{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:09:06Z","timestamp":1790662146821,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["03FH026I3 TETRACELL"],"award-info":[{"award-number":["03FH026I3 TETRACELL"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.envres.2017.12.007","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T11:01:56Z","timestamp":1513681316000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Terrestrial Trunked Radio (TETRA) exposure of neuronal in vitro networks"],"prefix":"10.1016","volume":"162","author":[{"given":"Tim","family":"K\u00f6hler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"W\u00f6lfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ciba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Bochtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Thielemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2017.12.007_bib1","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1109\/TMTT.2013.2250298","article-title":"Feasibility for microwaves energy to affect biological systems via nonthermal mechanisms: a systematic approach","volume":"61","author":"Apollonio","year":"2013","journal-title":"IEEE Trans. Microw. Theory Tech."},{"key":"10.1016\/j.envres.2017.12.007_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2006.05.028","article-title":"Spontaneous neuronal discharge patterns in developing organotypic mega-co-cultures of neonatal rat cerebral cortex","volume":"1101","author":"Baker","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.envres.2017.12.007_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/bem.20333","article-title":"The effect of GSM and TETRA mobile handset signals on blood pressure, catechol levels and heart rate variability","volume":"28","author":"Barker","year":"2007","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib4","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1073\/pnas.73.6.1999","article-title":"Sensitivity of calcium binding in cerebral tissue to weak environmental electric fields oscillating at low frequency","volume":"73","author":"Bawin","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.envres.2017.12.007_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/bem.2250010104","article-title":"Induction of calcium-ion efflux from brain tissue by radiofrequency radiation: effect of sample number and modulation frequency on the power-density window","volume":"1","author":"Blackman","year":"1980","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib6","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/09553008614551211","article-title":"The effects of low-level radiofrequency and microwave radiation on brain tissue and animal behaviour","volume":"50","author":"Blackwell","year":"1986","journal-title":"Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med."},{"key":"10.1016\/j.envres.2017.12.007_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.envres.2016.06.031","article-title":"Acute Exposure to Terrestrial Trunked Radio (TETRA) has effects on the electroencephalogram and electrocardiogram, consistent with vagal nerve stimulation","volume":"150","author":"Burgess","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2017.12.007_bib8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2006.03.049","article-title":"Dissociated cortical networks show spontaneously correlated activity patterns during in vitro development","volume":"1093","author":"Chiappalone","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.envres.2017.12.007_bib9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.envres.2015.09.022","article-title":"Terrestrial Trunked Radio (TETRA) exposure and its impact on slow cortical potentials","volume":"143","author":"Eggert","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2017.12.007_bib10","unstructured":"European Telecommunications Standards Institute, 2002. Technical Specification ETSI TS 100 392-15 V1.2.1 (2002-04)."},{"key":"10.1016\/j.envres.2017.12.007_bib11","unstructured":"European Telecommunications Standards Institute, 2005. Technical Report ETSI TR 102 491 V1.1.1 (2005-06) European Telecommunications Standards Institute."},{"key":"10.1016\/j.envres.2017.12.007_bib12","unstructured":"European Telecommunications Standards Institute, 2006. Technical Report ETSI TR 102 513 V1.1.1 (2006-12)."},{"key":"10.1016\/j.envres.2017.12.007_bib13","unstructured":"European Telecommunications Standards Institute, 2010. EN 300 392-2 V3.4.1 Terrestrial Trunked Radio (TETRA); Voice plus Data (V+D); Part 2: Air Interface (AI)."},{"key":"10.1016\/j.envres.2017.12.007_bib14","unstructured":"Federal Communications Commission, 1996. Guidelines for Evaluating the Environmental Effects of Radiofrequency Radiation."},{"key":"10.1016\/j.envres.2017.12.007_bib15","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.medengphy.2013.04.009","article-title":"TETRA mobile radios interfere with electroencephalography recording equipment","volume":"35","author":"Fouquet","year":"2013","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.envres.2017.12.007_bib16","first-page":"1140","article-title":"Auditory system response to radio frequency energy","volume":"32","author":"Frey","year":"1961","journal-title":"Tech. Note Aerosp. Med."