{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:09:16Z","timestamp":1780646956507,"version":"3.54.1"},"update-to":[{"DOI":"10.1016\/j.envres.2020.110190","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000}}],"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.envres.2020.110190","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T02:32:41Z","timestamp":1599791561000},"page":"110190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["RETRACTED: Association between prenatal exposure to ambient particulate matter and risk of hypospadias in offspring: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"192","author":[{"given":"Hua-Chuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Min","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envres.2020.110190_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1538-7836.2007.02300.x","article-title":"Effects of exposure to air pollution on blood coagulation","volume":"5","author":"Baccarelli","year":"2007","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.envres.2020.110190_bib2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s004410000345","article-title":"Urethral seam formation and hypospadias","volume":"305","author":"Baskin","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.envres.2020.110190_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/bdra.23021","article-title":"Environmental and genetic contributors to hypospadias: a review of the epidemiologic evidence","volume":"94","author":"Carmichael","year":"2012","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"10.1016\/j.envres.2020.110190_bib4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12940-017-0291-8","article-title":"Does air pollution play a role in infertility?: a systematic review","volume":"16","author":"Carre","year":"2017","journal-title":"Environ. Health"},{"key":"10.1016\/j.envres.2020.110190_bib5","first-page":"82","article-title":"Does air pollution play a role in infertility?: a systematic review","volume":"16","author":"Carr\u00e9","year":"2017","journal-title":"Environ Health-Glob."},{"key":"10.1016\/j.envres.2020.110190_bib6","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0140-6736(18)32225-6","volume":"392","author":"Collaborators","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.envres.2020.110190_bib7","first-page":"713652","article-title":"Endocrine-disrupting chemicals: associated disorders and mechanisms of action","author":"De Coster","year":"2012","journal-title":"Journal of Environmental and Public Health. 2012"},{"key":"10.1016\/j.envres.2020.110190_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Contr. Clin. Trials"},{"key":"10.1016\/j.envres.2020.110190_bib9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.envres.2020.110190_bib10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.envres.2020.110190_bib11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fonc.2019.00458","article-title":"Observational studies on the association between post-diagnostic metformin use and survival in ovarian cancer: a systematic review and meta-analysis","volume":"9","author":"Gong","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.envres.2020.110190_bib12","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.envres.2020.110190_bib13","first-page":"165","article-title":"Prenatal diagnosis of congenital renal and urinary tract malformations","volume":"3","author":"Hindryckx","year":"2011","journal-title":"Facts, Views & Vision in ObGyn."},{"key":"10.1016\/j.envres.2020.110190_bib14","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ijheh.2015.03.007","article-title":"Exposure misclassification due to residential mobility during pregnancy","volume":"218","author":"Hodgson","year":"2015","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2020.110190_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ije\/dyr154","article-title":"Environmental chemical exposures and human epigenetics","volume":"41","author":"Hou","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envres.2020.110190_bib16","doi-asserted-by":"crossref","first-page":"109151","DOI":"10.1016\/j.envres.2020.109151","article-title":"Periconceptional exposure to air pollution and congenital hypospadias among full-term infants","volume":"183","author":"Huang","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2020.110190_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201903490","article-title":"Heterojunction architecture of N-doped WO3 nanobundles with Ce2S3 nanodots hybridized on a carbon textile enables a highly efficient flexible photocatalyst","volume":"29","author":"Huang","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.envres.2020.110190_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.envpol.2007.06.012","article-title":"Human health effects of air pollution","volume":"151","author":"Kampa","year":"2008","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110190_bib19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.fertnstert.2013.11.128","article-title":"The effect of 5alpha-reductase-2 deficiency on human fertility","volume":"101","author":"Kang","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.envres.2020.110190_bib20","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1289\/ehp.9081","article-title":"Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential effect modification by nutrition","volume":"114","author":"Kannan","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2020.110190_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014944","article-title":"Cumulative lifetime burden of cardiovascular disease from early exposure to air pollution","volume":"9","author":"Kim","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.envres.2020.110190_bib22","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"62","author":"Liberati","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.envres.2020.110190_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0301-2115(99)00196-7","article-title":"Congenital anomalies are an independent risk factor for neonatal morbidity and perinatal mortality in preterm birth","volume":"90","author":"Linhart","year":"2000","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.envres.2020.110190_bib24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fpubh.2020.00014","article-title":"Environmental and health impacts of air pollution: a review","volume":"8","author":"Manisalidis","year":"2020","journal-title":"Frontiers in Public Health"},{"key":"10.1016\/j.envres.2020.110190_bib25","article-title":"Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta-analysis","volume":"354","author":"Odutayo","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.envres.2020.110190_bib26","series-title":"Birth defects in South-East Asia: a public health challenge: situation analysis","author":"Organization","year":"2013"},{"key":"10.1016\/j.envres.2020.110190_bib27","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/bdra.23175","article-title":"Traffic-related air pollution and selected birth defects in the San Joaquin Valley of California","volume":"97","author":"Padula","year":"2013","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.envres.2020.110190_bib28","doi-asserted-by":"crossref","first-page":"104845","DOI":"10.1016\/j.envint.2019.05.039","article-title":"Risk of congenital anomalies near municipal waste incinerators in England and Scotland: retrospective population-based cohort study","volume":"134","author":"Parkes","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envres.2020.110190_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jpeds.2017.09.076","article-title":"Periconception exposure to air pollution and risk of congenital malformations","volume":"193","author":"Ren","year":"2018","journal-title":"J. Pediatr."