{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:50:47Z","timestamp":1791575447063,"version":"4.3.4"},"reference-count":198,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.envres.2017.07.048","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T15:15:31Z","timestamp":1501600531000},"page":"82-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":252,"special_numbering":"C","title":["Metals and neurodegenerative diseases. A systematic review"],"prefix":"10.1016","volume":"159","author":[{"given":"Calogero Edoardo","family":"Cicero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Mostile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Vasta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venerando","family":"Rapisarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Santo","family":"Signorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Ferrante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Zappia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2017.07.048_bib1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/jama.1983.03340050054029","article-title":"Mercury intoxication simulating amyotrophic lateral sclerosis","volume":"250","author":"Adams","year":"1983","journal-title":"JAMA"},{"key":"10.1016\/j.envres.2017.07.048_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12291-008-0081-8","article-title":"Serum copper in Alzheimer\u2019s disease and vascular dementia","volume":"23","author":"Agarwal","year":"2008","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.envres.2017.07.048_bib3","doi-asserted-by":"crossref","first-page":"e11252","DOI":"10.1371\/journal.pone.0011252","article-title":"Metallomic profiling and linkage map analysis of early Parkinson\u2019s disease: a new insight to aluminum marker for the possible diagnosis","volume":"5","author":"Ahmed","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2017.07.048_bib4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrneurol.2013.203","article-title":"The epidemiology of ALS: a conspiracy of genes, environment and time","volume":"9","author":"Al-Chalabi","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.neuro.2006.12.001","article-title":"Serum chemical elements and oxidative status in Alzheimer\u2019s disease, Parkinson disease and multiple sclerosis","volume":"28","author":"Alimonti","year":"2007","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.envres.2017.07.048_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3233\/JAD-132180","article-title":"Relation between copper, lipid profile, and cognition in elderly Jordanians","volume":"41","author":"Al-khateeb","year":"2014","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.envres.2017.07.048_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/1533317512467680","article-title":"Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer\u2019s disease","volume":"28","author":"Alsadany","year":"2013","journal-title":"Am. J. Alzheimers Dis. Other Dement."},{"key":"10.1016\/j.envres.2017.07.048_bib8","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/mus.880151006","article-title":"Inorganic mercury is transported from muscular nerve terminals to spinal and brainstem motoneurons","volume":"15","author":"Arvidson","year":"1992","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.envres.2017.07.048_bib9","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.amjmed.2011.11.030","article-title":"Lead poisoning mimicking amyotrophic lateral sclerosis: an adverse effect of rituals","volume":"125","author":"Bachmeyer","year":"2012","journal-title":"Am. J. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib10","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1007\/s11064-010-0212-5","article-title":"The role of oxidative stress in amyotrophic lateral sclerosis and Parkinson\u2019s disease","volume":"35","author":"Baillet","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1684\/mrh.2011.0287","article-title":"Altered ionized magnesium levels in mild-to-moderate Alzheimer\u2019s disease","volume":"24","author":"Barbagallo","year":"2011","journal-title":"Magnes. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib12","first-page":"667","article-title":"Inorganic mercury intoxication reminiscent of amyotrophic lateral sclerosis","volume":"20","author":"Barber","year":"1978","journal-title":"J. Occup. Med. Off. Publ. Ind. Med. Assoc."},{"key":"10.1016\/j.envres.2017.07.048_bib13","first-page":"231","article-title":"Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer\u2019s disease","volume":"3","author":"Basun","year":"1991","journal-title":"J. Neural Transm. Park. Dis. Dement. Sect."},{"key":"10.1016\/j.envres.2017.07.048_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10534-009-9277-5","article-title":"Serum zinc is decreased in Alzheimer\u2019s disease and serum arsenic correlates positively with cognitive ability","volume":"23","author":"Baum","year":"2010","journal-title":"BioMetals"},{"key":"10.1016\/j.envres.2017.07.048_bib15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2016.06.027","article-title":"Adaptive regulation of the brain\u2019s antioxidant defences by neurons and astrocytes","volume":"100","author":"Baxter","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000443146","article-title":"Environmental risk factors and amyotrophic lateral sclerosis: an umbrella review and critical assessment of current evidence from systematic reviews and meta-analyses of observational studies","volume":"46","author":"Belbasis","year":"2016","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.envres.2017.07.048_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00002093-199806000-00005","article-title":"Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease","volume":"12","author":"Bell\u00e9s","year":"1998","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.envres.2017.07.048_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/enrs.2002.4361","article-title":"Environmental exposure to trace elements and risk of amyotrophic lateral sclerosis: a population-based case-control study","volume":"89","author":"Bergomi","year":"2002","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib19","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00415-009-0063-7","article-title":"Lower serum ceruloplasmin levels correlate with younger age of onset in Parkinson\u2019s disease","volume":"255","author":"Bharucha","year":"2008","journal-title":"J. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib20","first-page":"197","article-title":"Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer\u2019s disease","volume":"41","author":"Bocca","year":"2005","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.envres.2017.07.048_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jns.2006.05.007","article-title":"Metal changes in CSF and peripheral compartments of parkinsonian patients","volume":"248","author":"Bocca","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jns.2015.10.023","article-title":"Level of neurotoxic metals in amyotrophic lateral sclerosis: a population-based case-control study","volume":"359","author":"Bocca","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3940(99)00221-9","article-title":"Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson\u2019s disease","volume":"265","author":"Boll","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.envres.2017.07.048_bib24","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s11064-008-9610-3","article-title":"Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases","volume":"33","author":"Boll","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1001\/archneur.1974.00490370044005","article-title":"Reversible forms of motor neuron disease. Lead \u201cneuritis.