{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:18:21Z","timestamp":1791296301011,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.envres.2012.06.007","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T13:16:03Z","timestamp":1342790163000},"page":"112-119","source":"Crossref","is-referenced-by-count":107,"special_numbering":"C","title":["Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: A meta-analysis of epidemiological studies"],"prefix":"10.1016","volume":"117","author":[{"given":"Angela M.","family":"Malek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Barchowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bowser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Youk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn O.","family":"Talbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2012.06.007_bib2","first-page":"284","article-title":"Exposure to pesticides and risk of amyotrophic lateral sclerosis: a population-based case-control study","volume":"46","author":"Bonvicini","year":"2010","journal-title":"Ann. Ist Super Sanita"},{"key":"10.1016\/j.envres.2012.06.007_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-2001-15268","article-title":"Clinical characteristics and management of ALS","volume":"21","author":"Borasio","year":"2001","journal-title":"Semin Neurol."},{"key":"10.1016\/j.envres.2012.06.007_bib4","article-title":"Comprehensive Meta-Analysis Biostat, Englewood","author":"Borenstein","year":"2005","journal-title":"NJ"},{"key":"10.1016\/j.envres.2012.06.007_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/oem.58.1.24","article-title":"Mortality in chemical workers potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) 1945\u201394: an update","volume":"58","author":"Burns","year":"2001","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.envres.2012.06.007_bib6","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/jnnp.56.11.1200","article-title":"Risk factors for motor neuron disease: a case-control study based on patients from the Scottish Motor Neuron Disease Register","volume":"56","author":"Chancellor","year":"1993","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.envres.2012.06.007_bib7","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1136\/jnnp.2006.112581","article-title":"Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis","volume":"78","author":"Cronin","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.envres.2012.06.007_bib8","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/oxfordjournals.aje.a114308","article-title":"A case-control study of amyotrophic lateral sclerosis","volume":"123","author":"Deapen","year":"1986","journal-title":"Am J Epidemiol."},{"key":"10.1016\/j.envres.2012.06.007_bib9","series-title":"Clinical neurotoxicology: syndromes, substances, environments","author":"Dobbs","year":"2009"},{"key":"10.1016\/j.envres.2012.06.007_bib10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.crvi.2007.02.018","article-title":"Interaction between genes and environment in neurodegenerative diseases","volume":"330","author":"Elbaz","year":"2007","journal-title":"C. R. Biol."},{"key":"10.1016\/j.envres.2012.06.007_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0378-4274(95)03468-4","article-title":"Recent epidemics of poisoning by pesticides","volume":"82\u201383","author":"Ferrer","year":"1995","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2012.06.007_bib12","doi-asserted-by":"crossref","unstructured":"Fishel, F.M., 2009. Farm Family Exposure to Glyphosate. In: I. o. F. a. A. S. Florida Cooperative Extension Services, (Ed.), University of Florida, Gainesville.","DOI":"10.32473\/edis-pi214-2009"},{"key":"10.1016\/j.envres.2012.06.007_bib13","first-page":"420","article-title":"Obtaining occupational exposure histories in epidemiologic case-control studies","volume":"27","author":"Gerin","year":"1985","journal-title":"J. Occup. Med."},{"key":"10.1016\/j.envres.2012.06.007_bib14","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1007\/s00415-005-0859-z","article-title":"Amyotrophic lateral sclerosis, rural environment and agricultural work in the Local Health District of Ferrara, Italy, in the years 1964\u20131998","volume":"252","author":"Govoni","year":"2005","journal-title":"J. Neurol."},{"key":"10.1016\/j.envres.2012.06.007_bib15","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1212\/WNL.38.10.1604","article-title":"Motor neuron disease in the province of Ferrara, Italy, in 1964\u20131982","volume":"38","author":"Granieri","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2012.06.007_bib16","first-page":"791","article-title":"A case-control study of motor neurone disease: its relation to heritability, and occupational exposures, particularly to solvents","volume":"49","author":"Gunnarsson","year":"1992","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.envres.2012.06.007_bib17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.envres.2012.06.007_bib18","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1289\/ehp.7135","article-title":"Association of pesticide exposure with neurologic dysfunction and disease","volume":"112","author":"Kamel","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2012.06.007_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuro.2012.04.001","article-title":"Pesticide exposure and amyotrophic lateral sclerosis","author":"Kamel","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2012.06.007_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000089625","article-title":"Lead exposure as a risk factor for amyotrophic lateral sclerosis","volume":"2","author":"Kamel","year":"2005","journal-title":"Neurodegener Dis."