{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:02:10Z","timestamp":1780088530001,"version":"3.54.0"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2014 SGR 1012"],"award-info":[{"award-number":["2014 SGR 1012"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017 SGR 439"],"award-info":[{"award-number":["2017 SGR 439"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R35 CA197735"],"award-info":[{"award-number":["R35 CA197735"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004435","name":"Association for International Cancer Research","doi-asserted-by":"publisher","award":["AICR09-0780"],"award-info":[{"award-number":["AICR09-0780"]}],"id":[{"id":"10.13039\/100004435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["20132910"],"award-info":[{"award-number":["20132910"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.envres.2020.109781","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T01:57:03Z","timestamp":1591840623000},"page":"109781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma"],"prefix":"10.1016","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-7428","authenticated-orcid":false,"given":"Miquel","family":"Porta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Pumarega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 F.S.","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine M.","family":"Genkinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorelei","family":"Mucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Alguacil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Gasull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Ogino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2020.109781_bib1","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/S2542-5196(19)30010-5","article-title":"Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort","volume":"3","author":"Agier","year":"2019","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.envres.2020.109781_bib2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nrendo.2011.56","article-title":"Endocrine disruptors in the etiology of type 2 diabetes","volume":"7","author":"Alonso-Magdalena","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.envres.2020.109781_bib3","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1136\/gutjnl-2011-301086","article-title":"Pancreatic cancer risk and levels of trace elements","volume":"61","author":"Amaral","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.envres.2020.109781_bib4","doi-asserted-by":"crossref","unstructured":"Armitage, P., Berry, G., Matthews, J.N.S., 2002. Statistical methods in medical research, 4th ed. Oxford: Blackwell.","DOI":"10.1002\/9780470773666"},{"key":"10.1016\/j.envres.2020.109781_bib5","first-page":"1583","article-title":"Exposure to environmental chemicals and heavy metals, and risk of pancreatic cancer","volume":"26","author":"Antwi","year":"2015","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.envres.2020.109781_bib6","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1007\/s00204-016-1821-9","article-title":"Environmental risk factors for pancreatic cancer: an update","volume":"90","author":"Barone","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envres.2020.109781_bib7","doi-asserted-by":"crossref","unstructured":"Benetou, V., Ekbom, A., Mucci, L., 2018. Pancreatic cancer. In: Adami, H.O., Hunter, D.J., Lagiou, P., Mucci, L., eds. Textbook of cancer epidemiology. 3rd. edition. New York: Oxford University Press.","DOI":"10.1093\/oso\/9780190676827.003.0013"},{"key":"10.1016\/j.envres.2020.109781_bib8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1053\/j.gastro.2018.09.022","article-title":"Circulating nucleic acids are associated with outcomes of patients with pancreatic cancer","volume":"156","author":"Bernard","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.envres.2020.109781_bib9","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.chemosphere.2007.02.043","article-title":"Calculation of body \u201ctotal lipid\u201d concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples","volume":"68","author":"Bernert","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.109781_bib10","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.2217\/fon.15.98","article-title":"KRAS mutation status is associated with specific pattern of genes expression in pancreatic adenocarcinoma","volume":"11","author":"Bittoni","year":"2015","journal-title":"Future Oncol"},{"issue":"6","key":"10.1016\/j.envres.2020.109781_bib11","doi-asserted-by":"crossref","first-page":"E852","DOI":"10.3390\/cancers11060852","article-title":"Liquid biopsy approach for pancreatic ductal adenocarcinoma","volume":"11","author":"Buscail","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.envres.2020.109781_bib12","doi-asserted-by":"crossref","first-page":"20769","DOI":"10.1074\/jbc.C112.364620","article-title":"Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine","volume":"287","author":"Boldogh","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.envres.2020.109781_bib13","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1373\/clinchem.2016.257469","article-title":"Detection of KRAS mutations in circulating tumor DNA by digital PCR in early stages of pancreatic cancer","volume":"62","author":"Brychta","year":"2016","journal-title":"Clin. Chem."