\u201d","volume":"31","author":"Boothby","year":"1974","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib26","first-page":"283","article-title":"Magnesium and potassium status in elderly subjects with and without dementia of the Alzheimer type","volume":"3","author":"Borella","year":"1990","journal-title":"Magnes. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib27","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/1533317510375083","article-title":"Copper and ceruloplasmin abnormalities in Alzheimer\u2019s disease","volume":"25","author":"Brewer","year":"2010","journal-title":"Am. J. Alzheimers Dis. Other Dement."},{"key":"10.1016\/j.envres.2017.07.048_bib28","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/1533317510382283","article-title":"Subclinical zinc deficiency in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"25","author":"Brewer","year":"2010","journal-title":"Am. J. Alzheimers Dis. Other Dement."},{"key":"10.1016\/j.envres.2017.07.048_bib29","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/jnnp.33.6.877","article-title":"Motor neurone disease and exposure to lead","volume":"33","author":"Campbell","year":"1970","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.envres.2017.07.048_bib30","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1017\/S0007114509992832","article-title":"Nutritional status of selenium in Alzheimer\u2019s disease patients","volume":"103","author":"Cardoso","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.envres.2017.07.048_bib31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jtemb.2014.08.009","article-title":"Selenium status in elderly: relation to cognitive decline","volume":"28","author":"Cardoso","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.envres.2017.07.048_bib32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1439-0442.2006.00830.x","article-title":"Clinical, pathological and toxicological findings of a iatrogenic selenium toxicosis case in feeder pigs","volume":"53","author":"Casteignau","year":"2006","journal-title":"J. Vet. Med. A Physiol. Pathol. Clin. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0891-5849(95)02058-6","article-title":"Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer\u2019s type--place of the extracellular glutathione peroxidase","volume":"20","author":"Ceballos-Picot","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib34","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/jnnp.56.11.1200","article-title":"Risk factors for motor neuron disease: a case-control study based on patients from the Scottish Motor Neuron Disease Register","volume":"56","author":"Chancellor","year":"1993","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.envres.2017.07.048_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.toxlet.2006.12.006","article-title":"Differential neurotoxic effects of methylmercury and mercuric sulfide in rats","volume":"169","author":"Chuu","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envres.2017.07.048_bib36","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0022-510X(76)90175-1","article-title":"Abnormal tissue distribution of lead in amyotrophic lateral sclerosis","volume":"29","author":"Conradi","year":"1976","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib38","doi-asserted-by":"crossref","first-page":"e33552","DOI":"10.1371\/journal.pone.0033552","article-title":"The zinc dyshomeostasis hypothesis of Alzheimer\u2019s disease","volume":"7","author":"Craddock","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.envres.2017.07.048_bib39","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1126\/science.180.4085.511","article-title":"Brain aluminum distribution in Alzheimer\u2019s disease and experimental neurofibrillary degeneration","volume":"180","author":"Crapper","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.envres.2017.07.048_bib40","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.neurobiolaging.2013.10.078","article-title":"Genetic and biochemical markers in patients with Alzheimer\u2019s disease support a concerted systemic iron homeostasis dysregulation","volume":"35","author":"Crespo","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.envres.2017.07.048_bib41","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.scitotenv.2010.01.027","article-title":"Arsenic for the fool: an exponential connection","volume":"408","author":"Dani","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2017.07.048_bib42","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1177\/104063879901100410","article-title":"Selenium elimination in pigs after an outbreak of selenium toxicosis","volume":"11","author":"Davidson-York","year":"1999","journal-title":"J. Vet. Diagn. Investig. Off. Publ. Am. Assoc. Vet. Lab. Diagn. Inc."},{"key":"10.1016\/j.envres.2017.07.048_bib43","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/oxfordjournals.aje.a114308","article-title":"A case-control study of amyotrophic lateral sclerosis","volume":"123","author":"Deapen","year":"1986","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2017.07.048_bib44","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/mds.25462","article-title":"Lysosomal impairment in Parkinson\u2019s disease","volume":"28","author":"Dehay","year":"2013","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"10.1016\/j.envres.2017.07.048_bib45","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.fct.2014.04.022","article-title":"Chronic exposure to aluminum and melatonin through the diet: neurobehavioral effects in a transgenic mouse model of Alzheimer disease","volume":"69","author":"Di Paolo","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envres.2017.07.048_bib46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1753-4887.2010.00360.x","article-title":"Oral silicon supplementation: an effective therapy for preventing oral aluminum absorption and retention in mammals","volume":"69","author":"Domingo","year":"2011","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.envres.2017.07.048_bib47","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/01.jom.0000199678.86629.3b","article-title":"Comparison of patella lead with blood lead and tibia lead and their associations with neurobehavioral test scores","volume":"48","author":"Dorsey","year":"2006","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib48","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jtemb.2014.05.007","article-title":"The neurotoxicity of iron, copper and manganese in Parkinson\u2019s and Wilson\u2019s diseases","volume":"31","author":"Dusek","year":"2015","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. GMS"},{"key":"10.1016\/j.envres.2017.07.048_bib49","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1590\/0001-3765201620150595","article-title":"Biological functions of selenium and its potential influence on Parkinson\u2019s disease","volume":"88","author":"Ellwanger","year":"2016","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.envres.2017.07.048_bib50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF01257128","article-title":"Geographical distribution of Alzheimer\u2019s disease cases at birth and the geochemical profile of Saguenay-lac-Saint-Jean\/Qu\u00e9bec, Canada (image project)","volume":"72","author":"Emard","year":"1994","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.envres.2017.07.048_bib51","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/oxfordjournals.aje.a010295","article-title":"Trace element levels in drinking water and cognitive function among elderly Chinese","volume":"151","author":"Emsley","year":"2000","journal-title":"Am. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.envres.2017.07.048_bib52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1034\/j.1600-079X.2003.00048.x","article-title":"Aluminum-induced pro-oxidant effects in rats: protective role of exogenous melatonin","volume":"35","author":"Esparza","year":"2003","journal-title":"J. Pineal Res."},{"issue":"2","key":"10.1016\/j.envres.2017.07.048_bib53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-079X.2005.00225.x","article-title":"Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats","volume":"39","author":"Esparza","year":"2005","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.envres.2017.07.048_bib54","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/aje\/kwq063","article-title":"Association between blood lead and the risk of amyotrophic lateral sclerosis","volume":"171","author":"Fang","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2017.07.048_bib55","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuint.2012.12.006","article-title":"Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury","volume":"62","author":"Farina","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.envres.2017.07.048_bib56","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0140-6736(90)90868-6","article-title":"Defective gallium-transferrin binding in Alzheimer disease and Down syndrome: possible mechanism for accumulation of aluminium in brain","volume":"335","author":"Farrar","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.envres.2017.07.048_bib57","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/mp.2013.178","article-title":"An anemia of Alzheimer\u2019s disease","volume":"19","author":"Faux","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.envres.2017.07.048_bib58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1212\/WNL.26.2.167","article-title":"Antecedent events in amyotrophic lateral sclerosis","volume":"26","author":"Felmus","year":"1976","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib59","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00415-009-0144-7","article-title":"Acquired hepatocerebral degeneration","volume":"256","author":"Ferrara","year":"2009","journal-title":"J. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib60","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00128-009-9791-8","article-title":"Aluminum concentrations in water of elderly people's houses and retirement homes and its relation with elderly health","volume":"83","author":"Ferreira","year":"2009","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2017.07.048_bib61","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1212\/01.wnl.0000267846.97398.e2","article-title":"Lead poisoning from the beauty case: neurologic manifestations in an elderly woman","volume":"69","author":"Fluri","year":"2007","journal-title":"Neurology"},{"issue":"111","key":"10.1016\/j.envres.2017.07.048_bib62","first-page":"1031","article-title":"Trace and major elements in whole blood, serum, cerebrospinal fluid and urine of patients with Parkinson\u2019s disease","volume":"1996","author":"Forte","year":"2004","journal-title":"J. Neural Transm. Vienna Austria"},{"key":"10.1016\/j.envres.2017.07.048_bib63","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mam.2005.07.013","article-title":"Relevance, essentiality and toxicity of trace elements in human health","volume":"26","author":"Fraga","year":"2005","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000255462","article-title":"Relationship between blood levels of heavy metals and Parkinson\u2019s disease in China","volume":"34","author":"Fukushima","year":"2010","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.envres.2017.07.048_bib65","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/15563659509017991","article-title":"Determination of blood mercury concentrations in Alzheimer\u2019s patients","volume":"33","author":"Fung","year":"1995","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.envres.2017.07.048_bib66","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/aje\/kwk073","article-title":"Selenium level and cognitive function in rural elderly Chinese","volume":"165","author":"Gao","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2017.07.048_bib67","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/hipo.20612","article-title":"Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer's disease after chronic exposure to aluminum","volume":"20","author":"Garcia","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.envres.2017.07.048_bib68","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tox.2009.09.009","article-title":"Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease","volume":"265","author":"Garc\u00eda","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2017.07.048_bib69","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/JOM.0000000000000266","article-title":"Blood lead, manganese, and aluminum levels in a regional Italian cohort of ALS patients: does aluminum have an influence?","volume":"56","author":"Garzillo","year":"2014","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib70","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF02224396","article-title":"A case control study of CSF copper, iron and manganese in Parkinson disease","volume":"13","author":"Gazzaniga","year":"1992","journal-title":"Ital. J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib71","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2008.05.002","article-title":"Trace elements in serum from patients with Parkinson\u2019s disease \u2013 a prospective case-control study: the Nord-Tr\u00f8ndelag Health Study (HUNT)","volume":"1219","author":"Gellein","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.envres.2017.07.048_bib72","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1159\/000129365","article-title":"Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease","volume":"25","author":"Gerhardsson","year":"2008","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.envres.2017.07.048_bib73","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12011-014-0094-5","article-title":"Heavy metals and neurodegenerative diseases: an observational study","volume":"161","author":"Giacoppo","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib74","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.neurobiolaging.2011.03.005","article-title":"Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer\u2019s disease","volume":"33","author":"Giambattistelli","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.envres.2017.07.048_bib75","first-page":"300","article-title":"Evaluation of iron serum level in Alzheimer disease","volume":"63","author":"Goldust","year":"2013","journal-title":"JPMA J. Pak. Med. Assoc."