{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:52:21Z","timestamp":1791190341865,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1212060047"],"award-info":[{"award-number":["2023B1212060047"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20728"],"award-info":[{"award-number":["U25A20728"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031919","name":"Southern Marine Science and Engineering Guangdong Laboratory","doi-asserted-by":"publisher","award":["SML2024SP003"],"award-info":[{"award-number":["SML2024SP003"]}],"id":[{"id":"10.13039\/100031919","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515240032"],"award-info":[{"award-number":["2024A1515240032"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012453","name":"China Agricultural Research System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2025D04J0030"],"award-info":[{"award-number":["2025D04J0030"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.envpol.2026.129058","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:28:30Z","timestamp":1788503310000},"page":"129058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Aquaculture-relevant florfenicol exposure causes hepatopancreatic bioaccumulation and metabolic-immune toxicity in the mud crab Scylla paramamosain"],"prefix":"10.1016","volume":"410","author":[{"given":"Min-Ze","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Gang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Kang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Xun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.envpol.2026.129058_bib1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/jmcb\/mjt022","article-title":"The lysosome: from waste bag to potential therapeutic target","volume":"5","author":"Appelqvist","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2026.129058_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738447","article-title":"Histopathological aberrations and oxidative stress responses in nile tilapia Oreochromis niloticus as influenced by dietary florfenicol and its metabolites","volume":"559","author":"Bardhan","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.envpol.2026.129058_bib3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.envpol.2018.08.017","article-title":"Evaluation of the leaching of florfenicol from coated medicated fish feed into water","volume":"242","author":"Barreto","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129058_bib4","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.fsi.2018.10.069","article-title":"Effects of environmental stress on shrimp innate immunity and white spot syndrome virus infection","volume":"84","author":"Chen","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envpol.2026.129058_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128277","article-title":"Oxidative stress, cell cycle arrest, DNA damage and apoptosis in the mud crab (Scylla paramamosain) induced by cadmium exposure","volume":"263","author":"Cheng","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.129058_bib6","series-title":"National Food Safety standard-maximum Residue Limits for Veterinary Drugs in Foods. GB","first-page":"31650","author":"China","year":"2019"},{"key":"10.1016\/j.envpol.2026.129058_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ecoenv.2014.11.019","article-title":"Histopathological and biochemical evidence of hepatopancreatic toxicity caused by cadmium in white shrimp, Palaemonetes argentinus","volume":"113","author":"Chiodi Boudet","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129058_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122585","article-title":"Antibiotics in coastal aquaculture waters: occurrence and elimination efficiency in oxidative water treatment processes","volume":"396","author":"Choi","year":"2020","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/toxsci\/kfh007","article-title":"Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment","volume":"77","author":"Conolly","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2026.129058_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.fsi.2018.04.008","article-title":"Dietary effects of succinic acid on the growth, digestive enzymes, immune response and resistance to ammonia stress of Litopenaeus vannamei","volume":"78","author":"Duan","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envpol.2026.129058_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127513","article-title":"Impact of imidacloprid exposure on the biochemical responses, transcriptome, gut microbiota and growth performance of the Pacific white shrimp Litopenaeus vannamei","volume":"424","author":"Fu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129058_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133930","article-title":"Dinotefuran exposure alters biochemical, metabolomic, gut microbiome, and growth responses in decapoda Pacific white shrimp Penaeus vannamei","volume":"469","author":"Fu","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129058_bib13","series-title":"National Food Safety standard-determination of Chloramphenicol,Thiamphenicol,Florfenicoland and florfenicol-amine Residues in Aquatic Products by Gas