{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:51:53Z","timestamp":1791874313839,"version":"4.3.4"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0531600"],"award-info":[{"award-number":["2024ZD0531600"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42277428"],"award-info":[{"award-number":["42277428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.envpol.2026.129007","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:24:58Z","timestamp":1787930698000},"page":"129007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metal mixture exposure, metabolic networks, and hemoglobin reduction: A population-based metabolomics study"],"prefix":"10.1016","volume":"409","author":[{"given":"Ping","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runsong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-0316","authenticated-orcid":false,"given":"Jie","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-9806","authenticated-orcid":false,"given":"Wei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.129007_bib1","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1136\/gutjnl-2020-320723","article-title":"Identification and validation of a multivariable prediction model based on blood plasma and serum metabolomics for the distinction of chronic pancreatitis subjects from non-pancreas disease control subjects","volume":"70","author":"Adam","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.envpol.2026.129007_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmolb.2023.1218497","article-title":"Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities","volume":"10","author":"Akash","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.envpol.2026.129007_bib3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1515\/reveh-2025-0080","article-title":"Can cadmium toxicity be a driving force for iron deficiency anemia - a systematic review and meta-analysis","volume":"41","author":"Akin","year":"2026","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.envpol.2026.129007_bib4","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1210\/clinem\/dgaa521","article-title":"Markers of iron flux during testosterone-mediated erythropoiesis in older men with unexplained or iron-deficiency anemia","volume":"105","author":"Artz","year":"2020","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.envpol.2026.129007_bib5","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1038\/s41467-020-19335-2","article-title":"Application of an analytical framework for multivariate mediation analysis of environmental data","volume":"11","author":"Aung","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.129007_bib6","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann. Stat."},{"key":"10.1016\/j.envpol.2026.129007_bib7","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1016\/S2352-3026(24)00030-9","article-title":"Haemoglobin thresholds to define anaemia from age 6 months to 65 years: estimates from international data sources","volume":"11","author":"Braat","year":"2024","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.envpol.2026.129007_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132159","article-title":"Associations between multiple heavy metals exposure and glycated hemoglobin in a Chinese population","volume":"287","author":"Cai","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.129007_bib9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13253-014-0180-3","article-title":"Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting","volume":"20","author":"Carrico","year":"2014","journal-title":"J. Agric. Biol. Environ. Stat."},{"key":"10.1016\/j.envpol.2026.129007_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12011-015-0526-x","article-title":"Blood cadmium level associates with lower testosterone and sex hormone-binding globulin in Chinese men: from SPECT-China study, 2014","volume":"171","author":"Chen","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2026.129007_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118973","article-title":"Distribution of urinary trace element exposure and dietary sources in women over 50 in an agricultural region- A community-based KoGES cohort study","volume":"252","author":"Cho","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2026.129007_bib12","doi-asserted-by":"crossref","first-page":"ra34","DOI":"10.1126\/scisignal.aaa5903","article-title":"The mTORC1\/4E-BP pathway coordinates hemoglobin production with L-leucine availability","volume":"8","author":"Chung","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.envpol.2026.129007_bib13","doi-asserted-by":"crossref","first-page":"e713","DOI":"10.1016\/S2352-3026(23)00160-6","article-title":"Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the global burden of disease study 2021","volume":"10","author":"Collaborators","year":"2023","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.envpol.2026.129007_bib14","article-title":"Multiple plasma metal exposures and incident anemia in middle-aged and elderly individuals: the dongfeng-tongji cohort","volume":"303","author":"Dan","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129007_bib15","doi-asserted-by":"crossref","first-page":"402s","DOI":"10.3945\/ajcn.116.142323","article-title":"Predictors of anemia in preschool children: biomarkers reflecting inflammation and nutritional determinants of anemia (BRINDA) project","volume":"106","author":"Engle-Stone","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envpol.2026.129007_bib16","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.21037\/atm-20-624a","article-title":"Branched-chain amino acids are linked with iron metabolism","volume":"8","author":"Enko","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.envpol.2026.129007_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1439034","article-title":"Associations between antimony exposure and glycated hemoglobin levels in adolescents aged 12-19 years: results from the NHANES 2013-2016","volume":"12","author":"Feng","year":"2024","journal-title":"Front. Public Health"},{"key":"10.1016\/j.envpol.2026.129007_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12967-024-06021-w","article-title":"Associations between heavy metal exposure and vascular age: a large cross-sectional study","volume":"23","author":"Feng","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.envpol.2026.129007_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/sxmrev\/qeaf013","article-title":"Management of hematocrit levels for testosterone replacement patients, a narrative review","volume":"13","author":"Fink","year":"2025","journal-title":"Sex Med Rev"},{"key":"10.1016\/j.envpol.2026.129007_bib20","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijheh.2018.12.007","article-title":"Biomonitoring of metals and trace elements in urine of central Ethiopian