},{"key":"10.1016\/j.envres.2017.07.048_bib76","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tox.2008.05.004","article-title":"Aluminum exposure through the diet: metal levels in AbetaPP transgenic mice, a model for Alzheimer's disease","volume":"249","author":"G\u00f3mez","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2017.07.048_bib77","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1046\/j.1365-2362.1999.00471.x","article-title":"Serum zinc, copper, insulin and lipids in Alzheimer\u2019s disease epsilon 4 apolipoprotein E allele carriers","volume":"29","author":"Gonzalez","year":"1999","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.envres.2017.07.048_bib78","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1039\/C3MT00301A","article-title":"Characterization of metal profiles in serum during the progression of Alzheimer\u2019s disease","volume":"6","author":"Gonz\u00e1lez-Dom\u00ednguez","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.envres.2017.07.048_bib79","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1212\/WNL.48.3.650","article-title":"Occupational exposures to metals as risk factors for Parkinson\u2019s disease","volume":"48","author":"Gorell","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib80","first-page":"791","article-title":"A case-control study of motor neurone disease: its relation to heritability, and occupational exposures, particularly to solvents","volume":"49","author":"Gunnarsson","year":"1992","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib81","doi-asserted-by":"crossref","DOI":"10.1111\/j.1447-0594.2009.00571.x","article-title":"Lipids' peroxidation markers in Alzheimer\u2019s disease and vascular dementia","author":"Gustaw-Rothenberg","year":"2009","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.envres.2017.07.048_bib82","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jtemb.2004.09.003","article-title":"Serum trace element levels and the complexity of inter-element relations in patients with Parkinson\u2019s disease","volume":"18","author":"Hegde","year":"2004","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. GMS"},{"key":"10.1016\/j.envres.2017.07.048_bib83","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1212\/WNL.33.10.1350","article-title":"Cerebrospinal fluid trace element content in dementia Clinical, radiologic, and pathologic correlations","volume":"33","author":"Hershey","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib84","first-page":"295","article-title":"The environment and disease: association or causation?","volume":"58","author":"Hill","year":"1965","journal-title":"Proc. R. Soc. Med."},{"issue":"105","key":"10.1016\/j.envres.2017.07.048_bib85","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s007020050038","article-title":"Increased blood mercury levels in patients with Alzheimer\u2019s disease","volume":"1996","author":"Hock","year":"1998","journal-title":"J. Neural Transm. Vienna Austria"},{"key":"10.1016\/j.envres.2017.07.048_bib86","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jns.2011.01.003","article-title":"Patterns of levels of biological metals in CSF differ among neurodegenerative diseases","volume":"303","author":"Hozumi","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib87","first-page":"120","article-title":"Meta-analysis of the relationship between amyotrophic lateral sclerosis and susceptibility to serum ferritin level elevation","volume":"21","author":"Hu","year":"2016","journal-title":"Neuroscience Riyadh Saudi Arab"},{"key":"10.1016\/j.envres.2017.07.048_bib88","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.envres.2017.07.048_bib89","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000213037","article-title":"Lipid peroxidation and free radical scavengers in Alzheimer\u2019s disease","volume":"35","author":"Jeandel","year":"1989","journal-title":"Gerontology"},{"key":"10.1016\/j.envres.2017.07.048_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-410502-7.00002-8","article-title":"The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations","volume":"110","author":"Jellinger","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.envres.2017.07.048_bib91","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.brainres.2016.06.044","article-title":"Meta-analysis of the association between serum iron levels and Parkinson\u2019s disease: evidence from 11 publications","volume":"1646","author":"Jiao","year":"2016","journal-title":"Brain Res."},{"issue":"105","key":"10.1016\/j.envres.2017.07.048_bib92","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s007020050073","article-title":"Cerebrospinal fluid levels of transition metals in patients with Parkinson\u2019s disease","volume":"1996","author":"Jim\u00e9nez-Jim\u00e9nez","year":"1998","journal-title":"J. Neural Transm. Vienna Austria"},{"key":"10.1016\/j.envres.2017.07.048_bib93","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tox.2011.03.001","article-title":"Advances in metal-induced oxidative stress and human disease","volume":"283","author":"Jomova","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.envres.2017.07.048_bib94","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-010-0563-x","article-title":"Metals, oxidative stress and neurodegenerative disorders","volume":"345","author":"Jomova","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.envres.2017.07.048_bib95","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.envres.2017.07.048_bib96","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00001648-200205000-00012","article-title":"Lead exposure and amyotrophic lateral sclerosis","volume":"13","author":"Kamel","year":"2002","journal-title":"Epidemiology"},{"key":"10.1016\/j.envres.2017.07.048_bib97","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000089625","article-title":"Lead exposure as a risk factor for amyotrophic lateral sclerosis","volume":"2","author":"Kamel","year":"2005","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.envres.2017.07.048_bib98","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1600-0404.1989.tb03803.x","article-title":"Zinc, copper and magnesium concentration in serum and CSF of patients with neurological disorders","volume":"79","author":"Kapaki","year":"1989","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.envres.2017.07.048_bib99","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0022-510X(96)05334-8","article-title":"Essential trace element alterations in amyotrophic lateral sclerosis","volume":"147","author":"Kapaki","year":"1997","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1037\/a0013757","article-title":"Association of cumulative lead and neurocognitive function in an occupational