{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:35:22Z","timestamp":1793219722267,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571633"],"award-info":[{"award-number":["82571633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371444"],"award-info":[{"award-number":["82371444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2022ZD0211600"],"award-info":[{"award-number":["2022ZD0211600"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.envpol.2026.129182","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:38:14Z","timestamp":1789688294000},"page":"129182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Associations between compound heat exposure and cognitive impairment and the potential mediating role of plasma sphingolipid metabolites: Evidence from a large-scale population cohort study"],"prefix":"10.1016","volume":"410","author":[{"given":"Hua","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5733-2965","authenticated-orcid":false,"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qidi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-5448","authenticated-orcid":false,"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.129182_bib1","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/s41591-023-02419-z","article-title":"Heat-related mortality in Europe during the summer of 2022","volume":"29","author":"Ballester","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.envpol.2026.129182_bib2","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1002\/alz.13047","article-title":"Prevalence and risk factors for subjective cognitive decline and the correlation with objective cognition among community-dwelling older adults in China: results from the Hubei memory and aging cohort study","volume":"19","author":"Cheng","year":"2023","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.envpol.2026.129182_bib11","series-title":"ERA5 hourly time-series data on single levels from 1940 to present","year":"2025"},{"key":"10.1016\/j.envpol.2026.129182_bib3","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1007\/s12035-018-1448-3","article-title":"The role of ceramide and Sphingosine-1-Phosphate in Alzheimer's Disease and other neurodegenerative disorders","volume":"56","author":"Czubowicz","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.envpol.2026.129182_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jare.2024.10.007","article-title":"Metabolic responses of sea anemone and jellyfish to temperature and UV bleaching: insights into stress adaptation using LCMS-based metabolomics, molecular networking and chemometrics","volume":"74","author":"Farag","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.envpol.2026.129182_bib5","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.2147\/IJN.S258311","article-title":"PEG-Ceramide nanomicelles induce autophagy and degrade Tau proteins in N2a cells","volume":"15","author":"Gao","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.envpol.2026.129182_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s44360-025-00026-5","article-title":"The human airborne exposome","volume":"1","author":"Gao","year":"2026","journal-title":"Nat. Health"},{"key":"10.1016\/j.envpol.2026.129182_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.122360","article-title":"Humid heat's nonlinear impact on school-age children' sleep health: evidence from Guangdong, China","volume":"285","author":"Gao","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2026.129182_bib8","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1021\/acs.est.4c13020","article-title":"Acute impact of nonoptimal ambient temperatures on plasma levels of 3000 proteins in Chinese adults","volume":"59","author":"Guo","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129182_bib9","doi-asserted-by":"crossref","first-page":"e648","DOI":"10.1016\/S2542-5196(22)00139-5","article-title":"The effects of night-time warming on mortality burden under future climate change scenarios: a modelling study","volume":"6","author":"He","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.envpol.2026.129182_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2023.118145","article-title":"Spatiotemporally continuous estimates of daily 1-km PM2.5 concentrations and their long-term exposure in China from 2000 to 2020","volume":"342","author":"He","year":"2023","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.envpol.2026.129182_bib13","series-title":"Statistical Models in S","author":"John","year":"1992"},{"key":"10.1016\/j.envpol.2026.129182_bib14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0895-4356(88)90034-0","article-title":"A Chinese version of the mini-mental state examination; impact of illiteracy in a Shanghai dementia survey","volume":"41","author":"Katzman","year":"1988","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.envpol.2026.129182_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.uclim.2025.102726","article-title":"A novel index for assessing the compound drought, heat waves, and air pollution extremes","volume":"65","author":"Khan","year":"2026","journal-title":"Urban Clim."},{"key":"10.1016\/j.envpol.2026.129182_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126060","article-title":"Modeling spatial PM2.5 risk dynamics and projecting disease burden in Pakistan","volume":"373","author":"Khan","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129182_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13195-024-01515-7","article-title":"Heat-related illness and dementia: a study integrating epidemiological and experimental evidence","volume":"16","author":"Kuo","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.envpol.2026.129182_bib18","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3233\/JAD-215205","article-title":"Isoform-Dependent effects of apolipoprotein E on sphingolipid metabolism in neural cells","volume":"85","author":"Kurano","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envpol.2026.129182_bib19","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3233\/JAD-215129","article-title":"The Hubei memory and aging cohort Study: study design, baseline characteristics, and prevalence of cognitive impairments","volume":"85","author":"Li","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envpol.2026.129182_bib20","article-title":"Updating the baseline period affects the detection of extreme climate change in China","volume":"130","author":"Li","year":"2025","journal-title":"J. Geophys. Res. Atmos."