populations","volume":"222","author":"Godebo","year":"2019","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envpol.2026.129007_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3390\/ijerph19010189","article-title":"Gender difference in the associations among heavy metals with red blood cell hemogram","volume":"19","author":"Huang","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envpol.2026.129007_bib22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11011-024-01451-3","article-title":"Untargeted metabolomics unveils critical metabolic signatures in novel phenotypes of acute ischemic stroke","volume":"40","author":"Jiang","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.envpol.2026.129007_bib23","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5838","article-title":"A quantile-based g-Computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.129007_bib24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.envpol.2026.129007_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139403","article-title":"Low level prenatal exposure to a mixture of Sr, Se and Mn and neurocognitive development of 2-year-old children","volume":"735","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129007_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114477","article-title":"Exposure to metals and the disruption of sex hormones in 6\u201319 years old children: an exploration of mixture effects","volume":"250","author":"Li","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129007_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2023.114195","article-title":"Human biomonitoring reference values, exposure distribution, and characteristics of metals in the general population of Taiwan: taiwan environmental survey for toxicants (TESTs), 2013-2016","volume":"252","author":"Liao","year":"2023","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envpol.2026.129007_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2026.127884","article-title":"Effects of low-level lead exposure on hematological parameters and the possible underlying mechanisms","volume":"396","author":"Liao","year":"2026","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129007_bib29","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3390\/toxics11040322","article-title":"Effects of endocrine-disrupting heavy metals on human health","volume":"11","author":"Liu","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.129007_bib30","doi-asserted-by":"crossref","first-page":"20115","DOI":"10.1021\/acsanm.5c04298","article-title":"Integrated transcriptomic and metabolomic profiling of cobalt nanoparticle-induced cytotoxicity in THP-1 macrophages: implications for prosthetic implants","volume":"8","author":"Liu","year":"2025","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.envpol.2026.129007_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173954","article-title":"Association of exposure to multiple metals with hemoglobin levels in Chinese children and adolescents","volume":"944","author":"Luo","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129007_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105451","article-title":"Association of blood metal exposure with testosterone and hemoglobin: a cross-sectional study in hangzhou birth cohort study","volume":"136","author":"Luo","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129007_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0312964","article-title":"Cross-sectional study on urinary metal concentrations in young adult residents of emirate of Sharjah, United Arab Emirates","volume":"19","author":"Masarani","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.129007_bib34","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1002\/jat.70136","article-title":"Lead and cadmium induced toxicity under prolonged low-dose exposure: food chain driven source, molecular mechanisms, signaling Cascade, and health implications","volume":"46","author":"Mazumder","year":"2026","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envpol.2026.129007_bib35","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s10534-024-00623-z","article-title":"Analysis of serum lead, copper, iron, and zinc and hematological parameters in battery smelting workers: assessing lead toxicity","volume":"37","author":"Memon","year":"2024","journal-title":"Biometals"},{"key":"10.1016\/j.envpol.2026.129007_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-03410-z","article-title":"Hemoglobin and mean platelet volume abnormalities in children exposed to heavy metals and metalloids in a pilot biomonitoring study","volume":"15","author":"Mendoza-Cano","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.129007_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106459","article-title":"Association of branched-chain amino acids with mortality-the ludwigshafen risk and cardiovascular health (LURIC) study","volume":"26","author":"Moissl","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.envpol.2026.129007_bib38","article-title":"Erectile dysfunction in copper and cobalt miners: a cross-sectional study in the former katanga province, democratic Republic of the Congo","volume":"11","author":"Musa Obadia","year":"2023","journal-title":"Sex. Med."},{"key":"10.1016\/j.envpol.2026.129007_bib39","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1249\/MSS.0000000000003156","article-title":"Glucocorticoids accelerate erythropoiesis in healthy humans-should the use in sports be reevaluated?","volume":"55","author":"Nordsborg","year":"2023","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.envpol.2026.129007_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/s13102-025-01080-y","article-title":"Moderate aerobic exercise improves haematological indices without altering cardio-metabolic enzyme activities in sedentary healthy young adults","volume":"17","author":"Okon","year":"2025","journal-title":"BMC Sports Sci. Med. Rehabil."},{"key":"10.1016\/j.envpol.2026.129007_bib40","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1016\/j.tjnut.2023.08.014","article-title":"Blood levels of environmental heavy metals are associated with poorer iron status in Ugandan children: a cross-sectional study","volume":"153","author":"Park","year":"2023","journal-title":"J. Nutr."},{"key":"10.1016\/j.envpol.2026.129007_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envadv.2025.100642","article-title":"Non-occupational exposure to trace elements in Finland \u2013 urinary and blood biomonitoring study","volume":"20","author":"Porras","year":"2025","journal-title":"Environ. Adv."