects?","volume":"68","author":"Cani","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.128877_bib24","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.envpol.2026.128877_bib25","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.coph.2013.09.008","article-title":"Gut microbiota, enteroendocrine functions and metabolism","volume":"13","author":"Cani","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128877_bib26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11883-022-01040-8","article-title":"Bioactives in the food supply: effects on CVD health","volume":"24","author":"Cao","year":"2022","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib27","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/1751-7915.13772","article-title":"Alterations in the gut microbiome and metabolic profile in rats acclimated to high environmental temperature","volume":"15","author":"Cao","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzy005","article-title":"Health effects and sources of prebiotic dietary fiber","volume":"2","author":"Carlson","year":"2018","journal-title":"Curr. Dev. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3390\/nu11030635","article-title":"The role of probiotics and prebiotics in the prevention and treatment of obesity","volume":"11","author":"Cerd\u00f3","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib30","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/dom.13159","article-title":"Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans","volume":"20","author":"Chambers","year":"2018","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.envpol.2026.128877_bib31","doi-asserted-by":"crossref","first-page":"7489","DOI":"10.1038\/ncomms8489","article-title":"Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota","volume":"6","author":"Chang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.128877_bib32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1756283X10388682","article-title":"The association of bile acid excretion and atherosclerotic coronary artery disease. Therap","volume":"4","author":"Charach","year":"2011","journal-title":"Adv. Gastroenterol."},{"key":"10.1016\/j.envpol.2026.128877_bib33","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1039\/D2FO00560C","article-title":"Beneficial effects of psyllium on the prevention and treatment of cardiometabolic diseases","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.envpol.2026.128877_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.envint.2019.04.049","article-title":"Cold spell and mortality in 31 Chinese capital cities: definitions, vulnerability and implications","volume":"128","author":"Chen","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.128877_bib35","doi-asserted-by":"crossref","DOI":"10.1088\/1748-9326\/abaea0","article-title":"The modifying effects of heat and cold wave characteristics on cardiovascular mortality in 31 major Chinese cities","volume":"15","author":"Chen","year":"2020","journal-title":"Environ. Res. Lett."},{"key":"10.1016\/j.envpol.2026.128877_bib36","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3390\/nu11061225","article-title":"Preventive effects and mechanisms of garlic on dyslipidemia and gut microbiome dysbiosis","volume":"11","author":"Chen","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib37","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2022-003282","article-title":"Fecal microbiota transplantation ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota in db\/db mice","volume":"11","author":"Chen","year":"2023","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.envpol.2026.128877_bib38","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.clnu.2019.05.020","article-title":"Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system","volume":"39","author":"Chen","year":"2020","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib39","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006347","article-title":"Trimethylamine\u2010N\u2010oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3\u2010SOD2\u2010mtROS signaling pathway","volume":"6","author":"Chen","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.envpol.2026.128877_bib40","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.cmet.2019.08.021","article-title":"Trimethylamine N-Oxide binds and activates PERK to promote metabolic dysfunction","volume":"30","author":"Chen","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.envpol.2026.128877_bib41","article-title":"Exposure to heat-stress environment affects the physiology, circulation levels of cytokines, and microbiome in dairy cows","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib42","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1042\/CS20200128","article-title":"Short-chain fatty acid, acylation and cardiovascular diseases","volume":"134","author":"Chen","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/environments10100165","article-title":"The impact of climate change on environmental sustainability and human mortality","volume":"10","author":"Chen","year":"2023","journal-title":"Environments"},{"key":"10.1016\/j.envpol.2026.128877_bib44","doi-asserted-by":"crossref","first-page":"17791","DOI":"10.1073\/pnas.1112928108","article-title":"Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase","volume":"108","author":"Chen","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111691","article-title":"Extreme temperature exposure and acute myocardial infarction: elevated risk within hours?","volume":"202","author":"Cheng","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2026.128877_bib46","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.cell.2015.11.004","article-title":"Gut microbiota orchestrates energy homeostasis during cold","volume":"163","author":"Chevalier","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2026.128877_bib47","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3390\/nu11020338","article-title":"DASH dietary pattern and cardiometabolic outcomes: an umbrella review of systematic reviews and meta-analyses","volume":"11","author":"Chiavaroli","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib48","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1016\/S2542-5196(22)00003-1","article-title":"Associations between ambient temperature and enteric infections by pathogen: a systematic review and meta-analysis","volume":"6","author":"Chua","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.envpol.2026.128877_bib49","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1210\/en.2006-0536","article-title":"Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes","volume":"147","author":"Chung","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.envpol.2026.128877_bib50","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.721393","article-title":"Bacterial-Induced blood pressure reduction: mechanisms for the treatment of hypertension via the gut","volume":"8","author":"Cookson","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib52","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/molecules26030682","article-title":"The protective role of butyrate against obesity and obesity-related diseases","volume":"26","author":"Coppola","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.envpol.2026.128877_bib53","doi-asserted-by":"crossref","first-page":"21307","DOI":"10.1073\/pnas.1215689109","article-title":"Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme","volume":"109","author":"Craciun","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib54","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gutjnl-2014-308778","article-title":"Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology","volume":"65","author":"Dao","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.128877_bib55","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/foods8030092","article-title":"Prebiotics: definition, types, sources, mechanisms, and clinical applications","volume":"8","author":"Davani-Davari","year":"2019","journal-title":"Foods"},{"key":"10.1016\/j.envpol.2026.128877_bib56","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.128877_bib57","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000398787","article-title":"The effects of climate change on cardiac health","volume":"131","author":"De Blois","year":"2015","journal-title":"Cardiology"},{"key":"10.1016\/j.envpol.2026.128877_bib58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/nu11010051","article-title":"Higher fecal short-chain fatty acid levels are associated with gut microbiome dysbiosis, obesity, hypertension and cardiometabolic disease risk factors","volume":"11","author":"de la Cuesta-Zuluaga","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib59","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3390\/jcm13030759","article-title":"The impact of climate change and extreme weather conditions on cardiovascular health and acute cardiovascular diseases","volume":"13","author":"De Vita","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib60","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.aller.2018.12.009","article-title":"Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma","volume":"47","author":"Demirci","year":"2019","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.envpol.2026.128877_bib61","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1099\/ijs.0.02873-0","article-title":"Akkermansia muciniphila gen. Nov., sp. Nov., a human intestinal mucin-degrading bacterium","volume":"54","author":"Derrien","year":"2004","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib62","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00382-010-0977-x","article-title":"Uncertainty in climate change projections: the role of internal variability","volume":"38","author":"Deser","year":"2012","journal-title":"Clim. Dyn."