{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:59:24Z","timestamp":1790423964441,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.envpol.2026.128925","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:54:51Z","timestamp":1786722891000},"page":"128925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated computational and in vivo evidence prioritizes MYH6 as a candidate node in PFOS-associated HCM-like cardiac remodeling"],"prefix":"10.1016","volume":"408","author":[{"given":"Hao","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulei","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuepu","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.envpol.2026.128925_bib1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"issue":"7","key":"10.1016\/j.envpol.2026.128925_bib2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3390\/toxics11070567","article-title":"Cross-species transcriptomics analysis highlights conserved molecular responses to per- and polyfluoroalkyl substances","volume":"11","author":"Beccacece","year":"2023","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.envpol.2026.128925_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integrated Environ. Assess. Manag."},{"key":"10.1016\/j.envpol.2026.128925_bib4","series-title":"Safe and Sustainable by Design Chemicals and Materials \u2013 Framework for the Definition of Criteria and Evaluation Procedure for Chemicals and Materials","author":"Caldeira","year":"2022"},{"issue":"12","key":"10.1016\/j.envpol.2026.128925_bib5","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1039\/D0EM00355G","article-title":"The high persistence of PFAS is sufficient for their management as a chemical class","volume":"22","author":"Cousins","year":"2020","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.envpol.2026.128925_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108390","article-title":"Perfluorooctane sulfonic acid modulates expression of placental steroidogenesis-associated genes and hormone levels in pregnant rats","volume":"118","author":"Dangudubiyyam","year":"2023","journal-title":"Reprod. Toxicol."},{"issue":"9","key":"10.1016\/j.envpol.2026.128925_bib7","article-title":"Risk to human health related to the presence of perfluoroalkyl substances in food","volume":"18","author":"Schrenk","year":"2020","journal-title":"EFSA J."},{"issue":"3","key":"10.1016\/j.envpol.2026.128925_bib8","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1021\/acs.est.5c14563","article-title":"\"The dose makes the poison\": relevance of Paracelsus's principle for modern chemical hazard assessment with new approach methodologies","volume":"60","author":"Escher","year":"2026","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.128925_bib9","first-page":"1","article-title":"Directive (EU) 2020\/2184 of the European parliament and of the council of 16 December 2020 on the quality of water intended for human consumption","volume":"435","year":"2020","journal-title":"Off. J. Eur. Union L"},{"issue":"3","key":"10.1016\/j.envpol.2026.128925_bib10","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per- and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research","volume":"40","author":"Fenton","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"issue":"1","key":"10.1016\/j.envpol.2026.128925_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s40246-024-00665-x","article-title":"Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy","volume":"18","author":"Ford","year":"2024","journal-title":"Hum. Genom."},{"issue":"7","key":"10.1016\/j.envpol.2026.128925_bib12","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1021\/es001834k","article-title":"Global distribution of perfluorooctane sulfonate in wildlife","volume":"35","author":"Giesy","year":"2001","journal-title":"Environ. Sci. Technol."},{"issue":"6273","key":"10.1016\/j.envpol.2026.128925_bib13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1126\/science.aad3456","article-title":"A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice","volume":"351","author":"Green","year":"2016","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.envpol.2026.128925_bib14","first-page":"815","article-title":"[Research on the establishment of standard limits for perfluorooctanoic acid and perfluorooctane sulfonate in the \"Standards for Drinking Water Quality (GB 5749-2022)\" in China]","volume":"57","author":"Hu","year":"2023","journal-title":"Zhonghua Yufang Yixue Zazhi"},{"key":"10.1016\/j.envpol.2026.128925_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.envint.2018.05.051","article-title":"Serum polyfluoroalkyl chemicals are associated with risk of cardiovascular diseases in national US population","volume":"119","author":"Huang","year":"2018","journal-title":"Environ. Int."},{"issue":"6154","key":"10.1016\/j.envpol.2026.128925_bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1126\/science.1236921","article-title":"Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy","volume":"342","author":"Jiang","year":"2013","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.envpol.2026.128925_bib17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.chemosphere.2009.08.058","article-title":"PFOS and PFOA in environmental and tap water in China","volume":"77","author":"Jin","year":"2009","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.envpol.2026.128925_bib18","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/j.jacc.2004.09.044","article-title":"Impact of beta-myosin heavy chain expression on cardiac function during stress","volume":"44","author":"Krenz","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.envpol.2026.128925_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.envres.2016.10.002","article-title":"Circulating levels of perfluoroalkyl substances (PFASs) and carotid artery atherosclerosis","volume":"152","author":"Lind","year":"2017","journal-title":"Environ. Res."},{"issue":"7","key":"10.1016\/j.envpol.2026.128925_bib20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCRESAHA.117.311059","article-title":"Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy","volume":"121","author":"Marian","year":"2017","journal-title":"Circ. Res."