{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:37:33Z","timestamp":1792841853711,"version":"4.5.0"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.envpol.2026.129203","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:42:14Z","timestamp":1791960134000},"page":"129203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Acute ozone exposure induced lung impairments in aged mice: multi-omics evidence"],"prefix":"10.1016","volume":"411","author":[{"given":"Ruru","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingge","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurou","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaze","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.129203_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102569","article-title":"Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress","volume":"59","author":"Abulikemu","year":"2023","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.envpol.2026.129203_bib2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/metabo11070418","article-title":"Metabolomics: a scoping review of its role as a tool for disease biomarker discovery in selected non-communicable diseases","volume":"11","author":"Aderemi","year":"2021","journal-title":"Metabolites"},{"issue":"5","key":"10.1016\/j.envpol.2026.129203_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1042\/cs0810603","article-title":"Glutamine and alanine metabolism in lungs of septic rats","volume":"81","author":"Ardawi","year":"1991","journal-title":"Clin. Sci. (Lond.)"},{"issue":"10","key":"10.1016\/j.envpol.2026.129203_bib4","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1164\/rccm.201708-1613OC","article-title":"Respiratory responses to ozone exposure. MOSES (the multicenter ozone study in older subjects)","volume":"197","author":"Arjomandi","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"8","key":"10.1016\/j.envpol.2026.129203_bib5","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1289\/ehp.1003326","article-title":"Identification of candidate genes downstream of TLR4 signaling after ozone exposure in mice: a role for heat-shock protein 70","volume":"119","author":"Bauer","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.envpol.2026.129203_bib6","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3390\/ijms24021612","article-title":"Effects of ozone on sickness and depressive-like behavioral and biochemical phenotypes and their regulation by serum amyloid A in mice","volume":"24","author":"Baumann","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.envpol.2026.129203_bib7","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1001\/jama.292.19.2372","article-title":"Ozone and short-term mortality in 95 US urban communities, 1987-2000","volume":"292","author":"Bell","year":"2004","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40795-020-00398-9","article-title":"Increasing levels of Parasutterella in the gut microbiome correlate with improving low-density lipoprotein levels in healthy adults consuming resistant potato starch during a randomised trial","volume":"6","author":"Bush","year":"2020","journal-title":"BMC Nutr"},{"issue":"12","key":"10.1016\/j.envpol.2026.129203_bib9","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/toxics11121014","article-title":"Methylomic, proteomic, and metabolomic correlates of traffic-related air pollution in the context of cardiorespiratory health: a systematic review, pathway analysis, and network analysis","volume":"11","author":"Casella","year":"2023","journal-title":"Toxics"},{"issue":"2","key":"10.1016\/j.envpol.2026.129203_bib10","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/cr030105v","article-title":"Biosynthesis and mode of action of lantibiotics","volume":"105","author":"Chatterjee","year":"2005","journal-title":"Chem Rev"},{"issue":"7","key":"10.1016\/j.envpol.2026.129203_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200791","article-title":"Preventive effect of Indian gooseberry (Phyllanthus emblica L.) fruit extract on cognitive decline in high-fat diet (HFD)-fed rats","volume":"67","author":"Chen","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envpol.2026.129203_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2026.1859829","article-title":"Hypoxia-inducible factor 1-alpha: a dual regulator of ferroptosis in ischemic stroke and a promising therapeutic target","volume":"17","author":"Cui","year":"2026","journal-title":"Front. Neurol."