Chromatography","year":"2022"},{"key":"10.1016\/j.envpol.2026.129058_bib14","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399411002110","article-title":"Molecular mechanisms underlying chemical liver injury","volume":"14","author":"Gu","year":"2012","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.envpol.2026.129058_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117934","article-title":"A review on the antibiotic florfenicol: occurrence, environmental fate, effects, and health risks","volume":"244","author":"Guo","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2026.129058_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116092","article-title":"Assessing the ecotoxicity of florfenicol exposure at environmental levels: a case study of histology, apoptosis and microbiota in hepatopancreas of Eriocheir sinensis","volume":"272","author":"Guo","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.envpol.2026.129058_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054412","article-title":"Effects of florfenicol on intestinal histology, apoptosis and gut microbiota of Chinese mitten crab (Eriocheir sinensis)","volume":"24","author":"Guo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.envpol.2026.129058_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.envpol.2026.129058_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K\u2013AKT network at the interface of oncogenic signalling and cancer metabolism","volume":"20","author":"Hoxhaj","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.envpol.2026.129058_bib20","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.3390\/antiox12081548","article-title":"Effects of prometryn exposure on hepatopancreas oxidative stress and intestinal flora in Eriocheir sinensis (crustacea: decapoda)","volume":"12","author":"Huang","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.envpol.2026.129058_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2020.00065","article-title":"Defective mitochondrial fatty acid oxidation and lipotoxicity in kidney diseases","volume":"7","author":"Jang","year":"2020","journal-title":"Front. Med."},{"issue":"6","key":"10.1016\/j.envpol.2026.129058_bib22","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1111\/anu.12350","article-title":"Dietary arginine requirement of juvenile swimming crab, Portunus trituberculatus","volume":"22","author":"Jin","year":"2016","journal-title":"Aquac. Nutr."},{"issue":"4","key":"10.1016\/j.envpol.2026.129058_bib23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envpol.2026.129058_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.aquatox.2018.04.016","article-title":"Effects of environmental stressors on lipid metabolism in aquatic invertebrates","volume":"200","author":"Lee","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2026.129058_bib25","article-title":"Influence of environmental conditions on the distribution of burrows of the mud crab, Scylla serrata, in a fringing mangrove ecosystem","volume":"43","author":"Leoville","year":"2021","journal-title":"Reg. Stud. Mar. Sci."},{"key":"10.1016\/j.envpol.2026.129058_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109872","article-title":"Transcriptome analysis of Scylla paramamosain hepatopancreas response to mud crab dicistrovirus-1 infection","volume":"154","author":"Liao","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envpol.2026.129058_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2022.123112","article-title":"Genome-wide identification glutathione-S-transferase gene superfamily in Daphnia pulex and its transcriptional response to nanoplastics","volume":"230","author":"Liu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.aquatox.2010.10.006","article-title":"Environmentally induced oxidative stress in aquatic animals","volume":"101","author":"Lushchak","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2026.129058_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2025.110440","article-title":"Assessment of thyroid endocrine disruption induced by florfenicol: integrating in vivo zebrafish experiments and in silico molecular docking and dynamics simulations","volume":"301","author":"Ma","year":"2026","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.envpol.2026.129058_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.envpol.2026.129058_bib31","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.semcdb.2012.01.003","article-title":"PPARs: fatty acid sensors controlling metabolism","volume":"23","author":"Poulsen","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.envpol.2026.129058_bib32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1089\/omi.2013.0110","article-title":"RNA-Seq technology and its application in fish transcriptomics","volume":"18","author":"Qian","year":"2014","journal-title":"OMICS A J. Integr. Biol."