},{"key":"10.1016\/j.envres.2017.12.007_bib17","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1080\/09553000600555389","article-title":"An investigation of the effects of TETRA RF fields on intracellular calcium in neurones and cardiac myocytes","volume":"81","author":"Green","year":"2005","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.envres.2017.12.007_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0168-0102(93)90076-3","article-title":"Formation and maturation of synapses in primary cultures of rat cerebral cortical cells: an electron microscopic study","volume":"16","author":"Ichikawa","year":"1993","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.envres.2017.12.007_bib19","unstructured":"Independent Advisory Group on Non-ionising Radiation, 2012. RCE-20: health effects from radiofrequency electromagnetic fields. Documents of the Health Protection Agency Radiation, Chemical and Environmental Hazards. Public Health England."},{"key":"10.1016\/j.envres.2017.12.007_bib20","first-page":"494","article-title":"Guidelines for limiting exposure to time-varying electric, magnetic and electromagnetic fields (up to 300GHz)","volume":"74","author":"International Commission on Non-Ionizing Radiation Protection","year":"1998","journal-title":"HEALTH Phys."},{"key":"10.1016\/j.envres.2017.12.007_bib21","first-page":"494","article-title":"Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300GHz)","volume":"74","author":"International Commission on Non\u2010Ionizing Radiation Protection","year":"1998","journal-title":"Health Phys."},{"key":"10.1016\/j.envres.2017.12.007_bib22","unstructured":"International Telecommunication Union, 2016. Measuring the Information Society Report."},{"key":"10.1016\/j.envres.2017.12.007_bib23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0302-4598(99)00083-5","article-title":"Propagation of spontaneous synchronized activity in cortical slice cultures recorded by planar electrode arrays","volume":"51","author":"Jimbo","year":"2000","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.envres.2017.12.007_bib24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bem.20652","article-title":"Review of possible modulation-dependent biological effects of radiofrequency fields","volume":"32","author":"Juutilainen","year":"2011","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib25","unstructured":"GmbH, KaiTec, 2014. TETRA-TMO 2022-A Autarke Basisstation f\u00fcr die Objektversorgung."},{"key":"10.1016\/j.envres.2017.12.007_bib26","series-title":"Experimental EMF Exposure Assessment","author":"K\u00fchn","year":"2006"},{"key":"10.1016\/j.envres.2017.12.007_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuro.2013.11.008","article-title":"Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes","volume":"40","author":"Mack","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envres.2017.12.007_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/15368378.2015.1092158","article-title":"Effect of radiofrequency radiation in cultured mammalian cells: a review","volume":"35","author":"Manna","year":"2016","journal-title":"Electromagn. Biol. Med."},{"key":"10.1016\/j.envres.2017.12.007_bib29","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.bios.2004.09.012","article-title":"In vitro cortical neuronal networks as a new high-sensitive system for biosensing applications","volume":"20","author":"Martinoia","year":"2004","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.envres.2017.12.007_bib30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1109\/TMTT.2010.2100404","article-title":"Real-time RF exposure setup based on a Multiple Electrode Array (MEA) for electrophysiological recording of neuronal networks","volume":"59","author":"Merla","year":"2011","journal-title":"IEEE Trans. Microw. Theory Tech."},{"key":"10.1016\/j.envres.2017.12.007_bib31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/bem.2250030411","article-title":"Attempts to alter 45Ca2+ binding to brain tissue with pulse-modulated microwave energy","volume":"3","author":"Merritt","year":"1982","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib32","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/bem.21805","article-title":"In-vitro exposure of neuronal networks to the GSM-1800 signal","volume":"34","author":"Moretti","year":"2013","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib33","unstructured":"Multi Channel Systems MCS GmbH, 2016. Microelectrode Array (MEA) Manual."},{"key":"10.1016\/j.envres.2017.12.007_bib34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0149-7634(81)90021-X","article-title":"Radiation and brain calcium: a review and critique","volume":"5","author":"Myers","year":"1981","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.envres.2017.12.007_bib35","unstructured":"National Radiological Protection Board, 2001. Possible Health Effects from Terrestrial Trunked Radio (TETRA). In: A. G. o. N.-i. Radiation, (Ed.), Vol. 12."},{"key":"10.1016\/j.envres.2017.12.007_bib36","first-page":"96","article-title":"DrCell \u2013 A software tool for the analysis of cell signals recorded with extracellular microelectrodes","volume":"7","author":"Nick","year":"2013","journal-title":"Signal Process.: Int. J."