},{"issue":"9862","key":"10.1016\/j.envpol.2026.128925_bib21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0140-6736(12)60397-3","article-title":"Hypertrophic cardiomyopathy","volume":"381","author":"Maron","year":"2013","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.envpol.2026.128925_bib22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/01.RES.86.4.386","article-title":"Myosin heavy chain isoform expression in the failing and nonfailing human heart","volume":"86","author":"Miyata","year":"2000","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.envpol.2026.128925_bib23","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1161\/hc0402.102990","article-title":"Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly","volume":"105","author":"Niimura","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.128925_bib24","series-title":"Guidance Document on Good in Vitro Method Practices (GIVIMP)","year":"2018"},{"issue":"9","key":"10.1016\/j.envpol.2026.128925_bib25","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.128925_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104592","article-title":"An evaluation framework for new approach methodologies (NAMs) for human health safety assessment","volume":"112","author":"Parish","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"12","key":"10.1016\/j.envpol.2026.128925_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028872","article-title":"Cardiac alpha-myosin (MYH6) is the predominant sarcomeric disease gene for familial atrial septal defects","volume":"6","author":"Posch","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.128925_bib28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.toxrep.2019.12.010","article-title":"Acute PFOA exposure promotes epigenomic alterations in mouse kidney tissues","volume":"7","author":"Rashid","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.envpol.2026.128925_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117743","article-title":"Estimation of per- and polyfluoroalkyl substances (PFAS) half-lives in human studies: a systematic review and meta-analysis","volume":"242","author":"Rosato","year":"2024","journal-title":"Environ. Res."},{"issue":"9","key":"10.1016\/j.envpol.2026.128925_bib30","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1161\/CIRCRESAHA.124.323697","article-title":"Perfluoroalkyl\/polyfluoroalkyl substances: links to cardiovascular disease risk","volume":"134","author":"Schlezinger","year":"2024","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.envpol.2026.128925_bib31","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0092-8674(01)00242-2","article-title":"The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms","volume":"104","author":"Seidman","year":"2001","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.envpol.2026.128925_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCRESAHA.110.223834","article-title":"Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history","volume":"108","author":"Seidman","year":"2011","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.envpol.2026.128925_bib33","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1073\/pnas.1222878110","article-title":"Genomic responses in mouse models poorly mimic human inflammatory diseases","volume":"110","author":"Seok","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.envpol.2026.128925_bib34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3390\/jcdd12120500","article-title":"Early cytoskeletal remodeling drives hypertrophic cardiomyopathy pathogenesis in MYH6\/7 mutant hiPSC-derived cardiomyocytes","volume":"12","author":"Shameem","year":"2025","journal-title":"J. Cardiovasc. Dev. Dis."},{"issue":"48","key":"10.1016\/j.envpol.2026.128925_bib35","doi-asserted-by":"crossref","first-page":"25649","DOI":"10.1021\/acs.est.5c11122","article-title":"Next generation risk assessment of emerging PFOA alternatives using integrated new approach methodologies","volume":"59","author":"Song","year":"2025","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.envpol.2026.128925_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envpol.2026.128925_bib37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tox.2017.03.011","article-title":"Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes","volume":"382","author":"Tang","year":"2017","journal-title":"Toxicology"},{"issue":"82","key":"10.1016\/j.envpol.2026.128925_bib38","first-page":"32532","article-title":"PFAS national primary drinking water regulation","volume":"89","year":"2024","journal-title":"Fed. Regist."},{"issue":"5","key":"10.1016\/j.envpol.2026.128925_bib39","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00204-023-03477-5","article-title":"A review of cardiovascular effects and underlying mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFAS)","volume":"97","author":"Wen","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envpol.2026.128925_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106148","article-title":"Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: a pilot study in ronneby, Sweden","volume":"145","author":"Xu","year":"2020","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envpol.2026.128925_bib41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3892\/etm.2021.10936","article-title":"Perfluorooctane sulfonate induces heart toxicity involving cardiac apoptosis and inflammation in rats","volume":"23","author":"Xu","year":"2022","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.envpol.2026.128925_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/acs.chemrestox.5c00267","article-title":"Per- and polyfluoroalkyl substances induce cardiotoxicity and alter protein profiles of extracellular matrix, metabolism, and mitochondrial function in human cardiomyocytes","volume":"39","author":"Zhang","year":"2026","journal-title":"Chem. Res. Toxicol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126012959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126012959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:14:08Z","timestamp":1790421248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126012959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":42,"alternative-id":["S0269749126012959"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128925","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated computational and in vivo evidence prioritizes MYH6 as a candidate node in PFOS-associated HCM-like cardiac remodeling","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.128925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"128925"}}