{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:00:53Z","timestamp":1790424053546,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.envpol.2026.128878","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:34:35Z","timestamp":1785800075000},"page":"128878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Elucidating 6PPD-Q-induced metabolic reprogramming and systemic injury via ultrasensitive breathomics"],"prefix":"10.1016","volume":"408","author":[{"given":"Jiawei","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7176-4583","authenticated-orcid":false,"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5218-9007","authenticated-orcid":false,"given":"Mo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-4698","authenticated-orcid":false,"given":"Zhongbing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6514-5708","authenticated-orcid":false,"given":"Liwei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinwei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfa","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.128878_bib1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2119\/molmed.2016.00054","article-title":"Superoxide induces neutrophil extracellular trap formation in a TLR-4 and NOX-dependent mechanism","volume":"22","author":"Al-Khafaji Ab","year":"2016","journal-title":"Mol. Med."},{"issue":"5","key":"10.1016\/j.envpol.2026.128878_bib2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41575-020-0269-9","article-title":"Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders","volume":"17","author":"Aron-Wisnewsky","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envpol.2026.128878_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124969","article-title":"A bibliometric analysis of global research hotspots and progress on emerging environmental pollutants 6PPD and 6PPD-quinone from 2004 to 2024","volume":"362","author":"Babaei","year":"2024","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.envpol.2026.128878_bib4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1369\/0022155419852932","article-title":"Renal inflammation and fibrosis: a double-edged sword","volume":"67","author":"Black","year":"2019","journal-title":"J. Histochem. Cytochem."},{"issue":"2","key":"10.1016\/j.envpol.2026.128878_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/em.21824","article-title":"Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis","volume":"55","author":"Brooks","year":"2014","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.envpol.2026.128878_bib6","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3389\/fimmu.2017.01835","article-title":"Effects of anti-IL-17 on inflammation, remodeling, and oxidative stress in an experimental model of asthma exacerbated by LPS","volume":"8","author":"Camargo","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2026.128878_bib7","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1021\/acs.est.1c07376","article-title":"New evidence of rubber-derived quinones in water, air, and soil","volume":"56","author":"Cao","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128878_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2024.110062","article-title":"Tire rubber-derived contaminant 6PPD had the potential to induce metabolism disorder in early developmental stage of zebrafish","volume":"287","author":"Chanlin","year":"2025","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2026.128878_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131245","article-title":"Analysis, environmental occurrence, fate and potential toxicity of tire wear compounds 6PPD and 6PPD-quinone","volume":"452","author":"Chen","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128878_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143205","article-title":"Detection of 6-PPD and 6-PPDQ in airborne particulates and assessment of their toxicity in lung cells","volume":"364","author":"Chen","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.128878_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54180-7","article-title":"Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.128878_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137781","article-title":"Unveiling the systemic impact of airborne microplastics: integrating breathomics and machine learning with dual-tissue transcriptomics","volume":"490","author":"Chen","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.128878_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ani13182894","article-title":"Integrated metabolome and transcriptome analyses reveal the efficacy of steroidal saponins for glucose and lipid metabolism in hybrid grouper (\u2640epinephelus fuscoguttatus \u00d7 \u2642epinephelus lanceolatu) fed higher-lipid diets","volume":"13","author":"Deng","year":"2023","journal-title":"Animals"},{"issue":"21","key":"10.1016\/j.envpol.2026.128878_bib14","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1021\/acs.est.4c01106","article-title":"In vitro and in vivo biotransformation profiling of 6PPD-quinone toward their detection in human urine","volume":"58","author":"Deng","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128878_bib15","article-title":"Chiral perspective evaluations: enantioselective hydrolysis of 6PPD and 6PPD-quinone in water and enantioselective toxicity to Gobiocypris rarus and Oncorhynchus mykiss","volume":"166","author":"Di S","year":"2022","journal-title":"Environ. Int."