},{"issue":"2","key":"10.1016\/j.envpol.2026.129203_bib13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s13238-017-0423-5","article-title":"Structural and functional roles of ether lipids","volume":"9","author":"Dean","year":"2018","journal-title":"Protein Cell"},{"issue":"9","key":"10.1016\/j.envpol.2026.129203_bib14","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3390\/antiox9090867","article-title":"Regulatory functions of L-Carnitine, acetyl, and propionyl L-Carnitine in a PCOS mouse model: focus on antioxidant\/antiglycative molecular pathways in the ovarian microenvironment","volume":"9","author":"Di Emidio","year":"2020","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.envpol.2026.129203_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/cph4.70042","article-title":"Crosstalk between microbiome and ferroptosis in diseases: from mechanism to therapy","volume":"15","author":"Ding","year":"2025","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.envpol.2026.129203_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111611","article-title":"Regulation of ferroptosis ameliorates silica nanoparticle-induced lung injury by inhibiting NCOA4-mediated ferritinophagy","volume":"418","author":"Guo","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2026.129203_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2026.128708","article-title":"Ozone induced pulmonary injury and respiratory dysfunction: evidence, underlying mechanism and target investigation","volume":"406","author":"Guo","year":"2026","journal-title":"Environ Pollut"},{"issue":"7","key":"10.1016\/j.envpol.2026.129203_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13425","article-title":"Age-related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats","volume":"20","author":"Han","year":"2021","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.envpol.2026.129203_bib19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1164\/rccm.200809-1522ST","article-title":"An official research policy statement of the American thoracic society\/European Respiratory Society: standards for quantitative assessment of lung structure","volume":"181","author":"Hsia","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.envpol.2026.129203_bib20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jare.2025.07.043","article-title":"NCOA4-Mediated ferritinophagy induces ferroptosis and enriches ferritin-containing EVs via ferritin phase separation to promote mechanical ventilation-induced pulmonary fibrosis","volume":"82","author":"Huang","year":"2026","journal-title":"J. Adv. Res."},{"issue":"9","key":"10.1016\/j.envpol.2026.129203_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100630","article-title":"Dietary modulation of lung lipids influences inflammatory responses to inhaled ozone","volume":"65","author":"Hunter","year":"2024","journal-title":"J. Lipid Res."},{"issue":"9","key":"10.1016\/j.envpol.2026.129203_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11306-023-02043-5","article-title":"Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats","volume":"19","author":"Jackson","year":"2023","journal-title":"Metabolomics"},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12967-023-04603-8","article-title":"Potential roles of the interactions between gut microbiota and metabolites in LPS-induced intrauterine inflammation (IUI) and associated preterm birth (PTB)","volume":"22","author":"Jia","year":"2024","journal-title":"J. Transl. Med."},{"issue":"10","key":"10.1016\/j.envpol.2026.129203_bib24","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.envpol.2026.129203_bib25","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41396-019-0364-5","article-title":"Defining the role of Parasutterella, a previously uncharacterized member of the core gut microbiota","volume":"13","author":"Ju","year":"2019","journal-title":"ISME J."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12931-019-1168-x","article-title":"The interleukin-33 receptor contributes to pulmonary responses to ozone in male mice: role of the microbiome","volume":"20","author":"Kasahara","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.envpol.2026.129203_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115318","article-title":"Polysaccharides from Platycodon grandiflorus attenuates high-fat diet induced obesity in mice through targeting gut microbiota","volume":"166","author":"Ke","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"3.4","key":"10.1016\/j.envpol.2026.129203_bib28","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2152\/jmi.65.236","article-title":"Association of short-term ozone exposure with pulmonary function and respiratory symptoms in schoolchildren:a panel study in a Western Japanese city","volume":"65","author":"Kurai","year":"2018","journal-title":"J. Med. Investig."},{"issue":"4","key":"10.1016\/j.envpol.2026.129203_bib29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.envpol.2026.129203_bib30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/CIRCRESAHA.119.316448","article-title":"Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice","volume":"127","author":"Lee","year":"2020","journal-title":"Circ. Res."},{"issue":"23","key":"10.1016\/j.envpol.2026.129203_bib31","first-page":"2691","article-title":"NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss","volume":"136","author":"Li","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.envpol.2026.129203_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173222","article-title":"Fatty acids metabolism in ozone-induced pulmonary inflammatory injury: evidence, mechanism and prevention","volume":"933","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.envpol.2026.129203_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13621","article-title":"Ferritinophagy: a novel insight into the double-edged sword in ferritinophagy-ferroptosis axis and human diseases","volume":"57","author":"Li","year":"2024","journal-title":"Cell Prolif."