},{"key":"10.1016\/j.envres.2020.109781_bib14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.envint.2019.03.037","article-title":"Toenail concentrations of trace elements and occupational history in pancreatic cancer","volume":"127","author":"Camargo","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2020.109781_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12029-015-9724-1","article-title":"A\u00a0systematic review of the burden of pancreatic cancer in Europe: Real-world impact on survival, quality of life and costs","volume":"46","author":"Carrato","year":"2015","journal-title":"J.\u00a0Gastrointest. Cancer"},{"key":"10.1016\/j.envres.2020.109781_bib16","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1158\/1055-9965.EPI-07-0332","article-title":"Distinctive heavy metal composition of pancreatic juice in patients with pancreatic carcinoma","volume":"16","author":"Carrigan","year":"2007","journal-title":"Cancer Epidemiol. Biomarkers Prev"},{"key":"10.1016\/j.envres.2020.109781_bib17","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/carcin\/bgl063","article-title":"Kras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12","volume":"27","author":"C\u00e9spedes","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envres.2020.109781_bib18","doi-asserted-by":"crossref","first-page":"7665","DOI":"10.1007\/s11356-018-04105-x","article-title":"Co-exposure to environmental endocrine disruptors in the US population","volume":"26","author":"Chen","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2020.109781_bib19","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1039\/c2mt20033c","article-title":"Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium","volume":"4","author":"Chervona","year":"2012","journal-title":"Metallomics"},{"key":"10.1016\/j.envres.2020.109781_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nm.2344","article-title":"Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy","volume":"17","author":"Collisson","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.envres.2020.109781_bib21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1158\/2159-8290.CD-11-0347","article-title":"A\u00a0central role for RAF\u2192MEK\u2192ERK signaling in the genesis of pancreatic ductal adenocarcinoma","volume":"2","author":"Collisson","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.envres.2020.109781_bib22","unstructured":"Crous-Bou, M., 2009. Clinical and environmental influences on the prevalence of mutations in the Kras oncogene in patients with pancreatic ductal adenocarcinoma [Doctoral dissertation]. Barcelona: Universitat Aut\u00f2noma de Barcelona. In Catalan & English. Available: http:\/\/www.imim.es\/programesrecerca\/epidemiologia\/en_documentsgrecm.html accessed 24 October 2019."},{"key":"10.1016\/j.envres.2020.109781_bib23","unstructured":"Department of Health and Human Services, 2019. National Report on Human Exposure to Environmental Chemicals. Updated Tables, January 2019. Atlanta: Centers for Disease Control and Prevention. Available: http:\/\/www.cdc.gov\/exposurereport\/index.html accessed 24 October 2019."},{"key":"10.1016\/j.envres.2020.109781_bib24","first-page":"97","article-title":"Mutant KRAS in the initiation of pancreatic cancer","volume":"1756","author":"Deramaudt","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"16","key":"10.1016\/j.envres.2020.109781_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16162952","article-title":"Blood cadmium level is associated with short progression-free survival in nasopharyngeal carcinoma","volume":"16","author":"Du","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envres.2020.109781_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/jnci\/djp041","article-title":"Perfluorooctanoate and perfluorooctanesulfonate plasma levels and risk of cancer in the general Danish population","volume":"101","author":"Eriksen","year":"2009","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.envres.2020.109781_bib27","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/bjc.2014.215","article-title":"Oncogenic KRAS signalling in pancreatic cancer","volume":"111","author":"Eser","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.envres.2020.109781_bib28","first-page":"79","article-title":"Evaluation of trace elements in pancreatic cancer patients in Iran","volume":"4","author":"Farzin","year":"2013","journal-title":"Middle East J Cancer"},{"issue":"10","key":"10.1016\/j.envres.2020.109781_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001117","article-title":"STrengthening the Reporting of OBservational studies in Epidemiology \u2013 Molecular Epidemiology (STROBE-ME)","volume":"8","author":"Gallo","year":"2011","journal-title":"PLoS Medicine"},{"key":"10.1016\/j.envres.2020.109781_bib30","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/aje\/kwx267","article-title":"Blood concentrations of persistent organic pollutants and unhealthy metabolic phenotypes in normal-weight, overweight, and obese individuals","volume":"187","author":"Gasull","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envres.2020.109781_bib31","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.chemosphere.2010.03.011","article-title":"The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer","volume":"79","author":"Gasull","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.109781_bib32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.envres.2018.11.027","article-title":"Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort","volume":"169","author":"Gasull","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2020.109781_bib33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.canep.2012.12.002","article-title":"The prognostic role of time to diagnosis and presenting symptoms in patients with pancreatic cancer","volume":"37","author":"Gobbi","year":"2013","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.envres.2020.109781_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jtemb.2015.03.001","article-title":"Essential metals profile of the hair and nails of patients with laryngeal cancer","volume":"31","author":"Golasik","year":"2015","journal-title":"J.