{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:05:34Z","timestamp":1790787934322,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.envres.2015.03.036","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T21:45:19Z","timestamp":1428529519000},"page":"145-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue"],"prefix":"10.1016","volume":"140","author":[{"given":"Enrico","family":"Campioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam B.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Deschamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2015.03.036_bib1","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1098\/rstb.2008.0304","article-title":"Applications and societal benefits of plastics","volume":"364","author":"Andrady","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond B Biol. Sci."},{"key":"10.1016\/j.envres.2015.03.036_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/10937404.2013.876288","article-title":"Derivation of an oral reference dose (RfD) for the nonphthalate alternative plasticizer 1,2-cyclohexane dicarboxylic acid, di-isononyl ester (DINCH)","volume":"17","author":"Bhat","year":"2014","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.envres.2015.03.036_bib3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/endo.137.1.8536636","article-title":"Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat","volume":"137","author":"Braissant","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.envres.2015.03.036_bib4","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1101\/gad.10.8.974","article-title":"Differential activation of adipogenesis by multiple PPAR isoforms","volume":"10","author":"Brun","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.envres.2015.03.036_bib5","doi-asserted-by":"crossref","first-page":"e28750","DOI":"10.1371\/journal.pone.0028750","article-title":"The endocrine disruptor mono-(2-ethylhexyl) phthalate affects the differentiation of human liposarcoma cells (SW 872)","volume":"6","author":"Campioli","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2015.03.036_bib6","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1038\/nutd.2014.13","article-title":"In utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate promotes local adipose and systemic inflammation in adult male offspring","volume":"4","author":"Campioli","year":"2014","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.envres.2015.03.036_bib7","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1073\/pnas.88.6.2593","article-title":"CCAAT\/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes","volume":"88","author":"Christy","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.envres.2015.03.036_bib8","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1101\/gad.3.9.1323","article-title":"Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT\/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes","volume":"3","author":"Christy","year":"1989","journal-title":"Genes Dev."},{"key":"10.1016\/j.envres.2015.03.036_bib9","first-page":"895","article-title":"Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development","volume":"108","author":"Colon","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2015.03.036_bib10","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/app.25760","article-title":"Substitution of di(2-ethylhexyl) phthalate by di(isononyl) cyclohexane-1,2-dicarboxylate as a plasticizer for industrial vinyl plastisol formulations","volume":"104","author":"Crespo","year":"2007","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.envres.2015.03.036_bib11","doi-asserted-by":"crossref","first-page":"30057","DOI":"10.1074\/jbc.273.46.30057","article-title":"The role of C\/EBP genes in adipocyte differentiation","volume":"273","author":"Darlington","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2015.03.036_bib12","doi-asserted-by":"crossref","first-page":"27815","DOI":"10.1074\/jbc.M003593200","article-title":"Modulation of the murine peroxisome proliferator-activated receptor gamma 2 promoter activity by CCAAT\/enhancer-binding proteins","volume":"275","author":"Elberg","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2015.03.036_bib13","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1021\/pr200765v","article-title":"Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes","volume":"10","author":"Ellero-Simatos","year":"2011","journal-title":"J. Proteome. Res."},{"key":"10.1016\/j.envres.2015.03.036_bib14","first-page":"1","article-title":"Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request related to a 12th list of substances for food contact materials","volume":"395\u2013401","author":"European Food Safety Authority","year":"2006","journal-title":"EFSA J."},{"key":"10.1016\/j.envres.2015.03.036_bib15","first-page":"40","volume":"L344","author":"European Parliament and European Council","year":"2005","journal-title":"Off. J. Eur. Union"},{"key":"10.1016\/j.envres.2015.03.036_bib16","doi-asserted-by":"crossref","first-page":"19152","DOI":"10.1074\/jbc.M702724200","article-title":"The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis","volume":"282","author":"Feige","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2015.03.036_bib17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/mnfr.200600243","article-title":"Metabolism of phthalates in humans","volume":"51","author":"Frederiksen","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.envres.2015.03.036_bib18","doi-asserted-by":"crossref","unstructured":"German Federal Environment Agency, 2011. [Substance monograph for phthalates-New and updated reference and oxidized monoester metabolites in urine of children-and adults. Opinion of the Commission \u201cHuman-Biomonitoring\u201d by the Federal Environment Agency]. Bundesgesundheitsblatt. Gesundheitsforschung. Gesundheitsschutz. 54, 770-785.","DOI":"10.1007\/s00103-011-1278-1"},{"key":"10.1016\/j.envres.2015.03.036_bib19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1194\/jlr.M011320","article-title":"Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes","volume":"52","author":"Goto","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.envres.2015.03.036_bib200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2891-13-17","article-title":"Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications--a review","volume":"13","author":"Grygiel-G\u00f3rniak","year":"2014","journal-title":"Nutr. J."