{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:45:19Z","timestamp":1786988719196,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.envres.2006.01.001","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T10:24:20Z","timestamp":1140431060000},"page":"61-69","source":"Crossref","is-referenced-by-count":28,"title":["Effect modification by \u03b4-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase gene polymorphisms on associations between patella lead and renal function in lead workers"],"prefix":"10.1016","volume":"102","author":[{"given":"Virginia M.","family":"Weaver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Kook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Dong","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard G.","family":"Jaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl T.","family":"Kelsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Lustberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen K.","family":"Silbergeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2006.01.001_bib1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1539\/joh.46.316","article-title":"Investigations of vitamin D receptor polymorphism affecting workers\u2019 susceptibility to lead","volume":"46","author":"Chuang","year":"2004","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.envres.2006.01.001_bib2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/01621459.1979.10481038","article-title":"Robust locally weighted regression and smoothing scatterplots","volume":"74","author":"Cleveland","year":"1979","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.envres.2006.01.001_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.envres.2006.01.001_bib4","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/clinchem\/21.4.558","article-title":"Micromethod for lead determination in whole blood by atomic absorption, with use of the graphite furnace","volume":"21","author":"Fernandez","year":"1975","journal-title":"Clin. Chem."},{"key":"10.1016\/j.envres.2006.01.001_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1089-8603(02)00131-3","article-title":"Functional characterization of Glu298Asp mutant human endothelial nitric oxide synthase purified from a yeast expression system","volume":"8","author":"Golser","year":"2003","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.envres.2006.01.001_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1161\/01.HYP.32.3.521","article-title":"Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction","volume":"32","author":"Hibi","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.envres.2006.01.001_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/sj.jhh.1001801","article-title":"Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics","volume":"3","author":"Hoffmann","year":"2005","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.envres.2006.01.001_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1289\/ehp.981061","article-title":"Bone lead as a biological marker in epidemiological studies of chronic toxicity: Conceptual paradigms","volume":"106","author":"Hu","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib9","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1289\/ehp.6109","article-title":"Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes","volume":"111","author":"Kamel","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib10","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/ki.1992.181","article-title":"Experimental model of lead nephropathy. I. Continuous high-dose lead administration","volume":"41","author":"Khalil-Manesh","year":"1992","journal-title":"Kidney Int."},{"key":"10.1016\/j.envres.2006.01.001_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/00039896.1993.9940372","article-title":"Experimental model of lead nephropathy. III. Continuous low-level lead administration","volume":"48","author":"Khalil-Manesh","year":"1993","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.envres.2006.01.001_bib12","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1088\/0031-9155\/40\/9\/007","article-title":"K X-ray fluorescence measurements of bone lead concentration: the analysis of low-level data","volume":"40","author":"Kim","year":"1995","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.envres.2006.01.001_bib13","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.amjhyper.2004.02.013","article-title":"Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans","volume":"17","author":"Li","year":"2004","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.envres.2006.01.001_bib14","first-page":"383","article-title":"Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and \u03b4-aminolevulinic acid dehydratase genes","volume":"109","author":"Lee","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib15","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/01.jom.0000128158.32391.85","article-title":"The G(894)-T(894) polymorphism in the gene for endothelial nitric oxide synthase and blood pressure in lead-exposed workers from Korea","volume":"46","author":"Lustberg","year":"2004","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2006.01.001_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0049-3848(02)00208-6","article-title":"Lack of evidence for contribution of Glu298Asp (G894T) polymorphism of endothelial nitric oxide synthase gene to plasma nitric oxide levels","volume":"15","author":"Moon","year":"2002","journal-title":"Thromb. Res."},{"key":"10.1016\/j.envres.2006.01.001_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00041552-200003000-00001","article-title":"Multi-hit nature of chronic renal disease","volume":"9","author":"Nenov","year":"2000","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.envres.2006.01.001_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/01.HYP.0000033974.57407.82","article-title":"Association of eNOS Glu298Asp polymorphism with end-stage renal disease","volume":"40","author":"Noiri","year":"2002","journal-title":"Hypertension"},{"issue":"suppl. 1","key":"10.1016\/j.envres.2006.01.001_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1289\/ehp.00108s123","article-title":"Genetic susceptibility to lead poisoning","volume":"108","author":"Onalaja","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib21","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0584-8547(99)00007-5","article-title":"Electrothermal atomization atomic absorption spectrometry for the determination of lead in urine: results of an interlaboratory study","volume":"54","author":"Parsons","year":"1999","journal-title":"Spectrochim. Acta B"},{"key":"10.1016\/j.envres.2006.01.001_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/hmg\/11.3.229","article-title":"Modifier effect of eNOS in autosomal dominant polycystic kidney disease","volume":"11","author":"Persu","year":"2002","journal-title":"Hum. Mol. Gen."