},{"key":"10.1016\/j.envpol.2026.128877_bib63","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2026.128877_bib64","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1136\/gutjnl-2012-303304","article-title":"Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in Obese women","volume":"62","author":"Dewulf","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.128877_bib65","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"Di Vincenzo","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib66","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00012-21","article-title":"Host genome-wide association study of infant susceptibility to shigella -Associated diarrhea","volume":"89","author":"Duchen","year":"2021","journal-title":"Infect. Immun."},{"key":"10.1016\/j.envpol.2026.128877_bib67","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","article-title":"NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis","volume":"145","author":"Elinav","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2026.128877_bib68","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1161\/01.CIR.0000034509.14906.AE","article-title":"Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans","volume":"106","author":"Esposito","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.128877_bib69","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib70","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib71","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800937","article-title":"Gallotannins and Lactobacillus plantarum WCFS1 mitigate high\u2010fat diet\u2010induced inflammation and induce biomarkers for thermogenesis in adipose tissue in gnotobiotic mice","volume":"63","author":"Fang","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envpol.2026.128877_bib72","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jtherbio.2019.07.027","article-title":"Alteration in bile acids profile in large white pigs during chronic heat exposure","volume":"84","author":"Fang","year":"2019","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.envpol.2026.128877_bib73","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.1021\/acs.jafc.2c03564","article-title":"Interaction of pyrogallol-containing polyphenols with mucin reinforces intestinal mucus barrier properties","volume":"70","author":"Feng","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envpol.2026.128877_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.939571","article-title":"Dietary compounds in modulation of gut microbiota-derived metabolites","volume":"9","author":"Feng","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1271001","article-title":"Short-chain fatty acids are potential goalkeepers of atherosclerosis","volume":"14","author":"Feng","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128877_bib76","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00394-016-1199-8","article-title":"Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial","volume":"56","author":"Firouzi","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib77","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/gutjnl-2017-315543","article-title":"Potential of butyrate to influence food intake in mice and men","volume":"67","author":"Fluitman","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.128877_bib78","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017709118","article-title":"Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization","volume":"118","author":"Foley","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib79","article-title":"Environmental temperature alters the digestive performance and gut microbiota of a terrestrial amphibian","volume":"221","author":"Fontaine","year":"2018","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.envpol.2026.128877_bib80","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3390\/biology12081088","article-title":"Aging increases enterocyte damage during a 3-Hour exposure to very hot and dry heat: a preliminary study","volume":"12","author":"Foster","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.envpol.2026.128877_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/nu15092211","article-title":"Short-chain fatty-acid-producing bacteria: key components of the human gut microbiota","volume":"15","author":"Fusco","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib82","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2018.06.015","article-title":"Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors","volume":"178","author":"Gan","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.envpol.2026.128877_bib83","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice","volume":"58","author":"Gao","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.envpol.2026.128877_bib84","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41366-019-0445-6","article-title":"Regulation of thermogenic capacity in brown and white adipocytes by the prebiotic high-esterified pectin and its postbiotic acetate","volume":"44","author":"Garc\u00eda-Carrizo","year":"2020","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.envpol.2026.128877_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.00890","article-title":"Shifts on gut microbiota associated to mediterranean diet adherence and specific dietary intakes on general adult population","volume":"9","author":"Garcia-Mantrana","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib86","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.2337\/dc09-0979","article-title":"Increase in plasma endotoxin concentrations and the expression of toll-like receptors and suppressor of cytokine Signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal","volume":"32","author":"Ghanim","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.envpol.2026.128877_bib87","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tips.2010.01.003","article-title":"Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases","volume":"31","author":"Godin","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102165","article-title":"Short-chain fatty acids as modulators of redox signaling in health and disease","volume":"47","author":"Gonz\u00e1lez-Bosch","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2026.128877_bib89","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41558-020-0899-5","article-title":"Warming drives ecological community changes linked to host-associated microbiome dysbiosis","volume":"10","author":"Greenspan","year":"2020","journal-title":"Nat. Clim. Change"},{"key":"10.1016\/j.envpol.2026.128877_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111334","article-title":"Link between microbiota and hypertension: focus on LPS\/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics","volume":"137","author":"Grylls","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envpol.2026.128877_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.845942","article-title":"Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms","volume":"9","author":"Gui","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib92","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/oby.21344","article-title":"Cardiometabolic disease risk in metabolically healthy and unhealthy obesity: stability of metabolic health status in adults","volume":"24","author":"Guo","year":"2016","journal-title":"Obesity"},{"key":"10.1016\/j.envpol.2026.128877_bib93","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/oby.20585","article-title":"The progression of cardiometabolic disease: validation of a new cardiometabolic disease staging system applicable to obesity","volume":"22","author":"Guo","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.envpol.2026.128877_bib94","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40104-019-0402-1","article-title":"Clostridium species as probiotics: potentials and