},{"key":"10.1016\/j.envpol.2026.129058_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.marenvres.2013.07.006","article-title":"Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms","volume":"93","author":"Regoli","year":"2014","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.envpol.2026.129058_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.aquaculture.2014.04.024","article-title":"Effect of florfenicol on selected parameters of immune and antioxidant systems, and damage indexes of juvenile Litopenaeus vannamei following oral administration","volume":"432","author":"Ren","year":"2014","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.etap.2014.08.006","article-title":"Toxic effects upon exposure to benzo[a]pyrene in juvenile white shrimp Litopenaeus vannamei","volume":"39","author":"Ren","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129058_bib36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ecoenv.2017.05.003","article-title":"Effects of florfenicol on the antioxidant status, detoxification system and biomolecule damage in the swimming crab (Portunus trituberculatus)","volume":"143","author":"Ren","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"20","key":"10.1016\/j.envpol.2026.129058_bib38","doi-asserted-by":"crossref","first-page":"8117","DOI":"10.1158\/0008-5472.CAN-09-3871","article-title":"De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation","volume":"70","author":"Rysman","year":"2010","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.envpol.2026.129058_bib39","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nrg3603","article-title":"A new world of polycombs: unexpected partnerships and emerging functions","volume":"14","author":"Schwartz","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.envpol.2026.129058_bib40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.etap.2019.02.002","article-title":"Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure","volume":"67","author":"Sehonova","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"5","key":"10.1016\/j.envpol.2026.129058_bib41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3565","article-title":"Signals from the lysosome: a control centre for cellular clearance and energy metabolism","volume":"14","author":"Settembre","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.envpol.2026.129058_bib42","article-title":"Determination of 22 antibiotics in seawater by liquid chromatography-tandem mass spectrometry with large-volume injection","volume":"43","author":"Sheng","year":"2024","journal-title":"Mar. Environ. Sci."},{"issue":"12","key":"10.1016\/j.envpol.2026.129058_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbapap.2021.140719","article-title":"Structural, thermodynamic and functional studies of human 71 kDa heat shock cognate protein (HSPA8\/hHsc70)","volume":"1869","author":"Silva","year":"2021","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.aquaculture.2005.11.035","article-title":"Effects of enrofloxacin and florfenicol on survival and bacterial population in an experimental infection with luminescent Vibrio campbellii in shrimp larvae of Litopenaeus vannamei","volume":"255","author":"Soto-Rodr\u00edguez","year":"2006","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0044-8486(00)00411-7","article-title":"The proPO and clotting system in crustaceans","volume":"191","author":"Sritunyalucksana","year":"2000","journal-title":"Aquaculture"},{"issue":"6358","key":"10.1016\/j.envpol.2026.129058_bib46","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aao1495","article-title":"Reducing antimicrobial use in food animals","volume":"357","author":"Van Boeckel","year":"2017","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.envpol.2026.129058_bib47","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/1753425909102876","article-title":"Immunity mechanisms in crustaceans","volume":"15","author":"Vazquez","year":"2009","journal-title":"Innate Immun."},{"issue":"9","key":"10.1016\/j.envpol.2026.129058_bib48","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/jmor.21040","article-title":"Functional cytology of the hepatopancreas of decapod crustaceans","volume":"280","author":"Vogt","year":"2019","journal-title":"J. Morphol."},{"key":"10.1016\/j.envpol.2026.129058_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3354\/dao03443","article-title":"Cytopathology and immune response in the hepatopancreas of decapod crustaceans","volume":"138","author":"Vogt","year":"2020","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.envpol.2026.129058_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2021.104163","article-title":"Comparison of nutritional quality and nutrient compositions of three edible tissues from different sourced cultured female mud crabs (Scylla paramamosain)","volume":"104","author":"Wang","year":"2021","journal-title":"J. Food Compos. Anal."},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib51","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/microorganisms14010204","article-title":"Effects of florfenicol on intestinal structure, microbial community and antibiotic resistance genes in Penaeus vannamei","volume":"14","author":"Wang","year":"2026","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib52","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10695-021-01040-6","article-title":"Mildronate triggers growth suppression and lipid accumulation in largemouth bass (Micropterus salmoides) through disturbing lipid metabolism","volume":"48","author":"Wang","year":"2022","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.envpol.2026.129058_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737092","article-title":"Responses of energy homeostasis and lipid metabolism in Penaeus vannamei exposed to ammonia stress","volume":"544","author":"Wang","year":"2021","journal-title":"Aquaculture"},{"issue":"3","key":"10.1016\/j.envpol.2026.129058_bib54","doi-asserted-by":"crossref","first-page":"214","DOI":"10.17221\/183\/2008-CJFS","article-title":"Tissue distribution and elimination of florfenicol in topmouth culter (Culter alburnus) after oral administration","volume":"27","author":"Wang","year":"2009","journal-title":"Czech J. Food Sci."