},{"issue":"15","key":"10.1016\/j.envpol.2026.129203_bib34","article-title":"Subchronic ozone exposure leads to multi-organ injuries with differential reversibility in male C57BL\/6 J mice","volume":"492","author":"Li","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129203_bib35","article-title":"Comparison of the association between different ozone indicators and daily respiratory hospitalization in Guangzhou, China","volume":"11","author":"Lin","year":"2023","journal-title":"Front. Public Health"},{"issue":"13","key":"10.1016\/j.envpol.2026.129203_bib36","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1080\/10408398.2020.1867054","article-title":"Gut microbiota and aging","volume":"62","author":"Ling","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/nu10010079","article-title":"Pharmacological investigation of the anti-inflammation and anti-oxidation activities of diallyl disulfide in a rat emphysema model induced by cigarette smoke extract","volume":"10","author":"Liu","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/advances\/nmx009","article-title":"Butyrate: a double-edged sword for health?","volume":"9","author":"Liu","year":"2018","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.envpol.2026.129203_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108559","article-title":"Altered metabolome and microbiome associated with compromised intestinal barrier induced hepatic lipid metabolic disorder in mice after subacute and subchronic ozone exposure","volume":"185","author":"Lu","year":"2024","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41392-024-01772-w","article-title":"Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer","volume":"9","author":"Ma","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.envpol.2026.129203_bib41","article-title":"Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1\u03b1\/LSH\/SCD1-mediated ferroptosis","volume":"17","author":"Ma","year":"2026","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.envpol.2026.129203_bib42","doi-asserted-by":"crossref","first-page":"e958","DOI":"10.1016\/S2542-5196(22)00260-1","article-title":"Global trends in ozone concentration and attributable mortality for urban, peri-urban, and rural areas between 2000 and 2019: a modelling study","volume":"6","author":"Malashock","year":"2022","journal-title":"Lancet Planet. Health"},{"issue":"8","key":"10.1016\/j.envpol.2026.129203_bib43","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.envpol.2026.129203_bib44","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1165\/rcmb.2007-0250OC","article-title":"Ozone exposure of macrophages induces an alveolar epithelial chemokine response through IL-1alpha","volume":"38","author":"Manzer","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.envpol.2026.129203_bib45","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12989-023-00528-8","article-title":"Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone","volume":"20","author":"Mazumder","year":"2023","journal-title":"Part. Fibre Toxicol."},{"issue":"3","key":"10.1016\/j.envpol.2026.129203_bib47","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jaci.2017.11.044","article-title":"Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33","volume":"142","author":"Michaudel","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"15","key":"10.1016\/j.envpol.2026.129203_bib48","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1016\/j.molcel.2025.07.001","article-title":"HIF-independent oxygen sensing via KDM6A regulates ferroptosis","volume":"85","author":"Minikes","year":"2025","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s40168-026-02476-9","article-title":"Gut-protective metabolic phenotype for diarrhoeal remission caused by an environmental probiotic thermophile","volume":"14","author":"Miyamoto","year":"2026","journal-title":"Microbiome"},{"issue":"12","key":"10.1016\/j.envpol.2026.129203_bib50","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/gut.2010.215665","article-title":"Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models","volume":"59","author":"Murphy","year":"2010","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.envpol.2026.129203_bib51","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/cells8030214","article-title":"Hypoxia-inducible factors and the regulation of lipid metabolism","volume":"8","author":"Mylonis","year":"2019","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.envpol.2026.129203_bib52","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1084\/jem.20030298","article-title":"Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-Kinase\u2013TAT","volume":"198","author":"Myou","year":"2003","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1465-9921-11-33","article-title":"Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice","volume":"11","author":"Ni","year":"2010","journal-title":"Respir. Res."},{"key":"10.1016\/j.envpol.2026.129203_bib54","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2021.04.027","article-title":"Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis","volume":"169","author":"Ni","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10565-026-10150-x","article-title":"Ferritinophagy: molecular mechanisms and its crosstalk with ferroptosis in chronic respiratory diseases","volume":"42","author":"Ning","year":"2026","journal-title":"Cell Biol. Toxicol."