{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:41:34Z","timestamp":1791232894387,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 ES019217"],"award-info":[{"award-number":["RO1 ES019217"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P42 ES023716"],"award-info":[{"award-number":["P42 ES023716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.envres.2019.108890","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T19:42:05Z","timestamp":1572896525000},"page":"108890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"special_numbering":"C","title":["Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation"],"prefix":"10.1016","volume":"180","author":[{"given":"Daniel W.","family":"Riggs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagma","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathya","family":"Krishnasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Yeager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shesh N.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruni","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"O'Toole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2019.108890_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/CIRCRESAHA.107.164970","article-title":"Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress","volume":"102","author":"Araujo","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.envres.2019.108890_bib2","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.RES.0000243586.99701.cf","article-title":"Environmental cardiology: studying mechanistic links between pollution and heart disease","volume":"99","author":"Bhatnagar","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.envres.2019.108890_bib3","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.envres.2015.05.012","volume":"140","author":"Calderon-Garciduenas","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2019.108890_bib4","first-page":"243","article-title":"A systematic review of the relation between long-term exposure to ambient air pollution and chronic diseases","volume":"23","author":"Chen","year":"2008","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.envres.2019.108890_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/CIRCULATIONAHA.113.003532","article-title":"Spatial association between ambient fine particulate matter and incident hypertension","volume":"129","author":"Chen","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.envres.2019.108890_bib6","doi-asserted-by":"crossref","DOI":"10.1289\/EHP2311","article-title":"Concentrated ambient PM2.5-induced inflammation and endothelial dysfunction in a murine model of neural IKK2 deficiency","volume":"126","author":"Chen","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2019.108890_bib7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.envres.2016.04.008","article-title":"Occupational vehicle-related particulate exposure and inflammatory markers in trucking industry workers","volume":"148","author":"Chiu","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2019.108890_bib8","article-title":"Particulate matter exposure and health impacts of urban cyclists: a randomized crossover study","volume":"17","author":"Cole","year":"2018","journal-title":"Environ. Health Glob."},{"key":"10.1016\/j.envres.2019.108890_bib9","doi-asserted-by":"crossref","first-page":"868","DOI":"10.7150\/ijbs.19868","article-title":"Exposure to concentrated ambient fine particulate matter induces vascular endothelial dysfunction via miR-21","volume":"13","author":"Dai","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.envres.2019.108890_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tiv.2017.07.001","article-title":"Involvement of oxidative stress and calcium signaling in airborne particulate matter - induced damages in human pulmonary artery endothelial cells","volume":"45","author":"Deweirdt","year":"2017","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.envres.2019.108890_bib11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3945\/ajcn.112.034918","article-title":"Major metabolite of F2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself","volume":"96","author":"Dorjgochoo","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.envres.2019.108890_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113677","article-title":"Augmented backward elimination: a pragmatic and purposeful way to develop statistical models","volume":"9","author":"Dunkler","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2019.108890_bib13","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/ATVBAHA.117.310305","article-title":"Particulate matter air pollution and racial differences in cardiovascular disease risk","volume":"38","author":"Erqou","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.envres.2019.108890_bib14","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1289\/ehp.1104206","article-title":"Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow","volume":"120","author":"Haberzettl","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2019.108890_bib15","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1289\/EHP212","article-title":"Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress","volume":"124","author":"Haberzettl","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2019.108890_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/ATVBAHA.117.309971","article-title":"Inhalation of fine particulate matter impairs endothelial progenitor cell function via pulmonary oxidative stress","volume":"38","author":"Haberzettl","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.envres.2019.108890_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/md17010061","article-title":"Effect of fermented fish oil on fine particulate matter-induced skin aging","volume":"17","author":"Hyun","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.envres.2019.108890_bib18","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/CIRCRESAHA.110.237560","article-title":"Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways","volume":"108","author":"Kampfrath","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.envres.2019.108890_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11883-017-0678-6","article-title":"Oxidative stress in atherosclerosis","volume":"19","author":"Kattoor","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.envres.2019.108890_bib20","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/j.jacc.2012.08.973","article-title":"Vascular responses to long- and short-term exposure to fine particulate matter: MESA Air (Multi-Ethnic Study of Atherosclerosis and air pollution)","volume":"60","author":"Krishnan","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.envres.2019.108890_bib21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1289\/ehp.7523","article-title":"Ambient air pollution and atherosclerosis in Los Angeles","volume":"113","author":"Kunzli","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2019.108890_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002742","article-title":"Short-Term exposure to air pollution and biomarkers of oxidative stress: the framingham heart study","volume":"5","author":"Li","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.envres.2019.108890_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002270","article-title":"Prognostic value of flow-mediated vasodilation in brachial artery and fingertip artery for cardiovascular events: a systematic review and meta-analysis","volume":"4","author":"Matsuzawa","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.envres.2019.108890_bib24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nprot.2006.375","article-title":"Quantification