cohort","volume":"23","author":"Khalil","year":"2009","journal-title":"Neuropsychology"},{"key":"10.1016\/j.envres.2017.07.048_bib101","doi-asserted-by":"crossref","DOI":"10.1186\/s12877-016-0342-y","article-title":"Environmental risk factors for dementia: a systematic review","volume":"16","author":"Killin","year":"2016","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.envres.2017.07.048_bib102","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1001\/jama.1977.03270530051023","article-title":"Amyotrophic lateral sclerosis in a high selenium environment","volume":"237","author":"Kilness","year":"1977","journal-title":"JAMA"},{"key":"10.1016\/j.envres.2017.07.048_bib103","series-title":"Casarett and Doull\u2019s Toxicology \u2013 The Basic Science of Poisons","author":"Klaassen","year":"2013"},{"key":"10.1016\/j.envres.2017.07.048_bib104","first-page":"1095","article-title":"Hair aluminium in normal aged and senile dementia of Alzheimer type","volume":"317","author":"Kobayashi","year":"1989","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib105","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3906\/sag-1407-67","article-title":"A comparison of hair and serum trace elements in patients with Alzheimer disease and healthy participants","volume":"45","author":"Ko\u00e7","year":"2015","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib106","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/1874609811104010042","article-title":"A high accumulation of hair minerals in Mongolian people: 2(nd) report; influence of manganese, iron, lead, cadmium and aluminum to oxidative stress, Parkinsonism and arthritis","volume":"4","author":"Komatsu","year":"2011","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib107","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jtemb.2016.09.002","article-title":"Trace metal concentrations in hair and nails from Alzheimer\u2019s disease patients: relations with clinical severity","volume":"39","author":"Koseoglu","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.envres.2017.07.048_bib108","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12011-014-9930-x","article-title":"Evaluation of selenium, redox status and their association with plasma amyloid\/tau in Alzheimer\u2019s disease","volume":"158","author":"Krishnan","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib109","first-page":"121","article-title":"Association of Parkinson\u2019s disease with altered serum levels of lead and transition metals among South Indian subjects","volume":"51","author":"Kumudini","year":"2014","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.envres.2017.07.048_bib110","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2217\/epi.10.43","article-title":"Role of epigenetics in Alzheimer\u2019s and Parkinson\u2019s disease","volume":"2","author":"Kwok","year":"2010","journal-title":"Epigenomics"},{"key":"10.1016\/j.envres.2017.07.048_bib111","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/mp.2009.82","article-title":"The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases","volume":"14","author":"Lahiri","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.envres.2017.07.048_bib112","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1353-8020(01)00054-2","article-title":"Occupational and environmental risk factors for Parkinson\u2019s disease","volume":"8","author":"Lai","year":"2002","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.envres.2017.07.048_bib113","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000330538","article-title":"Reduced serum caeruloplasmin levels in non-wilsonian movement disorders","volume":"66","author":"Ling","year":"2011","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib114","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/bmj.4.5627.387-d","article-title":"Chronic lead intoxication mimicking motor neurone disease","volume":"4","author":"Livesley","year":"1968","journal-title":"Br. Med. J."},{"key":"10.1016\/j.envres.2017.07.048_bib115","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3233\/JAD-2011-110414","article-title":"Selenium and Alzheimer\u2019s disease: a systematic review","volume":"26","author":"Loef","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envres.2017.07.048_bib116","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3233\/JAD-2012-121528","article-title":"Oxidative stress in Alzheimer\u2019s disease and mild cognitive impairment with high sensitivity and specificity","volume":"33","author":"L\u00f3pez","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envres.2017.07.048_bib117","first-page":"1049","article-title":"The effect of sodium selenite on cattle","volume":"21","author":"Maag","year":"1960","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib118","first-page":"1","article-title":"Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia","volume":"43","author":"Maeda","year":"1997","journal-title":"Osaka City Med. J."},{"key":"10.1016\/j.envres.2017.07.048_bib119","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.neurobiolaging.2012.05.015","article-title":"Fe and Cu do not differ in Parkinson\u2019s disease: a replication study plus meta-analysis","volume":"34","author":"Mariani","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.envres.2017.07.048_bib120","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer\u2019s disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"issue":"106","key":"10.1016\/j.envres.2017.07.048_bib121","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s007020050160","article-title":"Cerebrospinal fluid levels of selenium in patients with Alzheimer\u2019s disease","volume":"1996","author":"Meseguer","year":"1999","journal-title":"J. Neural Transm. Vienna Austria"},{"issue":"Suppl. 1","key":"10.1016\/j.envres.2017.07.048_bib122","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0167-4943(96)86910-X","article-title":"Determination of selected trace elements in patients affected by dementia","volume":"22","author":"Molaschi","year":"1996","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"105","key":"10.1016\/j.envres.2017.07.048_bib123","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s007020050071","article-title":"Cerebrospinal fluid levels of transition metals in patients with Alzheimer\u2019s disease","volume":"1996","author":"Molina","year":"1998","journal-title":"J. Neural Transm. Vienna Austria"},{"key":"10.1016\/j.envres.2017.07.048_bib124","doi-asserted-by":"crossref","first-page":"147251","DOI":"10.1155\/2014\/147251","article-title":"Copper and copper proteins in Parkinson\u2019s disease","volume":"2014","author":"Montes","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.envres.2017.07.048_bib125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0022-510X(93)90243-R","article-title":"Mercury and selenium contents in amyotrophic lateral sclerosis in Hokkaido, the northernmost island of Japan","volume":"118","author":"Moriwaka","year":"1993","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib126","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1212\/WNL.0b013e3182698ced","article-title":"Associations of welding and manganese exposure with Parkinson disease: review and meta-analysis","volume":"79","author":"Mortimer","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib127","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.3892\/mmr.2017.6386","article-title":"Iron