{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:42:44Z","timestamp":1792222964785,"version":"4.4.0"},"reference-count":164,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100011862","name":"University of North Carolina at Greensboro","doi-asserted-by":"publisher","award":["127313"],"award-info":[{"award-number":["127313"]}],"id":[{"id":"10.13039\/100011862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.envpol.2026.129187","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:38:19Z","timestamp":1789688299000},"page":"129187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Polystyrene microplastic uptake drives inflammatory, epitranscriptomic, and metabolic reprogramming in human aortic endothelial cells"],"prefix":"10.1016","volume":"411","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9703-2428","authenticated-orcid":false,"given":"Ajmal","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Koher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7863-3288","authenticated-orcid":false,"given":"Kyla","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1890-060X","authenticated-orcid":false,"given":"Ho Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-0087","authenticated-orcid":false,"given":"Warren S.","family":"Vidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Morales-Shnaider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwame A.","family":"Darfour-Oduro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-7254","authenticated-orcid":false,"given":"Ramji K.","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-0930","authenticated-orcid":false,"given":"Xuewei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-1549","authenticated-orcid":false,"given":"Zhenquan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.129187_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123799","article-title":"Human exposure to microplastics: a study in Iran","volume":"403","author":"Abbasi","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129187_bib2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/ATVBAHA.110.207415","article-title":"Recent advances on the role of cytokines in atherosclerosis","volume":"31","author":"Ait-Oufella","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/NSA.S232517","article-title":"Loading amlodipine on diamond nanoparticles: a novel drug delivery system","volume":"12","author":"Alawdi","year":"2019","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.envpol.2026.129187_bib4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbrc.2018.03.133","article-title":"The blocking of aquaporin-3 (AQP3) impairs extravillous trophoblast cell migration","volume":"499","author":"Alejandra","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envpol.2026.129187_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1365-2362.2010.02441.x","article-title":"Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy","volume":"41","author":"Alexander","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.envpol.2026.129187_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126124","article-title":"Presence of airborne microplastics in human lung tissue","volume":"416","author":"Amato-Lourenco","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129187_bib7","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1038\/s41467-021-23313-7","article-title":"Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives","volume":"12","author":"Amporndanai","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.129187_bib167","doi-asserted-by":"crossref","first-page":"152665","DOI":"10.1016\/j.tox.2020.152665","article-title":"Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats","volume":"449","author":"An","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2026.129187_bib8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.15252\/embr.201643391","article-title":"A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability","volume":"18","author":"Antonicka","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.envpol.2026.129187_bib9","doi-asserted-by":"crossref","first-page":"17431","DOI":"10.1074\/jbc.272.28.17431","article-title":"The role of platelet-activating factor-dependent transacetylase in the biosynthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine by stimulated endothelial cells","volume":"272","author":"Balestrieri","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.129187_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.154002","article-title":"Exposure to polystyrene nanoplastics promotes premature cellular senescence through mitochondrial ROS production and dysfunction in pre-differentiated skeletal myoblasts","volume":"510","author":"Bang","year":"2025","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2026.129187_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/nano11051247","article-title":"Anti-inflammatory effect and cellular uptake mechanism of carbon nanodots in human microvascular endothelial cells","volume":"11","author":"Belperain","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.envpol.2026.129187_bib12","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1194\/jlr.R800074-JLR200","article-title":"The role of oxidized phospholipids in atherosclerosis","volume":"50","author":"Berliner","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.envpol.2026.129187_bib13","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nm876","article-title":"Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL","volume":"9","author":"Binder","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib15","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/ars.2009.2597","article-title":"Generation and biological activities of oxidized phospholipids","volume":"12","author":"Bochkov","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.envpol.2026.129187_bib16","doi-asserted-by":"crossref","first-page":"8932","DOI":"10.1021\/acs.est.5b01090","article-title":"Potential health impact of environmentally released Micro- and nanoplastics in the human food production chain: experiences from nanotoxicology","volume":"49","author":"Bouwmeester","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129187_bib17","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1073\/pnas.85.21.7972","article-title":"Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells","volume":"85","author":"Bowman","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.envpol.2026.129187_bib18","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1039\/D2EN01077A","article-title":"Polystyrene