{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T13:01:49Z","timestamp":1778331709939,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.envres.2014.08.011","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T08:15:39Z","timestamp":1411892139000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population"],"prefix":"10.1016","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-3570","authenticated-orcid":false,"given":"Hongmin","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Ducatman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11\u201312","key":"10.1016\/j.envres.2014.08.011_bib22","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1289\/ehp.1306615","article-title":"Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant","volume":"121","author":"Barry","year":"2013","journal-title":"Environ.Health Perspect."},{"issue":"18","key":"10.1016\/j.envres.2014.08.011_bib3","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","article-title":"The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert\u2019s syndrome","volume":"333","author":"Bosma","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.envres.2014.08.011_bib1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.dld.2006.12.019","article-title":"Inheritance of hyperbilirubinemia: evidence for a major autosomal recessive gene","volume":"39","author":"Clementi","year":"2007","journal-title":"Dig. Liver Dis."},{"issue":"3","key":"10.1016\/j.envres.2014.08.011_bib23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/JOM.0b013e3181965d80","article-title":"Thirty years of medical surveillance in perfluooctanoic acid production workers","volume":"51","author":"Costa","year":"2009","journal-title":"J. Occup. Environ. Med."},{"issue":"10","key":"10.1016\/j.envres.2014.08.011_bib14","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1289\/ehp.1206372","article-title":"Serum perfluorooctanoic acid and perfluorooctane sulfonate concentrations in relation to birth outcomes in the Mid-Ohio valley, 2005\u20132010","volume":"121","author":"Darrow","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.envres.2014.08.011_bib25","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/01.jom.0000233380.13087.37","article-title":"Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters","volume":"48","author":"Emmett","year":"2006","journal-title":"J. Occup. Environ. Med."},{"issue":"1","key":"10.1016\/j.envres.2014.08.011_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00431-011-1641-0","article-title":"Gilbert syndrome","volume":"171","author":"Fretzayas","year":"2012","journal-title":"Eur. J. Pediatr."},{"issue":"12","key":"10.1016\/j.envres.2014.08.011_bib27","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1289\/ehp.0800379","article-title":"The C8 health project: design, methods, and participants","volume":"117","author":"Frisbee","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.envres.2014.08.011_bib16","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1001\/archpediatrics.2010.163","article-title":"Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 health project","volume":"164","author":"Frisbee","year":"2010","journal-title":"Arch. Pediatr. Adolesc. Med."},{"issue":"5","key":"10.1016\/j.envres.2014.08.011_bib26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1289\/ehp.1104436","article-title":"Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure","volume":"120","author":"Gallo","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"11","key":"10.1016\/j.envres.2014.08.011_bib17","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/aje\/kws392","article-title":"Positive association between perfluoroalkyl chemicals and hyperuricemia in children","volume":"177","author":"Geiger","year":"2013","journal-title":"Am. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.envres.2014.08.011_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/jama.2011.2034","article-title":"Serum vaccine antibody concentrations in children exposed to perfluorinated compounds","volume":"307","author":"Grandjean","year":"2012","journal-title":"J. Am. Med. Assoc."},{"issue":"2","key":"10.1016\/j.envres.2014.08.011_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.envres.2004.12.003","article-title":"Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion","volume":"99","author":"Harada","year":"2005","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.envres.2014.08.011_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/01.ATV.16.2.250","article-title":"Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease","volume":"16","author":"Hopkins","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.envres.2014.08.011_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.envint.2012.03.007","article-title":"Serum concentrations of major perfluorinated compounds among the general population in Korea: dietary sources and potential impact on thyroid hormones","volume":"45","author":"Ji","year":"2012","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.envres.2014.08.011_bib30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1399-3046.2012.01662.x","article-title":"Gilbert\u2019s syndrome\u2014a frequent cause of unconjugated hyperbilirubinemia in children after orthotopic liver transplantation","volume":"16","author":"Kathemann","year":"2012","journal-title":"Pediatr. Transplant."},{"issue":"4","key":"10.1016\/j.envres.2014.08.011_bib19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2131\/jts.36.403","article-title":"Perfluorocarbon exposure, gender and thyroid function in the C8 health project","volume":"36","author":"Knox","year":"2011","journal-title":"J. Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.envres.2014.08.011_bib11","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"19","key":"10.1016\/j.envres.2014.08.011_bib10","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1021\/es2011622","article-title":"Polyfluorinated compounds: past, present, and future","volume":"45","author":"Lindstrom","year":"2011","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.envres.2014.08.011_bib8","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.mehy.2006.12.069","article-title":"Iatrogenic Gilbert syndrome\u2014a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin","volume":"69","author":"McCarty","year":"2007","journal-title":"Med. Hypotheses"},{"issue":"1","key":"10.1016\/j.envres.2014.08.011_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1742-7843.2007.00155.x","article-title":"Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid","volume":"103","author":"Nakagawa","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.envres.2014.08.011_bib29","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/jmg.12.2.152","article-title":"Population studies on Gilbert\u2019s syndrome","volume":"12","author":"Owens","year":"1975","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.envres.2014.08.011_bib34","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2013.06.004","article-title":"Accumulation of perfluoroalkyl substances in human tissues","volume":"59","author":"Perez","year":"2013","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envres.2014.08.011_bib5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/ATVBAHA.107.153262","article-title":"Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National health and nutrition examination survey (NHANES) 1999 to 2004","volume":"28","author":"Perlstein","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.envres.2014.08.011_bib9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1053\/jhep.2001.22499","article-title":"Hepatic uptake of organic anions affects the plasma bilirubin level in subjects with Gilbert\u2019s syndrome mutations in UGT1A1","volume":"33","author":"Persico","year":"2001","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.envres.2014.08.011_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bcmd.2012.01.004","article-title":"Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects","volume":"48","author":"Rodrigues","year":"2012","journal-title":"Blood Cells Mol. Dis."},{"issue":"10","key":"10.1016\/j.envres.2014.08.011_bib24","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1097\/JOM.0b013e318156eca3","article-title":"Cross-sectional study of lipids and liver enzymes related to a serum biomarker of exposure (ammonium perfluorooctanoate or APFO) as part of a general health survey in a cohort of occupationally exposed workers","volume":"49","author":"Sakr","year":"2007","journal-title":"J. Occup. Environ. Med."},{"issue":"2","key":"10.1016\/j.envres.2014.08.011_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0021-9150(97)00232-3","article-title":"Association of smoking and low serum bilirubin antioxidant concentrations","volume":"136","author":"Schwertner","year":"1998","journal-title":"Atherosclerosis"},{"issue":"10","key":"10.1016\/j.envres.2014.08.011_bib15","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/aje\/kwp279","article-title":"Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant","volume":"170","author":"Steenland","year":"2009","journal-title":"Am. J. Epidemiol."},{"issue":"38","key":"10.1016\/j.envres.2014.08.011_bib7","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.3748\/wjg.v19.i38.6398","article-title":"New insights in bilirubin metabolism and their clinical implications","volume":"19","author":"Sticova","year":"2013","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.envres.2014.08.011_bib21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1289\/ehp.1205673","article-title":"Association of osteoarthritis with perfluorooctanoate and perfluorooctane sulfonate in NHANES 2003\u20132008","volume":"121","author":"Uhl","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2014.08.011_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2423(06)43001-8","article-title":"The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases","volume":"43","author":"Vitek","year":"2007","journal-title":"Adv. Clin. Chem."},{"issue":"9","key":"10.1016\/j.envres.2014.08.011_bib33","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1016\/j.watres.2012.03.027","article-title":"Input characterization of perfluoroalkyl substances in wastewater treatment plants: source discrimination by exploratory data analysis","volume":"46","author":"Xiao","year":"2012","journal-title":"Water Res."},{"issue":"2","key":"10.1016\/j.envres.2014.08.011_bib12","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/toxsci\/kfq219","article-title":"Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates","volume":"117","author":"Yang","year":"2010","journal-title":"Toxicol. Sci."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935114002710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935114002710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T10:16:49Z","timestamp":1565864209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935114002710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":34,"alternative-id":["S0013935114002710"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2014.08.011","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2014.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}