and Parkinson's disease: a systematic review and meta-analysis","volume":"15","author":"Mostile","year":"2017","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.envres.2017.07.048_bib128","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3233\/JAD-2010-100705","article-title":"Does inorganic mercury play a role in Alzheimer\u2019s disease? A systematic review and an integrated molecular mechanism","volume":"22","author":"Mutter","year":"2010","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.envres.2017.07.048_bib129","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0022-510X(85)90113-3","article-title":"Heavy metal concentrations in blood cells in patients with amyotrophic lateral sclerosis","volume":"67","author":"Nagata","year":"1985","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000110175","article-title":"Epidemiologic study on the association between body burden mercury level and idiopathic Parkinson\u2019s disease","volume":"8","author":"Ngim","year":"1989","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.envres.2017.07.048_bib131","doi-asserted-by":"crossref","first-page":"e74259","DOI":"10.1371\/journal.pone.0074259","article-title":"Multiple Sclerosis in the Mount Etna region: possible role of volcanogenic trace elements","volume":"8","author":"Nicoletti","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2017.07.048_bib132","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/ene.12973","article-title":"The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region: a possible pathogenic role of volcanogenic metals","volume":"23","author":"Nicoletti","year":"2016","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib133","first-page":"69","article-title":"Bone aluminium content in Alzheimer\u2019s disease","volume":"6","author":"O\u2019Mahony","year":"1995","journal-title":"Dementia Basel Switz."},{"key":"10.1016\/j.envres.2017.07.048_bib134","first-page":"28","article-title":"Malondialdehyde, superoxide dismutase, melatonin, iron, copper, and zinc blood concentrations in patients with Alzheimer disease: cross-sectional study","volume":"43","author":"Ozcankaya","year":"2002","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.envres.2017.07.048_bib135","doi-asserted-by":"crossref","first-page":"22769","DOI":"10.1038\/srep22769","article-title":"Distinctive pattern of serum elements during the progression of Alzheimer\u2019s disease","volume":"6","author":"Paglia","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2017.07.048_bib136","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0140-6736(87)90827-0","article-title":"Raised cerebrospinal-fluid copper concentration in Parkinson\u2019s disease","volume":"2","author":"Pall","year":"1987","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.envres.2017.07.048_bib137","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1177\/1533317513506778","article-title":"Serum trace metal levels in Alzheimer\u2019s disease and normal control groups","volume":"29","author":"Park","year":"2014","journal-title":"Am. J. Alzheimers Dis. Dementias\u00ae"},{"key":"10.1016\/j.envres.2017.07.048_bib138","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuro.2016.03.022","article-title":"Blood levels of trace metals and amyotrophic lateral sclerosis","volume":"54","author":"Peters","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2017.07.048_bib139","first-page":"102","article-title":"Repeat study of antecedent events in motor neuron disease","volume":"13","author":"Pierce-Ruhland","year":"1981","journal-title":"Ann. Clin. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib140","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ajhg.2012.01.017","article-title":"Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease","volume":"90","author":"Quadri","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.envres.2017.07.048_bib141","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-3-211-33328-0_24","article-title":"Impact of selenium, iron, copper and zinc in on\/off Parkinson\u2019s patients on L-dopa therapy","author":"Qureshi","year":"2006","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.envres.2017.07.048_bib142","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1212\/WNL.0000000000003533","article-title":"Dose-dependent progression of parkinsonism in manganese-exposed welders","volume":"88","author":"Racette","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib143","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3233\/JAD-121474","article-title":"Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer\u2019s disease","volume":"34","author":"Rembach","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envres.2017.07.048_bib144","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.expneurol.2008.08.017","article-title":"Effects of oral aluminum exposure on behavior and neurogenesis in a transgenic mouse model of Alzheimer's disease","volume":"214","author":"Ribes","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib145","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1258\/ebm.2012.011396","article-title":"Manganese in cerebrospinal fluid and blood plasma of patients with amyotrophic lateral sclerosis","volume":"237","author":"Roos","year":"2012","journal-title":"Exp. Biol. Med. Maywood NJ"},{"key":"10.1016\/j.envres.2017.07.048_bib146","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12011-012-9547-x","article-title":"Metal concentrations in cerebrospinal fluid and blood plasma from patients with amyotrophic lateral sclerosis","volume":"151","author":"Roos","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib147","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000026222","article-title":"A family history of Parkinson\u2019s disease and its effect on other PD risk factors","volume":"18","author":"Rybicki","year":"1999","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.envres.2017.07.048_bib148","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1136\/oem.2006.028209","article-title":"Occupational risk factors in Alzheimer\u2019s disease: a review assessing the quality of published epidemiological studies","volume":"64","author":"Santibanez","year":"2007","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib149","first-page":"1271","article-title":"Trends in motor neuron disease: association with latitude and air lead levels in Spain","volume":"37","author":"Santurt\u00fan","year":"2016","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"10.1016\/j.envres.2017.07.048_bib150","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/jnnp.60.6.698","article-title":"Amyotrophic lateral sclerosis after accidental injection of mercury","volume":"60","author":"Schwarz","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.envres.2017.07.048_bib151","first-page":"107","article-title":"A study of serum copper and ceruloplasmin in Alzheimer\u2019s disease in Kerman, Iran","volume":"11","author":"Sedighi","year":"2006","journal-title":"Neurology Asia"},{"key":"10.1016\/j.envres.2017.07.048_bib152","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1212\/WNL.46.5.1275","article-title":"Possible environmental, occupational, and other etiologic factors for Parkinson\u2019s disease: a case-control study in Germany","volume":"46","author":"Seidler","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib153","article-title":"Can serum levels of copper and zinc distinguish Alzheimer\u2019s patients from normal subjects?","volume":"24","author":"Sevim","year":"2007","journal-title":"J. Neurol. Sci. Turk."