\u00a0Trace Elem. Med. Biol."},{"key":"10.1016\/j.envres.2020.109781_bib35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/em.22296","article-title":"Concentrations of trace elements and KRAS mutations in pancreatic ductal adenocarcinoma","volume":"60","author":"G\u00f3mez-Tom\u00e1s","year":"2019","journal-title":"Environ. Molec. Mutag."},{"key":"10.1016\/j.envres.2020.109781_bib36","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.envres.2020.109781_bib37","unstructured":"Goyer, R.A., Clarkson, T.W., 2001. Toxic effects of metals. In: Klaassen CD, editor. Casarett and Doull\u2019s Toxicology: The basic science of poisons. New York: McGraw Hill, pp 861\u2013867."},{"key":"10.1016\/j.envres.2020.109781_bib38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.biopha.2007.04.006","article-title":"Decreased survival in pancreatic cancer patients with high concentrations of organochlorines in adipose tissue","volume":"61","author":"Hardell","year":"2007","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.envres.2020.109781_bib39","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s10534-010-9330-4","article-title":"Mechanisms in cadmium-induced carcinogenicity: recent insights","volume":"23","author":"Hartwig","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.envres.2020.109781_bib40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2362.2010.02373.x","article-title":"Trace elements in nails as biomarkers in clinical research","volume":"41","author":"He","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.envres.2020.109781_bib41","doi-asserted-by":"crossref","first-page":"28055","DOI":"10.1007\/s11356-017-0412-5","article-title":"Blood cadmium levels associated with short distant metastasis-free survival time in invasive breast cancer","volume":"24","author":"He","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2020.109781_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jech.2008.083881","article-title":"Adverse health effects of environmental chemical agents through non-genotoxic mechanisms","volume":"65","author":"Henkler","year":"2011","journal-title":"J.\u00a0Epidemiol. Community Health"},{"key":"10.1016\/j.envres.2020.109781_bib43","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3390\/cancers2020376","article-title":"The role of oxidative stress in carcinogenesis induced by metals and xenobiotics","volume":"2","author":"Henkler","year":"2010","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.envres.2020.109781_bib44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.mrrev.2009.07.002","article-title":"Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach","volume":"682","author":"Hern\u00e1ndez","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envres.2020.109781_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1047-2797(01)00250-2","article-title":"Potential for selection bias with tumor tissue retrieval in molecular epidemiology studies","volume":"12","author":"Hoppin","year":"2002","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.envres.2020.109781_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0048-9697(77)90018-3","article-title":"The biological bases for using hair and nail for analyses of trace elements","volume":"7","author":"Hopps","year":"1977","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2020.109781_bib47","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/gutjnl-2017-314828","article-title":"Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations","volume":"68","author":"Huang","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.envres.2020.109781_bib50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1289\/ehp.8035","article-title":"Serum cadmium levels in pancreatic cancer patients from the East Nile Delta region of Egypt","volume":"114","author":"Kriegel","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2020.109781_bib51","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/JOM.0b013e31821854da","article-title":"Toenail, blood and urine as biomarkers of manganese exposure","volume":"53","author":"Laohaudomchok","year":"2011","journal-title":"J.\u00a0Occup. Environ. Med."