},{"issue":"12","key":"10.1016\/j.envpol.2026.128878_bib16","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acs.estlett.2c00821","article-title":"First report on the occurrence of N-(1, 3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine (6PPD) and 6PPD-quinone as pervasive pollutants in human urine from South China","volume":"9","author":"Du","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"issue":"2","key":"10.1016\/j.envpol.2026.128878_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/acs.chemrestox.9b00322","article-title":"Isoprene-derived secondary organic aerosol induces the expression of microRNAs associated with inflammatory\/oxidative stress response in lung cells","volume":"33","author":"Eaves","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2026.128878_bib18","first-page":"640157","article-title":"Sphingolipid metabolism drives mitochondria remodeling during aging and oxidative stress","author":"Ebert","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.envpol.2026.128878_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161836","article-title":"Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice","volume":"869","author":"Fang","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envpol.2026.128878_bib20","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00427-2022","article-title":"Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study","volume":"9","author":"Fenn","year":"2023","journal-title":"ERJ Open Research"},{"issue":"1","key":"10.1016\/j.envpol.2026.128878_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41392-024-01811-6","article-title":"Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets","volume":"9","author":"Fleishman","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.envpol.2026.128878_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113993","article-title":"Mechanobiology and the extracellular matrix in pulmonary fibrosis","author":"Ganzleben","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.envpol.2026.128878_bib23","article-title":"Fatty acid \u03b2-oxidation in kidney diseases: perspectives on pathophysiological mechanisms and therapeutic opportunities","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.envpol.2026.128878_bib24","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3390\/nu13051580","article-title":"Sugar or fat? Renal tubular metabolism reviewed in health and disease","volume":"13","author":"Gewin","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.128878_bib25","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1002\/jmv.26094","article-title":"Protective role of overexpressed MUC5AC against fibrosis in MHV-68-induced combined pulmonary fibrosis and emphysema mouse model","volume":"92","author":"He","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.envpol.2026.128878_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164842","article-title":"Four-week repeated exposure to tire-derived 6-PPD quinone causes multiple organ injury in male BALB\/c mice","volume":"894","author":"He","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128878_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132265","article-title":"Tire-rubber related pollutant 6-PPD quinone: a review of its transformation, environmental distribution, bioavailability, and toxicity","volume":"459","author":"Hua","year":"2023","journal-title":"J. Hazard Mater."},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3390\/metabo13030426","article-title":"Cross-regulation of the cellular redox system, oxygen, and sphingolipid signalling","volume":"13","author":"Huwiler","year":"2023","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.envpol.2026.128878_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-19232-y","article-title":"Oxidative stress generated DNA damage by 6PPD and other tyre additives in A549 human lung epithelial cells","volume":"15","author":"Hyman","year":"2025","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.envpol.2026.128878_bib30","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.3390\/ijms22115717","article-title":"Pathophysiological aspects of alcohol metabolism in the liver","volume":"22","author":"Hyun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128878_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.119492","article-title":"Environmental fate of tire-rubber related pollutants 6PPD and 6PPD-Q: a review","volume":"258","author":"Ihenetu","year":"2024","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib32","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1039\/D2AY01865A","article-title":"Direct detection of acetonitrile at the pptv level with photoinduced associative ionization time-of-flight mass spectrometry","volume":"15","author":"Jiang","year":"2023","journal-title":"Anal. Methods"},{"key":"10.1016\/j.envpol.2026.128878_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108677","article-title":"Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone","volume":"187","author":"Jiang","year":"2024","journal-title":"Environ. Int."},{"issue":"8","key":"10.1016\/j.envpol.2026.128878_bib34","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3390\/biom15081205","article-title":"Integrated multi-omics investigation of gypenosides' mechanisms in lowering hepatic cholesterol","volume":"15","author":"Jiang","year":"2025","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.envpol.2026.128878_bib35","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3390\/toxins17120592","article-title":"Correlations between Trimethylamine-N-Oxide, megalin, lysine and markers of tubular damage in chronic kidney disease","volume":"17","author":"Kapetanaki","year":"2025","journal-title":"Toxins"},{"key":"10.1016\/j.envpol.2026.128878_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2025.107073","article-title":"Amino acids mixture ameliorates alcohol-induced liver and behavioral impairments by modulating Nrf2 and ethanol metabolism","volume":"134","author":"Kim","year":"2025","journal-title":"J. Funct.Foods"},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib37","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3390\/ijms19030722","article-title":"Divergent role of sphingosine 1-phosphate in liver health and disease","volume":"19","author":"Kleuser","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.128878_bib38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/toxsci\/kfad020","article-title":"Fine particulate matter (PM2.5)-induced pulmonary oxidative stress contributes to changes in the plasma lipidome and liver transcriptome in mice","volume":"192","author":"Kurlawala","year":"2023","journal-title":"Toxicol. Sci."