{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:51:19Z","timestamp":1792061479993,"version":"4.4.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["2025BS008"],"award-info":[{"award-number":["2025BS008"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42230404"],"award-info":[{"award-number":["42230404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.envpol.2026.129285","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:18:55Z","timestamp":1791587935000},"page":"129285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Deep-learning histopathradiomics enables high-throughput quantification of pollutant-induced tissue injury in marine mussels"],"prefix":"10.1016","volume":"411","author":[{"given":"Ruoxuan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuimei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6582-2863","authenticated-orcid":false,"given":"Yanan","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.129285_bib1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.marenvres.2004.03.121","article-title":"Biochemical and histological responses in mussel (Mytilus edulis) exposed to North Sea oil and to a mixture of North Sea oil and alkylphenols","volume":"58","author":"Aarab","year":"2004","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.envpol.2026.129285_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/joim.13030","article-title":"Artificial intelligence as the next step towards precision pathology","volume":"288","author":"Acs","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.envpol.2026.129285_bib3","article-title":"Recurrent residual convolutional neural network based on U-Net (R2U-Net) for medical image segmentation","author":"Alom","year":"2018","journal-title":"arXiv preprint arXiv 1802, 06955"},{"key":"10.1016\/j.envpol.2026.129285_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41377-023-01104-7","article-title":"Deep learning-enabled virtual histological staining of biological samples","volume":"12","author":"Bai","year":"2023","journal-title":"Light Sci. Appl."},{"key":"10.1016\/j.envpol.2026.129285_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aquatox.2015.03.012","article-title":"Prevalence and intensity of pathologies induced by the toxic dinoflagellate, Heterocapsa circularisquama, in the Mediterranean mussel, Mytilus galloprovincialis","volume":"163","author":"Basti","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2026.129285_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41571-019-0252-y","article-title":"Artificial intelligence in digital pathology \u2014 new tools for diagnosis and precision oncology","volume":"16","author":"Bera","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.envpol.2026.129285_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1365-2761.1999.00134.x","article-title":"Histopathology in fish: proposal for a protocol to assess aquatic pollution","volume":"22","author":"Bernet","year":"1999","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.envpol.2026.129285_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mrgentox.2007.08.011","article-title":"Assessment of the genotoxic potential of benzo(a)pyrene and pp'-dichlorodiphenyldichloroethylene in Zebra mussel (Dreissena polymorpha)","volume":"649","author":"Binelli","year":"2008","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.envpol.2026.129285_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jip.2015.07.012","article-title":"Comparative pathology in bivalves: aetiological agents and disease processes","volume":"131","author":"Carella","year":"2015","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.envpol.2026.129285_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jip.2015.03.001","article-title":"Quantitative histopathology of the Mediterranean mussel (Mytilus galloprovincialis L.) exposed to the harmful dinoflagellate Ostreopsis cf. ovata","volume":"127","author":"Carella","year":"2015","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.envpol.2026.129285_bib11","series-title":"IEEE Conference on Visual Communications and Image Processing (VCIP)","first-page":"1","article-title":"Linknet: exploiting encoder representations for efficient semantic segmentation","author":"Chaurasia","year":"2017"},{"key":"10.1016\/j.envpol.2026.129285_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130634","article-title":"Sulfamethoxazole induced systematic and tissue-specific antioxidant defense in marine mussels (Mytilus galloprovincialis): implication of antibiotic's ecotoxicity","volume":"279","author":"Chen","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.129285_bib13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/fishes8070368","article-title":"Copper-induced ionoregulatory disturbance, histopathology, and transcriptome responses in freshwater mussel (Anodonta woodiana) gills","volume":"8","author":"Chen","year":"2023","journal-title":"Fishes"},{"key":"10.1016\/j.envpol.2026.129285_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2020.110674","article-title":"Oxidative stress, metabolic and histopathological alterations in mussels exposed to remediated seawater by GO-PEI after contamination with Mercury","volume":"243","author":"Coppola","year":"2020","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"key":"10.1016\/j.envpol.2026.129285_bib15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.aquatox.2015.03.011","article-title":"Development of histopathological indices in the digestive gland and gonad of mussels: integration with contamination levels and effects of confounding factors","volume":"162","author":"Cuevas","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2026.129285_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmed.2023.100094","article-title":"A hybrid U-Net model with attention and advanced convolutional learning modules for simultaneous gland segmentation and cancer grade prediction in colorectal histopathological images","volume":"7","author":"Dabass","year":"2023","journal-title":"Intell. Based Med."