},{"key":"10.1016\/j.envres.2020.109781_bib52","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1210\/er.2013-1084","article-title":"Chlorinated persistent organic pollutants, obesity, and type 2 diabetes","volume":"35","author":"Lee","year":"2014","journal-title":"Endocr. Reviews"},{"key":"10.1016\/j.envres.2020.109781_bib53","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4143\/crt.2015.282","article-title":"Serum concentrations of selenium and copper in patients diagnosed with pancreatic cancer","volume":"48","author":"Lener","year":"2016","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.envres.2020.109781_bib54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.chemosphere.2014.04.066","article-title":"Adjusting serum concentrations of organochlorine compounds by lipids and symptoms: a causal framework for the association with K-ras mutations in pancreatic cancer","volume":"114","author":"L\u00f3pez","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envres.2020.109781_bib55","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jclinepi.2012.12.018","article-title":"Time from (clinical or certainty) diagnosis to treatment onset in cancer patients: the choice of diagnostic date strongly influences differences in therapeutic delay by tumor site and stage","volume":"66","author":"Maci\u00e0","year":"2013","journal-title":"J.\u00a0Clin. Epidemiol."},{"key":"10.1016\/j.envres.2020.109781_bib56","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.ijheh.2017.01.015","article-title":"The impacts of emission trends of POPs on human concentration dynamics: Lessons learned from a longitudinal study in Norway (1979-2007)","volume":"220","author":"N\u00f8st","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envres.2020.109781_bib57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mrgentox.2013.03.008","article-title":"Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water","volume":"754","author":"O'Brien","year":"2013","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envres.2020.109781_bib58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejca.2015.11.023","article-title":"Polychlorinated biphenyls and their association with survival following breast cancer","volume":"56","author":"Parada","year":"2016","journal-title":"Eur. J. Cancer."},{"key":"10.1016\/j.envres.2020.109781_bib59","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/ijc.29806","article-title":"Organochlorine insecticides DDT and chlordane in relation to survival following breast cancer","volume":"138","author":"Parada","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.envres.2020.109781_bib60","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.envint.2019.01.032","article-title":"Plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) and survival following breast cancer in the Carolina Breast Cancer Study","volume":"125","author":"Parada","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2020.109781_bib61","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1365-2362.2011.02495.x","article-title":"How useful is it clinically to analyse the K-ras mutational status for the diagnosis of exocrine pancreatic cancer? A systematic review and meta-analysis","volume":"41","author":"Parker","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.envres.2020.109781_bib62","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10654-011-9547-8","article-title":"Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients","volume":"26","author":"Parker","year":"2011","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.envres.2020.109781_bib63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/toxsci\/kft190","article-title":"Temporal changes in K-ras mutant fraction in lung tissue of big blue B6C3F\u2081 mice exposed to ethylene oxide","volume":"136","author":"Parsons","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envres.2020.109781_bib64","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2217\/pme.13.1","article-title":"KRAS mutant tumor subpopulations can subvert durable responses to personalized cancer treatments","volume":"10","author":"Parsons","year":"2013","journal-title":"Per. Med."},{"key":"10.1016\/j.envres.2020.109781_bib65","first-page":"231","article-title":"Development of exposome correlation globes to map out environment-wide associations","author":"Patel","year":"2015","journal-title":"Pac. Symp. Biocomput. 2015"},{"key":"10.1016\/j.envres.2020.109781_bib66","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/BF01055015","article-title":"Chlorinated hydrocarbon concentrations in human body: effects of fasting and feeding","volume":"18","author":"Phillips","year":"1989","journal-title":"Arch Environ. Contam. Toxicol."},{"key":"10.1016\/j.envres.2020.109781_bib67","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00001648-200103000-00024","article-title":"Role of organochlorine compounds in the etiology of pancreatic cancer: a proposal to develop methodological standards","volume":"12","author":"Porta","year":"2001","journal-title":"Epidemiology"},{"key":"10.1016\/j.envres.2020.109781_bib68","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0140-6736(06)69174-5","article-title":"Persistent organic pollutants and the burden of diabetes","volume":"368","author":"Porta","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.envres.2020.109781_bib69","doi-asserted-by":"crossref","first-page":"14560","DOI":"10.1007\/s11356-014-3460-0","article-title":"Human contamination by persistent toxic substances: the rationale to improve exposure assessment","volume":"22","author":"Porta","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envres.2020.109781_bib70","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1023\/A:1007692408457","article-title":"Validity of the hospital discharge diagnosis in epidemiologic studies of biliopancreatic