},{"issue":"4","key":"10.1016\/j.envpol.2026.129203_bib56","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1164\/rccm.202107-1599OC","article-title":"Long-term ozone exposure and small airway dysfunction: the China Pulmonary Health (CPH) study","volume":"205","author":"Niu","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.envpol.2026.129203_bib57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10661-024-12416-5","article-title":"High-resolution estimation of near-surface ozone concentration and population exposure risk in China","volume":"196","author":"Pan","year":"2024","journal-title":"Environ. Monit. Assess."},{"issue":"27","key":"10.1016\/j.envpol.2026.129203_bib58","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1039\/D0SC02393K","article-title":"Switchable foldamer ion channels with antibacterial activity","volume":"11","author":"Peters","year":"2020","journal-title":"Chem. Sci."},{"issue":"2","key":"10.1016\/j.envpol.2026.129203_bib59","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01471-19","article-title":"Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis","volume":"94","author":"Prochnow","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.envpol.2026.129203_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121537","article-title":"Linderalactone attenuates pulmonary fibrosis by suppressing HIF-1\u03b1-associated ferroptotic stress","volume":"364","author":"Qiu","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.envpol.2026.129203_bib61","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/s41366-024-01581-9","article-title":"Butyrate and tributyrin reduce LPS-induced inflammatory cytokine production from human visceral fat","volume":"48","author":"Rafiei","year":"2024","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.envpol.2026.129203_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.120533","article-title":"Indoor dust exposure induces lung injury and disrupts the lung-bone marrow immune axis in C57BL\/6J mice","volume":"322","author":"Ren","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129203_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111345","article-title":"The potential roles of HIF-1\u03b1 in epithelial-mesenchymal transition and ferroptosis in tumor cells","volume":"122","author":"Shen","year":"2024","journal-title":"Cell. Signal."},{"issue":"7","key":"10.1016\/j.envpol.2026.129203_bib64","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2174\/138920011796504527","article-title":"Age-related changes in pharmacokinetics","volume":"12","author":"Shi","year":"2011","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.envpol.2026.129203_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.117823","article-title":"Metabolomics and lipidomics in non-small cell lung cancer","volume":"555","author":"Shi","year":"2024","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib66","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12302-020-00450-2","article-title":"Urban population exposure to air pollution in Europe over the last decades","volume":"33","author":"Sicard","year":"2021","journal-title":"Environ. Sci. Eur."},{"issue":"6","key":"10.1016\/j.envpol.2026.129203_bib67","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00851-21","article-title":"Muribaculaceae genomes assembled from metagenomes suggest genetic drivers of differential response to acarbose treatment in mice","volume":"6","author":"Smith","year":"2021","journal-title":"mSphere"},{"issue":"6","key":"10.1016\/j.envpol.2026.129203_bib68","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13821","article-title":"Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome","volume":"22","author":"Sol","year":"2023","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.envpol.2026.129203_bib69","first-page":"757","article-title":"Effects of simulated heat wave and ozone on high fat diet ApoE deficient mice","volume":"31","author":"Song","year":"2018","journal-title":"Biomed. Environ. Sci."},{"issue":"6","key":"10.1016\/j.envpol.2026.129203_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0350129","article-title":"Lipid droplet associated protein HILPDA promotes hypoxia-induced ferroptosis by driving LPCAT3-mediated polyunsaturated phospholipids enrichment","volume":"21","author":"Song","year":"2026","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib71","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/toxsci\/kfac117","article-title":"Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice","volume":"191","author":"Stevens","year":"2023","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2026.129203_bib72","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/7854_2016_23","article-title":"Mechanisms of inflammation-associated depression: immune influences on tryptophan and phenylalanine metabolisms","volume":"31","author":"Strasser","year":"2017","journal-title":"Curr Top Behav Neurosci"},{"issue":"3","key":"10.1016\/j.envpol.2026.129203_bib73","article-title":"Cohort-based long-term ozone exposure-associated mortality risks with adjusted metrics: a systematic review and meta-analysis","volume":"3","author":"Sun","year":"2022","journal-title":"Innovation"},{"key":"10.1016\/j.envpol.2026.129203_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111075","article-title":"Drp1-mediated mitochondrial fission promotes pulmonary fibrosis progression through the regulation of lipid metabolic reprogramming by ROS\/HIF-1\u03b1","volume":"117","author":"Tong","year":"2024","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib75","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12929-025-01179-x","article-title":"From dysbiosis to longevity: a narrative review into the gut microbiome's impact on aging","volume":"32","author":"Tseng","year":"2025","journal-title":"J. Biomed. Sci."