},{"key":"10.1016\/j.envpol.2026.129285_bib17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.scitotenv.2019.01.406","article-title":"Antibiotic pollution in surface fresh waters: occurrence and effects","volume":"664","author":"Danner","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129285_bib18","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1007\/s11356-023-28126-3","article-title":"Spatial and seasonal use of biomarkers in dreissenids: implications for biomonitoring","volume":"32","author":"Devin","year":"2025","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2026.129285_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/mutage\/gew049","article-title":"Integrated biological responses and tissue-specific expression of p53 and ras genes in marine mussels following exposure to benzo(\u03b1)pyrene and C60 fullerenes, either alone or in combination","volume":"32","author":"Di","year":"2017","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envpol.2026.129285_bib20","doi-asserted-by":"crossref","first-page":"8974","DOI":"10.1021\/es201547x","article-title":"Tissue-specific expression of p53 and ras genes in response to the environmental genotoxicant benzo(\u03b1)pyrene in marine mussels","volume":"45","author":"Di","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129285_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2022.918104","article-title":"Artificial intelligence and automated monitoring for assisting conservation of marine ecosystems: a perspective","volume":"9","author":"Ditria","year":"2022","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.envpol.2026.129285_bib22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.compmedimag.2011.02.006","article-title":"Computational pathology: challenges and promises for tissue analysis","volume":"35","author":"Fuchs","year":"2011","journal-title":"Comput. Med. Imag. Graph."},{"key":"10.1016\/j.envpol.2026.129285_bib23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3390\/rs12030489","article-title":"Monitoring of coral reefs using artificial intelligence: a feasible and cost-effective approach","volume":"12","author":"Gonz\u00e1lez-Rivero","year":"2020","journal-title":"Remote Sens."},{"key":"10.1016\/j.envpol.2026.129285_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131280","article-title":"Fate and effects of graphene oxide alone and with sorbed benzo (a) pyrene in mussels Mytilus galloprovincialis","volume":"452","author":"Gonz\u00e1lez-Soto","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129285_bib25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.envpol.2012.05.020","article-title":"In vitro immunotoxicity of environmentally representative antibiotics to the freshwater mussel Elliptio complanata","volume":"169","author":"Gust","year":"2012","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129285_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.614174","article-title":"A hybrid-attention nested UNet for nuclear segmentation in histopathological images","volume":"8","author":"He","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.envpol.2026.129285_bib27","series-title":"IEEE Conference on Computer Vision and Pattern Recognition (CVPR)","first-page":"770","article-title":"Deep residual learning for image recognition","author":"He","year":"2016"},{"key":"10.1016\/j.envpol.2026.129285_bib28","article-title":"Toxicological effects of polystyrene nanoplastics on marine organisms","volume":"30","author":"Hsieh","year":"2023","journal-title":"Environ. Technol. Innovat."},{"key":"10.1016\/j.envpol.2026.129285_bib29","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/etojnl\/vgae063","article-title":"Advancing the quantitative understanding of adverse outcome pathways: current status, methodologies, and future directions","volume":"44","author":"Jeong","year":"2025","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envpol.2026.129285_bib30","series-title":"IEEE Conference on International Symposium on Multimedia (ISM)","article-title":"ResUNet++: an advanced architecture for medical image segmentation","author":"Jha","year":"2019"},{"key":"10.1016\/j.envpol.2026.129285_bib31","series-title":"Ecology and Environmental Omics, Integrative Omics","first-page":"315","author":"Kesheri","year":"2024"},{"key":"10.1016\/j.envpol.2026.129285_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.watbs.2026.100678","article-title":"Microbiota-associated intestinal injury in bivalves exposed to 6PPD-Quinone and TiO2 nanoparticles","author":"Khalid","year":"2026","journal-title":"Water Biol. Secur."