nanoplastics target lysosomes interfering with lipid metabolism through the PPAR system and affecting macrophage functionalization","volume":"10","author":"Brandts","year":"2023","journal-title":"Environ. Sci. Nano"},{"key":"10.1016\/j.envpol.2026.129187_bib19","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1089\/ars.2010.3534","article-title":"Basic principles and emerging concepts in the redox control of transcription factors","volume":"15","author":"Brigelius-Floh\u00e9","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.envpol.2026.129187_bib20","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1161\/01.CIR.102.21.2569","article-title":"Expression of platelet-activating factor receptor in human carotid atherosclerotic plaques","volume":"102","author":"Broch\u00e9riou","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.129187_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2091-8-25","article-title":"Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling","volume":"8","author":"Bullinger","year":"2007","journal-title":"BMC Biochem."},{"key":"10.1016\/j.envpol.2026.129187_bib22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0021-9150(02)00331-3","article-title":"Induction of cellular glutathione and glutathione S-transferase by 3H-1, 2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity","volume":"166","author":"Cao","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.envpol.2026.129187_bib23","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tips.2022.03.008","article-title":"Decoding pseudouridine: an emerging target for therapeutic development","volume":"43","author":"Cerneckis","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.envpol.2026.129187_bib24","doi-asserted-by":"crossref","first-page":"R906","DOI":"10.1152\/ajpregu.00298.2016","article-title":"Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice","volume":"311","author":"Chandler","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.envpol.2026.129187_bib25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib26","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2026.129187_bib27","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190459","article-title":"Type-I interferons in atherosclerosis","volume":"217","author":"Chen","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib28","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1093\/nar\/gky1250","article-title":"Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs","volume":"47","author":"Chen","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.129187_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127871","article-title":"The nephrotoxic potential of polystyrene microplastics at realistic environmental concentrations","volume":"427","author":"Chen","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129187_bib30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bbamem.2015.01.009","article-title":"Multiple effects of anthracene-9-carboxylic acid on the TMEM16B\/anoctamin2 calcium-activated chloride channel","volume":"1848","author":"Cherian","year":"2015","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.envpol.2026.129187_bib31","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s42003-025-08368-2","article-title":"Opposing role of phagocytic receptors MERTK and AXL in progranulin deficient FTD","volume":"8","author":"Clelland","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.placenta.2020.07.006","article-title":"Placental syncytiotrophoblast extracellular vesicles enter primary endothelial cells through clathrin-mediated endocytosis","volume":"100","author":"Cronqvist","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.envpol.2026.129187_bib33","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1017\/plc.2024.6","article-title":"Mitochondria as a target of micro- and nanoplastic toxicity","volume":"2","author":"Dal Y\u00f6ntem","year":"2024","journal-title":"Cambridge Prisms: Plastics"},{"key":"10.1016\/j.envpol.2026.129187_bib34","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa032804","article-title":"C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease","volume":"350","author":"Danesh","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-19064-w","article-title":"Polystyrene microplastics are internalized by human gingival fibroblasts, enhance cell motility and induce molecular changes revealed through proteomic analysis","volume":"15","author":"Di Cintio","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.129187_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2026.129187_bib37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nature16998","article-title":"The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA","volume":"530","author":"Dominissini","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.129187_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024438","article-title":"Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines","volume":"6","author":"dos Santos","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.envpol.2026.129187_bib39","doi-asserted-by":"crossref","first-page":"111546","DOI":"10.1016\/j.cclet.2025.111546","article-title":"Mass spectrometry analysis reveals changes in patterns and correlations of nucleic acid epigenetic modifications in mouse tissues exposed to polystyrene microplastics","volume":"37","author":"Feng","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.envpol.2026.129187_bib40","doi-asserted-by":"crossref","first-page":"8753","DOI":"10.1021\/acs.jpcb.4c03290","article-title":"Synergistic effects of microplastics and marine pollutants on the destabilization of lipid bilayers","volume":"128","author":"Fleury","year":"2024","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.envpol.2026.129187_bib42","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2217\/nnm-2018-0446","article-title":"Limits and challenges in using transport inhibitors to characterize how nano-sized drug carriers enter cells","volume":"14","author":"Francia","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.envpol.2026.129187_bib43","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.129187_bib44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3390\/toxics10050215","article-title":"Amino-functionalized