{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:42:21Z","timestamp":1792230141829,"version":"4.4.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2026A1515012885"],"award-info":[{"award-number":["2026A1515012885"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.envpol.2026.129278","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:08:23Z","timestamp":1791040103000},"page":"129278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Multi-omics analysis reveals oxidative stress-associated alterations in glycerophospholipid metabolism and inflammatory response in 6PPDQ-exposed macrophages"],"prefix":"10.1016","volume":"411","author":[{"given":"Wenjie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banghua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-6516","authenticated-orcid":false,"given":"Yiru","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.129278_bib1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.5483\/BMBRep.2008.41.8.560","article-title":"Phospholipase A2, reactive oxygen species, and lipid peroxidation in CNS pathologies","volume":"41","author":"Adibhatla","year":"2008","journal-title":"BMB Rep."},{"key":"10.1016\/j.envpol.2026.129278_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2023.109697","article-title":"Apical and mechanistic effects of 6PPD-quinone on different life-stages of the fathead minnow (Pimephales promelas)","volume":"271","author":"Anderson-Bain","year":"2023","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129278_bib3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.freeradbiomed.2011.11.014","article-title":"Autotaxin protects microglial cells against oxidative stress","volume":"52","author":"Awada","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envpol.2026.129278_bib4","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3390\/biom12121851","article-title":"Differential mobilization of the phospholipid and triacylglycerol pools of arachidonic acid in murine macrophages","volume":"12","author":"Berm\u00fadez","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.envpol.2026.129278_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1139\/cjfas-2020-0240","article-title":"Acute cerebrovascular effects in juvenile coho salmon exposed to roadway runoff","volume":"78","author":"Blair","year":"2021","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.envpol.2026.129278_bib6","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/ars.2009.2597","article-title":"Generation and biological activities of oxidized phospholipids","volume":"12","author":"Bochkov","year":"2010","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.envpol.2026.129278_bib7","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1021\/acs.est.1c07376","article-title":"New evidence of rubber-derived quinones in water, air, and soil","volume":"56","author":"Cao","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.envpol.2026.129278_bib8","article-title":"Concentration and leachability of N-(1,3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine (6PPD) and its quinone transformation product (6PPD-Q) in road dust collected in Tokyo, Japan","volume":"12","author":"Hiki","year":"2024","journal-title":"Environmental Pollution 302"},{"key":"10.1016\/j.envpol.2026.129278_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.70133","article-title":"Melatonin protects mouse oocytes from the environmental toxicant 6PPD\u2010Quinone by preserving mitochondrial and endomembrane homeostasis","volume":"78","author":"Chen","year":"2026","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.envpol.2026.129278_bib10","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1002\/jcb.21564","article-title":"Specific LPA receptor subtype mediation of LPA\u2010induced hypertrophy of cardiac myocytes and involvement of Akt and NF\u03baB signal pathways","volume":"103","author":"Chen","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.envpol.2026.129278_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.envpol.2026.129278_bib12","article-title":"Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders","volume":"16","author":"Cheng","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129278_bib13","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-7","article-title":"Phospholipase A2 in eicosanoid generation","volume":"161","author":"Dennis","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.envpol.2026.129278_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.ento.52.110405.091440","article-title":"The sublethal effects of pesticides on beneficial arthropods","volume":"52","author":"Desneux","year":"2007","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.envpol.2026.129278_bib15","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1039\/D1FO03952K","article-title":"N-Acetylcysteine alleviates high fat diet-induced hepatic steatosis and liver injury via regulating the intestinal microecology in mice","volume":"13","author":"Ding","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.envpol.2026.129278_bib16","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acs.estlett.2c00821","article-title":"First report on the occurrence of N-(1, 3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine (6PPD) and 6PPD-quinone as pervasive pollutants in human urine from South China","volume":"9","author":"Du","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envpol.2026.129278_bib17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41419-023-05741-z","article-title":"GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway","volume":"14","author":"Fan","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.envpol.2026.129278_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133312","article-title":"6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by \u03b1-synuclein preformed fibrils seeding","volume":"465","author":"Fang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envpol.2026.129278_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161836","article-title":"Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice","volume":"869","author":"Fang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129278_bib20","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.bbadis.2007.04.009","article-title":"Oxidized phospholipids: from molecular properties to disease","volume":"1772","author":"Fruhwirth","year":"2007","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.envpol.2026.129278_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175736","article-title":"Environmental concentrations of 6PPD and 6PPD-Q cause oxidative damage and alter metabolism in Eichhornia crassipes","volume":"951","author":"Ge","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129278_bib22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-physiol-022516-034348","article-title":"Macrophages and the recovery from acute and chronic inflammation","volume":"79","author":"Hamidzadeh","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.envpol.2026.129278_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171220","article-title":"Evaluation of 6-PPD quinone toxicity on lung of male BALB\/c mice by quantitative proteomics","volume":"922","author":"He","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129278_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cbpc.2018.06.004","article-title":"Oxidative stress and genotoxic effect of deltamethrin exposure on the Chinese mitten crab, Eriocheir sinensis","volume":"212","author":"Hong","year":"2018","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.envpol.2026.129278_bib25","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2147\/DDDT.S238695","article-title":"Ubiquitin-fold modifier-1 participates in the diabetic inflammatory response by regulating NF-\u03baB p65 nuclear translocation and the ubiquitination and degradation of I\u03baB\u03b1","author":"Hu","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.envpol.2026.129278_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131495","article-title":"Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpse engulfment in Caenorhabditis elegans","volume":"454","author":"Hua","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envpol.2026.129278_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132265","article-title":"Tire-rubber related pollutant 6-PPD quinone: a review of its transformation, environmental distribution, bioavailability, and toxicity","author":"Hua","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envpol.2026.129278_bib28","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1021\/envhealth.3c00205","article-title":"Unexpected exposure risks to emerging aromatic amine antioxidants and p-phenylenediamine quinones to residents: evidence from external and internal exposure as well as hepatotoxicity evaluation","volume":"2","author":"Guo","year":"2024","journal-title":"Environ. Health"},{"key":"10.1016\/j.envpol.2026.129278_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-19232-y","article-title":"Oxidative stress generated DNA damage by 6PPD and other tyre additives in A549 human lung epithelial cells","volume":"15","author":"Hyman","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.129278_bib30","first-page":"2595","article-title":"Hydroxysafflor yellow A attenuates ischemia\/reperfusion-induced liver injury by suppressing macrophage activation","volume":"7","author":"Jiang","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.envpol.2026.129278_bib31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jgr.2021.02.001","article-title":"Gintonin regulates inflammation in human IL-1\u03b2-stimulated fibroblast-like synoviocytes and carrageenan\/kaolin-induced arthritis in rats through LPAR2","volume":"45","author":"Kim","year":"2021","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.envpol.2026.129278_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2026.125328","article-title":"6PPD-quinone biomonitoring of salmon and mussels in Puget Sound, WA, USA","author":"Kuo","year":"2026","journal-title":"Environ. Res."},{"key":"10.1016\/j.envpol.2026.129278_bib33","doi-asserted-by":"crossref","first-page":"10211","DOI":"10.1021\/acs.est.5c18681","article-title":"Estimation of tire wear particle emissions from civilian vehicles","volume":"60","author":"Li","year":"2026","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.envpol.2026.129278_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12060394","article-title":"A review of N-(1, 3-Dimethylbutyl)-N\u2019-phenyl-p-Phenylenediamine (6PPD) and its derivative 6PPD-Quinone in the environment","volume":"12","author":"Li","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.129278_bib35","article-title":"Global multi-media distribution and transport of 6PPD and 6PPD-Q: a source-to-sink continuum","author":"Li","year":"2026","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129278_bib36","series-title":"Role of Glycerophospholipid Metabolism in Epilepsy","author":"Li","year":"2025"},{"key":"10.1016\/j.envpol.2026.129278_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.toxlet.2022.08.008","article-title":"Energy metabolism disorders and oxidative stress in the SH-SY5Y cells following PM2. 