},{"key":"10.1016\/j.envres.2006.01.001_bib23","first-page":"949","article-title":"Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and \u03b4-aminolevulinic acid dehydratase genes","volume":"108","author":"Schwartz","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1289\/ehp.00108199","article-title":"Associations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers","volume":"108","author":"Schwartz","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/aje\/153.5.453","article-title":"Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers","volume":"153","author":"Schwartz","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2006.01.001_bib26","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/00008571-200112000-00009","article-title":"In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism","volume":"11","author":"Sofowora","year":"2001","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.envres.2006.01.001_bib27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00008571-200207000-00008","article-title":"Effects of endothelial nitric oxide synthase gene polymorphisms on platelet.function, nitric oxide release, and interactions with estradiol","volume":"12","author":"Tanus-Santos","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.envres.2006.01.001_bib29","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/01.jom.0000128151.94272.5b","article-title":"Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes","volume":"46","author":"Theppeang","year":"2004","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2006.01.001_bib30","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1088\/0031-9155\/45\/7\/318","article-title":"Coherent scattering and matrix correction in bone-lead measurements","volume":"45","author":"Todd","year":"2000","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.envres.2006.01.001_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1088\/0031-9155\/45\/1\/316","article-title":"Contamination of in vivo bone-lead measurements","volume":"45","author":"Todd","year":"2000","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.envres.2006.01.001_bib32","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1088\/0031-9155\/48\/13\/314","article-title":"Calculating the uncertainty in lead concentration for in vivo bone lead X-ray fluorescence","volume":"48","author":"Todd","year":"2003","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.envres.2006.01.001_bib33","series-title":"Human Body Composition Studies","first-page":"299","article-title":"In vivo measurements of lead in bone using a 109Cd \u201cspot\u201d source","author":"Todd","year":"1993"},{"key":"10.1016\/j.envres.2006.01.001_bib34","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1088\/0031-9155\/47\/4\/309","article-title":"Measurements of lead in human tibiae. A comparison between K-shell X-ray fluorescence and electrothermal atomic absorption spectrometry","volume":"47","author":"Todd","year":"2002","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.envres.2006.01.001_bib35","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/clinchem\/32.10.1863","article-title":"Measurement of urinary retinol-binding protein by enzyme-linked immunosorbent assay, and its application to detection of tubular proteinuria","volume":"32","author":"Topping","year":"1986","journal-title":"Clin. Chem."},{"key":"10.1016\/j.envres.2006.01.001_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gene.2004.05.014","article-title":"Genetics and biology of vitamin D receptor polymorphisms","volume":"338","author":"Uitterlinden","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.envres.2006.01.001_bib37","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1097\/00004872-200210000-00022","article-title":"The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide","volume":"20","author":"Veldman","year":"2002","journal-title":"J. Hypertens."},{"key":"10.1016\/j.envres.2006.01.001_bib38","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/oem.60.8.551","article-title":"Associations of lead biomarkers with renal function in Korean lead workers","volume":"60","author":"Weaver","year":"2003","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2006.01.001_bib39","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1289\/ehp.6116","article-title":"Associations of renal function with polymorphisms in the \u03b4-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers","volume":"111","author":"Weaver","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/01.jom.0000155971.10111.6d","article-title":"Associations of patella lead and other lead biomarkers with renal function in lead workers","volume":"47","author":"Weaver","year":"2005","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2006.01.001_bib42","first-page":"1","article-title":"Associations of uric acid with polymorphisms in the \u03b4-aminolevulinic acid dehydratase, Vitamin D receptor, and nitric oxide synthase genes in Korean lead workers","volume":"1","author":"Weaver","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib43","series-title":"Applied Linear Regression","author":"Weisberg","year":"1985"},{"key":"10.1016\/j.envres.2006.01.001_bib44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1289\/ehp.5504","article-title":"A \u03b4-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the Normative Aging Study","volume":"111","author":"Wu","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2006.01.001_bib45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/15376510309840","article-title":"Associations of blood lead levels, kidney function, and blood pressure with \u03b4-aminolevulinic acid dehydratase and vitamin D receptor gene polymorphisms","volume":"13","author":"Ye","year":"2003","journal-title":"Toxicol. Mechanisms Methods"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935106000028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935106000028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T16:29:56Z","timestamp":1586708996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935106000028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0013935106000028"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2006.01.001","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}