},{"key":"10.1016\/j.envpol.2026.129182_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108424","article-title":"The influence of humid heat on morbidity of megacity Shanghai in China","volume":"183","author":"Liang","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129182_bib22","doi-asserted-by":"crossref","DOI":"10.1136\/gpsych-2021-100564","article-title":"Urban-rural disparities in mild cognitive impairment and its functional subtypes among community-dwelling older residents in central China","volume":"34","author":"Liu","year":"2021","journal-title":"Gen Psychiatr"},{"key":"10.1016\/j.envpol.2026.129182_bib23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41467-025-56067-7","article-title":"Nonlinear exposure-response associations of daytime, nighttime, and day-night compound heatwaves with mortality amid climate change","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.129182_bib24","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41558-024-02137-5","article-title":"Rising cause-specific mortality risk and burden of compound heatwaves amid climate change","volume":"14","author":"Liu","year":"2024","journal-title":"Nat. Clim. Change"},{"key":"10.1016\/j.envpol.2026.129182_bib25","article-title":"Constipation symptoms are associated with worse cognitive outcomes in older adults without dementia","volume":"12","author":"Liu","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.envpol.2026.129182_bib26","article-title":"Different mechanisms for daytime, nighttime, and compound heatwaves in southern China","volume":"36","author":"Luo","year":"2022","journal-title":"Weather Clim. Extrem."},{"key":"10.1016\/j.envpol.2026.129182_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/acn3.50973","article-title":"Circulating ceramide ratios and risk of vascular brain aging and dementia","volume":"7","author":"McGrath","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.envpol.2026.129182_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jpsychires.2008.04.014","article-title":"A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment","volume":"43","author":"Mitchell","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.envpol.2026.129182_bib29","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3233\/JAD-220349","article-title":"Cerebrospinal fluid sphingomyelins in Alzheimer's Disease, neurodegeneration, and neuroinflammation","volume":"90","author":"Morrow","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envpol.2026.129182_bib30","series-title":"Thermal Biology: Temperature Sensing and Temperature-Responding Systems","first-page":"79","article-title":"Lipid-Mediated mechanisms of thermal adaptation and thermoregulatory behavior in animals","author":"Nagao","year":"2024"},{"key":"10.1016\/j.envpol.2026.129182_bib31","doi-asserted-by":"crossref","first-page":"12210","DOI":"10.1021\/acs.est.3c00302","article-title":"Effects of Short- and medium-term exposures to lower air temperature on 71 novel biomarkers of subclinical inflammation: results from the KORA F4 study","volume":"57","author":"Ni","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129182_bib32","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1194\/jlr.M080374","article-title":"Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis","volume":"59","author":"Novgorodov","year":"2018","journal-title":"JLR (J. Lipid Res.)"},{"key":"10.1016\/j.envpol.2026.129182_bib33","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1111\/ina.12876","article-title":"Correlating indoor and outdoor temperature and humidity in a sample of buildings in tropical climates","volume":"31","author":"Pan","year":"2021","journal-title":"Indoor Air"},{"key":"10.1016\/j.envpol.2026.129182_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11175030","article-title":"Plasma Lipidomics approach in early and specific Alzheimer's Disease diagnosis","volume":"11","author":"Pe\u00f1a-Bautista","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.envpol.2026.129182_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18115981","article-title":"The Association of Meteorological factors with cognitive function in older adults","volume":"18","author":"Qiu","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envpol.2026.129182_bib36","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00484-016-1299-4","article-title":"Health symptoms in relation to temperature, humidity, and self-reported perceptions of climate in New York city residential environments","volume":"61","author":"Quinn","year":"2017","journal-title":"Int. J. Biometeorol."},{"key":"10.1016\/j.envpol.2026.129182_bib37","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1016\/S0140-6736(25)01919-1","article-title":"The 2025 report of the Lancet Countdown on health and climate change: climate change action offers a lifeline","volume":"406","author":"Romanello","year":"2025","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.envpol.2026.129182_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph23020164","article-title":"Global warming and the elderly: a socio-ecological framework","volume":"23","author":"Russin","year":"2026","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.envpol.2026.129182_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126913","article-title":"Daytime, nighttime, and day-night compound heatwaves and the risk of depression: a Chinese nationwide cohort","volume":"384","author":"Shen","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129182_bib40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/10803548.2019.1699728","article-title":"The influence of air humidity on human heat stress in a hot environment","volume":"27","author":"Sobolewski","year":"2021","journal-title":"Int. J. Occup. Saf. Ergon."