challenges","volume":"11","author":"Guo","year":"2020","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib95","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ajpath.2012.10.014","article-title":"Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14","volume":"182","author":"Guo","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.envpol.2026.128877_bib96","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1080\/00365521.2017.1377285","article-title":"Heat stress modulated gastrointestinal barrier dysfunction: role of tight junctions and heat shock proteins","volume":"52","author":"Gupta","year":"2017","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.envpol.2026.128877_bib97","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: the role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.envpol.2026.128877_bib98","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000001419","article-title":"Nonoptimal temperature and cardiovascular health: a scientific statement from the American heart association","author":"Hanneman","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.128877_bib99","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700300","article-title":"Consumption of two healthy dietary patterns restored microbiota dysbiosis in Obese patients with metabolic dysfunction","volume":"61","author":"Haro","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envpol.2026.128877_bib100","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2337\/dc11-1593","article-title":"High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects","volume":"35","author":"Harte","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.envpol.2026.128877_bib101","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s40104-019-0391-0","article-title":"Heat stress affects fecal microbial and metabolic alterations of primiparous sows during late gestation","volume":"10","author":"He","year":"2019","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.00903","article-title":"Associations of gut microbiota with heat stress-induced changes of growth, fat deposition, intestinal morphology, and antioxidant capacity in ducks","volume":"10","author":"He","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib103","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1111\/1751-7915.13893","article-title":"High ambient temperature exposure during late gestation disrupts glycolipid metabolism and hepatic mitochondrial function tightly related to gut microbial dysbiosis in pregnant mice","volume":"14","author":"He","year":"2021","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib104","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.3390\/ijms21176356","article-title":"Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib105","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jacc.2019.11.060","article-title":"Long-term changes in gut microbial metabolite trimethylamine N-Oxide and coronary heart disease risk","volume":"75","author":"Heianza","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.envpol.2026.128877_bib106","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/nu10020179","article-title":"In vivo assessment of resistant starch degradation by the caecal microbiota of mice using RNA-based stable isotope probing\u2014A proof-of-principle study","volume":"10","author":"Herrmann","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib107","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envpol.2026.128877_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000523712","article-title":"Gut microbiome: profound implications for diet and disease","author":"Hills","year":"2022","journal-title":"Komp. Nutr. Diet."},{"key":"10.1016\/j.envpol.2026.128877_bib109","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.717723","article-title":"A comprehensive analysis of the colonic flora diversity, short chain fatty acid metabolism, transcripts, and biochemical indexes in heat-stressed pigs","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2026.128877_bib110","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.phrs.2018.11.042","article-title":"Fecal microbiota transplantation alleviates myocardial damage in myocarditis by restoring the microbiota composition","volume":"139","author":"Hu","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.envpol.2026.128877_bib111","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1038\/s41366-020-0566-y","article-title":"Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodeling","volume":"44","author":"Hui","year":"2020","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.envpol.2026.128877_bib112","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00707-21","article-title":"Blowing hot and cold: body temperature and the microbiome","volume":"6","author":"Huus","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.envpol.2026.128877_bib113","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/metabo12010020","article-title":"Cold exposure during the active phase affects the short-chain fatty acid production of mice in a time-specific manner","volume":"12","author":"Ichikawa","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.envpol.2026.128877_bib114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128877_bib115","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/ijms21041362","article-title":"Marine Omega-3 (N-3) fatty acids for cardiovascular health: an update for 2020","volume":"21","author":"Innes","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib116","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1038\/s41467-018-05184-7","article-title":"Gut microbiota associations with common diseases and prescription medications in a population-based cohort","volume":"9","author":"Jackson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.128877_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1065780","article-title":"A Chinese herbs complex ameliorates gut microbiota dysbiosis induced by intermittent cold exposure in female rats","volume":"13","author":"Jin","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib118","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1073\/pnas.0804437105","article-title":"Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome","volume":"105","author":"Jones","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib119","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1073\/pnas.1323599111","article-title":"Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut","volume":"111","author":"Joyce","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib120","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3390\/microorganisms9091881","article-title":"Cholesterol-to-Coprostanol conversion by the gut microbiota: what we know, suspect, and ignore","volume":"9","author":"Juste","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.envpol.2026.128877_bib121","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ejcn.2010.19","article-title":"Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with Obese tendencies in a randomized controlled trial","volume":"64","author":"Kadooka","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib122","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00592-014-0662-3","article-title":"Endotoxemia, nutrition, and cardiometabolic disorders","volume":"52","author":"Kallio","year":"2015","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.envpol.2026.128877_bib123","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3390\/antiox12010160","article-title":"Protective role of short-chain fatty acids against Ang- II-Induced mitochondrial dysfunction in brain endothelial cells: a potential role of heme oxygenase 2","volume":"12","author":"Kassan","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.envpol.2026.128877_bib124","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3390\/nu7042839","article-title":"Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation","volume":"7","author":"Kasubuchi","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib125","doi-asserted-by":"crossref","first-page":"8850","DOI":"10.1039\/D1FO01125A","article-title":"Fruits and their impact on the gut microbiota, gut motility and constipation","volume":"12","author":"Katsirma","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.envpol.2026.128877_bib126","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40168-020-00821-0","article-title":"Gut microbiota and cardiovascular disease: opportunities and challenges","volume":"8","author":"Kazemian","year":"2020","journal-title":"Microbiome"},{"key":"10.1016\/j.envpol.2026.128877_bib127","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.chom.2020.05.013","article-title":"Cholesterol metabolism by uncultured human gut bacteria influences host cholesterol level","volume":"28","author":"Kenny","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.envpol.2026.128877_bib128","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cbi.2016.06.007","article-title":"Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: a comparative study with metformin","volume":"254","author":"Khan","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2026.128877_bib129","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.3390\/nu11102512","article-title":"Short chain fatty acids and fecal microbiota abundance in humans with obesity: a systematic review and meta-analysis","volume":"11","author":"Kim","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib130","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1073\/pnas.1016088108","article-title":"Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)","volume":"108","author":"Kimura","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib131","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib132","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/1462-2920.13255","article-title":"Effects of environmental temperature on the gut microbial communities of tadpoles","volume":"18","author":"Kohl","year":"2016","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib133","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12866-017-1027-1","article-title":"Association between body mass index and firmicutes\/bacteroidetes ratio in an adult Ukrainian population","volume":"17","author":"Koliada","year":"2017","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib134","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/catal9020167","article-title":"Microbial reduction of cholesterol to coprostanol: an old concept and new insights","volume":"9","author":"Kriaa","year":"2019","journal-title":"Catalysts"},{"key":"10.1016\/j.envpol.2026.128877_bib135","doi-asserted-by":"crossref","first-page":"E108","DOI":"10.1152\/ajpendo.00471.2005","article-title":"Influence of TNF-\u03b1 and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans","volume":"291","author":"Krogh-Madsen","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.envpol.2026.128877_bib136","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.4049\/jimmunol.1001864","article-title":"Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-Mediated Th17 bias","volume":"186","author":"Lau","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.envpol.2026.128877_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01107","article-title":"Detection of increased plasma Interleukin-6 levels and prevalence of Prevotella copri and Bacteroides vulgatus in the feces of type 2 diabetes patients","volume":"8","author":"Leite","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2026.128877_bib138","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s40572-018-0199-7","article-title":"Climate change impacts on waterborne diseases: moving toward designing interventions","volume":"5","author":"Levy","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib139","first-page":"350","article-title":"Lactobacillus plantarum DR7 reduces cholesterol via phosphorylation of AMPK that down-regulated the mRNA expression of HMG-CoA reductase","volume":"38","author":"Lew","year":"2018","journal-title":"Korean J. Food Sci. Anim. Resour."},{"key":"10.1016\/j.envpol.2026.128877_bib140","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/ibd.21177","article-title":"Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate","volume":"16","author":"Lewis","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.envpol.2026.128877_bib141","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/ajcn\/nqac074","article-title":"Gut microbiota\u2013derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis","volume":"116","author":"Li","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib142","article-title":"The anti-inflammatory effects of short chain fatty acids on Lipopolysaccharide- or tumor necrosis factor \u03b1-Stimulated endothelial cells via activation of GPR41\/43 and inhibition of HDACs","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128877_bib143","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/MOG.0000000000000156","article-title":"Bile acids as metabolic regulators","volume":"31","author":"Li","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.envpol.2026.128877_bib144","first-page":"91","article-title":"Extremely cold and hot temperatures increase the risk of diabetes mortality in metropolitan areas of two Chinese cities","volume":"134","author":"Li","year":"2014","journal-title":"Environ. Res., Linking Exposure and Health in Environmental Public Health Tracking"},{"key":"10.1016\/j.envpol.2026.128877_bib145","article-title":"Reduction of intestinal trimethylamine by probiotics ameliorated lipid metabolic disorders associated with atherosclerosis","volume":"79\u201380","author":"Liang","year":"2020","journal-title":"Nutrition"},{"key":"10.1016\/j.envpol.2026.128877_bib146","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1017\/S0007114514003110","article-title":"Effect of oligofructose supplementation on body weight in overweight and Obese children: a randomised, double-blind, placebo-controlled trial","volume":"112","author":"Liber","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib147","article-title":"Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-Independent mechanisms","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.128877_bib148","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1016\/S2542-5196(24)00332-2","article-title":"Climate change effects on the human gut microbiome: complex mechanisms and global inequities","volume":"9","author":"Litchman","year":"2025","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.envpol.2026.128877_bib149","first-page":"362","article-title":"Colonocyte metabolism shapes the gut microbiota","author":"Litvak","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.envpol.2026.128877_bib150","article-title":"Associations between non-optimum temperatures and cardiovascular hospital admissions and effect modification by ambient particulate air pollution: a two-stage time-series study in China","volume":"68","author":"Liu","year":"2026","journal-title":"Lancet Reg. Health West. Pac."},{"key":"10.1016\/j.envpol.2026.128877_bib151","article-title":"Regulation of short-chain fatty acids in the immune system","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2026.128877_bib152","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.634897","article-title":"Modulation of gut microbiota and immune system by probiotics, pre-biotics, and post-biotics","volume":"8","author":"Liu","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib153","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2337\/dc20-0884","article-title":"Association of serum bile acids profile and pathway dysregulation with the risk of developing diabetes among normoglycemic Chinese adults: findings from the 4C study","volume":"44","author":"Lu","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.envpol.2026.128877_bib154","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1289\/ehp.1307429","article-title":"Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis","volume":"122","author":"Lu","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.128877_bib155","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ehf2.12155","article-title":"Heart failure is associated with depletion of core intestinal microbiota","volume":"4","author":"Luedde","year":"2017","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.envpol.2026.128877_bib156","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/ijo.2010.50","article-title":"The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years","volume":"34","author":"Luoto","year":"2010","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.envpol.2026.128877_bib157","doi-asserted-by":"crossref","DOI":"10.1007\/s13105-024-01019-w","article-title":"Effect of chronic cold stress on gut microbial diversity, intestinal inflammation and pyroptosis in mice","author":"Lv","year":"2024","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.envpol.2026.128877_bib158","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160244","article-title":"Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion","volume":"37","author":"Ma","year":"2017","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib159","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.aninu.2021.09.012","article-title":"The interaction among gut microbes, the intestinal barrier and short chain fatty acids","volume":"9","author":"Ma","year":"2022","journal-title":"Animal