5 air pollution exposure","volume":"369","author":"Li","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envpol.2026.129278_bib38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.scib.2023.12.045","article-title":"Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout","volume":"69","author":"Liao","year":"2024","journal-title":"Sci. Bull."},{"key":"10.1016\/j.envpol.2026.129278_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134818","article-title":"Emerging N-(1, 3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine (6PPD) and 6PPD quinone in paired human plasma and urine from Tianjin, China: preliminary assessment with demographic factors","volume":"476","author":"Liu","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129278_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.envpol.2026.129278_bib41","doi-asserted-by":"crossref","DOI":"10.1177\/00368504221113709","article-title":"Alterations of IL-1beta and TNF-alpha expression in RAW264. 7 cell damage induced by two samples of PM2. 5 with different compositions","volume":"105","author":"Lyu","year":"2022","journal-title":"Sci. Prog."},{"key":"10.1016\/j.envpol.2026.129278_bib42","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/acs.estlett.2c00431","article-title":"Exposure to the tire rubber-derived contaminant 6PPD-Quinone causes mitochondrial dysfunction in vitro","volume":"9","author":"Mahoney","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envpol.2026.129278_bib43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jat.1117","article-title":"Comparative acute and combinative toxicity of aflatoxin B1 and T\u20102 toxin in animals and immortalized human cell lines","volume":"26","author":"McKean","year":"2006","journal-title":"J. Appl. Toxicol.: Int. J."},{"key":"10.1016\/j.envpol.2026.129278_bib44","first-page":"112","article-title":"Comparison on neurotoxicity and immunotoxicity between 6PPD and 6PPD-Q in zebrafish under equimolar exposure conditions","volume":"42","author":"Meng","year":"2026","journal-title":"Sheng wu gong cheng xue bao= Chinese journal of biotechnology"},{"key":"10.1016\/j.envpol.2026.129278_bib45","doi-asserted-by":"crossref","first-page":"12949","DOI":"10.1074\/jbc.270.22.12949","article-title":"Lysophosphatidic acid, a multifunctional phospholipid messenger","volume":"270","author":"Moolenaar","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.129278_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.envpol.2026.129278_bib47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.envpol.2026.129278_bib48","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envpol.2026.129278_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109455","article-title":"Correlation between 6PPD-Q and immune along with metabolic dysregulation induced liver lesions in outdoor workers","volume":"199","author":"Qin","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129278_bib50","article-title":"Unveiling a macrophage-driven inflammatory dysregulation: NF-\u03baB-mediated hyperinflammation links 6PPD-Q exposure to viral immunopathology","author":"Qiu","year":"2026","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129278_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.177742","article-title":"Environmental occurrence, fate, human exposure, and human health risks of p-phenylenediamines and their quinones","volume":"957","author":"Shi","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129278_bib52","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.envpol.2026.129278_bib53","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.envpol.2026.129278_bib54","article-title":"Zinc oxide nanoparticles cause hepatotoxicity in rare minnow (Gobiocypris rarus) via ROS-mediated oxidative stress and apoptosis activation and inhibition of lipid peroxidation","volume":"38","author":"Su","year":"2024","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.envpol.2026.129278_bib55","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3390\/antiox10060967","article-title":"N-acetylcysteine (NAC): impacts on human health","volume":"10","author":"Ten\u00f3rio","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.envpol.2026.129278_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112128","article-title":"Immunometabolism-modulation and immunotoxicity evaluation of perfluorooctanoic acid in macrophage","volume":"215","author":"Tian","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129278_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.abd6951","article-title":"A ubiquitous tire rubber\u2013derived chemical induces acute mortality in coho salmon","volume":"371","author":"Tian","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.envpol.2026.129278_bib58","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/978-3-030-50621-6_2","article-title":"Biosynthetic enzymes of membrane glycerophospholipid diversity as therapeutic targets for drug development","author":"Valentine","year":"2020","journal-title":"Druggable Lipid Signaling Pathways"},{"key":"10.1016\/j.envpol.2026.129278_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101470","article-title":"Update and nomenclature proposal for Mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity","volume":"298","author":"Valentine","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envpol.2026.129278_bib60","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"Van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2026.129278_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.139088","article-title":"6PPD and 6PPDQ exposure promote the proliferation and migration of non-small cell lung cancer cells through PTEN dysfunction and ARG2-mediated metabolic reprogramming","volume":"495","author":"Wang","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129278_bib62","doi-asserted-by":"crossref","first-page":"10629","DOI":"10.1021\/acs.est.2c02463","article-title":"Beyond substituted p-Phenylenediamine antioxidants: prevalence of their quinone derivatives in PM2. 