polystyrene nano-plastics induce mitochondria damage in human umbilical vein endothelial cells","volume":"10","author":"Fu","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.129187_bib45","doi-asserted-by":"crossref","first-page":"11855","DOI":"10.1093\/nar\/gkab879","article-title":"Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication","volume":"49","author":"Fukuda","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.129187_bib47","article-title":"xOmicsShiny: an R shiny application for cross-omics data analysis and pathway mapping","author":"Gao","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.envpol.2026.129187_bib48","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s12859-018-2486-6","article-title":"iDEP: an integrated web application for differential expression and pathway analysis of RNA-seq data","volume":"19","author":"Ge","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.envpol.2026.129187_bib46","series-title":"Marine Anthropogenic Litter","article-title":"Micro-and nano-plastics and human health","author":"Galloway","year":"2015"},{"key":"10.1016\/j.envpol.2026.129187_bib49","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envpol.2026.129187_bib50","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3390\/antiox14121462","article-title":"Reprogramming the mitochondrion in atherosclerosis: targets for vascular protection","volume":"14","author":"Glogowski","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.envpol.2026.129187_bib51","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/acs.chemrestox.0c00486","article-title":"Exposure of human lung cells to polystyrene microplastics significantly retards cell proliferation and triggers morphological changes","volume":"34","author":"Goodman","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envpol.2026.129187_bib52","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cmet.2010.06.008","article-title":"Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions","volume":"12","author":"Goossens","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.envpol.2026.129187_bib53","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib54","doi-asserted-by":"crossref","first-page":"11807","DOI":"10.1093\/nar\/gkz1043","article-title":"Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth","volume":"47","author":"Heissenberger","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.129187_bib55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12989-020-00387-7","article-title":"Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature","volume":"17","author":"Hirt","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.envpol.2026.129187_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101620","article-title":"Micro-and nano-plastics activation of oxidative and inflammatory adverse outcome pathways","volume":"37","author":"Hu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib57","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1021\/acs.est.1c03859","article-title":"Detection and analysis of microplastics in human sputum","volume":"56","author":"Huang","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129187_bib58","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1002\/tox.24387","article-title":"Polystyrene microplastics induce injury to the vascular endothelial through NLRP3-Mediated pyroptosis","volume":"39","author":"Huo","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envpol.2026.129187_bib59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/physrev.00059.2009","article-title":"Role of rab GTPases in membrane traffic and cell physiology","volume":"91","author":"Hutagalung","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envpol.2026.129187_bib60","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1002\/eji.1830271109","article-title":"Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression","volume":"27","author":"Im","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.envpol.2026.129187_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154907","article-title":"Detection of microplastics in human lung tissue using \u03bcFTIR spectroscopy","volume":"831","author":"Jenner","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129187_bib62","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1113\/jphysiol.2006.124719","article-title":"Chloride and the endosomal\u2013lysosomal pathway: emerging roles of CLC chloride transporters","volume":"578","author":"Jentsch","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.envpol.2026.129187_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2008.11.007","article-title":"Upregulation of cellular glutathione by 3H-1, 2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity","volume":"30","author":"Jia","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envpol.2026.129187_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70190","article-title":"Deciphering the pseudouridine nucleobase modification in human diseases: from molecular mechanisms to clinical perspectives","volume":"15","author":"Jia","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib65","doi-asserted-by":"crossref","first-page":"8939","DOI":"10.7150\/thno.45178","article-title":"METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications","volume":"10","author":"Jian","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.envpol.2026.129187_bib66","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1039\/c0an00333f","article-title":"A practical approach to detect unique metabolic patterns for personalized medicine","volume":"135","author":"Johnson","year":"2010","journal-title":"Analyst"},{"key":"10.1016\/j.envpol.2026.129187_bib67","doi-asserted-by":"crossref","first-page":"36046","DOI":"10.1007\/s11356-018-3508-7","article-title":"Occurrence, sources, human health impacts and mitigation of microplastic pollution","volume":"25","author":"Karbalaei","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envpol.2026.129187_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106061","article-title":"Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts","volume":"26","author":"Khan","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.envpol.2026.129187_bib70","first-page":"1809","article-title":"Nuclear