},{"key":"10.1016\/j.envpol.2026.129007_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115828","article-title":"Associations of urinary metal concentrations with anemia: a cross-sectional study of Chinese community-dwelling elderly","volume":"270","author":"Qiao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129007_bib43","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1007\/s12011-026-05022-8","article-title":"Plasma multi-metal exposure, renal function, and anemia risk in rural China: the mediating role of serum creatinine","volume":"204","author":"Qiu","year":"2026","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2026.129007_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.118864","article-title":"Effect of exposures to mixtures of lead and various metals on hypertension, pre-hypertension, and blood pressure: a cross-sectional study from the China national human biomonitoring","volume":"299","author":"Qu","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129007_bib45","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1007\/s12011-025-04806-8","article-title":"Levels, exposure and risk assessment to metals in urine from adult population in Valencian region (Spain)","volume":"204","author":"Saez","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envpol.2026.129007_bib46","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13045-021-01202-2","article-title":"Burden of anemia and its underlying causes in 204 countries and territories, 1990-2019: results from the global burden of disease study 2019","volume":"14","author":"Safiri","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.envpol.2026.129007_bib47","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s13023-021-01865-7","article-title":"Severe anemia in patients with propionic acidemia is associated with branched-chain amino acid imbalance","volume":"16","author":"Stanescu","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.envpol.2026.129007_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117097","article-title":"Independent and combined associations of urinary heavy metals exposure and serum sex hormones among adults in NHANES 2013-2016","volume":"281","author":"Tao","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129007_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104949","article-title":"Cord blood lipid correlation network profiles are associated with subsequent attention-deficit\/hyperactivity disorder and autism spectrum disorder symptoms at 2 years: a prospective birth cohort study","volume":"100","author":"Vacy","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.envpol.2026.129007_bib50","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/j.cell.2024.03.030","article-title":"BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis","volume":"187","author":"Verkerke","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2026.129007_bib51","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1289\/ehp.1409551","article-title":"Variability of metal levels in spot, first morning, and 24-Hour urine samples over a 3-Month period in healthy adult Chinese men","volume":"124","author":"Wang","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.129007_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2022.101653","article-title":"Haematological actions of androgens","volume":"36","author":"Warren","year":"2022","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.envpol.2026.129007_bib53","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.2337\/dc24-0646","article-title":"Accelerated longitudinal glycemic changes in relation to urinary toxic\/essential metals and metal mixtures among Mexican Americans living in starr county, Texas","volume":"47","author":"Weiss","year":"2024","journal-title":"Diabetes Care"},{"key":"10.1016\/j.envpol.2026.129007_bib54","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.3390\/nu16193424","article-title":"Exploring associations and mediating factors between multiple trace metals with anemia in US adults: insight from NHANES 2017-2020","volume":"16","author":"Xie","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.envpol.2026.129007_bib55","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1038\/s41467-025-57253-3","article-title":"Associations of prenatal metal exposure with child neurodevelopment and mediation by perturbation of metabolic pathways","volume":"16","author":"Xie","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.129007_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111433","article-title":"HDL cholesterol: a potential mediator of the association between urinary cadmium concentration and cardiovascular disease risk","volume":"208","author":"Xu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129007_bib57","doi-asserted-by":"crossref","first-page":"9955","DOI":"10.1021\/acs.est.5c02054","article-title":"Associations of serum Per- and polyfluoroalkyl substances with genotoxic biomarkers: new insights from cross-sectional and in vivo evidence","volume":"59","author":"Xu","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129007_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118122","article-title":"Associations of metals with hemoglobin and anemia in a Chinese early adolescent cohort","volume":"295","author":"Yuan","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129007_bib59","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.freeradbiomed.2021.09.028","article-title":"Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion","volume":"176","author":"Zeng","year":"2021","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.envpol.2026.129007_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11060488","article-title":"Urinary levels of 14 metal elements in general population: a region-based exploratory study in China","volume":"11","author":"Zhang","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.129007_bib61","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1038\/s41467-024-46837-0","article-title":"NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.129007_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158227","article-title":"Kindergarten indoor dust metal(loid) exposure associates with elevated risk of anemia in children","volume":"851","author":"Zheng","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129007_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172608","article-title":"Integrative investigation of hematotoxic effects induced by low doses of lead, cadmium, mercury and arsenic mixture: in vivo and in silico approach","volume":"930","author":"\u017divan\u010devi\u0107","year":"2024","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126013771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126013771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:33:45Z","timestamp":1791873225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126013771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":64,"alternative-id":["S0269749126013771"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129007","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metal mixture exposure, metabolic networks, and hemoglobin reduction: A population-based metabolomics study","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129007"}}