},{"key":"10.1016\/j.envres.2017.12.007_bib37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/oem.2010.055889","article-title":"Can exposure to a terrestrial trunked radio (TETRA)-like signal cause symptoms? A randomised double-blind provocation study","volume":"68","author":"Nieto-Hernandez","year":"2011","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.envres.2017.12.007_bib38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/bem.21974","article-title":"Long-term electromagnetic exposure of developing neuronal networks: a flexible experimental setup","volume":"37","author":"Oster","year":"2016","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.telpol.2015.11.004","article-title":"Can you hear me now? The rise of smartphones and their welfare effects","volume":"40","author":"Rennhoff","year":"2016","journal-title":"Telecommun. Policy"},{"key":"10.1016\/j.envres.2017.12.007_bib40","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/bem.20571","article-title":"No effect of TETRA hand portable transmission signals on human cognitive function and symptoms","volume":"31","author":"Riddervold","year":"2010","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.envres.2015.03.021","article-title":"Do signals of a hand-held TETRA transmitter affect cognitive performance, well-being, mood or somatic complaints in healthy young men? Results of a randomized double-blind cross-over provocation study","volume":"140","author":"Sauter","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2017.12.007_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/bem.21895","article-title":"The discrepancy between maximum in vitro exposure levels and realistic conservative exposure levels of mobile phones operating at 900\/1800MHz","volume":"36","author":"Schmid","year":"2015","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib43","first-page":"52","article-title":"In vitro exposure systems for RF exposures at 900 MHz","author":"Schuderer","year":"2004","journal-title":"IEEE Trans. Microw. Theory Tech."},{"key":"10.1016\/j.envres.2017.12.007_bib44","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0956-5663(03)00267-7","article-title":"Measuring synchronization in neuronal networks for biosensor applications","volume":"19","author":"Selinger","year":"2004","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.envres.2017.12.007_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/bem.2250020207","article-title":"In vitro study of microwave effects on calcium efflux in rat brain tissue","volume":"2","author":"Shelton","year":"1981","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib46","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/01.HP.0000319903.20660.37","article-title":"Quantitative evaluations of mechanisms of radiofrequency interactions with biological molecules and processes","volume":"95","author":"Sheppard","year":"2008","journal-title":"Health Phys."},{"key":"10.1016\/j.envres.2017.12.007_bib47","first-page":"13","article-title":"Quality matters: systematic analysis of endpoints related to \"Cellular Life\" in vitro data of radiofrequency electromagnetic field exposure","author":"Simko","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envres.2017.12.007_bib48","unstructured":"The European Parliament and of the Council, 2013. Directive 2013\/35\/EU."},{"key":"10.1016\/j.envres.2017.12.007_bib49","unstructured":"Thermo Fisher Scientific Corporation, 2014. Protocol: Primary Rat Cortex and Hippocampus Neurons."},{"key":"10.1016\/j.envres.2017.12.007_bib50","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/bem.20323","article-title":"Neurophysiological effects of mobile phone electromagnetic fields on humans: a comprehensive review","volume":"28","author":"Valentini","year":"2007","journal-title":"Bioelectromagnetics"},{"key":"10.1016\/j.envres.2017.12.007_bib51","first-page":"147","article-title":"Dynamics and plasticity in developing neuronal networks in vitro","author":"Van Pelt","year":"2005","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.envres.2017.12.007_bib52","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1289\/ehp.0901416","article-title":"Do TETRA (Airwave) base station signals have a short-term impact on health and well-being? A randomized double-blind provocation study","volume":"118","author":"Wallace","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2017.12.007_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/bem.20681","article-title":"Cognitive and physiological responses in humans exposed to a TETRA base station signal in relation to perceived electromagnetic hypersensitivity","volume":"33","author":"Wallace","year":"2012","journal-title":"Bioelectromagnetics"}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935117317310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935117317310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T20:55:56Z","timestamp":1655499356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935117317310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":53,"alternative-id":["S0013935117317310"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2017.12.007","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Terrestrial Trunked Radio (TETRA) exposure of neuronal in vitro networks","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2017.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}