factor kappaB dependency of platelet-activating factor-induced angiogenesis","volume":"62","author":"Ko","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.envpol.2026.129187_bib71","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1016\/j.febslet.2005.10.027","article-title":"Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3K-dependent signaling pathway in a human vascular endothelial cell line","volume":"579","author":"Ko","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.envpol.2026.129187_bib73","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200908086","article-title":"Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling","volume":"188","author":"Koivusalo","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib74","doi-asserted-by":"crossref","first-page":"14928","DOI":"10.1074\/jbc.270.25.14928","article-title":"Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway","volume":"270","author":"Kravchenko","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.129187_bib75","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/CIRCRESAHA.111.256859","article-title":"Role of phospholipid oxidation products in atherosclerosis","volume":"111","author":"Lee","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.envpol.2026.129187_bib76","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/metabo12100897","article-title":"Impact of Micro- and nanoplastics on mitochondria","volume":"12","author":"Lee","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.envpol.2026.129187_bib77","doi-asserted-by":"crossref","first-page":"12010","DOI":"10.1073\/pnas.96.21.12010","article-title":"In: Structurally Similar Oxidized Phospholipids Differentially Regulate Endothelial Binding of Monocytes and Neutrophils","volume":"96","author":"Leitinger","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.envpol.2026.129187_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129187_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118190","article-title":"Environmental microplastic and nanoplastic: exposure routes and effects on coagulation and the cardiovascular system","volume":"291","author":"Lett","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129187_bib80","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.scitotenv.2016.05.084","article-title":"Plastic waste in the marine environment: a review of sources, occurrence and effects","volume":"566\u2013567","author":"Li","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129187_bib81","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nchembio.2040","article-title":"Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome","volume":"12","author":"Li","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125492","article-title":"Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice","volume":"244","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.129187_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109736","article-title":"Inhalable microplastics of different shapes disrupt airway epithelial homeostasis: a comparative study of fibers and irregular particles","volume":"203","author":"Li","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129187_bib84","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.129187_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115771","article-title":"Lysosomal dependent transcytosis of polystyrene nanoplastics within macrophages","volume":"206","author":"Liu","year":"2025","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2026.129187_bib86","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib87","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/CIRCRESAHA.115.307674","article-title":"NSun2 deficiency protects endothelium from inflammation via mRNA methylation of ICAM-1","volume":"118","author":"Luo","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.envpol.2026.129187_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154306","article-title":"Micro- and nanoplastic-induced mitochondrial dysfunction and organelle miscommunication: a toxicological perspective","volume":"519","author":"Maharana","year":"2026","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2026.129187_bib89","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3390\/pharmaceutics12040371","article-title":"Endocytosis: the nanoparticle and submicron nanocompounds gateway into the cell","volume":"12","author":"Manzanares","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.envpol.2026.129187_bib90","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.1093\/nar\/gkab603","article-title":"Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6","volume":"49","author":"Mao","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.129187_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/nano14050429","article-title":"Polystyrene Nano- and microplastic particles induce an inflammatory gene expression profile in rat neural stem cell-derived astrocytes in vitro","volume":"14","author":"Marcellus","year":"2024","journal-title":"Nanomaterials"},{"key":"10.1016\/j.envpol.2026.129187_bib92","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMoa2309822","article-title":"Microplastics and nanoplastics in atheromas and cardiovascular events","volume":"390","author":"Marfella","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib93","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/mvre.1996.0058","article-title":"Chloride ion channels are associated with adherence of lymphatic endothelial cells","volume":"52","author":"Martin","year":"1996","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.envpol.2026.129187_bib94","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-74892-6","article-title":"Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells","volume":"14","author":"Moon","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.129187_bib95","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12672-025-02066-5","article-title":"Multi-omics analysis identifies OSGEPL1 as an oncogene in hepatocellular carcinoma","volume":"16","author":"Mui","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.envpol.2026.129187_bib96","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0925-4439(01)00028-X","article-title":"Molecular requirements for the internalisation step of endocytosis: insights from