},{"key":"10.1016\/j.envres.2015.03.036_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.publhealth.012809.103714","article-title":"Plastics and health risks","volume":"31","author":"Halden","year":"2010","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.envres.2015.03.036_bib21","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1126\/science.284.5422.1988","article-title":"Prehistoric polymers: rubber processing in ancient mesoamerica","volume":"284","author":"Hosler","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.envres.2015.03.036_bib22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/10408449609048302","article-title":"Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk","volume":"26","author":"Huber","year":"1996","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envres.2015.03.036_bib23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/toxsci\/kfg145","article-title":"Activation of PPARalpha and PPARgamma by environmental phthalate monoesters","volume":"74","author":"Hurst","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2015.03.036_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/35013000","article-title":"Roles of PPARs in health and disease","volume":"405","author":"Kersten","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.envres.2015.03.036_bib25","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00204-012-0990-4","article-title":"Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH((R))) in humans after single oral doses","volume":"87","author":"Koch","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2015.03.036_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1463-1326.2009.01149.x","article-title":"Selective effects of PPARgamma agonists and antagonists on human pre-adipocyte differentiation","volume":"12","author":"Leyvraz","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.envres.2015.03.036_bib27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1074\/jbc.M113.534172","article-title":"De novo synthesis of steroids and oxysterols in adipocytes","volume":"289","author":"Li","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envres.2015.03.036_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/taap.1999.8809","article-title":"trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals","volume":"161","author":"Maloney","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envres.2015.03.036_bib29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ijheh.2010.08.005","article-title":"Diisononyl 1,2-cyclohexanedicarboxylic acid (DINCH) and Di(2-ethylhexyl) terephthalate (DEHT) in indoor dust samples: concentration and analytical problems","volume":"214","author":"Nagorka","year":"2011","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envres.2015.03.036_bib201","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/physrev.00027.2013","article-title":"Physiological functions of peroxisome proliferator-activated receptor \u00df","volume":"94","author":"Neels","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.envres.2015.03.036_bib30","unstructured":"PlasticsEurope, 2013. Plastics-the Facts 2013. An analysis of European latest plastics production, demand and waste data. Plastics Europe."},{"key":"10.1016\/j.envres.2015.03.036_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBPalpha induces adipogenesis through PPARgamma: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.envres.2015.03.036_bib32","unstructured":"Shelby, M.D., 2006. NTP-CERHR monograph on the potential human reproductive and developmental effects of di (2-ethylhexyl) phthalate (DEHP). NTP. CERHR. MON. v, vii-iii."},{"key":"10.1016\/j.envres.2015.03.036_bib33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/jes.2011.43","article-title":"Identification of potential biomarkers of exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), an alternative for phthalate plasticizers","volume":"22","author":"Silva","year":"2012","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envres.2015.03.036_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.envres.2013.05.007","article-title":"Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) in U.S. adults (2000\u20132012)","volume":"126","author":"Silva","year":"2013","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2015.03.036_bib35","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-X","article-title":"Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor","volume":"79","author":"Tontonoz","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.envres.2015.03.036_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.envres.2006.04.006","article-title":"An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare","volume":"103","author":"Wilson","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2015.03.036_bib37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1097-2765(00)80306-8","article-title":"Cross-regulation of C\/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity","volume":"3","author":"Wu","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envres.2015.03.036_bib38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/10937404.2014.882194","article-title":"Estrogenic endocrine-disrupting chemicals: molecular mechanisms of actions on putative human diseases.","volume":"17","author":"Yoon","year":"2014","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."}],"updated-by":[{"DOI":"10.1016\/j.envres.2015.11.007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000}}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935115001140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935115001140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T19:55:10Z","timestamp":1757966110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935115001140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":40,"alternative-id":["S0013935115001140"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2015.03.036","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.envres.2015.11.007","asserted-by":"object"}]},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2015.03.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}