},{"issue":"8","key":"10.1016\/j.envpol.2026.128878_bib39","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3109\/1061186X.2014.928715","article-title":"Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism and providing new hope for metabolic syndrome","volume":"22","author":"Li","year":"2014","journal-title":"J. Drug Target."},{"key":"10.1016\/j.envpol.2026.128878_bib40","article-title":"Residues of 6PPD-Q in the aquatic environment and toxicity to aquatic organisms: a review","volume":"10","author":"Li","year":"2025","journal-title":"Fishes"},{"key":"10.1016\/j.envpol.2026.128878_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174449","article-title":"P-phenylenediamine antioxidants and their quinone derivatives: a review of their environmental occurrence, accessibility, potential toxicity, and human exposure","volume":"948","author":"Liang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128878_bib42","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1038\/s41467-023-39482-6","article-title":"The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.128878_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175592","article-title":"Comparative toxic effect of tire wear particle-derived compounds 6PPD and 6PPD-quinone to Chlorella vulgaris","volume":"951","author":"Liu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib44","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1021\/acs.est.4c09276","article-title":"Long-Term exposure to tire-derived 6-PPD quinone causes neurotoxicity and neuroinflammation via inhibition of HTR2A in C57BL\/6 mice","volume":"59","author":"Ma","year":"2025","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.envpol.2026.128878_bib45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3164\/jcbn.21-50","article-title":"The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure","volume":"70","author":"Mizota","year":"2022","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.envpol.2026.128878_bib46","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1165\/rcmb.2019-0454OC","article-title":"Genome-wide analysis reveals mucociliary remodeling of the nasal airway epithelium induced by urban PM2.5","volume":"63","author":"Montgomery MT","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.105679","article-title":"Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling","volume":"300","author":"Morimoto","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.envpol.2026.128878_bib48","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41580-024-00767-3","article-title":"Mechanisms of assembly and remodelling of the extracellular matrix","volume":"25","author":"Naba","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2026.128878_bib49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.19040\/ecocycles.v9i3.347","article-title":"Review of 6PPD-quinone environmental occurrence, fate, and toxicity in stormwater","volume":"9","author":"Nicomel NR","year":"2023","journal-title":"ECOCYCLES"},{"issue":"2","key":"10.1016\/j.envpol.2026.128878_bib50","doi-asserted-by":"crossref","DOI":"10.1088\/1752-7155\/3\/2\/027005","article-title":"Endogenous volatile organic compounds in breath and blood of healthy volunteers: examining breath analysis as a surrogate for blood measurements","volume":"3","author":"O'hara","year":"2009","journal-title":"J. Breath Res."},{"issue":"8","key":"10.1016\/j.envpol.2026.128878_bib51","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.3390\/ijerph20085484","article-title":"Adhesion molecules in lung inflammation from repeated glyphosate exposures","volume":"20","author":"Pandher","year":"2023","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"12","key":"10.1016\/j.envpol.2026.128878_bib52","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.3390\/cells10123351","article-title":"Extracellular matrix oxidised by the granulocyte oxidants hypochlorous and hypobromous acid reduces lung fibroblast adhesion and proliferation in vitro","volume":"10","author":"Papanicolaou","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.envpol.2026.128878_bib53","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1152\/physrev.00049.2019","article-title":"Molecular physiology of bile acid signaling in health, disease, and aging","volume":"101","author":"Perino","year":"2021","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.envpol.2026.128878_bib54","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nm1238","article-title":"Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice","volume":"11","author":"Petrache","year":"2005","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.envpol.2026.128878_bib55","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/toxics12060389","article-title":"Effects of 6PPD-Quinone on human liver cell lines as revealed with cell viability assay and metabolomics analysis","volume":"12","author":"Qi","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.128878_bib56","article-title":"The cellular stability hypothesis: evidence of ferroptosis and accelerated aging-associated diseases as newly identified nutritional pentadecanoic acid (C15:0) deficiency syndrome","volume":"14","author":"S","year":"2024","journal-title":"Metabolites"},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib57","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4161\/oxim.3.3.12288","article-title":"Acetaldehyde adducts in alcoholic liver disease","volume":"3","author":"Setshedi","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib58","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3390\/ijms23031254","article-title":"The role of sphingolipid signaling in oxidative lung injury and pathogenesis of bronchopulmonary dysplasia","volume":"23","author":"Thomas","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6525","key":"10.1016\/j.envpol.2026.128878_bib59","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.abd6951","article-title":"A ubiquitous tire rubber\u2013derived chemical induces acute mortality in coho salmon","volume":"371","author":"Tian","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.envpol.2026.128878_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/bios9020055","article-title":"Breath