yeast","volume":"1535","author":"Munn","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.envpol.2026.129187_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212486","article-title":"Natural compound resveratrol attenuates TNF-Alpha-Induced vascular dysfunction in mice and human endothelial cells: the involvement of the NF-\u03baB signaling pathway","volume":"22","author":"Nallasamy","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.129187_bib98","doi-asserted-by":"crossref","first-page":"518","DOI":"10.5551\/jat.25650","article-title":"Lysophosphatidylserine has bilateral effects on macrophages in the pathogenesis of atherosclerosis","volume":"22","author":"Nishikawa","year":"2015","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.envpol.2026.129187_bib99","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.atherosclerosis.2022.11.004","article-title":"The epitranscriptome: RNA modifications in vascular remodelling","volume":"374","author":"Nossent","year":"2023","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.envpol.2026.129187_bib100","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/BF00581068","article-title":"Antracene-9-carboxylic acid inhibits renal chloride reabsorption","volume":"398","author":"Oberleithner","year":"1983","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.envpol.2026.129187_bib101","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.taap.2008.07.001","article-title":"Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway","volume":"232","author":"Oesterling","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129187_bib102","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/BF02631364","article-title":"Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase","volume":"29A","author":"Ohkuma","year":"1993","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.envpol.2026.129187_bib103","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJM200010193431603","article-title":"Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group","volume":"343","author":"Packard","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129187_bib105","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.envpol.2026.129187_bib106","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jemt.20845","article-title":"Cellular uptake pathway and drug release characteristics of drug\u2010encapsulated glycol chitosan nanoparticles in live cells","volume":"73","author":"Park","year":"2010","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.envpol.2026.129187_bib107","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","article-title":"Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association","volume":"107","author":"Pearson","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.129187_bib108","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ajpath.2023.09.012","article-title":"The role of endothelial cells in atherosclerosis: insights from genetic association studies","volume":"194","author":"Pepin","year":"2024","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.envpol.2026.129187_bib169","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainres.2004.08.051","article-title":"The effects of ebselen on [3H]glutamate uptake by synaptic vesicles from rat brain","volume":"1027","author":"Porciuncula","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.envpol.2026.129187_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134455","article-title":"Environmental exposure to microplastics: an overview on possible human health effects","volume":"702","author":"Prata","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129187_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127842","article-title":"Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis","volume":"425","author":"Qin","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129187_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: first evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129187_bib112","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib113","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ccep.2016.02.003","article-title":"Pharmacogenetics of potassium channel blockers","volume":"8","author":"Roden","year":"2016","journal-title":"Card. Electrophysiol. Clin."},{"key":"10.1016\/j.envpol.2026.129187_bib114","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.3390\/molecules24152748","article-title":"Aristoteline, an indole-alkaloid, induces relaxation by activating potassium channels and blocking calcium channels in isolated rat aorta","volume":"24","author":"Romero","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.envpol.2026.129187_bib115","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA modifications in gene expression regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2026.129187_bib116","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1469-7793.1998.093bz.x","article-title":"K+ channel block\u2010induced Mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation","volume":"510","author":"Rouzaire\u2010Dubois","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.envpol.2026.129187_bib117","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature24456","article-title":"The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution","volume":"551","author":"Safra","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.129187_bib118","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.lfs.2009.10.012","article-title":"Effects of endocytosis inhibitors on internalization of human IgG by Caco-2 human intestinal epithelial cells","volume":"85","author":"Sato","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.envpol.2026.129187_bib119","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of various microplastics in human stool","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.03.034","article-title":"Endosome maturation, transport and functions","volume":"31","author":"Scott","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116925","article-title":"Integrated transcriptomics and metabolomics reveal the mechanism of polystyrene nanoplastics toxicity to mice","volume":"284","author":"Shi","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129187_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107248","article-title":"Effects of polystyrene nanoplastics on endothelium