},{"key":"10.1016\/j.envpol.2026.129285_bib82","doi-asserted-by":"crossref","first-page":"114563","DOI":"10.1016\/j.marpolbul.2022.114563","article-title":"Co-occurrence of microplastics and organic\/inorganic contaminants in organisms living in aquatic ecosystems: A review","volume":"187","author":"Khoshmanesh","year":"2023","journal-title":"Marine Pollution Bulletin"},{"key":"10.1016\/j.envpol.2026.129285_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2021.106501","article-title":"HFRU-Net: High-level feature fusion and recalibration UNet for automatic liver and tumor segmentation in CT images","volume":"213","author":"Kushnure","year":"2022","journal-title":"Comput. Methods Progr. Biomed."},{"key":"10.1016\/j.envpol.2026.129285_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.envpol.2015.03.025","article-title":"Genotoxic and immunotoxic potential effects of selected psychotropic drugs and antibiotics on blue mussel (Mytilus edulis) hemocytes","volume":"202","author":"Lacaze","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129285_bib35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","article-title":"Deep learning","volume":"521","author":"LeCun","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.129285_bib36","article-title":"Histological alterations as a recommended biomarker in the mussel Mytilus platensis (Bivalvia, Mytilidae) to study anthropic impact on seaports","volume":"70","author":"Leis","year":"2024","journal-title":"Reg. Stud. Mar. Sci."},{"key":"10.1016\/j.envpol.2026.129285_bib37","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3390\/metabo13080943","article-title":"Impact of heavy metal exposure on Mytilus galloprovincialis spermatozoa: a metabolomic investigation","volume":"13","author":"Lettieri","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.envpol.2026.129285_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110186","article-title":"Systemic protection through enhanced immunity and antioxidant defenses in immune-primed Mytilus coruscus: insights from cell\/tissue-specific analyses","volume":"159","author":"Li","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.envpol.2026.129285_bib39","series-title":"IEEE Conference on Computer Vision and Pattern Recognition (CVPR)","first-page":"2117","article-title":"Feature pyramid networks for object detection","author":"Lin","year":"2017"},{"key":"10.1016\/j.envpol.2026.129285_bib83","doi-asserted-by":"crossref","DOI":"10.48130\/newcontam-0026-0006","article-title":"Unveiling the hidden ecological risks of emerging entangled with legacy pollutants within coastal-marine interfaces","volume":"2","author":"Liu","year":"2026","journal-title":"New Contaminants"},{"key":"10.1016\/j.envpol.2026.129285_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111309","article-title":"Toxicological effects and potential reproductive risk of microplastic-induced molecular changes in protamine-like proteins and their DNA binding","volume":"405","author":"Marinaro","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.envpol.2026.129285_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2026.119634","article-title":"Nanoplastics exacerbate cadmium toxicity in Mytilus coruscus through bioenergetic exhaustion and tissue disintegration","volume":"228","author":"Mei","year":"2026","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envpol.2026.129285_bib42","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s42979-023-01854-6","article-title":"Brain tumor segmentation from 3D MRI scans using U-Net","volume":"4","author":"Montaha","year":"2023","journal-title":"SN Comput. Sci."},{"key":"10.1016\/j.envpol.2026.129285_bib43","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1016\/S1470-2045(19)30154-8","article-title":"Digital pathology and artificial intelligence","volume":"20","author":"Niazi","year":"2019","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.envpol.2026.129285_bib44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/fishes10070339","article-title":"Molecular mechanisms and biomarker-based early-warning indicators of heavy metal toxicity in marine fish","volume":"10","author":"Oros","year":"2025","journal-title":"Fishes"},{"key":"10.1016\/j.envpol.2026.129285_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006651","article-title":"Predicting protein targets for drug-like compounds using transcriptomics","volume":"14","author":"Pabon","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.envpol.2026.129285_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2025.118204","article-title":"Combined effects of polyamide microplastics and the pathogenic bacterium Vibrio parahaemolyticus on the immune parameters of Mytilus coruscus","volume":"218","author":"Pan","year":"2025","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envpol.2026.129285_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.753647","article-title":"Contrasting effects of environmental concentrations of sulfonamides on microbial heterotrophic activities in freshwater sediments","volume":"12","author":"Pesce","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envpol.2026.129285_bib48","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.aquatox.2019.03.017","article-title":"Ecotoxicological effects of lanthanum in Mytilus galloprovincialis: biochemical and histopathological