},{"issue":"4","key":"10.1016\/j.envpol.2026.129058_bib55","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/2211-5463.13388","article-title":"Lysosomes and lysosome-related organelles in immune responses","volume":"12","author":"Watts","year":"2022","journal-title":"FEBS Open Bio"},{"issue":"19","key":"10.1016\/j.envpol.2026.129058_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911574","article-title":"Down-regulation of lipid metabolism in the hepatopancreas of shrimp Litopenaeus vannamei upon light and heavy infection of enterocytozoon hepatopenaei: a comparative proteomic study","volume":"23","author":"Wu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.envpol.2026.129058_bib57","doi-asserted-by":"crossref","DOI":"10.1172\/JCI153247","article-title":"IL-9\/STAT3\/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity","volume":"132","author":"Xiao","year":"2022","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.envpol.2026.129058_bib58","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2095.2007.00461.x","article-title":"Dietary methionine requirement for juvenile rockfish, Sebastes schlegeli","volume":"13","author":"Yan","year":"2007","journal-title":"Aquac. Nutr."},{"key":"10.1016\/j.envpol.2026.129058_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158727","article-title":"Responses of zebrafish (Danio rerio) cells to antibiotic erythromycin stress at the subcellular levels","volume":"853","author":"Yang","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.envpol.2026.129058_bib60","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.fsi.2014.05.014","article-title":"Immune responses of prophenoloxidase in the mud crab Scylla paramamosain against Vibrio alginolyticus infection: in vivo and in vitro gene silencing evidence","volume":"39","author":"Yang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envpol.2026.129058_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154586","article-title":"Polystyrene microplastics increase Pb bioaccumulation and health damage in the Chinese mitten crab Eriocheir sinensis","volume":"829","author":"Yang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129058_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121646","article-title":"Toxicities of polystyrene microplastics (MPs) and hexabromocyclododecane (HBCD), alone or in combination, to the hepatopancreas of the whiteleg shrimp, Litopenaeus vannamei","volume":"329","author":"Yu","year":"2023","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.envpol.2026.129058_bib64","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fsi.2018.05.013","article-title":"A clip domain serine protease regulates the expression of proPO and hemolymph clotting in mud crab, Scylla paramamosain","volume":"79","author":"Zhang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envpol.2026.129058_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114597","article-title":"Maternal transfer of florfenicol impacts development and disrupts metabolic pathways in F1 offspring zebrafish by destroying mitochondria","volume":"252","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.envpol.2026.129058_bib66","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1038\/s41467-025-59035-3","article-title":"Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.129058_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735326","article-title":"Study on florfenicol-contained feeds delivery in Dicentrarchus labrax seawater recirculating and flowing aquaculture systems","volume":"526","author":"Zhang","year":"2020","journal-title":"Aquaculture"},{"issue":"2","key":"10.1016\/j.envpol.2026.129058_bib68","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00128-009-9923-1","article-title":"Research on florfenicol residue in coastal area of dalian (northern China) and analysis of functional diversity of the microbial community in marine sediment","volume":"84","author":"Zong","year":"2010","journal-title":"Bull. Environ. Contam. Toxicol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126014284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126014284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:05:19Z","timestamp":1791187519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126014284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":68,"alternative-id":["S0269749126014284"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129058","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aquaculture-relevant florfenicol exposure causes hepatopancreatic bioaccumulation and metabolic-immune toxicity in the mud crab Scylla paramamosain","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129058"}}