senescence and its underlying mechanism","volume":"164","author":"Shiwakoti","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129187_bib123","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvaf282","article-title":"Endothelial mitochondrial dysfunction in hypertension, diabetes and atherosclerosis","author":"Singh","year":"2026","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.envpol.2026.129187_bib124","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/microplastics4030052","article-title":"From environment to endothelium: the role of microplastics in vascular aging","volume":"4","author":"Sivakumar","year":"2025","journal-title":"Microplastics"},{"key":"10.1016\/j.envpol.2026.129187_bib125","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1336369","article-title":"The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis","volume":"15","author":"Song","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129187_bib126","doi-asserted-by":"crossref","first-page":"D219","DOI":"10.1093\/nar\/gkaf1284","article-title":"MODOMICS: a database of RNA modifications and related information. 2025 update and 20th anniversary","volume":"54","author":"Sordyl","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envpol.2026.129187_bib127","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1161\/01.ATV.18.4.568","article-title":"Biphasic regulation of transcription factor nuclear factor-kappaB activity in human endothelial cells by lysophosphatidylcholine through protein kinase C-mediated pathway","volume":"18","author":"Sugiyama","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib168","first-page":"51","article-title":"Mechanism of the inhibition of hog gastric H+,K+-ATPase by the seleno-organic compound ebselen","volume":"44","author":"Tabuchi","year":"1994","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.envpol.2026.129187_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116169","article-title":"Toxic effects of exposure to microplastics with environmentally relevant shapes and concentrations: accumulation, energy metabolism and tissue damage in oyster Crassostrea gigas","volume":"269","author":"Teng","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129187_bib129","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fcell.2018.00082","article-title":"Endothelial cell metabolism in atherosclerosis","volume":"6","author":"Theodorou","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib130","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1056\/NEJM199503093321003","article-title":"Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group","volume":"332","author":"Thompson","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envpol.2026.129187_bib131","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/374549a0","article-title":"Anti-inflammatory properties of a platelet-activating factor acetylhydrolase","volume":"374","author":"Tjoelker","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.129187_bib132","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.152.2.566","article-title":"Autocrine stimulation of B lymphocytes by a platelet-activating factor receptor agonist, 1-palmitoyl-2-acetyl-sn-glycero-3-phosphocholine","volume":"152","author":"Tordai","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.envpol.2026.129187_bib133","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/19440049.2019.1583381","article-title":"Review of micro- and nanoplastic contamination in the food chain","volume":"36","author":"Toussaint","year":"2019","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"key":"10.1016\/j.envpol.2026.129187_bib134","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0090-6980(98)00060-4","article-title":"Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases","volume":"56","author":"Travers","year":"1998","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.envpol.2026.129187_bib135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0005-2760(91)90053-K","article-title":"Biological effects of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in the human neutrophil","volume":"1084","author":"Triggiani","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.envpol.2026.129187_bib136","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.toxrep.2022.05.001","article-title":"Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Oryzias javanicus bleeker, 1854)","volume":"9","author":"Usman","year":"2022","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.envpol.2026.129187_bib137","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0092-8674(03)00111-9","article-title":"The molecular motor toolbox for intracellular transport","volume":"112","author":"Vale","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.envpol.2026.129187_bib138","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbrc.2006.01.028","article-title":"Human endothelial progenitors constitute targets for environmental atherogenic polycyclic aromatic hydrocarbons","volume":"341","author":"van Grevenynghe","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.envpol.2026.129187_bib139","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.aquatox.2017.06.014","article-title":"Pathway analysis of systemic transcriptome responses to injected polystyrene particles in zebrafish larvae","volume":"190","author":"Veneman","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2026.129187_bib140","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1021\/acs.jnatprod.2c00518","article-title":"Interaction metabolomics to discover synergists in natural product mixtures","volume":"86","author":"Vidar","year":"2023","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.envpol.2026.129187_bib141","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260181","article-title":"Polystyrene microplastic particles induce endothelial activation","volume":"16","author":"Vlacil","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.envpol.2026.129187_bib142","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1083\/jcb.123.5.1107","article-title":"Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation","volume":"123","author":"Wang","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib143","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13104-021-05563-2","article-title":"Epitranscriptomic profile of Lactobacillus agilis