pathology","volume":"16","author":"Porta","year":"2000","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.envres.2020.109781_bib71","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mrrev.2009.07.003","article-title":"Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes","volume":"682","author":"Porta","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envres.2020.109781_bib74","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/mutage\/gep037","article-title":"In pancreatic ductal adenocarcinoma blood concentrations of some organochlorine compounds and coffee intake are independently associated with KRAS mutations","volume":"24","author":"Porta","year":"2009","journal-title":"Mutagenesis"},{"key":"10.1016\/j.envres.2020.109781_bib72","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF02712816","article-title":"Exocrine pancreatic cancer: symptoms at presentation and their relation to tumour site and stage","volume":"7","author":"Porta","year":"2005","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.envres.2020.109781_bib73","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jclinepi.2007.08.013","article-title":"Exocrine pancreatic cancer clinical factors were related to timing of blood extraction and influenced serum concentrations of lipids","volume":"61","author":"Porta","year":"2008","journal-title":"J.\u00a0Clin. Epidemiol."},{"key":"10.1016\/j.envres.2020.109781_bib75","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/S0140-6736(99)04232-4","article-title":"Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer","volume":"354","author":"Porta","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.envres.2020.109781_bib76","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/jech.56.10.734","article-title":"Incomplete overlapping of biological, clinical and environmental information in molecular epidemiologic studies: a variety of causes and a cascade of consequences","volume":"56","author":"Porta","year":"2002","journal-title":"J.\u00a0Epidemiol. Community Health"},{"key":"10.1016\/j.envres.2020.109781_bib77","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/1354750X.2012.701331","article-title":"Relationships of hepatic and pancreatic biomarkers with the cholestatic syndrome and tumor stage in pancreatic cancer","volume":"17","author":"Porta","year":"2012","journal-title":"Biomarkers"},{"key":"10.1016\/j.envres.2020.109781_bib78","first-page":"1893","article-title":"Influence of tumor stage, symptoms and time of blood draw on serum concentrations of organochlorine compounds in exocrine pancreatic cancer","volume":"20","author":"Porta","year":"2009","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.envres.2020.109781_bib79","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jclinepi.2019.03.009","article-title":"There are good clinical, scientific, and social reasons to strengthen links between biomedical and environmental research","volume":"111","author":"Porta","year":"2019","journal-title":"J.\u00a0Clin. Epidemiol."},{"key":"10.1016\/j.envres.2020.109781_bib80","unstructured":"Puigdef\u00e0bregas, A., Freitas, A., Molina, P., Gibert, A., Zaragoza, S., Ribas, G., et\u00a0al., 2013. Impacte del canvi de documents i circuits per comunicar les defuncions. Butllet\u00ed Epidemiol\u00f2gic de Catalunya Volum XXXIV, Gener 2013, N\u00famero 1. http:\/\/canalsalut.gencat.cat\/web\/.content\/_Actualitat\/Butlletins\/Promocio_proteccio_salut\/bec_butlleti_epidemiologic_de_catalunya\/2013\/bec_gener_2013.pdf, accessed 24 October 2019."},{"key":"10.1016\/j.envres.2020.109781_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160432","article-title":"Number of Persistent Organic Pollutants Detected at High Concentrations in Blood Samples of the United States Population","volume":"11","author":"Pumarega","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.envres.2020.109781_bib82","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2017.3420","article-title":"Association of alterations in main driver genes with outcomes of patients with resected pancreatic ductal adenocarcinoma","volume":"4","author":"Qian","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.envres.2020.109781_bib83","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1289\/ehp.1104236","article-title":"Understanding differences in the body burden-age relationships of bioaccumulating contaminants based on population cross sections versus individuals","volume":"120","author":"Quinn","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2020.109781_bib84","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1289\/ehp.1002415","article-title":"Investigating intergenerational differences in human PCB exposure due to variable emissions and reproductive behaviors","volume":"119","author":"Quinn","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2020.109781_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060870","article-title":"Somatic mutations in exocrine pancreatic tumors: association with patient survival","volume":"8","author":"Rachakonda","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.envres.2020.109781_bib86","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3892\/or.2013.2285","article-title":"ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium","volume":"29","author":"Rizzato","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.envres.2020.109781_bib87","unstructured":"Robertson, L.W., Hansen, L.G. (Eds), 2001. PCBs. Recent advances in environmental toxicology and health effects. Lexington, Kentucky: The University Press of Kentucky."