},{"key":"10.1016\/j.envres.2012.06.007_bib21","doi-asserted-by":"crossref","unstructured":"Kiernan, M.C., et al., 2011. Amyotrophic lateral sclerosis. Lancet.","DOI":"10.1016\/S0140-6736(10)61156-7"},{"key":"10.1016\/j.envres.2012.06.007_bib22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/17482960802233177","article-title":"A common haplotype within the PON1 promoter region is associated with sporadic ALS","volume":"9","author":"Landers","year":"2008","journal-title":"Amyotroph Lateral Scler."},{"key":"10.1016\/j.envres.2012.06.007_bib23","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/oxfordjournals.aje.a009070","article-title":"Occupational exposures and amyotrophic lateral sclerosis. A population-based case-control study","volume":"145","author":"McGuire","year":"1997","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2012.06.007_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mrfmmm.2008.10.011","article-title":"Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases","volume":"667","author":"Migliore","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envres.2012.06.007_bib25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000095552","article-title":"Amyotrophic lateral sclerosis and exposure to environmental toxins: an Australian case-control study","volume":"27","author":"Morahan","year":"2006","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.envres.2012.06.007_bib26","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.neuro.2006.11.007","article-title":"A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis","volume":"28","author":"Morahan","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2012.06.007_bib27","first-page":"327","article-title":"Epidemiology of ALS","volume":"3","author":"Nelson","year":"1995","journal-title":"Clin. Neurosci."},{"key":"10.1016\/j.envres.2012.06.007_bib28","unstructured":"Office of Federal Statistical Policy and Standards, 1980. Standard occupational classification manual. In: U. D. o. Commerce, (Ed.), US GPO, Washington, DC."},{"key":"10.1016\/j.envres.2012.06.007_bib29","unstructured":"Office of Management and Budget, 1987. E. O. o. t. U. P., Standard industrial classification manual. National Technical Information Service, Springfield, VA."},{"key":"10.1016\/j.envres.2012.06.007_bib30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1212\/01.wnl.0000227187.52002.88","article-title":"Paraoxonase cluster polymorphisms are associated with sporadic ALS","volume":"67","author":"Saeed","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2012.06.007_bib31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000110279","article-title":"A case-control study of amyotrophic lateral sclerosis","volume":"10","author":"Savettieri","year":"1991","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.envres.2012.06.007_bib32","series-title":"Risk factors for cancer in the workplace","author":"Siemiatycki","year":"1991"},{"key":"10.1016\/j.envres.2012.06.007_bib33","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1212\/01.wnl.0000219565.32247.11","article-title":"Paraoxonase gene polymorphisms and sporadic ALS","volume":"67","author":"Slowik","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2012.06.007_bib34","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","article-title":"Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis","volume":"54","author":"Sterne","year":"2001","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.envres.2012.06.007_bib35","first-page":"205","article-title":"Risk and protective factors for sporadic Alzheimer's disease","volume":"51","author":"Stozicka","year":"2007","journal-title":"Acta Virol."},{"key":"10.1016\/j.envres.2012.06.007_bib36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3109\/17482960802430799","article-title":"What we truly know about occupation as a risk factor for ALS: a critical and systematic review","volume":"10","author":"Sutedja","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1016\/j.envres.2012.06.007_bib37","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3109\/17482960802455416","article-title":"Exposure to chemicals and metals and risk of amyotrophic lateral sclerosis: a systematic review","volume":"10","author":"Sutedja","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1016\/j.envres.2012.06.007_bib38","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1002\/(SICI)1097-0258(19991030)18:20<2693::AID-SIM235>3.0.CO;2-V","article-title":"Explaining heterogeneity in meta-analysis: a comparison of methods","volume":"18","author":"Thompson","year":"1999","journal-title":"Stat. Med."},{"key":"10.1016\/j.envres.2012.06.007_bib39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4612-5910-7_3","article-title":"Inorganic sulfur as a fumigant","volume":"78","author":"Tweedy","year":"1981","journal-title":"Residue Rev."},{"key":"10.1016\/j.envres.2012.06.007_bib40","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1212\/01.wnl.0000324997.21272.0c","article-title":"Association of paraoxonase gene cluster polymorphisms with ALS in France, Quebec, and Sweden","volume":"71","author":"Valdmanis","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2012.06.007_bib41","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/jnnp.2008.156976","article-title":"Prospective study of chemical exposures and amyotrophic lateral sclerosis","volume":"80","author":"Weisskopf","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.envres.2012.06.007_bib1","unstructured":"World Health Organization, 1990. WHO. Public Health Impact of Pesticides Used in Agriculture. Geneva. http:\/\/whqlibdoc.who.int\/publications\/1990\/9241561394.pdf."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935112001909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935112001909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T07:11:51Z","timestamp":1642835511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935112001909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":41,"alternative-id":["S0013935112001909"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2012.06.007","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}