of F2-isoprostanes as a biomarker of oxidative stress","volume":"2","author":"Milne","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.envres.2019.108890_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/01.ATV.0000152605.64964.c0","article-title":"Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans","volume":"25","author":"Morrow","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.envres.2019.108890_bib26","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1161\/CIRCULATIONAHA.104.517110","article-title":"Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function","volume":"111","author":"O'Neill","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.envres.2019.108890_bib27","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/CIRCRESAHA.110.222679","article-title":"Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells","volume":"107","author":"O'Toole","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.envres.2019.108890_bib28","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/JOM.0000000000001437","article-title":"Experimental woodsmoke exposure during exercise and blood oxidative stress","volume":"60","author":"Peters","year":"2018","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.envres.2019.108890_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/01.CIR.0000108927.80044.7F","article-title":"Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease","volume":"109","author":"Pope","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.envres.2019.108890_bib30","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1161\/CIRCULATIONAHA.106.636977","article-title":"Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution","volume":"114","author":"Pope","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.envres.2019.108890_bib31","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.116.309279","article-title":"Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation","volume":"119","author":"Pope","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.envres.2019.108890_bib32","first-page":"23","article-title":"Oxidative and nitrosative stress markers in bus drivers","volume":"617","author":"Rossner","year":"2007","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envres.2019.108890_bib33","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1289\/ehp.11666","article-title":"Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals","volume":"116","author":"Schneider","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2019.108890_bib34","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1001\/jama.294.23.3003","article-title":"Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model","volume":"294","author":"Sun","year":"2005","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.envres.2019.108890_bib35","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/CIRCULATIONAHA.108.799015","article-title":"Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity","volume":"119","author":"Sun","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.envres.2019.108890_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198813","article-title":"Exposure to PM2.5 via vascular endothelial growth factor relationship: meta-analysis","volume":"13","author":"Sun","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2019.108890_bib37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tox.2017.05.008","article-title":"Diesel exhaust particles contribute to endothelia apoptosis via autophagy pathway","volume":"156","author":"Wang","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2019.108890_bib38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1476-069X-10-45","article-title":"Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study","volume":"10","author":"Wilker","year":"2011","journal-title":"Environ. Health"},{"key":"10.1016\/j.envres.2019.108890_bib39","series-title":"Ambient Air Pollution: a Global Assessment of Exposure and Burden of Disease","author":"World Health Organization","year":"2016"},{"key":"10.1016\/j.envres.2019.108890_bib40","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/1354750X.2017.1306753","article-title":"Determination of air pollution-related biomarkers of exposure in urine of travellers between Germany and China using liquid chromatographic and liquid chromatographic-mass spectrometric methods: a pilot study","volume":"22","author":"Wu","year":"2017","journal-title":"Biomarkers"},{"key":"10.1016\/j.envres.2019.108890_bib41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/toxsci\/kfr211","article-title":"Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue","volume":"124","author":"Xu","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.envres.2019.108890_bib42","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.118.313948","article-title":"Extreme levels of air pollution associated with changes in biomarkers of atherosclerotic plaque vulnerability and thrombogenicity in healthy adults: the beijing AIRCHD study","volume":"124","author":"Xu","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.envres.2019.108890_bib43","doi-asserted-by":"crossref","first-page":"36136","DOI":"10.1007\/s11356-018-3492-y","article-title":"Effect of PM2.5 environmental pollution on rat lung","volume":"25","author":"Yang","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2019.108890_bib44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/toxsci\/kfp004","article-title":"Ambient particulates alter vascular function through induction of reactive oxygen and nitrogen species","volume":"111","author":"Ying","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2019.108890_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205851","article-title":"Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction","volume":"13","author":"Zafar","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2019.108890_bib46","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1289\/ehp.1206136","article-title":"Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: a repeated-measures study","volume":"122","author":"Zanobetti","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2019.108890_bib47","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/tox.22200","article-title":"Inflammatory response and endothelial dysfunction in the hearts of mice co-exposed to SO2 , NO2 , and PM2.5","volume":"31","author":"Zhang","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envres.2019.108890_bib48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12940-016-0157-5","article-title":"Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential","volume":"15","author":"Zhang","year":"2016","journal-title":"Environ. Health"},{"key":"10.1016\/j.envres.2019.108890_bib49","article-title":"PM2.5 induced the expression of fibrogenic mediators via HMGB1-RAGE signaling in human airway epithelial cells","volume":"2018","author":"Zou","year":"2018","journal-title":"Can. Respir. J."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935119306875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935119306875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:40:06Z","timestamp":1777390806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935119306875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":49,"alternative-id":["S0013935119306875"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2019.108890","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2019.108890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108890"}}