},{"key":"10.1016\/j.envres.2017.07.048_bib154","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3233\/JAD-140153","article-title":"Positive relationship between mortality from Alzheimer\u2019s disease and soil metal concentration in mainland China","volume":"42","author":"Shen","year":"2014","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.envres.2017.07.048_bib155","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1532-5415.1984.tb00889.x","article-title":"Hair and serum copper, zinc, calcium, and magnesium concentrations in Alzheimer-type dementia","volume":"32","author":"Shore","year":"1984","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.envres.2017.07.048_bib156","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/archneur.1990.00530010046017","article-title":"Amyotrophic lateral sclerosis. A case-control study following detection of a cluster in a small Wisconsin community","volume":"47","author":"Sienko","year":"1990","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib157","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/0891988714522698","article-title":"Polymorphism in cytochrome P450 2D6, glutathione s-transferases Pi 1 genes, and organochlorine pesticides in Alzheimer disease: a case\u2013control study in North Indian population","volume":"27","author":"Singh","year":"2014","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib158","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/oem.53.1.32","article-title":"Effects on the nervous system among welders exposed to aluminium and manganese","volume":"53","author":"Sj\u00f6gren","year":"1996","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib159","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/JAD-2010-1239","article-title":"Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment","volume":"19","author":"Smith","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envres.2017.07.048_bib160","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.archger.2004.04.050","article-title":"Trace elements and cognitive impairment: an elderly cohort study","volume":"38","author":"Smorgon","year":"2004","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.envres.2017.07.048_bib161","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000017067","article-title":"Copper, ceruloplasmin and superoxide dismutase in patients with Alzheimer\u2019s disease. A case-control study","volume":"9","author":"Snaedal","year":"1998","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.envres.2017.07.048_bib162","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1212\/WNL.59.8.1153","article-title":"Elevation of serum copper levels in Alzheimer\u2019s disease","volume":"59","author":"Squitti","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib163","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1212\/01.WNL.0000154531.79362.23","article-title":"Excess of serum copper not related to ceruloplasmin in Alzheimer disease","volume":"64","author":"Squitti","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib164","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1212\/01.wnl.0000223343.82809.cf","article-title":"Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF \u03b2-amyloid, and h-tau","volume":"67","author":"Squitti","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.envres.2017.07.048_bib165","first-page":"294","article-title":"Dismetabolismo dei metalu e stress ossidativo in pazienti con in parkinson\u2019s disease di un\u2019area industriale esposta ad inquinamento da metalli","volume":"29","author":"Squitti","year":"2007","journal-title":"G. Ital. Med. Lav. Ergon."},{"key":"10.1016\/j.envres.2017.07.048_bib166","first-page":"205","article-title":"Ceruloplasmin (2-D PAGE) pattern and copper content in serum and brain of Alzheimer disease patients","volume":"1","author":"Squitti","year":"2007","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.envres.2017.07.048_bib167","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s00702-007-0777-6","article-title":"\u201cFree\u201d copper in serum of Alzheimer\u2019s disease patients correlates with markers of liver function","volume":"114","author":"Squitti","year":"2007","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.envres.2017.07.048_bib168","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4161\/pri.2.1.6297","article-title":"Ceruloplasmin fragmentation is implicated in \u201cfree\u201d copper deregulation of Alzheimer\u2019s disease","volume":"2","author":"Squitti","year":"2008","journal-title":"Prion"},{"key":"10.1016\/j.envres.2017.07.048_bib169","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s12017-013-8237-y","article-title":"ATP7B variants as modulators of copper dyshomeostasis in Alzheimer\u2019s disease","volume":"15","author":"Squitti","year":"2013","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.envres.2017.07.048_bib170","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ana.24136","article-title":"Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease: copper and MCI conversion","volume":"75","author":"Squitti","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib171","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3233\/JAD-131247","article-title":"Meta-analysis of serum non-ceruloplasmin copper in Alzheimer\u2019s disease","volume":"38","author":"Squitti","year":"2014","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.envres.2017.07.048_bib172","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.abb.2013.02.021","article-title":"Selenium homeostasis and antioxidant selenoproteins in brain: implications for disorders in the central nervous system","volume":"536","author":"Steinbrenner","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.envres.2017.07.048_bib173","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1001\/archneur.1996.00550080044011","article-title":"Amyotrophic lateral sclerosis and occupational history. A pilot case-control study","volume":"53","author":"Strickland","year":"1996","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.envres.2017.07.048_bib174","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0197-4580(91)90001-Z","article-title":"Calcium and phosphorus levels in serum and CSF in dementia","volume":"12","author":"Subhash","year":"1991","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.envres.2017.07.048_bib175","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3143\/geriatrics.31.865","article-title":"Trace elements analysis of serum and cerebrospinal fluid with PIXE--effect of age and changes in parkinsonian patients","volume":"31","author":"Takahashi","year":"1994","journal-title":"Nihon Ronen Igakkai Zasshi Jpn. J. Geriatr."