Nutrition"},{"key":"10.1016\/j.envpol.2026.128877_bib160","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.toxlet.2016.12.017","article-title":"Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria","volume":"267","author":"Makrecka-Kuka","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2026.128877_bib161","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/CIRCULATIONAHA.116.024545","article-title":"High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice","volume":"135","author":"Marques","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.128877_bib162","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00042-15","article-title":"Characterization and detection of a widely distributed gene cluster that predicts anaerobic choline utilization by human gut bacteria","volume":"6","author":"Mart\u00ednez-del Campo","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.envpol.2026.128877_bib163","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/CIRCRESAHA.118.313348","article-title":"The mediterranean diet and cardiovascular health","volume":"124","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.envpol.2026.128877_bib164","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.616506","article-title":"Impaired intestinal barrier and tissue bacteria: pathomechanisms for metabolic diseases","volume":"12","author":"Massier","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envpol.2026.128877_bib165","doi-asserted-by":"crossref","first-page":"13065","DOI":"10.1074\/jbc.RA120.014266","article-title":"Carnitine metabolism in the human gut: characterization of the two-component carnitine monooxygenase CntAB from Acinetobacter baumannii","volume":"295","author":"Massmig","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.128877_bib166","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3382\/ps.2010-01220","article-title":"Effect of lactic acid bacteria probiotic culture for the treatment of Salmonella enterica serovar heidelberg in neonatal broiler chickens and Turkey poults","volume":"90","author":"Menconi","year":"2011","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2024.106620","article-title":"Gut-mammary pathway: breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut","volume":"124","author":"Meng","year":"2025","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.envpol.2026.128877_bib168","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cmet.2005.09.010","article-title":"Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein","volume":"2","author":"Mithieux","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.envpol.2026.128877_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123981","article-title":"The gut microbiota and cardiovascular disease: exploring the role of microbial dysbiosis and metabolites in pathogenesis and therapeutics","volume":"381","author":"Mohsenzadeh","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib170","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12265-020-10052-1","article-title":"Probiotics supplementation on cardiac remodeling following myocardial infarction: a single-center double-blind clinical study","volume":"14","author":"Moludi","year":"2021","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.envpol.2026.128877_bib171","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nclimate3322","article-title":"Global risk of deadly heat","volume":"7","author":"Mora","year":"2017","journal-title":"Nat. Clim. Change"},{"key":"10.1016\/j.envpol.2026.128877_bib172","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.envpol.2026.128877_bib173","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the global Burden of disease study 2019","volume":"396","author":"Murray","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.envpol.2026.128877_bib174","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1136\/gutjnl-2020-323617","article-title":"Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial","volume":"71","author":"Ng","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.128877_bib175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.017400","article-title":"How informative is the mouse for human gut microbiota research?","volume":"8","author":"Nguyen","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.envpol.2026.128877_bib176","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1053\/j.gastro.2017.05.055","article-title":"Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity","volume":"153","author":"Nicolucci","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.envpol.2026.128877_bib177","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1897212","article-title":"The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health","volume":"13","author":"Nogal","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.envpol.2026.128877_bib178","doi-asserted-by":"crossref","first-page":"660","DOI":"10.5551\/jat.RV17006","article-title":"Are short chain fatty acids in gut microbiota defensive players for inflammation and atherosclerosis?","volume":"24","author":"Ohira","year":"2017","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.envpol.2026.128877_bib179","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbrc.2010.11.086","article-title":"The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver. Biochem","volume":"404","author":"Oiso","year":"2011","journal-title":"Biophys. Res. Commun"},{"key":"10.1016\/j.envpol.2026.128877_bib180","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56817-w","article-title":"Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPAR\u03b3 signaling","volume":"9","author":"Park","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib181","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-061297","article-title":"How do high ambient temperatures affect infant feeding practices? A prospective cohort study of postpartum women in bobo-dioulasso, Burkina Faso","volume":"12","author":"Part","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.envpol.2026.128877_bib182","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005784","article-title":"Gut-derived serum lipopolysaccharide is associated with enhanced risk of major adverse cardiovascular events in atrial fibrillation: effect of adherence to Mediterranean Diet","volume":"6","author":"Pastori","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.envpol.2026.128877_bib183","doi-asserted-by":"crossref","first-page":"263","DOI":"10.12944\/CRNFSJ.3.3.10","article-title":"Inflammation and metabolic syndrome: an overview","volume":"3","author":"Patel","year":"2015","journal-title":"Current Research in Nutrition and Food Science Journal"},{"key":"10.1016\/j.envpol.2026.128877_bib184","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.128877_bib185","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202200337","article-title":"Impact of intermittent fasting on the gut microbiota: a systematic review","volume":"7","author":"P\u00e9rez-Gerdel","year":"2023","journal-title":"Adv. Biol."},{"key":"10.1016\/j.envpol.2026.128877_bib186","article-title":"Distinct metabolic features of pathogenic Escherichia coli and Shigella spp. determined by label-free quantitative proteomics","volume":"21","author":"Pettersen","year":"2021","journal-title":"Proteomics"},{"key":"10.1016\/j.envpol.2026.128877_bib187","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102534","article-title":"Health benefits of heat-killed (Tyndallized) probiotics: an overview","volume":"20","author":"Piqu\u00e9","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib188","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4161\/gmic.27492","article-title":"A novel SCFA receptor, the microbiota, and blood pressure regulation","volume":"5","author":"Pluznick","year":"2014","journal-title":"Gut Microbes"},{"issue":"25","key":"10.1016\/j.envpol.2026.128877_bib189","article-title":"Microbial short-chain fatty acids and blood pressure regulation","volume":"19","author":"Pluznick","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib190","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cmet.2011.11.006","article-title":"TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading","volume":"14","author":"Pols","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.envpol.2026.128877_bib191","first-page":"1","article-title":"Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes","volume":"2014","author":"Puddu","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.envpol.2026.128877_bib192","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.756810","article-title":"The association of plant-based diet with cardiovascular disease and mortality: a meta-analysis and systematic review of prospect cohort studies","volume":"8","author":"Quek","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib193","first-page":"1057","article-title":"The vascular endothelium and human diseases. Int","volume":"9","author":"Rajendran","year":"2013","journal-title":"J. Biol. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib194","doi-asserted-by":"crossref","DOI":"10.3390\/nu14204411","article-title":"The association between circulating branched chain amino acids and the temporal risk of developing type 2 diabetes mellitus: a systematic review & meta-analysis","volume":"14","author":"Ramzan","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2021.111217","article-title":"Dietary fibers as beneficial microbiota modulators: a proposed classification by prebiotic categories","volume":"89","author":"Rezende","year":"2021","journal-title":"Nutrition"},{"key":"10.1016\/j.envpol.2026.128877_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/foods11020146","article-title":"Polyunsaturated fatty acids as prebiotics: innovation or confirmation?","volume":"11","author":"Rinninella","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.envpol.2026.128877_bib197","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1111\/gcb.16877","article-title":"Climate change drives loss of bacterial gut mutualists at the expense of host survival in wild meerkats","volume":"29","author":"Risely","year":"2023","journal-title":"Glob. Change Biol."},{"key":"10.1016\/j.envpol.2026.128877_bib198","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00277","article-title":"Protective effects of short-chain fatty acids on endothelial dysfunction induced by angiotensin II","volume":"11","author":"Robles-Vera","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.envpol.2026.128877_bib199","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/ijms24010045","article-title":"Polyphenols as drivers of a homeostatic gut microecology and immuno-metabolic traits of Akkermansia muciniphila: from mouse to man","volume":"24","author":"Rodr\u00edguez-Daza","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib200","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ijo.2016.23","article-title":"Reprogramming of hepatic fat accumulation and \u201cbrowning\u201d of adipose tissue by the short-chain fatty acid acetate","volume":"40","author":"Sahuri-Arisoylu","year":"2016","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.envpol.2026.128877_bib201","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","article-title":"The international scientific association of probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics","volume":"18","author":"Salminen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envpol.2026.128877_bib202","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/s41591-019-0485-4","article-title":"Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism","volume":"25","author":"Scheiman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib203","doi-asserted-by":"crossref","DOI":"10.1038\/srep16643","article-title":"Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice","volume":"5","author":"Schneeberger","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib204","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.celrep.2017.05.077","article-title":"The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue","volume":"19","author":"Schugar","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091105","article-title":"The warmer the weather, the more gram-negative bacteria - impact of temperature on clinical isolates in intensive care units","volume":"9","author":"Schwab","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.128877_bib206","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.00384","article-title":"The effects of temperature on animal gut microbiomes","volume":"11","author":"Sepulveda","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib207","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2174\/1570179420666230607124949","article-title":"The golden spice for life: turmeric with the pharmacological benefits of curcuminoids components, including curcumin, bisdemethoxycurcumin, and demethoxycurcumins","volume":"21","author":"Shahrajabian","year":"2024","journal-title":"Curr. Org. Synth."},{"key":"10.1016\/j.envpol.2026.128877_bib208","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3945\/ajcn.117.157107","article-title":"Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes","volume":"106","author":"Shan","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib209","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/ph16040504","article-title":"Gut-derived metabolite, Trimethylamine-N-oxide (TMAO) in cardio-metabolic diseases: detection, mechanism, and potential therapeutics","volume":"16","author":"Shanmugham","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.envpol.2026.128877_bib210","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.3382\/ps\/pez026","article-title":"Impact of gut microbiota structure in heat-stressed broilers","volume":"98","author":"Shi","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib211","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced Obese mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.128877_bib212","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s13205-025-04675-x","article-title":"Soil influences on rural versus urban human gut microbiota and implications on cardio-metabolic health: a comparative pilot study","volume":"16","author":"Shukla","year":"2026","journal-title":"3 Biotech"},{"key":"10.1016\/j.envpol.2026.128877_bib213","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.kint.2016.09.040","article-title":"Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects","volume":"91","author":"Soleimani","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.envpol.2026.128877_bib214","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.anifeedsci.2013.08.001","article-title":"Cello-oligosaccharide ameliorates heat stress-induced impairment of intestinal microflora, morphology and barrier integrity in broilers","volume":"185","author":"Song","year":"2013","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128877_bib215","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3382\/ps.2013-03455","article-title":"Effect of a probiotic mixture on intestinal microflora, morphology, and barrier integrity of broilers subjected to heat stress","volume":"93","author":"Song","year":"2014","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib216","first-page":"143","article-title":"Effects of microencapsulated cinnamon oil on antioxidant capacity and gut microbiota in mice","volume":"42","author":"Song","year":"2021","journal-title":"Shipin Kexue\/Food Science"},{"key":"10.1016\/j.envpol.2026.128877_bib217","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3390\/microorganisms8111715","article-title":"The influence of probiotics on the firmicutes\/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease","volume":"8","author":"Stojanov","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.envpol.2026.128877_bib218","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s13238-018-0546-3","article-title":"Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives","volume":"9","author":"Sun","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.envpol.2026.128877_bib219","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/HYPERTENSIONAHA.118.12109","article-title":"Gut microbiota composition and blood pressure","volume":"73","author":"Sun","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.envpol.2026.128877_bib220","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1205323","article-title":"Bacteroides dorei BDX-01 alleviates DSS-Induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway","volume":"14","author":"Sun","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128877_bib221","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.3390\/nu14132649","article-title":"Dietary therapy in prevention of cardiovascular disease (CVD)\u2014Tradition or modernity? A review of the latest approaches to nutrition in CVD","volume":"14","author":"Szczepa\u0144ska","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib222","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3390\/nu10060773","article-title":"Dose-dependent effects of multispecies probiotic supplementation on the lipopolysaccharide (LPS) level and cardiometabolic profile in Obese postmenopausal women: a 12-Week randomized clinical trial","volume":"10","author":"Szuli\u0144ska","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib223","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/biomedicines12030537","article-title":"Metabolic effects of brown adipose tissue activity due to cold exposure in humans: a systematic review and meta-analysis of RCTs and Non-RCTs","volume":"12","author":"Tabei","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.envpol.2026.128877_bib224","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3164\/jcbn.15-15","article-title":"Dietary polyphenols increase fecal mucin and immunoglobulin A and ameliorate the disturbance in gut microbiota caused by a high fat diet","volume":"57","author":"Taira","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.anaerobe.2006.12.001","article-title":"Influence of high temperature and humidity on rumen