},{"key":"10.1016\/j.envres.2020.109781_bib88","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.envres.2016.12.011","article-title":"Exposure to multiple chemicals in a cohort of reproductive-aged Danish women","volume":"154","author":"Rosofsky","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2020.109781_bib89","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.envres.2018.02.003","article-title":"Organochlorine concentrations in adipose tissue and survival in postmenopausal, Danish breast cancer patients","volume":"163","author":"Roswall","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2020.109781_bib90","doi-asserted-by":"crossref","first-page":"41064","DOI":"10.1038\/srep41064","article-title":"Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes","volume":"7","author":"Schlitter","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2020.109781_bib91","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0962-8924(00)01740-2","article-title":"Understanding Ras: 'it ain't over 'til it's over'","volume":"10","author":"Shields","year":"2000","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.envres.2020.109781_bib92","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.envres.2005.12.001","article-title":"Validity of human nails as a biomarker of arsenic and selenium exposure: a review","volume":"102","author":"Slotnick","year":"2006","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2020.109781_bib93","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/15287390600755232","article-title":"Toenails as a biomarker of inorganic arsenic intake from drinking water and foods","volume":"70","author":"Slotnick","year":"2007","journal-title":"J.\u00a0Toxicol. Environ. Health A."},{"key":"10.1016\/j.envres.2020.109781_bib94","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1023\/A:1026635005363","article-title":"Medical conditions in patients with pancreatic and biliary diseases: validity and agreement between data from questionnaires and medical records","volume":"44","author":"Soler","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.envres.2020.109781_bib95","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/jech.2010.130690","article-title":"Epigenetics and environmental exposures","volume":"66","author":"Stein","year":"2012","journal-title":"J.\u00a0Epidemiol. Community Health"},{"key":"10.1016\/j.envres.2020.109781_bib96","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1470-2045(09)70134-2","article-title":"A\u00a0review of human carcinogens\u2013part C: metals, arsenic, dusts, and fibres","volume":"10","author":"Straif","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.envres.2020.109781_bib97","doi-asserted-by":"crossref","first-page":"18425","DOI":"10.1038\/srep18425","article-title":"Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer","volume":"5","author":"Takai","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envres.2020.109781_bib98","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.envint.2018.11.067","article-title":"The early-life exposome: Description and patterns in six European countries","volume":"123","author":"Tamayo-Uria","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2020.109781_bib99","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.6004\/jnccn.2017.0131","article-title":"Pancreatic adenocarcinoma, version 2.2017, NCCN Clinical Practice Guidelines in Oncology","volume":"15","author":"Tempero","year":"2017","journal-title":"J.\u00a0Natl. Compr. Canc. Netw."},{"key":"10.1016\/j.envres.2020.109781_bib100","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic doses responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envres.2020.109781_bib101","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature14169","article-title":"Whole genomes redefine the mutational landscape of pancreatic cancer","volume":"518","author":"Waddell","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.envres.2020.109781_bib102","doi-asserted-by":"crossref","first-page":"a031435","DOI":"10.1101\/cshperspect.a031435","article-title":"KRAS: the critical driver and therapeutic target for pancreatic cancer","volume":"8","author":"Waters","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.envres.2020.109781_bib103","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3200\/AEOH.59.8.400-409","article-title":"Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community","volume":"59","author":"Wickre","year":"2004","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.envres.2020.109781_bib104","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1289\/ehp.1205248","article-title":"Persistent organic pollutants and type 2 diabetes: A prospective analysis in the Nurses' Health Study and meta-analysis","volume":"121","author":"Wu","year":"2013","journal-title":"Environ. Health Perspect."}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935120306745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935120306745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:42:44Z","timestamp":1779727364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935120306745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":102,"alternative-id":["S0013935120306745"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2020.109781","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2020.109781","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109781"}}