},{"key":"10.1016\/j.envres.2017.07.048_bib176","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1159\/000330467","article-title":"Ceruloplasmin and iron proteins in the serum of patients with Alzheimer\u2019s disease","volume":"1","author":"Torsdottir","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord. Extra"},{"key":"10.1016\/j.envres.2017.07.048_bib177","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-0773.1999.tb02015.x","article-title":"Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson\u2019s disease","volume":"85","author":"T\u00f3rsd\u00f3ttir","year":"1999","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.envres.2017.07.048_bib178","doi-asserted-by":"crossref","first-page":"15286","DOI":"10.3390\/ijms140815286","article-title":"Exposure to environmental toxicants and pathogenesis of amyotrophic lateral sclerosis: state of the art and research perspectives","volume":"14","author":"Trojsi","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib179","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1093\/hmg\/ddt572","article-title":"Zn2+ dyshomeostasis caused by loss of ATP13A2\/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation","volume":"23","author":"Tsunemi","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.envres.2017.07.048_bib180","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/B978-0-12-410502-7.00013-2","article-title":"Manganese and the brain","volume":"110","author":"Tuschl","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.envres.2017.07.048_bib181","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2174\/0929867053764635","article-title":"Metals, toxicity and oxidative stress","volume":"12","author":"Valko","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.envres.2017.07.048_bib182","first-page":"197","article-title":"Trace element imbalances in hair and nails of Alzheimer\u2019s disease patients","volume":"9","author":"Vance","year":"1988","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2017.07.048_bib183","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00001648-199609000-00014","article-title":"Amyotrophic lateral sclerosis after long-term exposure to drinking water with high selenium content","volume":"7","author":"Vinceti","year":"1996","journal-title":"Epidemiology Camb. Mass"},{"key":"10.1016\/j.envres.2017.07.048_bib184","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01999568","article-title":"Lead, cadmium, and selenium in the blood of patients with sporadic amyotrophic lateral sclerosis","volume":"18","author":"Vinceti","year":"1997","journal-title":"Ital. J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib185","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0895-4356(00)00233-X","article-title":"Mortality in a population with long-term exposure to inorganic selenium via drinking water","volume":"53","author":"Vinceti","year":"2000","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.envres.2017.07.048_bib186","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neuro.2013.05.016","article-title":"Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite","volume":"38","author":"Vinceti","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2017.07.048_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2016.12.012","article-title":"Lead, cadmium and mercury in cerebrospinal fluid and risk of amyotrophic lateral sclerosis: a case-control study","author":"Vinceti","year":"2017","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. GMS"},{"key":"10.1016\/j.envres.2017.07.048_bib188","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12011-008-8291-8","article-title":"The role of arginine\u2013nitric oxide pathway in patients with Alzheimer disease","volume":"129","author":"Vural","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib189","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jtemb.2010.02.002","article-title":"Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer\u2019s disease","volume":"24","author":"Vural","year":"2010","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.envres.2017.07.048_bib190","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.jinorgbio.2009.07.027","article-title":"APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer\u2019s disease","volume":"103","author":"Walton","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.envres.2017.07.048_bib191","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1097\/JOM.0000000000000323","article-title":"A meta-analysis of observational studies of the association between chronic occupational exposure to lead and amyotrophic lateral sclerosis","volume":"56","author":"Wang","year":"2014","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib192","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3233\/JAD-143108","article-title":"Serum iron, zinc, and copper levels in patients with Alzheimer\u2019s Disease: a replication study and meta-analyses","volume":"47","author":"Wang","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.envres.2017.07.048_bib193","unstructured":"World Alzheimer Report, 2015. The Global Impact of Dementia | Alzheimer\u2019s Disease International, 2015 URL \u3008https:\/\/www.alz.co.uk\/research\/world-report-2015\u3009 (Accessed 2 June 2017)."},{"key":"10.1016\/j.envres.2017.07.048_bib194","first-page":"402","article-title":"Serum copper, zinc and selenium levels in Tunisian patients with Parkinson\u2019s disease","volume":"91","author":"Younes-Mhenni","year":"2013","journal-title":"Tunis. Med."},{"key":"10.1016\/j.envres.2017.07.048_bib195","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF02790122","article-title":"Serum aluminum levels in Alzheimer\u2019s disease and other senile dementias","volume":"47","author":"Zapatero","year":"1995","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envres.2017.07.048_bib196","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.brainres.2008.03.066","article-title":"An observational study on the influence of the APOE-\u03b54 allele on the correlation between \u201cfree\u201d copper toxicosis and EEG activity in Alzheimer disease","volume":"1215","author":"Zappasodi","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.envres.2017.07.048_bib197","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1017\/S0317167100030584","article-title":"Environmental factors in the etiology of Parkinson\u2019s disease","volume":"17","author":"Zayed","year":"1990","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.envres.2017.07.048_bib198","doi-asserted-by":"crossref","first-page":"e83060","DOI":"10.1371\/journal.pone.0083060","article-title":"Assessing plasma levels of selenium, copper, iron and zinc in patients of Parkinson\u2019s disease","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935117312240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935117312240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T15:50:09Z","timestamp":1750780209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935117312240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":198,"alternative-id":["S0013935117312240"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2017.07.048","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metals and neurodegenerative diseases. A systematic review","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2017.07.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}