},{"issue":"3","key":"10.1016\/j.envpol.2026.129203_bib76","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1165\/rcmb.2018-0140ED","article-title":"The gut-lung axis and pulmonary responses to ozone","volume":"59","author":"Voynow","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.envpol.2026.129203_bib77","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1165\/rcmb.2008-0135OC","article-title":"Glutamate mediates hyperoxia-induced newborn rat lung injury through N-methyl-D-aspartate receptors","volume":"40","author":"Wang","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.envpol.2026.129203_bib78","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1001\/jama.2019.10255","article-title":"Association between long-term exposure to ambient air pollution and change in quantitatively assessed emphysema and lung function","volume":"322","author":"Wang","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.envpol.2026.129203_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.04.014","article-title":"Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis","volume":"186","author":"Wang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2026.129203_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113033","article-title":"Ozone preconditioning protects rabbit heart against global ischemia-reperfusion injury in vitro by up-regulating HIF-1\u03b1","volume":"150","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib81","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41420-023-01753-y","article-title":"Ferritinophagy: research advance and clinical significance in cancers","volume":"9","author":"Wang","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.envpol.2026.129203_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114839","article-title":"Perturbation of arachidonic acid and glycerolipid metabolism promoted particulate matter-induced inflammatory responses in human bronchial epithelial cells","volume":"256","author":"Wang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129203_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.178103","article-title":"Effects of combined exposure to PM2.5, O3, and NO2 on health risks of different disease populations in the beijing-tianjin-hebei region","volume":"958","author":"Wang","year":"2025","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib84","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-024-55450-0","article-title":"Substantially underestimated global health risks of current ozone pollution","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.envpol.2026.129203_bib85","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/toxics13060468","article-title":"Subacute inhalation exposure of mice to ozone induces damage to various organs","volume":"13","author":"Wang","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.129203_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176219","article-title":"Sodium butyrate ameliorates sepsis-associated lung injury by enhancing gut and lung barrier function in combination with modulation of CD4(+)Foxp3(+) regulatory T cells","volume":"963","author":"Wei","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129203_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170668","article-title":"TRPA1-PI3K\/Akt-OPA1-ferroptosis axis in ozone-induced bronchial epithelial cell and lung injury","volume":"918","author":"Weng","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.envpol.2026.129203_bib88","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/CS20130039","article-title":"A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model","volume":"126","author":"Wiegman","year":"2014","journal-title":"Clin. Sci. (Lond.)"},{"issue":"2","key":"10.1016\/j.envpol.2026.129203_bib89","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.3389\/fimmu.2020.01957","article-title":"Oxidative stress in ozone-induced chronic lung inflammation and emphysema: a facet of chronic obstructive pulmonary disease","volume":"11","author":"Wiegman","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envpol.2026.129203_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116289","article-title":"DiDang decoction improves mitochondrial function and lipid metabolism via the HIF-1 signaling pathway to treat atherosclerosis and hyperlipidemia","volume":"308","author":"Wu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.envpol.2026.129203_bib91","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s12035-021-02304-1","article-title":"Insights from animal models on the pathophysiology of