},{"key":"10.1016\/j.envres.2020.110190_bib30","series-title":"World Health Organization ROfSEA. New Delhi: WHO; 2013. in","article-title":"Birth defects in South-East Asia e a public health challenge","author":"ROfSEA","year":"2013"},{"key":"10.1016\/j.envres.2020.110190_bib31","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ijheh.2018.07.008","article-title":"The association of air pollution with congenital anomalies: an exploratory study in the northern Netherlands","volume":"221","author":"Salavati","year":"2018","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2020.110190_bib32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1289\/ehp.1306802","article-title":"Traffic-related air pollution and congenital anomalies in Barcelona","volume":"122","author":"Schembari","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2020.110190_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jpurol.2015.12.002","article-title":"Worldwide prevalence of hypospadias","volume":"12","author":"Springer","year":"2016","journal-title":"J. Pediatr. Urol."},{"key":"10.1016\/j.envres.2020.110190_bib34","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00431-017-2864-5","article-title":"Hypospadias, all there is to know","volume":"176","author":"van der Horst","year":"2017","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.envres.2020.110190_bib35","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.scitotenv.2015.09.051","article-title":"Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study","volume":"541","author":"Vinceti","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envres.2020.110190_bib36","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/bdra.23159","article-title":"Early prenatal exposure to air pollution and its associations with birth defects in a state-wide birth cohort from North Carolina","volume":"97","author":"Vinikoor-Imler","year":"2013","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.envres.2020.110190_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2015.03.001","article-title":"An exploratory analysis of the relationship between ambient ozone and particulate matter concentrations during early pregnancy and selected birth defects in Texas","volume":"202","author":"Vinikoor-Imler","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envres.2020.110190_bib38","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1289\/ehp.1002946","article-title":"Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis","volume":"119","author":"Vrijheid","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envres.2020.110190_bib39","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/pubmed\/fdy137","article-title":"Association between early prenatal exposure to ambient air pollution and birth defects: evidence from newborns in Xi\u2019an, China","volume":"41","author":"Wang","year":"2019","journal-title":"J Public Health-Uk"},{"key":"10.1016\/j.envres.2020.110190_bib40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.envres.2018.03.034","article-title":"Lung cancer and particulate pollution: a critical review of spatial and temporal analysis evidence","volume":"164","author":"Wang","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envres.2020.110190_bib41","series-title":"Symposium on Systematic Reviews: beyond the Basics","article-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","author":"WELLS","year":"2000"},{"key":"10.1016\/j.envres.2020.110190_bib42","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.lfs.2017.11.039","article-title":"Is testicular dysgenesis syndrome a genetic, endocrine, or environmental disease, or an unexplained reproductive disorder?","volume":"194","author":"Xing","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.envres.2020.110190_bib43","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.eururo.2019.06.027","article-title":"Hypospadias prevalence and trends in international birth defect surveillance systems, 1980-2010","volume":"76","author":"Yu","year":"2019","journal-title":"Eur. Urol."},{"key":"10.1016\/j.envres.2020.110190_bib44","doi-asserted-by":"crossref","first-page":"113453","DOI":"10.1016\/j.ijheh.2020.113453","article-title":"Association between maternal exposure to ambient PM10 and neural tube defects: a case-control study in Liaoning Province, China","volume":"225","author":"Zhang","year":"2020","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.envres.2020.110190_bib45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ecoenv.2019.06.039","article-title":"Prenatal ambient air pollution exposure and SOD2 promoter methylation in maternal and cord blood","volume":"181","author":"Zhou","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."}],"updated-by":[{"DOI":"10.1016\/j.envres.2020.110190","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000}},{"DOI":"10.1016\/j.envres.2026.124854","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Environmental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935120310872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0013935120310872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T16:48:15Z","timestamp":1779468495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0013935120310872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":45,"alternative-id":["S0013935120310872"],"URL":"https:\/\/doi.org\/10.1016\/j.envres.2020.110190","relation":{},"ISSN":["0013-9351"],"issn-type":[{"value":"0013-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Association between prenatal exposure to ambient particulate matter and risk of hypospadias in offspring: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Environmental Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envres.2020.110190","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110190"}}