{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:33:41Z","timestamp":1785720821641,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.envres.2014.12.002","type":"journal-article","created":{"date-parts":[[2014,12,6]],"date-time":"2014-12-06T15:45:20Z","timestamp":1417880720000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Gestational exposure to polychlorinated biphenyls and dibenzofurans induced asymmetric hearing loss: Yucheng children study"],"prefix":"10.1016","volume":"137","author":[{"given":"Ming-Chieh","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Pin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu-Yueh","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau-Chung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George H.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Leon Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2014.12.002_bib1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1210\/endo-101-1-292","article-title":"Enhanced thyroxine metabolism and high uptake goiters in rats after a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"101","author":"Bastomsky","year":"1977","journal-title":"Endocrinology"},{"key":"10.1016\/j.envres.2014.12.002_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuro.2010.04.005","article-title":"Prenatal exposure to methylmercury and PCBs affects distinct stages of information processing: an event-related potential study with Inuit children","volume":"31","author":"Boucher","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2014.12.002_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/00039899709602195","article-title":"Middle-ear disease in children exposed prenatally to polychlorinated biphenyls and polychlorinated dibenzofurans","volume":"52","author":"Chao","year":"1997","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.envres.2014.12.002_bib4","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/lary.20873","article-title":"Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss","volume":"120","author":"Chau","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.envres.2014.12.002_bib5","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1001\/jama.1992.03490220057028","article-title":"Cognitive development of Yu-Cheng (\u2018oil-disease\u2019) children prenatally exposed to heat-degraded PCBs","volume":"268","author":"Chen","year":"1992","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.envres.2014.12.002_bib6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0378-5955(00)00062-9","article-title":"Hearing loss following exposure during development to polychlorinated biphenyls: a cochlear site of action","volume":"144","author":"Crofton","year":"2000","journal-title":"Hear. Res."},{"issue":"1142","key":"10.1016\/j.envres.2014.12.002_bib7","first-page":"e1","article-title":"Body mass index, waist circumference, physical activity, and risk of hearing loss in women","volume":"126","author":"Curhan","year":"2013","journal-title":"Am. J. Med."},{"key":"10.1016\/j.envres.2014.12.002_bib8","first-page":"94","article-title":"Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats","volume":"45","author":"Goldey","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2014.12.002_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/taap.1995.1210","article-title":"Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats","volume":"135","author":"Goldey","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2014.12.002_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0300-483X(87)90031-X","article-title":"Dose\u2013response and time course of hypothyroxinemia and hypo-insulinemia and characterization of insulin hypersensitivity in 2,3,7,8-tetrachloro-dibenzo-p-dioxin(TCDD)-treated rats","volume":"44","author":"Gorski","year":"1987","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2014.12.002_bib11","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.envres.2014.12.002_bib12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0892-0362(01)00155-6","article-title":"Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants","volume":"23","author":"Grandjean","year":"2001","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envres.2014.12.002_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s002449900193","article-title":"Monitoring of polychlorinated biphenyls in human blood plasma: methodological developments and influence of age, lactation, and fish consumption","volume":"32","author":"Grimvall","year":"1997","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2014.12.002_bib14","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/0045-6535(94)90408-1","article-title":"Early development of Yu-Cheng children born seven to twelve years after the Taiwan PCB outbreak","volume":"29","author":"Guo","year":"1994","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2014.12.002_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s002449900230","article-title":"Blood serum levels of PCBs and PCDFs in Yucheng women 14 years after exposure to a toxic rice oil","volume":"33","author":"Guo","year":"1997","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2014.12.002_bib16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1289\/ehp.99107715","article-title":"Chloracne, goiter, arthritis, and anemia after polychlorinated biphenyl poisoning: 14-year follow-up of the Taiwan Yucheng cohort","volume":"107","author":"Guo","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2014.12.002_bib17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/faat.1996.0149","article-title":"Developmental exposure to Aroclor 1254 produces low-frequency alterations in adult rat brainstem auditory evoked responses","volume":"33","author":"Herr","year":"1996","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.envres.2014.12.002_bib18","first-page":"5","article-title":"Discovery and epidemiology of PCB poisoning in Taiwan: a four-year follow up","volume":"59","author":"Hsu","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2014.12.002_bib19","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2307\/1130097","article-title":"The effect of intrauterine PCB exposure on visual recognition memory","volume":"56","author":"Jacobson","year":"1985","journal-title":"Child Dev."},{"key":"10.1016\/j.envres.2014.12.002_bib20","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1056\/NEJM199609123351104","article-title":"Intellectual impairment in children exposed to polychlorinated biphenyls in utero","volume":"335","author":"Jacobson","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envres.2014.12.002_bib21","first-page":"96","article-title":"An epidemiological study on polychlorinated biphenyls poisoning in Taichung area","volume":"7","author":"Lan","year":"1981","journal-title":"Clin. Med."