impacts","volume":"211","author":"Pinto","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2026.129285_bib49","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.drudis.2010.09.001","article-title":"The role and impact of quantitative discovery pathology","volume":"15","author":"Potts","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.envpol.2026.129285_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114365","article-title":"Assessment of sulfamethoxazole toxicity to marine mussels (Mytilus galloprovincialis): combine p38-MAPK signaling pathway modulation with histopathological alterations","volume":"249","author":"Qu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129285_bib84","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.chemosphere.2017.04.030","article-title":"Coexposure to sulfamethoxazole and cadmium impairs development and attenuates transcriptional response in sea urchin embryo","volume":"180","author":"Ragusa","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.envpol.2026.129285_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1392550","article-title":"Comparative analysis of the bioaccumulation of bisphenol A in the blood serum and follicular fluid of women living in two areas with different environmental impacts","volume":"15","author":"Raimondo","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envpol.2026.129285_bib52","series-title":"International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI)","first-page":"234","article-title":"U-net: convolutional networks for biomedical image segmentation","author":"Ronneberger","year":"2015"},{"key":"10.1016\/j.envpol.2026.129285_bib53","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s42979-021-00815-1","article-title":"Deep learning: a comprehensive overview on techniques, taxonomy, applications and research directions","volume":"2","author":"Sarker","year":"2021","journal-title":"SN Comput. Sci."},{"key":"10.1016\/j.envpol.2026.129285_bib54","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-bioeng-071516-044442","article-title":"Deep learning in medical image analysis","volume":"19","author":"Shen","year":"2017","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.envpol.2026.129285_bib55","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41580-022-00456-z","article-title":"Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology","volume":"23","author":"Sies","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envpol.2026.129285_bib56","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3390\/eng7070310","article-title":"A hybrid ResNet U-Net++ architecture with ASPP and SE for fish histological image segmentation","volume":"7","author":"Silva","year":"2026","journal-title":"Eng"},{"key":"10.1016\/j.envpol.2026.129285_bib57","article-title":"Very deep convolutional networks for large-scale image recognition","author":"Simonyan","year":"2014","journal-title":"arXiv preprint arXiv: 1409., 1556"},{"key":"10.1016\/j.envpol.2026.129285_bib58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.media.2016.08.008","article-title":"Gland segmentation in colon histology images: the glas challenge contest","volume":"35","author":"Sirinukunwattana","year":"2017","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.envpol.2026.129285_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13090714","article-title":"Integration of \"Omics\"-Based approaches in environmental risk assessment to establish cause and effect relationships: a review","volume":"13","author":"Smith","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.envpol.2026.129285_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/feart.2023.1090185","article-title":"A review of artificial intelligence in marine science","volume":"11","author":"Song","year":"2023","journal-title":"Front. Earth Sci."},{"key":"10.1016\/j.envpol.2026.129285_bib61","doi-asserted-by":"crossref","first-page":"438","DOI":"10.5455\/medarh.2022.76.438-442","article-title":"A review study toward clinical and histopathological diagnosis agreement in skin diseases","volume":"76","author":"Sopjani","year":"2022","journal-title":"Med. Arch."},{"key":"10.1016\/j.envpol.2026.129285_bib62","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/biology14040438","article-title":"Battle of the biomarkers of systemic inflammation","volume":"14","author":"Stec-Martyna","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.envpol.2026.129285_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119385","article-title":"Multigenerational and persistent toxicity of environmentally relevant concentrations of Benzo [a] pyrene in Marine Medaka (Oryzias melastigma)","volume":"306","author":"Sun","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envpol.2026.129285_bib64","series-title":"International Conference on Machine Learning","first-page":"6105","article-title":"Efficientnet: rethinking model scaling for convolutional neural networks","author":"Tan","year":"2019"},{"key":"10.1016\/j.envpol.2026.129285_bib65","first-page":"1171","article-title":"Active biomonitoring in streams by using multimarker approaches of mussels","volume":"10","author":"Ukasha","year":"2024","journal-title":"Global J. Environ. Sci. Manag. (GJESM)"},{"key":"10.1016\/j.envpol.2026.129285_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/plants14060865","article-title":"Multi-omics approaches against abiotic and biotic Stress-A