hyperphenylalaninemia: role of mitochondrial dysfunction, oxidative stress and inflammation","volume":"58","author":"Wyse","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib92","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s10753-026-02501-x","article-title":"HIF-1A-Mediated lactate metabolism confers ferroptosis resistance in M1 macrophages through histone lactylation during acute lung injury","volume":"49","author":"Xie","year":"2026","journal-title":"Inflammation"},{"key":"10.1016\/j.envpol.2026.129203_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176604","article-title":"Modification of gut and airway microbiota on ozone-induced airway inflammation","volume":"954","author":"Xu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib94","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2474142","article-title":"Gut microbiota and derived metabolites mediate obstructive sleep apnea induced atherosclerosis","volume":"12","author":"Xue","year":"2024","journal-title":"Gut Microbes"},{"issue":"14","key":"10.1016\/j.envpol.2026.129203_bib95","doi-asserted-by":"crossref","first-page":"42152","DOI":"10.1007\/s11356-022-24809-5","article-title":"Ozone exposure and health risks of different age structures in major urban agglomerations in People's Republic of China from 2013 to 2018","volume":"30","author":"Yang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib96","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12940-020-00687-7","article-title":"Short-term exposure to air pollution and hospital admission for pneumonia: a systematic review and meta-analysis","volume":"20","author":"Yee","year":"2021","journal-title":"Environ. Health"},{"issue":"1","key":"10.1016\/j.envpol.2026.129203_bib97","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13158","article-title":"Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1\u03b1\/SLC7A11 pathway","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.envpol.2026.129203_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131539","article-title":"Ambient PM2.5, ozone and mortality in Chinese older adults: a nationwide cohort analysis (2005-2018)","volume":"454","author":"Zhang","year":"2023","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envpol.2026.129203_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134870","article-title":"Glycerophospholipid metabolism changes association with ozone exposure","volume":"475","author":"Zhang","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.envpol.2026.129203_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2026.110128","article-title":"Combined effects of ozone and heat on intestinal barrier integrity and epithelial renewal: mediating roles of gut microbiota and tryptophan metabolism","volume":"208","author":"Zhang","year":"2026","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.envpol.2026.129203_bib101","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00031.2024","article-title":"Ferroptosis: when metabolism meets cell death","volume":"105","author":"Zheng","year":"2025","journal-title":"Physiol. Rev."},{"issue":"19","key":"10.1016\/j.envpol.2026.129203_bib102","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.2174\/0109298673271261231213051410","article-title":"Modulation of the HIF-1\u03b1-NCOA4-FTH1 signaling axis regulating ferroptosis-induced hepatic stellate cell senescence to explore the anti-hepatic fibrosis mechanism of curcumol","volume":"31","author":"Zheng","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.envpol.2026.129203_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108852","article-title":"Isoliquiritin apioside relieves intestinal ischemia\/reperfusion-induced acute lung injury by blocking Hif-1\u03b1-mediated ferroptosis","volume":"108","author":"Zhongyin","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.envpol.2026.129203_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.950062","article-title":"Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota","volume":"9","author":"Zhou","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.envpol.2026.129203_bib105","article-title":"Ferroptosis and hyperoxic lung injury: insights into pathophysiology and treatment approaches","volume":"16","author":"Zhou","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129203_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.meatsci.2024.109692","article-title":"Hypoxia-inducible factor-1\u03b1 promotes ferroptosis by inducing ferritinophagy and promoting lactate production in yak longissimus thoracis et lumborum postmortem","volume":"220","author":"Zhu","year":"2025","journal-title":"Meat Sci."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126015733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126015733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:02:25Z","timestamp":1792839745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126015733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":106,"alternative-id":["S0269749126015733"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129203","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute ozone exposure induced lung impairments in aged mice: multi-omics evidence","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"129203"}}