},{"key":"10.1016\/j.envres.2014.12.002_bib22","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0045-6535(90)90232-I","article-title":"Enzyme induction and alterations in thyroid hormone, vitamin A and K levels by TCDD in neonatal and maternal rats","volume":"20","author":"Lans","year":"1990","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2014.12.002_bib23","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1021\/es0608646","article-title":"Induced CYP1A2 activity as a phenotypic biomarker in humans highly exposed to certain PCBs\/PCDFs","volume":"40","author":"Lambert","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2014.12.002_bib24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/toxsci\/68.2.458","article-title":"Perinatal exposure to Aroclor 1254 impairs distortion product otoacoustic emissions (DPOAEs) in rats","volume":"68","author":"Lasky","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2014.12.002_bib25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/toxsci\/kfr077","article-title":"Auditory effects of developmental exposure to purity-controlled polychlorinated biphenyls (PCB52 and PCB180) in rats","volume":"122","author":"Lilienthal","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2014.12.002_bib26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1289\/ehp.10134","article-title":"Neurocognitive changes among elderly exposed to PCBs\/PCDFs in Taiwan","volume":"116","author":"Lin","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2014.12.002_bib27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ntt.2004.04.007","article-title":"In utero exposure to polychlorinated biphenyls and sensorineural hearing loss in 8-year-old children","volume":"26","author":"Longnecker","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envres.2014.12.002_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1289\/ehp.856141","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) as a potent and persistent thyroxine agonist: a mechanistic model for toxicity based on molecular reactivity","volume":"61","author":"Mc Kinney","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2014.12.002_bib29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/taap.1996.0034","article-title":"Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254)","volume":"136","author":"Morse","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2014.12.002_bib30","first-page":"3329","article-title":"Half-life of each dioxin and PCB congener in the human body","volume":"66","author":"Ogura","year":"2004","journal-title":"Organohalog. Compd."},{"key":"10.1016\/j.envres.2014.12.002_bib31","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1021\/ac00142a023","article-title":"High-resolution gas chromatographic\/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"59","author":"Patterson","year":"1987","journal-title":"Anal. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.envres.2014.12.002_bib32","doi-asserted-by":"crossref","first-page":"S261","DOI":"10.1016\/j.chemosphere.2007.08.074","article-title":"reference range (PCDDs, PCDFs, cPCBs, mono-PCBs) for the US population 2001\u20132002","volume":"73","author":"Patterson","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2014.12.002_bib33","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1021\/es801966w","article-title":"Levels in the U.S. population of those persistent organic pollutants (2003\u20132004) included in the Stockholm convention or in other long-range transboundary air pollution agreements","volume":"43","author":"Patterson","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envres.2014.12.002_bib34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/BF01055015","article-title":"Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding","volume":"18","author":"Phillips","year":"1989","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2014.12.002_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/toxsci\/kfr214","article-title":"Effects of developmental exposure to polychlorinated biphenyls and\/or polybrominated diphenyl ethers on cochlear function","volume":"124","author":"Poon","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2014.12.002_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0041-008X(86)90415-1","article-title":"Thyroid status and thermogenesis in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"84","author":"Potter","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2014.12.002_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0041-008X(83)90123-0","article-title":"Hypothyroxinemia and hypothermia in rat in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration","volume":"69","author":"Potter","year":"1983","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2014.12.002_bib38","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1289\/ehp.0800428","article-title":"Developmental exposure to PCBs, MeHg, or both: long-term effects on auditory function","volume":"117","author":"Powers","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2014.12.002_bib39","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/toxsci\/kfj051","article-title":"Auditory deficits in rats exposed to an environmental PCB mixture during development","volume":"89","author":"Powers","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2014.12.002_bib40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0041-008X(88)90228-1","article-title":"Activity of thyroid hormone-inducible enzymes following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"92","author":"Roth","year":"1988","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2014.12.002_bib41","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0045-6535(94)90257-7","article-title":"Blood serum levels of PCDFs and PCBs in Yu-Cheng children perinatally exposed to a toxic rice oil","volume":"29","author":"Ryan","year":"1994","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2014.12.002_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0048-9697(97)00245-3","article-title":"stm man C, Hagmar L. The impact of age, lactation and dietary habits on PCB in plasma in Swedish women","volume":"207","author":"Rylander","year":"1997","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2014.12.002_bib43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5271\/sjweh.533","article-title":"Medical and psychometric examinations of conscripts born to mothers with a high intake of fish contaminated with persistent organochlorines","volume":"26","author":"Rylander","year":"2000","journal-title":"Scand J. Work Environ. Health"},{"key":"10.1016\/j.envres.2014.12.002_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0892-0362(96)90001-X","article-title":"Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here","volume":"18","author":"Schantz","year":"1996","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.envres.2014.12.002_bib45","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1289\/ehp.5461","article-title":"Effects of PCBS exposure on neuropsychological function in children","volume":"11","author":"Schantz","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2014.12.002_bib46","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0378-4274(98)00271-9","article-title":"Neurotoxicity of environmental chemicals and their mechanism of action","volume":"102\u2013103","author":"Tilson","year":"1998","journal-title":"Toxicol. Lett."},{"issue":"Suppl. 429","key":"10.1016\/j.envres.2014.12.002_bib47","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.3109\/00016488609122726","article-title":"Periods of sensitivity to thyroid hormone during the development of the organ of Corti","volume":"101","author":"Uziel","year":"1986","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.envres.2014.12.002_bib48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/kfl055","article-title":"The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds","volume":"93","author":"Van den Berg","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2014.12.002_bib49","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.jes.7500609","article-title":"Serum dioxin levels in residents of Calcasieu and Lafayette parishes, Louisiana with comparison to the US population","volume":"18","author":"Wong","year":"2008","journal-title":"J. Expo Sci. Environ. Epidemiol."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935114004514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935114004514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T19:54:15Z","timestamp":1757966055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935114004514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":49,"alternative-id":["S0013935114004514"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2014.12.002","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational exposure to polychlorinated biphenyls and dibenzofurans induced asymmetric hearing loss: Yucheng children study","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2014.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}