and its adaptation to growth on inulin","volume":"14","author":"Wang","year":"2021","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.envpol.2026.129187_bib144","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1038\/s41467-021-22111-5","article-title":"Molecular basis of V-ATPase inhibition by bafilomycin A1","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.envpol.2026.129187_bib145","article-title":"Analysis of m(7)G methylation modification patterns and pulmonary vascular immune microenvironment in pulmonary arterial hypertension","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2026.129187_bib146","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41392-023-01638-7","article-title":"RNA modification in cardiovascular disease: implications for therapeutic interventions","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.envpol.2026.129187_bib147","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jes.2024.10.011","article-title":"Mechanism of nano-plastics induced inflammation injury in vascular endothelial cells","volume":"154","author":"Wang","year":"2025","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.envpol.2026.129187_bib148","doi-asserted-by":"crossref","first-page":"110","DOI":"10.7164\/antibiotics.37.110","article-title":"Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity","volume":"37","author":"Werner","year":"1984","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.envpol.2026.129187_bib150","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1085\/jgp.79.2.283","article-title":"Irreversible inactivation of red cell chloride exchange with phenylglyoxal, an arginine-specific reagent","volume":"79","author":"Wieth","year":"1982","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.envpol.2026.129187_bib149","series-title":"World Heart Report 2023","author":"World Heart Federation","year":"2023"},{"key":"10.1016\/j.envpol.2026.129187_bib151","article-title":"Induction and testing of hypoxia in cell culture","volume":"2899","author":"Wu","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.envpol.2026.129187_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119565","article-title":"RNA modifications in cardiovascular diseases, the potential therapeutic targets","volume":"278","author":"Wu","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.envpol.2026.129187_bib153","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.723137","article-title":"Emerging role of E2F family in cancer stem cells","volume":"11","author":"Xie","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.envpol.2026.129187_bib154","doi-asserted-by":"crossref","first-page":"19592","DOI":"10.1002\/anie.202105253","article-title":"Programmable RNA N1\u2010Methyladenosine demethylation by a Cas13d\u2010Directed demethylase","volume":"60","author":"Xie","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.envpol.2026.129187_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126092","article-title":"Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells","volume":"417","author":"Xu","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129187_bib156","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1247\/csf.23.33","article-title":"Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells","volume":"23","author":"Yamamoto","year":"1998","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.envpol.2026.129187_bib157","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.atherosclerosis.2021.06.912","article-title":"Targeting the chemokine network in atherosclerosis","volume":"330","author":"Yan","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.envpol.2026.129187_bib158","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/cr.2017.55","article-title":"5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.envpol.2026.129187_bib159","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1021\/acs.est.2c07179","article-title":"Detection of various microplastics in patients undergoing cardiac surgery","volume":"57","author":"Yang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129187_bib160","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/hq1001.097027","article-title":"Increased transcription of IL-8 in endothelial cells is differentially regulated by TNF-alpha and oxidized phospholipids","volume":"21","author":"Yeh","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.envpol.2026.129187_bib161","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cca.2021.01.001","article-title":"The epitranscriptome of long noncoding RNAs in metabolic diseases","volume":"515","author":"Yin","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.envpol.2026.129187_bib163","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells","volume":"266","author":"Yoshimori","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.129187_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125321","article-title":"Photolytic degradation elevated the toxicity of polylactic acid microplastics to developing zebrafish by triggering mitochondrial dysfunction and apoptosis","volume":"413","author":"Zhang","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129187_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122891","article-title":"Microplastics induced inflammation in the spleen of developmental Japanese quail (Coturnix japonica) via ROS-mediated p38 MAPK and TNF signaling pathway activation","volume":"341","author":"Zhang","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129187_bib166","article-title":"Epileptic encephalopathy linked to a DALRD3 missense variant that impairs tRNA modification","volume":"6","author":"Zhang","year":"2025","journal-title":"Hum. Genet. Genomics Adv."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126015575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126015575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:28:34Z","timestamp":1792222114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126015575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":164,"alternative-id":["S0269749126015575"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129187","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polystyrene microplastic uptake drives inflammatory, epitranscriptomic, and metabolic reprogramming in human aortic endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129187"}}