analysis using eNose and ion mobility technology to diagnose inflammatory bowel disease\u2014A pilot study","volume":"9","author":"Tiele","year":"2019","journal-title":"Biosensors"},{"key":"10.1016\/j.envpol.2026.128878_bib61","doi-asserted-by":"crossref","DOI":"10.5275\/ijcr.2012.07.04","article-title":"Volatile organic compounds in exhaled breath as biomarkers for the early detection and screening of lung cancer","author":"Tisch","year":"2012","journal-title":"International Journal of Clinical Reviews"},{"issue":"5","key":"10.1016\/j.envpol.2026.128878_bib62","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3390\/biology11050792","article-title":"PPAR alpha as a metabolic modulator of the liver: role in the pathogenesis of nonalcoholic steatohepatitis (NASH)","volume":"11","author":"Todisco","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.envpol.2026.128878_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13061431","article-title":"Exploring volatile organic compounds in breath for high-accuracy prediction of lung cancer","volume":"13","author":"Tsou","year":"2021","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib64","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3390\/antiox10030364","article-title":"Changes in glutathione content in liver diseases: an update","volume":"10","author":"Vairetti","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.envpol.2026.128878_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102725","article-title":"Volatomics in inflammatory bowel disease and irritable bowel syndrome","volume":"54","author":"Van Malderen","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.envpol.2026.128878_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175057","article-title":"Potential human health risk of the emerging environmental contaminant 6-PPD quinone","volume":"949","author":"Wan","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.128878_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101264","article-title":"The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: a transcriptome analysis","volume":"26","author":"Wang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2026.128878_bib68","first-page":"12","article-title":"Hmgcs2 is the hub gene in diabetic cardiomyopathy and is negatively regulated by Hmgcs2, promoting high glucose-induced cardiomyocyte injury","author":"Wang","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.envpol.2026.128878_bib69","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1093\/nar\/gkad1151","article-title":"Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle","volume":"52","author":"Wang","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.envpol.2026.128878_bib70","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/10408444.2020.1744514","article-title":"Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting","volume":"50","author":"Wastensson","year":"2020","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envpol.2026.128878_bib71","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6793346","article-title":"Exploration of the mechanism of linoleic acid metabolism dysregulation in metabolic syndrome","author":"Wen","year":"2022","journal-title":"Genetics Research"},{"issue":"1","key":"10.1016\/j.envpol.2026.128878_bib72","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s11658-024-00550-4","article-title":"Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor","volume":"29","author":"Xie","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"4","key":"10.1016\/j.envpol.2026.128878_bib73","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1513\/pats.201001-009SM","article-title":"Mechanisms and modification of chlorine-induced lung injury in animals","volume":"7","author":"Yadav","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.envpol.2026.128878_bib74","article-title":"Identification of natural killer cell-characteristic genes in atherosclerosis based on bioinformatics analysis","volume":"15","author":"Yang","year":"2025","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.envpol.2026.128878_bib75","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/acs.estlett.2c00193","article-title":"Widespread N-(1, 3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine quinone in size-fractioned atmospheric particles and dust of different indoor environments","volume":"9","author":"Zhang","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"issue":"36","key":"10.1016\/j.envpol.2026.128878_bib76","doi-asserted-by":"crossref","first-page":"13429","DOI":"10.1021\/acs.est.3c05026","article-title":"Urine excretion, organ distribution, and placental transfer of 6PPD and 6PPD-quinone in mice and potential developmental toxicity through nuclear receptor pathways","volume":"57","author":"Zhao","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128878_bib77","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jep.2019.01.041","article-title":"Fructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism","volume":"235","author":"Zhou","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.envpol.2026.128878_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138334","article-title":"6PPD-quinone exposure induces oxidative damage and physiological disruption in Eisenia fetida: an integrated analysis of phenotypes, multi-omics, and intestinal microbiota","volume":"493","author":"Zhou","year":"2025","journal-title":"J. Hazard Mater."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126012480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126012480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:28:23Z","timestamp":1790422103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126012480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":78,"alternative-id":["S0269749126012480"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128878","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating 6PPD-Q-induced metabolic reprogramming and systemic injury via ultrasensitive breathomics","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128878"}}