bacterial diversity in Holstein heifers","volume":"13","author":"Tajima","year":"2007","journal-title":"Anaerobe"},{"key":"10.1016\/j.envpol.2026.128877_bib226","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900257","article-title":"Trimethylamine N \u2010oxide aggravates liver steatosis through modulation of bile acid metabolism and inhibition of Farnesoid X receptor signaling in nonalcoholic fatty liver disease","volume":"63","author":"Tan","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envpol.2026.128877_bib227","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1172\/JCI72331","article-title":"The contributory role of gut microbiota in cardiovascular disease","volume":"124","author":"Tang","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.envpol.2026.128877_bib228","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/CIRCRESAHA.117.309715","article-title":"Gut microbiota in cardiovascular health and disease","volume":"120","author":"Tang","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.envpol.2026.128877_bib229","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1017\/S0007114512002723","article-title":"Higher level of faecal SCFA in women correlates with metabolic syndrome risk factors","volume":"109","author":"Teixeira","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib230","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s40104-023-00886-5","article-title":"Characteristics of glucose and lipid metabolism and the interaction between gut microbiota and colonic mucosal immunity in pigs during cold exposure","volume":"14","author":"Teng","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib231","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrd2619","article-title":"Targeting bile-acid signalling for metabolic diseases","volume":"7","author":"Thomas","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.envpol.2026.128877_bib232","first-page":"1","article-title":"A possible change process of inflammatory cytokines in the prolonged chronic stress and its ultimate implications for health","author":"Tian","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.envpol.2026.128877_bib233","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1080\/19490976.2020.1732268","article-title":"The microbiome modulating activity of bile acids","volume":"11","author":"Tian","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.envpol.2026.128877_bib234","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1016\/j.psj.2019.12.046","article-title":"High-temperature exposure alters the community structure and functional features of the intestinal microbiota in Shaoxing ducks (Anas platyrhynchos)","volume":"99","author":"Tian","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib235","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.3390\/nu12092671","article-title":"The role of specific components of a plant-based diet in management of dyslipidemia and the impact on cardiovascular risk","volume":"12","author":"Trautwein","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib236","doi-asserted-by":"crossref","DOI":"10.1016\/j.gfs.2021.100539","article-title":"Climate change and obesity: a global analysis","volume":"29","author":"Trentinaglia","year":"2021","journal-title":"Global Food Secur."},{"key":"10.1016\/j.envpol.2026.128877_bib237","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.2337\/dc13-0451","article-title":"Plasma Lipopolysaccharide is closely associated with glycemic control and abdominal obesity","volume":"36","author":"Tr\u00f8seid","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.envpol.2026.128877_bib238","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/microorganisms8040573","article-title":"The controversial role of human gut Lachnospiraceae","volume":"8","author":"Vacca","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.envpol.2026.128877_bib239","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.3390\/nu13051450","article-title":"Brown adipose tissue: new challenges for prevention of childhood obesity. A narrative review","volume":"13","author":"Verduci","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib240","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1093\/eurheartj\/ehaa704","article-title":"Associations between gut microbiota, faecal short-chain fatty acids, and blood pressure across ethnic groups: the HELIUS study","volume":"41","author":"Verhaar","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.envpol.2026.128877_bib241","article-title":"Effects of heat stress on carbohydrate and lipid metabolism in growing pigs","volume":"3","author":"Victoria Sanz Fernandez","year":"2015","journal-title":"Phys. Rep."},{"key":"10.1016\/j.envpol.2026.128877_bib242","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41569-022-00737-2","article-title":"Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease","volume":"20","author":"Violi","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.envpol.2026.128877_bib243","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke Statistics\u20142021 update","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.128877_bib244","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/bph.14178","article-title":"Eicosanoids in the gastrointestinal tract","volume":"176","author":"Wallace","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128877_bib245","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155199","article-title":"Cold exposure, gut microbiota, and hypertension: a mechanistic study","volume":"833","author":"Wang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128877_bib246","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41591-020-01223-3","article-title":"The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk","volume":"27","author":"Wang","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib247","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.3390\/ani11051286","article-title":"Effects of heat stress on gut-microbial metabolites, gastrointestinal peptides, glycolipid metabolism, and performance of broilers","volume":"11","author":"Wang","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.envpol.2026.128877_bib248","doi-asserted-by":"crossref","first-page":"8943","DOI":"10.1021\/acsnano.8b02037","article-title":"Targeted therapy of atherosclerosis by a broad-spectrum reactive oxygen species scavenging nanoparticle with intrinsic anti-inflammatory activity","volume":"12","author":"Wang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.envpol.2026.128877_bib249","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jconrel.2021.01.002","article-title":"Recent advances of nanomedicine-based strategies in diabetes and complications management: diagnostics, monitoring, and therapeutics","volume":"330","author":"Wang","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.envpol.2026.128877_bib250","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnaa134","article-title":"Gut microbiome adaptation to extreme cold winter in wild Plateau pika (Ochotona curzoniae) on the Qinghai-Tibet Plateau","volume":"367","author":"Wang","year":"2020","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.envpol.2026.128877_bib251","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.128877_bib252","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1172\/JCI21025","article-title":"Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c","volume":"113","author":"Watanabe","year":"2004","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.envpol.2026.128877_bib253","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1038\/s41396-019-0480-2","article-title":"Global change-driven use of onshore habitat impacts polar bear faecal microbiota","volume":"13","author":"Watson","year":"2019","journal-title":"ISME J."