5","volume":"56","author":"Wang","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129278_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125208","article-title":"Transgenerational intestinal toxicity of 6-PPD quinone in causing ROS production, enhancement in intestinal permeability and suppression in innate immunity in C. elegans","author":"Wang","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129278_bib64","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1021\/acs.est.3c10248","article-title":"First evidence of the bioaccumulation and trophic transfer of tire additives and their transformation products in an estuarine food web","volume":"58","author":"Wei","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129278_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161373","article-title":"A new toxicity mechanism of N-(1, 3-Dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine quinone: formation of DNA adducts in Mammalian cells and aqueous organisms","volume":"866","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129278_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143719","article-title":"6-PPD quinone at environmentally relevant concentrations induces immunosenescenece by causing immunosuppression during the aging process","volume":"368","author":"Wu","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.129278_bib67","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.129278_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122549","article-title":"Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264. 7 cells: the role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK","volume":"394","author":"Xie","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129278_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.119812","article-title":"From exposure models to multi-organ toxicity of 6PPD-quinone in mice: a mini-review","volume":"310","author":"Yang","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129278_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170679","article-title":"Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation","volume":"918","author":"Yang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129278_bib71","article-title":"Toxicity of ubiquitous tire rubber antiozonant N-(1, 3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids","volume":"43","author":"Yeisley","year":"2025","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.envpol.2026.129278_bib72","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1021\/acs.est.2c07652","article-title":"Widespread occurrence and transport of p-phenylenediamines and their quinones in sediments across urban rivers, estuaries, coasts, and deep-sea regions","volume":"57","author":"Zeng","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129278_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154235","article-title":"EGFR and CYP signaling disruption underlies 6PPD-quinone hepatotoxicity: insights from a network and machine learning approach","volume":"517","author":"Zhang","year":"2025","journal-title":"Toxicology"},{"key":"10.1016\/j.envpol.2026.129278_bib74","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/acs.estlett.2c00193","article-title":"Widespread N-(1, 3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine quinone in size-fractioned atmospheric particles and dust of different indoor environments","volume":"9","author":"Zhang","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envpol.2026.129278_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171393","article-title":"A nation-wide study for the occurrence of PPD antioxidants and 6PPD-quinone in road dusts of China","volume":"922","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129278_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134862","article-title":"Alterations of gut microbiota and its metabolomics in children with 6PPDQ, PBDE, PCB, and metal (loid) exposure","volume":"475","author":"Zhang","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129278_bib77","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/acs.chemrestox.4c00328","article-title":"Mitochondrial dysfunction in environmental toxicology: mechanisms, impacts, and health implications","volume":"37","author":"Zuo","year":"2024","journal-title":"Chem. Res. Toxicol."}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126016489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126016489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:05:34Z","timestamp":1792227934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126016489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":77,"alternative-id":["S0269749126016489"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129278","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics analysis reveals oxidative stress-associated alterations in glycerophospholipid metabolism and inflammatory response in 6PPDQ-exposed macrophages","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129278"}}