review","volume":"14","author":"Varadharajan","year":"2025","journal-title":"Plants"},{"key":"10.1016\/j.envpol.2026.129285_bib67","series-title":"Zebrafish Model for Biomedical Research","first-page":"381","article-title":"Supporting the next generation of risk assessment in toxicology: the design of AOPs based on the alternative model zebrafish","author":"Vieira","year":"2022"},{"key":"10.1016\/j.envpol.2026.129285_bib68","series-title":"Morphologic Manifestations of Toxic Cell Injury","author":"Wallig","year":"2013"},{"key":"10.1016\/j.envpol.2026.129285_bib69","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/j.fct.2011.06.015","article-title":"Biomarkers and bioaccumulation of clam Ruditapes philippinarum in response to combined cadmium and benzo[\u03b1]pyrene exposure","volume":"49","author":"Wang","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envpol.2026.129285_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2022.105839","article-title":"Time-and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis","volume":"183","author":"Wang","year":"2023","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.envpol.2026.129285_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2025.107326","article-title":"Unraveling the immunotoxic effects of benzo [a] pyrene on Mytilus coruscus through histopathological, enzymatic, and transcriptomic analyses","volume":"282","author":"Wang","year":"2025","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envpol.2026.129285_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.137006","article-title":"Laboratory-simulated marine heatwave enhances physiological damage to mussels exposed to titanium dioxide nanoparticles by disrupting the gut\u2212 hepatopancreas axis","volume":"486","author":"Wei","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129285_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.eehl.2026.100265","article-title":"Adverse outcome pathways of titanium dioxide nanoparticles and marine heatwaves on byssal performance in mussels","author":"Wei","year":"2026","journal-title":"Eco-Environ. Health"},{"key":"10.1016\/j.envpol.2026.129285_bib74","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/etc.3695","article-title":"Evaluating the credibility of histopathology data in environmental endocrine toxicity studies","volume":"36","author":"Wolf","year":"2017","journal-title":"Toxicol. Environ. Chem."},{"key":"10.1016\/j.envpol.2026.129285_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2024.117437","article-title":"Effects of functionalized nanoplastics on oxidative stress in the mussel Mytilus coruscus","volume":"211","author":"Yang","year":"2025","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.envpol.2026.129285_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114431","article-title":"Pollution status of PAHs in surface sediments from different marginal seas along China Mainland: a quantitative evaluation on a national scale","volume":"263","author":"Yang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envpol.2026.129285_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160164","article-title":"Meta-analysis reveals the species-, dose-and duration-dependent effects of cadmium toxicities in marine bivalves","volume":"859","author":"Zhan","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envpol.2026.129285_bib78","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tiv.2017.05.018","article-title":"Utilization of isolated marine mussel cells as an in vitro model to assess xenobiotics induced genotoxicity","volume":"44","author":"Zhang","year":"2017","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.envpol.2026.129285_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137620","article-title":"Trophic-transferred hierarchical fragmentation of microplastics inducing distinct bio-adaptations via a microalgae-mussel-crab food chain","volume":"489","author":"Zhao","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.envpol.2026.129285_bib80","first-page":"1","article-title":"Investigating byssus self-assembly of Mytilus coruscus: synergy of biological regulations and spatial heterogeneity in mussel foot","author":"Zhao","year":"2026","journal-title":"Mar. Life Sci. Technol."},{"key":"10.1016\/j.envpol.2026.129285_bib81","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1021\/envhealth.5c00035","article-title":"Aging enhances the ecotoxicological effects of biobased microplastic Poly(Lactic acid) and its adsorbed Tris(1-chloro-2-propyl)phosphate on mussels","volume":"3","author":"Zhong","year":"2025","journal-title":"Environ. Health (Lond.)"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126016556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749126016556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:25:07Z","timestamp":1792059907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749126016556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":84,"alternative-id":["S0269749126016556"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129285","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep-learning histopathradiomics enables high-throughput quantification of pollutant-induced tissue injury in marine mussels","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129285","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129285"}}