},{"key":"10.1016\/j.envpol.2026.128877_bib254","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.706772","article-title":"Heat stress alters the intestinal microbiota and metabolomic profiles in mice","volume":"12","author":"Wen","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib255","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature24628","article-title":"Salt-responsive gut commensal modulates TH17 axis and disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.128877_bib256","doi-asserted-by":"crossref","DOI":"10.1128\/aem.00530-22","article-title":"Sustained drought, but not short-term warming, alters the gut microbiomes of wild anolis lizards","volume":"88","author":"Williams","year":"2022","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib257","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00004836-200603000-00015","article-title":"Colonic health: fermentation and short chain fatty acids","volume":"40","author":"Wong","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.envpol.2026.128877_bib258","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1675652","article-title":"Hyperoxia as a driver of gut dysbiosis","volume":"16","author":"Wu","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib259","article-title":"Impact of miR-223-3p and miR-2909 on inflammatory factors IL-6, IL-1\u00df, and TNF-\u03b1, and the TLR4\/TLR2\/NF-\u03baB\/STAT3 signaling pathway induced by lipopolysaccharide in human adipose stem cells","volume":"14","author":"Wu","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.128877_bib260","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.985636","article-title":"Washed microbiota transplantation improves patients with high blood glucose in South China","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envpol.2026.128877_bib261","first-page":"578","article-title":"Supplementation of fermented barley extracts with Lactobacillus Plantarum dy-1 inhibits obesity via a UCP1-dependent mechanism","volume":"32","author":"Xiao","year":"2019","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib262","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.3390\/nu13041104","article-title":"Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease","volume":"13","author":"Xie","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib263","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.3390\/foods11182863","article-title":"Health benefits and side effects of short-chain fatty acids","volume":"11","author":"Xiong","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.envpol.2026.128877_bib264","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/1751-7915.13524","article-title":"The gut microbiota and its interactions with cardiovascular disease","volume":"13","author":"Xu","year":"2020","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib265","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/nu10111618","article-title":"The immunomodulatory and anti-inflammatory role of polyphenols","volume":"10","author":"Yahfoufi","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib266","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/FJC.0000000000000747","article-title":"Dietary apigenin reduces induction of LOX-1 and NLRP3 expression, leukocyte adhesion, and acetylated low-density lipoprotein uptake in human endothelial cells exposed to Trimethylamine-N-Oxide","volume":"74","author":"Yamagata","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128877_bib267","doi-asserted-by":"crossref","first-page":"15213","DOI":"10.1021\/acs.jafc.2c04509","article-title":"Dietary turmeric consumption alleviates ulcerative colitis via restoring tryptophan metabolism and alleviating gut microbiota dysbiosis in mice","volume":"70","author":"Yang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.envpol.2026.128877_bib268","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.115.05315","article-title":"Gut dysbiosis is linked to hypertension","volume":"65","author":"Yang","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.envpol.2026.128877_bib269","doi-asserted-by":"crossref","DOI":"10.1093\/ehjopen\/oeac021","article-title":"High-circulating gut microbiota-dependent metabolite trimethylamine N-oxide is associated with poor prognosis in pulmonary arterial hypertension","volume":"2","author":"Yang","year":"2022","journal-title":"European Heart Journal Open"},{"key":"10.1016\/j.envpol.2026.128877_bib270","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144568","article-title":"Effect of temperature stress on gut-brain axis in mice: regulation of intestinal microbiome and central NLRP3 inflammasomes","volume":"772","author":"Yi","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128877_bib271","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.747136","article-title":"The effect of exogenous bile acids on antioxidant status and gut microbiota in heat-stressed broiler chickens","volume":"8","author":"Yin","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib272","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00253-024-13007-7","article-title":"Therapeutic applications of gut microbes in cardiometabolic diseases: current state and perspectives","volume":"108","author":"Yuan","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib273","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1007\/s00253-015-6564-7","article-title":"Evidence for cholesterol-lowering activity by Bifidobacterium bifidum PRL2010 through gut microbiota modulation","volume":"99","author":"Zanotti","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib274","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3390\/microorganisms10081672","article-title":"The association between gut microbiome diversity and composition and heat tolerance in cattle","volume":"10","author":"Zhang","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.envpol.2026.128877_bib275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41522-022-00283-2","article-title":"Porcine gut microbiota in mediating host metabolic adaptation to cold stress","volume":"8","author":"Zhang","year":"2022","journal-title":"npj Biofilms Microbiomes"},{"key":"10.1016\/j.envpol.2026.128877_bib276","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.3390\/nu14245373","article-title":"The interaction of polyphenols and the gut microbiota in neurodegenerative diseases","volume":"14","author":"Zhang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128877_bib277","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2337\/db19-0920","article-title":"Branched-chain amino acids exacerbate obesity-related hepatic glucose and lipid metabolic disorders via attenuating Akt2 signaling","volume":"69","author":"Zhao","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.envpol.2026.128877_bib278","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.aao5774","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.envpol.2026.128877_bib279","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.3748\/wjg.v28.i23.2546","article-title":"Fecal microbiota transplantation in the metabolic diseases: current status and perspectives","volume":"28","author":"Zheng","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.envpol.2026.128877_bib280","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2017.01.009","article-title":"High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation","volume":"104","author":"Zhenyukh","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2026.128877_bib281","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.679624","article-title":"Washed microbiota transplantation lowers blood pressure in patients with hypertension","volume":"11","author":"Zhong","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.envpol.2026.128877_bib282","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1007\/s00253-019-09673-7","article-title":"Temperature and humidity index (THI)-induced rumen bacterial community changes in goats","volume":"103","author":"Zhong","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib283","article-title":"Gut microbiota and serum metabolite potential interactions in growing layer hens exposed to high-ambient temperature","volume":"9","author":"Zhou","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.envpol.2026.128877_bib284","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170060","article-title":"Cold exposure, gut microbiota and health implications: a narrative review","volume":"916","author":"Zhou","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128877_bib285","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00253-018-9465-8","article-title":"Heat stress mediates changes in fecal microbiome and functional pathways of laying hens","volume":"103","author":"Zhu","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.envpol.2026.128877_bib286","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1073\/pnas.1316569111","article-title":"Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota","volume":"111","author":"Zhu","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.envpol.2026.128877_bib287","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.cmet.2016.05.001","article-title":"Altered microbiota contributes to reduced diet-induced obesity upon cold exposure","volume":"23","author":"Zi\u0119tak","year":"2016","journal-title":"Cell Metab."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126012479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126012479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:26:54Z","timestamp":1790422014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126012479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":287,"alternative-id":["S0269749126012479"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128877","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of climatic extreme temperatures on gut microbiome-mediated cardio-metabolic health","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128877"}}