},{"key":"10.1016\/j.envpol.2026.129182_bib41","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.3390\/ijms26072843","article-title":"Dynamic lipidome reorganization in response to heat shock stress","volume":"26","author":"Solano","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.129182_bib42","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbalip.2011.06.027","article-title":"Analysis of mammalian sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS\/MS) and tissue imaging mass spectrometry (TIMS)","volume":"1811","author":"Sullards","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.envpol.2026.129182_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/oxfclm\/kgab005","article-title":"Climate change adaptation to extreme heat: a global systematic review of implemented action","volume":"1","author":"Turek-Hankins","year":"2021","journal-title":"Oxford Open Climate Change"},{"key":"10.1016\/j.envpol.2026.129182_bib44","article-title":"Plasma ceramides relate to mild cognitive impairment in middle-aged men: the Maastricht Study","volume":"15","author":"van Kruining","year":"2023","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.envpol.2026.129182_bib45","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41467-019-14233-8","article-title":"Anthropogenically-driven increases in the risks of summertime compound hot extremes","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.129182_bib46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(20)32290-X","article-title":"The 2020 report of the lancet countdown on health and climate change: responding to converging crises","volume":"397","author":"Watts","year":"2021","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.envpol.2026.129182_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117746","article-title":"Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality","volume":"290","author":"Wu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129182_bib48","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/s41591-024-02880-4","article-title":"Risk factors associated with heatwave mortality in Chinese adults over 65 years","volume":"30","author":"Xi","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.envpol.2026.129182_bib49","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.1021\/acs.est.1c04548","article-title":"Tracking PM(2.5) and O(3) pollution and the related health burden in China 2013-2020","volume":"56","author":"Xiao","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129182_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.179332","article-title":"Asymmetry in the intensity and frequency of extreme high temperature during daytime and nighttime in China in the summer 2022","volume":"976","author":"Xing","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129182_bib51","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2025-084675","article-title":"Effects of extreme heat on physiology, morbidity, and mortality under climate change: mechanisms and clinical implications","volume":"391","author":"Xu","year":"2025","journal-title":"Bmj"},{"key":"10.1016\/j.envpol.2026.129182_bib52","doi-asserted-by":"crossref","first-page":"21885","DOI":"10.1021\/acs.est.5c07999","article-title":"Nonoptimal temperature exposure and sphingolipid metabolism: implications for cardiovascular risk","volume":"59","author":"Xu","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129182_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.buildenv.2021.108572","article-title":"Association of bedroom environment with the sleep quality of elderly subjects in summer: a field measurement in Shanghai, China","volume":"208","author":"Yan","year":"2022","journal-title":"Build. Environ."},{"key":"10.1016\/j.envpol.2026.129182_bib54","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/febs.16344","article-title":"Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise","volume":"290","author":"Yin","year":"2023","journal-title":"FEBS J."},{"key":"10.1016\/j.envpol.2026.129182_bib55","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jacc.2025.01.034","article-title":"Nonlinear relation between cardiac mortality and excess temperature in heatwaves: exposure response in 2.39 million patients","volume":"85","author":"Yu","year":"2025","journal-title":"J. Am. Coll."},{"key":"10.1016\/j.envpol.2026.129182_bib56","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41398-025-03365-9","article-title":"Effects of self-managed lifestyle behavioral changes on cognitive impairment control in Chinese older adults: a population-based prospective study","volume":"15","author":"Zhang","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.envpol.2026.129182_bib57","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1186\/s12889-025-22822-0","article-title":"Association between heatwave exposure and rapid kidney function decline: a longitudinal cohort study from CHARLS","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Public Health"},{"key":"10.1016\/j.envpol.2026.129182_bib58","article-title":"Effect of heatwaves on mortality of Alzheimer's disease and other dementias among elderly aged 60 years and above in China, 2013-2020: a population-based study","volume":"52","author":"Zhang","year":"2024","journal-title":"Lancet Reg. Health West. Pac."},{"key":"10.1016\/j.envpol.2026.129182_bib59","article-title":"Operators' cognitive performance under extreme hot-humid exposure and its physiological-psychological mechanism based on ECG, fNIRS, and Eye Tracking","author":"Zhang","year":"2024","journal-title":"fNIRS, and Eye Tracking"},{"key":"10.1016\/j.envpol.2026.129182_bib60","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/13872877251376581","article-title":"Population-attributable fractions for modifiable risk factors across the continuum of cognitive decline: Hubei Memory and Aging Cohort study","volume":"108","author":"Zhou","year":"2025","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envpol.2026.129182_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121986","article-title":"Escalating heatwave exposure of the elderly across China","volume":"282","author":"Zhou","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2026.129182_bib62","doi-asserted-by":"crossref","first-page":"27432","DOI":"10.1074\/jbc.M114.560334","article-title":"Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase","volume":"289","author":"Zhu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.129182_bib12","series-title":"Special Report on Chinese Population Studies: China's Population Projections for 2025-2100 and Policy recommendations","year":"2025"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126015526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126015526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:08:57Z","timestamp":1793218137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126015526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":62,"alternative-id":["S0269749126015526"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129182","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between compound heat exposure and cognitive impairment and the potential mediating role of plasma sphingolipid metabolites: Evidence from a large-scale population cohort study","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129182"}}